3OTB


Conserved Protein Domain Family
Thg1C
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pfam14413: Thg1C 
Thg1 C terminal domain
Thg1 polymerases contain an additional region of conservation C-terminal to the core palm domain that comprise of 5 helices and two strands. This region has several well-conserved charged residues including a basic residue found towards the end of the first helix of this unit might contribute to the Thg1-specific active site. This C-terminal module of Thg1 is predicted to form a helical bundle that functions equivalently to the fingers of the other nucleic acid polymerases, probably in interacting with the template HtRNA.
Links
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Statistics
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PSSM-Id: 464167
Aligned: 94 rows
Threshold Bit Score: 154.988
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3OTB_A       138 QTLKDYLSWRQADCHINNLYNTVFWALIQ--QSGLTPVQAQGRLQGTLAADKNEILFSEFNINYNNELPMYRKGTVLIWQ 215 human
XP_006677557 138 LNLKDYLSWRQADCHINNLYNTAFWALVLdpKEPKSETEAEAILRVTDAAAKNELLFSRFGINYNTIDPLFRKGSVLFR- 216
XP_010652869 404 EILRDYLTWRQVDCHINNQYNTCFWMLV---KSGKSKSEAQAYLKGTQAREKNEVLLQQFGIDYNTLPLMFRQGSSAFW- 479
XP_002862851 404 DILLDYLAWRQVDCHINNQYNTCFWMLV---KSGKSKTQAQDYLKGTQTREKNELLIQQFGIEYNSLPVIFRLGSSVFR- 479
XP_009132804 404 KILLDYLAWRQVDCHINNQYNTCFWMLV---KSGKTKTQSQDYLKGTQAREKNELLSNQFGIEYNSLPLIFRMGSSVFRL 480
XP_018686197 138 KIVQDYLAWRQVDCHINNQYNTCFWMLV---KSGKTQREAQVLLKGTQAKDKNELLFRQFNVNYDKLPQMFRKGSCVYR- 213
XP_004961388 139 KTIRDYLAWRQVDCHINNQYNTCFWMLV---KSGKSEQEAQLALKGTFAKDKNELLAQQFQINYDDEPAMFRKGSSVYR- 214
KQK05204     139 KTILDYLAWRQVDCHINNHYNTCFWMLVM---SGKTEKEAQQTLKGTFSKDKNELLSQQFQINYDNEPAMFRKGSSVYR- 214
EDQ63631     138 SILRDYLSWRQVDCHINNQYNTCFWNLV---GSGKSTAESQNMLKGTTADVKNNLLFDTFKINYNDLPQIFRKGSIVYR- 213
Q4UGI9       163 RAVVDYFSWRHVDCHINNQYNTCFWCLIL---DGKSNDEAYNWLKGTTKVEKNEYLFTTHKLNYNNLPNIFKKGTTLVKS 239 Theileria annulata

3OTB_A       216 KVDEVMT----------------------------------------KEIKLPtEMEGKKMAVTRT-RTKPVPLHCDIIG 254 human
XP_006677557 217 -----------------------------------------------QKTKSVeKIREDGSPVMRD-RSEIKTEHVDIIG 248
XP_010652869 480 -----------------------------------------------NEEEKT-GMYENGASAEKS-GKKVVVEQCNIIE 510
XP_002862851 480 -----------------------------------------------LKTQEG-VAEENGEVSGKQvEAEVVVDYSNIID 511
XP_009132804 481 -----------------------------------------------KEAAAV-ENGVVSGKKLRL-EGEVVVDHCNIIE 511
XP_018686197 214 -----------------------------------------------KKVEEVvKLDDTGNPVTRT-RSKVVVEHMDIIG 245
XP_004961388 215 -----------------------------------------------EKVETTvKIDDYGNPIKRP-RLKVTVAHIDIIG 246
KQK05204     215 -----------------------------------------------EKVETKlKTDNYGNPIKRT-RMAITVSNVDIIG 246
EDQ63631     214 -----------------------------------------------KKVEKV-VKVEDGQEIKRL-RSCAVVEHEDIIR 244
Q4UGI9       240 TTKAVNVddenclnyntfdqldnlsrrefseglgedlvdkerkiwleISPSEL-NELEFKVKEKAS-EHNILVLHCDIVK 317 Theileria annulata
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