Conserved Protein Domain Family
TonB-tbp-lbp

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TIGR01776: TonB-tbp-lbp 
TonB-dependent lactoferrin and transferrin receptors
This family of TonB-dependent receptors are responsible for import of iron from the mammalian iron carriers lactoferrin and transferrin across the outer membrane. These receptors are found only in bacteria which can infect mammals such as Moraxella, Mannheimia, Neisseria, Actinobacillus, Pasteurella, Haemophilus and Histophilus species. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]
Statistics
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PSSM-Id: 273799
Aligned: 7 rows
Threshold Bit Score: 956.576
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAC31366   17 TTHRLNLAIKAALFGVAVLPLsvwaqentqtdansdakdtKTPVVYLDAITVTAAPSApvSRFDTDVTGLGKTVKTADTL 96   Moraxella catarrh...
CAA90896    1 MKNKLNLISLALLSLFAVQSY-------------------AEQAVQLNDVYVTGTKKKa-HKKENEVTGLGKVVKTPDSL 60   Actinobacillus pl...
AAB93473    4 KYHHFRYSPVALTVLFALSHSygaate-------nkkieeNNDLAVLDEVIVTESHYA--HERQNEVTGLGKVVKNYHEM 74   Mannheimia haemol...
Q06987      3 QQHLFRLNILCLSLMTALPvyaen------------vqaeQAQEKQLDTIQVKAKKQK--TRRDNEVTGLGKLVKSSDTL 68   Neisseria meningi...
AAN27377   13 SKQVLKLSALSLGLLNITQVAlanttad-----kaeatdkTNLVVVLDETVVTAKKN---ARKANEVTGLGKVVKTAETI 84  
Q06379      3 KKHGFPLTLTALAIATAFPayaaqa---------ggatpdAAQTQSLKEITVRAAKV---GRRSKEATGLGKIVKTSETL 70   Neisseria meningi...
AAG15587   17 KYCVIHQLVLSGSLIFPTLSFadsds----------tkttPNKASYLEEISVVATTVQ--HIFSST--------QSTEQL 76   Pasteurella multo...
AAC31366   97 AKEQVQGIRDLVRYETGVSVVEQGRGGSSGFAIHGVDKNRVGITVDGIAQIQSYKDESTKRag---aGSGAMNEIEIENI 173  Moraxella catarrh...
CAA90896   61 SKEQVLGMRDLTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQIQSYVSQYSRS------SSGAINEIEYENL 134  Actinobacillus pl...
AAB93473   75 SKNQILGIRDLTRYDPGISVVEQGRGASSGYAIRGVDKNRVSLLVDGLPQAHSYHTLGSDA------NGGAINEIEYENI 148  Mannheimia haemol...
Q06987     69 SKEQVLNIRDLTRYDPGIAVVEQGRGASSGYSIRGMDKNRVSLTVDGVSQIQSYTAQAALGgtrtagSSGAINEIEYENV 148  Neisseria meningi...
AAN27377   85 NKEQVLNIRDLTRYDPGIAVVEQGRGASSGYSIRGMDKNRVAVLVDGINQAQHYALQGPVAgknyaaG-GAINEIEYENV 163 
Q06379     71 NKEQVLGIRDLTRYDPGVAVVEQGNGASGGYSIRGVDKNRVAVSVDGVAQIQAFTVQGSLSgyggrgGSGAINEIEYENI 150  Neisseria meningi...
AAG15587   77 RKNMVSNERDLFRYEVGIGVPESGRSGSNGFAIRGVDKDRVAVIVDGIPQAESTISTSARYst--erHNGNINNIEYENV 154  Pasteurella multo...
AAC31366  174 AAVAINKGGNALEAGSGALGGSVAFHTKDVSDVLKSGKNLGAQSKTTYNSKNDHFSQTLAAAGKTERVEAMVQYTYRKGK 253  Moraxella catarrh...
CAA90896  135 RSIQISKGASSSEFGSGSLGGSVQFRTKEVSDIIKPGQSWGLDTKSAYSSKNQQWLNSLAFAGTHNGFESLVIYTHRDGK 214  Actinobacillus pl...
AAB93473  149 RSIELSKGASSAEYGSGAHGGAIGFRTKDAQDIIKEGQHWGLDSKTSYASKNSHFLQSIAAAGEAGGFEALVIATHRHGK 228  Mannheimia haemol...
Q06987    149 KAVEISKGSNSSEYGNGALAGSVAFQTKTAADIIGEGKQWGIQSKTAYSGKDHALTQSLALAGRSGGAEALLIYTKRRGR 228  Neisseria meningi...
AAN27377  164 RSVEISKGANSSEYGSGALSGSVAFVTKTADDIIKDGKDWGVQTKTAYASKNNAWVNSVAAAGKAGSFSGLIIYTDRRGQ 243 
Q06379    151 STVEIDKGAGSSDHGSGALGGAVAFRTKEAADLISDGKSWGIQAKTAYGSKNRQFMKSLGAGFSKDGWEGLLIRTERQGR 230  Neisseria meningi...
AAG15587  155 SSLKVQKGAASVMYGSGALGGTVEFTTKDIEDFVEPGRHLGFLSKTGYTSKNREYRQVIGVGGKGEHFFGFVQLTKRWGH 234  Pasteurella multo...
AAC31366  254 ENKAHSDLNGINQS-LYRLGAWQQkydlrkPNElf--aGTSYITESCLASDDPKSCVQYPYVYTKArpdgignrnfse-- 328  Moraxella catarrh...
CAA90896  215 ETKAHKDAESRSKS-IQRVDLADN------NPQg----SNWFKVKNDCPSLNCEPRQQVGVSYDGQ-------------- 269  Actinobacillus pl...
AAB93473  229 ETKIHSEANKLKHN-IRRITGFENrydftqIPHrmlleDLLLIVEDTCPTLDCTPRARVKLNRDNFpvrtfpeytp---- 303  Mannheimia haemol...
Q06987    229 EIHAHKDAGKGVQS-FNRLVLDEDkke--ggSQ-----YRYFIVEEECHNG-YAACKNklkeda---------------- 283  Neisseria meningi...
AAN27377  244 EYKAHDDAYQGSQS-FDRAVATTDpn------------nRTFLIANECANGNYEACAAGgqtklq--------------- 295 
Q06379    231 ETRPHGDIADGVEYgIDRLDAFRQtydikrKTR-----EPFFSVEGERESKPVAKLAGYGKYLNNQlnrwvkerieqnqp 305  Neisseria meningi...
AAG15587  235 ETINNGKG------------------------------------------------------------------------ 242  Pasteurella multo...
AAC31366  329 lsdaekaqylasTHPHEVVSAKDYTGIYRLLPDPMDYRSDSYLARLNIKITPNLVSKLLLEDTKQTYNIRDMRHCSYHGA 408  Moraxella catarrh...
CAA90896  270 ------------KYITEQLSAKEYTGEERALPDPVKYKSDSWLVKLGYSLSPKHYVAGVYEHSKQRYDTRDMTYPAYWQL 337  Actinobacillus pl...
AAB93473  304 ---eerkqleqiPYRTEQLSAQEYTGKDRIAPNPLDYKSNSVFMKFGYHFNSSHYLGAILEDTKTRYDIRDMQTPAYYTK 380  Mannheimia haemol...
Q06987    284 -------svkdeRK---TVSTQDYTGSNRLLANPLEYGSQSWLFRPGWHLDNRHYVGAVLERTQQTFDTRDMTVPAYFTS 353  Neisseria meningi...
AAN27377  296 ------akptnvRD---KVNVKDYTGPNRLIPNPLTQDSKSLLLRPGYQLNDKHYVGGVYEITKQNYAMQDKTVPAYLTV 366 
Q06379    306 lsaeeeaqvreaQARHENLSAQAYTGGGRILPDPMDYRSGSWLAKLGYRFGGRHYVGGVFEDTKQRYDIRDMTEKQYYGT 385  Neisseria meningi...
AAG15587  243 ------------------T---DILGEHQGKPNPLNYYTTSWLTKVGYDINNTHRFTLFLEDRRE----KKLTEEKTLGL 297  Pasteurella multo...
AAC31366  409 RLGNDGKPAN---GGSIVLCDDYQEYLNANd---ASQALFRPgandapipkLAYARSSVFNQEHGKTRYGLSFEFKPDT- 481  Moraxella catarrh...
CAA90896  338 SDLKNGDKWYpmnNAKGLYRDNALDGVAIDyfteDGVKSSKG---------LRWAKARFIDEWHTRDRLGALYRYTNQDg 408  Actinobacillus pl...
AAB93473  381 DDINLSLRNYvy------eGDNILDGLVFK------PRIPYG---------LRYSHVKFFDERHHKRRLGFTYKYKPENn 439  Mannheimia haemol...
Q06987    354 EDYVPGSLK----GLGKYSGDNKAERLFVQ----GEGSTLQG---------IGYGTGVFYDERHTKNRYGVEYVYHNADk 416  Neisseria meningi...
AAN27377  367 HDIEKSRLSNhaqANGYYQGNNLGERIRDT----IGPDSGYG---------INYAHGVFYDEKHQKDRLGLEYVYDSKGe 433 
Q06379    386 DEAEKFRDK-----SGVYDGDDFRDGLYFV----PNIEEWKGdknlvrgigLKYSRTKFIDEHHRRRRMGLLYRYENEAy 456  Neisseria meningi...
AAG15587  298 SDAVR-----------------------------------------------------FANDQTPYLRYGIEYRYNGLS- 323  Pasteurella multo...
AAC31366  482 --PWFKQAKLNLHQQNIQIINHDIKKSCSQYPKVDLNCGISEIGHYEYQNNYR--YKEGRASLTGKLDFNFDLLG----- 552  Moraxella catarrh...
CAA90896  409 -nRLIDRLSLSFDQQKINLSTRLRENNCSEYPTIDKNCRATLDKLWSSTKNEQssYEEKHDTIQLSLDKTVQTGLg---- 483  Actinobacillus pl...
AAB93473  440 --RWLDSIKLSADKQDIELYSRLHRLHCSDYPVVDKNCRPTLDKSWSMYRTERnnYQEKHRVIHLEFDKALNAGQgvfnq 517  Mannheimia haemol...
Q06987    417 -dTWADYARLSYDRQGIDLDNRLQQTHCS-HDGSDKNCRPDGNKPYSFYKSDRmiYEESRNLFQAVFKKAFDTAKi---- 490  Neisseria meningi...
AAN27377  434 -nKWFDDVRVSYDKQDITLRSQLTNTHCSTYPHIDKNCTPDVNKPFSVKEVDNnaYKEQHNLIKAVFNKKMALGSt---- 508 
Q06379    457 sdNWADKAVLSFDKQGVATDNNTLKLNCAVYPAVDKSCRASADKPYSYDSSDRfhYREQHNVLNASFEKSLKNKWt---- 532  Neisseria meningi...
AAG15587  324 ---WLETVKLFLAKQKIEQRSALQEF--------DINNRNKLDSTMSFVYLQR------QNIARGEFSTSPLYWGp---s 383  Pasteurella multo...
AAC31366  553 QHDLTVLAGA-DKVKSQFRANNPRRTIIDTTQGDAIIDEStl-------------------------------------- 593  Moraxella catarrh...
CAA90896  484 KHQLNMLLGS-DRFNSTLKRHEILSEFSVGTWHRIRGNGY---------------------------------------- 522  Actinobacillus pl...
AAB93473  518 THKLNLGLGF-DRFNSLMDHGDMTAQYTKGGYTSYRGRGR---------------------------------------- 556  Mannheimia haemol...
Q06987    491 RHNLSINLGY-DRFKSQLSHSDYYLQNAVQAYDLITPKKPpfp------------------------------------- 532  Neisseria meningi...
AAN27377  509 HHHINLQVGY-DKFNSSLSREDYRLA-THQSYEKLDYTPPsnplpdkfkpilgsnnkpicldaygyghdhpqacnaknst 586 
Q06379    533 KHHLTLGFGY-DASK-AISRPEQLSHNAARISESTGFDEN---------------------------------------- 570  Neisseria meningi...
AAG15587  384 RHRLSAKFEFrDKFLENMNKHFTFRPWQIN-------------------------------------------------- 413  Pasteurella multo...
AAC31366  594 -------------------------------tAQEQ---------AKFKQSg---------------------------- 605  Moraxella catarrh...
CAA90896  523 --------------------------------KDTP---------YIYELK----------------------------- 532  Actinobacillus pl...
AAB93473  557 --------------------------------LDNP---------YIYRRD----------------------------- 566  Mannheimia haemol...
Q06987    533 -----------------------------ngsKDNP---------YRVSIG----------------------------- 545  Neisseria meningi...
AAN27377  587 yqnfaikkgieqynqktntdkidyqaiidqydKQNPnstlkpfekIKQSLGqekynkidelgfkaykdlrnewagwtndn 666 
Q06379    571 --------------------------------NQD-----------KYLLG----------------------------- 578  Neisseria meningi...
AAG15587  414 ----------------------------------------------TFRQQ----------------------------- 418  Pasteurella multo...
AAC31366  606 ----------------AAWIVKNRLGRLEEkdACGNANECERAPIHGSNQYVGINNLYTPNDYVDLSFGGRLDKQRIH-- 667  Moraxella catarrh...
CAA90896  533 ----------------DQAIYSKNECDYSG--TIAGRADCATSKIKGHNHYIALRDNFAITKYLDIGLGYRFDKHKFR-- 592  Actinobacillus pl...
AAB93473  567 ----------------PRSIETVSLCNN----TRGDILNCEPRKIKGDSHFVSFRD-LVISEYVDLGLGVRFDQHRFK-- 623  Mannheimia haemol...
Q06987    546 ----------------KTTVNTSPICRFGN---NTYTDC-TPRNIGGNGYYAAVQDNVRLGRWADVGAGIRYDYRSTH-- 603  Neisseria meningi...
AAN27377  667 sqqnankgtdniyqpnQATVVKDDKCKYSE--TNSYADCSTTAHISGDNYFIALKDNMTINKYVDLGLGARYDRIKHK-- 742 
Q06379    579 ----------------KPEVVEGSVCGYIE--TLRSRKC-VPRKINGSNIHISLNDRFSIGKYFDFSLGGRYDRKNFT-- 637  Neisseria meningi...
AAG15587  419 ----------------------------------GRNNYTEVFPVKSREFSFSLMDDIKIGELLHLGLGGRWDHYNYKpl 464  Pasteurella multo...
AAC31366  668 --------STDSNIISKTYTNKSYNFGAAVHLTPDFSLLYKTAKGFRTPSFYELYNYNSTAAQHKNdp--------dVSF 731  Moraxella catarrh...
CAA90896  593 --------STHRWANQGDYKNSAWNIGIVAKPTSFLSLSYRASSGFRVPSFQELFGLRYDGAMKGS-----------SDA 653  Actinobacillus pl...
AAB93473  624 --------SDDPWTLSRTYRNWSWNGGITLKPTEFVSLSYRISNGFRVPAFYELYGKRDHIGLKDNe---------yVQR 686  Mannheimia haemol...
Q06987    604 --------SEDKSVSTGTHRNLSWNAGVVLKPFTWMDLTYRASTGFRLPSFAEMYGWRAG-------------------E 656  Neisseria meningi...
AAN27377  743 --------SDVPLVDNSASNQLSWNFGVVVKPTNWLDIAYRSSQGFRMPSFSEMYGERFGVTIGKGtqhgckglyyiCQQ 814 
Q06379    638 --------TSEELVRSGRYVDRSWNSGILFKPNRHFSVSYRASSGFRTPSFQELFGIDIYHDYP---------------K 694  Neisseria meningi...
AAG15587  465 lnsqhninRTQRLPYPKTSSKFSYQLSLEYQLHPSHQIAYRLSTGFRVPRVEDLYFEDRGKSSS---------------Q 529  Pasteurella multo...
AAC31366  732 PKRAVDVKPETSNTNEYGFRYQHPWGDVEMSMFKSRYKDMLDKAipNLtkaqqeyckaHLDSNECVGnpptpktsdevFA 811  Moraxella catarrh...
CAA90896  654 YQKTEKLSPEKSLNQEVAATFKGDFGVVEVSYFKNDYKQLIAPA--ER----------MHQTQSMIN-----------YF 710  Actinobacillus pl...
AAB93473  687 AQRSHQLEPEKSTNHEIGVSFKGQFGYLDVSYFRNNYKNMIATA--CKr--------iIQKSHCFYN-----------YH 745  Mannheimia haemol...
Q06987    657 SLKTLDLKPEKSFNREAGIVFKGDFGNLEASYFNNAYRDLIAFGy-ETrtq-----ngQTSASGDPG-----------YR 719  Neisseria meningi...
AAN27377  815 TVHQTKLKPEKSFNQEIGATLHNHLGSLEVSYFKNRYTDLIVGKseEIrtltqgdnagKQRGKGDLG-----------FH 883 
Q06379    695 GWQRPALKSEKAANREIGLQWKGDFGFLEISSFRNRYTDMIAVAdhKTklpn---qagQLTEIDIRD-----------YY 760  Neisseria meningi...
AAG15587  530 FLPNPDLQPETALNHEISYRFQNQYAHFSVGLFRTRYHNFIQER--EMtcdkipyeynRTYGYCTHNty-------vmFV 600  Pasteurella multo...
AAC31366  812 NLYNATIKGVSVKGKLDLHAMTSKLPDGLEMTLGYGHTKLGKFDYIAPKDAdgwyqARPAFWDAITPARYVVGLNYDHPS 891  Moraxella catarrh...
CAA90896  711 NVQDIKLDGINLIGKLDWNGVFDKIPEGIYTTLAYSKMRVKEVKNYQGYMN-----IRSPLLDTIQPARYVVGVGYDQPD 785  Actinobacillus pl...
AAB93473  746 NIQDVALNGINLVAKFDLHGILSMLPDGFYSSVAYNRVKVKERKLTDSRLDs----VNDPILDAIQPARYVLGFGYDHPE 821  Mannheimia haemol...
Q06987    720 NAQNARIAGINILGKIDWHGVWGGLPDGLYSTLAYNRIKVKDADIRADRTF-----VTSYLFDAVQPSRYVLGLGYDHPD 794  Neisseria meningi...
AAN27377  884 NGQDADLTGINILGRLDLNAVNSRLPYGLYSTLAYNKVDVKGKTLNPT-LA-----GTNILFDAIQPSRYVVGLGYDAPS 957 
Q06379    761 NAQNMSLQGVNILGKIDWNGVYGKLPEGLYTTLAYNRIKPKSVSNRPG-LS-----LRSYALDAVQPSRYVLGFGYDQPE 834  Neisseria meningi...
AAG15587  601 NEPEAVIKGVEVSGAL--NGSAFGLSDG----LTF-RLKGSYSKGQNHDGDp---------LKSIQPWTVVTGIDYETEG 664  Pasteurella multo...
AAC31366  892 QVWGIGTTLTHSKQKDENELSALRIR-NGKrETQTLTHTIPKAYTLLDMTGYYSPTESITARLGINNVLNTRYTTWEAA- 969  Moraxella catarrh...
CAA90896  786 EKWGVNLTMTHSSGKNPNELRGNEQVgFAN-YERTATKKRTRSWHTFDLTGYITPWKHTTVRAGVYNLMNYRYTTWESV- 863  Actinobacillus pl...
AAB93473  822 EKWGIGITTTYSKAKNADEVAGTRHHgIHR-VDLGG--KLTGSWYTHDITGYIN-YKNYTLRGGIYNVTNRKYSTWESV- 896  Mannheimia haemol...
Q06987    795 GIWGINTMFTYSKAKSVDELLGSQALlNGNaNAKKAASRRTRPWYVTDVSGYYNIKKHLTLRAGVYNLLNYRYVTWENV- 873  Neisseria meningi...
AAN27377  958 QKWGANAIFTHSDAKNPSELLADKNLgNGNiQTKQATKAKSTPWQTLDLSGYVNIKDNFTLRAGVYNVFNTYYTTWEAL- 1036
Q06379    835 GKWGANIMLTYSKGKNPDELAYLAGD-----QKRYSTKRASSSWSTADVSAYLNLKKRLTLRAAIYNIGNYRYVTWESL- 908  Neisseria meningi...
AAG15587  665 --WSVSLSGRYSAAKKAKDAIETEYThDKKvVKQWP--HLSPSYFVVDFTGQVNLSKNVILNMGVFNLFNRDYMTWDSAy 740  Pasteurella multo...
AAC31366  970 ----RQLPSEAASSTQS-------TRYIAPGRSYFASLEMKF 1000 Moraxella catarrhalis
CAA90896  864 ----RQSSLNAIHQHTNvk---dyARYAAPGRNYVVSFEMKF 898  Actinobacillus pleuropneumoniae
AAB93473  897 ----RQSGVNAVNQDRgs----nyTRFGAPGRNFSLAFEMKF 930  Mannheimia haemolytica
Q06987    874 ----RQTAGGAVNQHKNvg---vyNRYAAPGRNYTFSLEMKF 908  Neisseria meningitidis serogroup B
AAN27377 1037 ----RQTAEGAVNQHTGlsqdkhyGRYAAPGRNYQLALEMKF 1074
Q06379    909 ----RQTAESTANRHGGds---nyGRYAAPGRNFSLALEMKF 943  Neisseria meningitidis MC58
AAG15587  741 nlftRGYTSRSVRANSPg-----iNRFTAPKRNFAASVEIRF 777  Pasteurella multocida
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