Conserved Protein Domain Family
S_4TM

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pfam18159: S_4TM 
SMODS-associating 4TM effector domain
Predicted pore-forming effector domain found in conserved genome contexts with diverse nucleotide synthetases including the SMODS synthetases. Predicted to function as a pore-forming effector in a class of conflict systems reliant on the production of second messenger nucleotide or nucleotide derivatives. S-4TM domains are predicted to initiate cell suicide responses upon their activation.
Statistics
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PSSM-Id: 465669
Aligned: 26 rows
Threshold Bit Score: 232.563
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_014811257              3 NDIPEKQSSDRLLEYLAASSYLYGRAKVRLGCQILFTVLIPILFSIITV-LVGDsqd------wkhLKVWAVAYGVALSI 75  Desu...
EOS72870                  3 NGIRLRQNEEHSIEMLAAQRQLYSNAKRYDWLSTALSVWIPFGMAIILV-FIPEd----------sLAGIVSYIVSITSA 71 
PRJNA305323:AT746_16865   3 NDINRNQNIERSINMIAAFRQKYSEVKRLGFIQVLMSVWIPIFLALLALaLKSQiitgmlgishrdISVYVSIYCVFIAL 82 
ADO57444                  6 NDIFLRQNEDGNIDLLAAQRQMYSEAKRASNYQFAICVVVPILVPFLKA-VALSnm---------iYLGFITLLPLVIIV 75 
BAM48049                  6 SSIHIRQNLPESIEQLRAQRSCYNIVEKMYIWRMIISIFLPIFSVSMYF-LFDN------------DLANFVLILTGIGL 72 
EST34698                  7 APIVRRQNDEDLLTVLRAGESAHARARRLASARVVVSASLAA-GAVLAV-VVPA------------LQTALTTAGFLWAL 72 
AIY19582                  2 PEIRAAQNATENLRLQAAARRLYSRTKLLDGLGLTFSLALALAAPVIAS-MSDR------------AGLWVAALAGVWLF 68 
WP_052425754             12 ADIAKAQNADPNLRLLLAQRRFYSRAKRWAGVRGIGTGIIAVAAPLLAA-FVAS------------AAVPAATTAAIWYV 78  Cell...
WP_045471428              2 NRITQKQNEPKFIEFLKAQRVAYSQCKTYQVFDL-ISILMAIVLPIIGM-YKSD------------IVNYLGAFGVLWTI 67  Wino...
CDD10700                  6 HKIFKRQNESAMQQLIVAQHYTYTNAKHWCFILFCILVVFPIGINIALFfDLPD------------FATGILALSSLVLL 73 
WP_014811257             76 LDVLFLDSEQKRLKLEAAKIQEIFDCELFDMEWRTFKI-GSKPS-AESIVAAAKAYk-KTAKNEID-KTWYA-PEVGDLP 150 Desu...
EOS72870                 72 VISFIVDGIINNKKELAAAIQQKFDTYIYNMPWDTRIF-GKNRNlNNEIAVYSSKIl-SDEEEKKSlYDWYT-PLVDEKE 148
PRJNA305323:AT746_16865  83 ADLFLFNRLIDSGKELAAKIQEQFDTSVFGMPWNTTLA-GIKPD-DEIINSLKNKFyrVNSNKREHlTNWYN-PKVADVD 159
ADO57444                 76 VNQYFFEKIIKNKKEKAAKFQELFDTNVFKLSWNNRLS-GSKEFaTKDLSNTAQKYk-KKHVSLSNlKNWYP-KEYSTVD 152
BAM48049                 73 LVCLMLEYYEKTYSVKGAKIQEMFDTQVFQINWNTALL-GDKVS-LEDIHLLALKD----KTPESElANWYTgL--VSDE 144
EST34698                 73 VYAVGAGSWTESEFRTAALLQETFDTRLYDIPWNETLA-GNAPS-ADEISRLARRY----KGPEERlRDYYE---IRELP 143
AIY19582                 69 ASRLVLAPVARRVQRAAAGVQDSFDAAVLGTPCGRSLA---TPAsGEEIHAATREV------DLGRfRNWYPaE--STSP 137
WP_052425754             79 LSRVLFRHLERRDATRGASVQEQFDTAIFGMP--PIAVrEPRVL-PEDVTRIVGTRr-RPAYAVERlRNWYPiQ--EGVP 152 Cell...
WP_045471428             68 IY-LVTENYRKKKTEQGAKIQEQFDTELFEIPWNQILC-KNKVN-TDTCIDLAKEY------DGNDlSNWYSlEVDSSLP 138 Wino...
CDD10700                 74 ILGEIIRDYVQGQKQRAAMLQQKFDTYVFNI-VNQYGI-----D-ENIIAEQLEKY---KNKDWNRkKDWY--QNYENMQ 141
WP_014811257            151 LYQGIVACQRSNVMWDANLRRRYNKWIRLILTLAIILTIVIGIGKQLSVSDLV--LSVFAPISPAILWAIREYRRQVDTC 228 Desu...
EOS72870                149 LKEGILSCQRENVWWDVGLRKRFKMGSIMAIIILCIAVFIMGICKNESTVKLLwrFAFVAPMLEWLFSTIKQLNKDINEL 228
PRJNA305323:AT746_16865 160 KNKGVLLCQRMNLYWDKAIRETVNERTLISLVCWCTFVLVVALIQDLSLQTFL--LTAVCPLIPILIYSLKLITDNRKSI 237
ADO57444                153 ISAGRVMCQKVNASWDGEIRASFQSFLIKLLFVCIFLIIAISMLLNKTFAETL--ISIIAPLFPITFYIFKRYSENKETI 230
BAM48049                145 ERINILTAQRMNLSWTHRQKHKFKWVLILTFSIILISSIVIGCLIKLSLITFL--ITFIFPSLSLYTYLLKNFIEIHIQG 222
EST34698                144 RPLDLLSCILQNLAWGARIRRRYAAAVQAGVIGWIVTGVAVGVATRMTLASLL--TTWFIPSLGLLLLGADIVRAQRETA 221
AIY19582                138 WPLSVALCQRANAVWARRQHRLYGRLLTGATVAVTALGITVAITNAQSLQTYL--AVILLPSLPLLLDASELAGAHRAAA 215
WP_052425754            153 GRIAIAIAQRANVSYTRRLLERHATLWLWVLVGWSLVAVIISLLARFSLATFL--LAVAIPVLPPLVDAWDEYVSVRAAS 230 Cell...
WP_045471428            139 KSIAVILCQRINFSWELKLRKRYVTFLIILLVAYYGIFIGFFVAKNIGFYDIL---LLIAPSLSFLIYGVQNSLSLKNHI 215 Wino...
CDD10700                142 DEKAVFYCQKENIDWTNAIGNKYCGFLLISLTVILLSFIVNFIIHNSSFIRVI---SIILAMVPLVSYGISSYKKIKHDN 218
WP_014811257            229 DTLDKLIKHADSLwtkakdp---asspekITTEARFLQDEIYDH-RRSCPLIFDRIHDWLKDEQEEQMRRGVQEL 299 Desulfomo...
EOS72870                229 QELDEIINDDESK----------------SMEDLQDIQKLIFIH-RKDCFAIPNFFYKHFKDNDEDKAHRAASMH 286
PRJNA305323:AT746_16865 238 TTLTRLKEVLESTwmdat-------nrhlTLAKLREVQNEIYQH-RKTNRPISDRFYWKRKDDFENDAQYSIEQM 304
ADO57444                231 VRLDKLTDKADRLwedvlsg---sveqndLQIQSRKLQDEIYKH-RSSALLIWDWFYLRNRSKQENNMNDTANLI 301
BAM48049                223 KELQRVILLIEQYien----------gspKKSDLRSIQDAVYIYgRIPNHIVPNFIYKLLRPKYESSFEKTNKKL 287
EST34698                222 AAREHARQVILREmrehahsglppgrvpdLLVLARQAQDVLLRT-RLAQARVPNWFFRRFLDSDRADFAAAMDEV 295
AIY19582                216 RKRGAIEAALDEFcrap--------dpatASDTVSAAQRDLLEL-RSRGPLVPDWLYRLVAPRYDDDMRFAARSA 281
WP_052425754            231 REREALANEIHDAiaadaa-------apippEHLVAWQSQLFAL-RRDAPLVPDWLYGLLRRGNEAEMSEAAETI 297 Cellulomo...
WP_045471428            216 KSKNETLSQIDEIlnnhse-----nqempTDSTLRQIQDIIYTE-RTVPEKVPDWFYKLSKSKNENRTDNIIKSI 284 Winograds...
CDD10700                219 YELARINGFINEIdndlnt-----mnefdLKNRINVLQVMIYGF-RQTKYLIPDWFENIYHKRRQAIETRKARNH 287
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