6A0E


Conserved Protein Domain Family
N_Asn_amidohyd

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pfam14736: N_Asn_amidohyd 
Protein N-terminal asparagine amidohydrolase
This family of enzymes catalyze the deamindation of N-terminal asparagines in peptides and proteins to aspartic acid.
Statistics
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PSSM-Id: 464288
Aligned: 33 rows
Threshold Bit Score: 279.098
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6A0E_A        36 QSVQQVGPQG----LLYVQQRELAVTSPKdgSISILGSDDATTCHIVVLRHT---GNGATCLTHCDGTDTKA-EVPLIMN 107
XP_002109751  36 SGKRNFHSGK----VLYVAQREYAVVQFSddNVQIMGSEDATTCHIVIIRHT---GCGTTALGHFDGTNVGD-SLNRMIA 107
XP_002178407 170 RHYHASSPAR----ILYVAQGEVAYAVPR--QCDVIVSDKATTCHVLILKSVsdhAAPLVSCAHIDGDRYET-CIRDMFR 242
XP_006850005  48 STSERHSSLR----HVYVFQREYATVNPS--LVELVGTDEATTCVGLVVRNR---KSGFTSVGHLDSPGLVDsGLSQMLS 118
EFH56370      57 SDSESSTKDR----YVYIFQREFAVVNPA--LVDFVGTDEATTCVGLVIRNR---KSGMTSVAHMDSPEIVDlGISQMLS 127
XP_010659556  55 AGSEGSSQSK----CVYVFQREYATVDPE--LVDLVGTDEATTCVGIVIRNR---KSGMISVAHMDSPTVVDgGLTQMLS 125
XP_006359165  54 SSSGISRHNR----WVYIFQREYATVDPA--LVDVVGTDEATTCVGLVIRNQ---NSGMTSVAHLDSPDVVDiGLAQMLA 124
4_pfamImport   1 LKSTPVTLVTrcqcCLYVMQGELATVGGAdkSIKCVGTDMATTCHIVVIRCR---QTATTSLAHFDGSFLVD-GAKEMLK 76 
ESO05173      33 LKSQKVDIVGetryVLYVAQKEFAVVAPGpdAPELVGTDESTTCHILILVHS---GSGVCCLAHLDGSYTRE-GINRLLT 108
XP_009386019  48 SSAERPPPGR----LVYIFQSEYATVDPA--LVQLVGTDEATTCVGLVIRSR---NTGITSVSHMDFPGVVDnGLAQMLS 118
6A0E_A       108 SIKSFSDHAQC-GR--LEVHLVGGFSD-----------------DRQLSQKLTHQLLSEFDRQEDD----IHLVTL--CV 161
XP_002109751 108 TIQVYADKSNIsGR--LEIHIIGGFKD-----------------SKGLSLQLSLEIIGALASSAFD----LHLVTP--CF 162
XP_002178407 243 RHQTHHEESAD-AE--MDIHIMGGFGD-----------------EHGASRVITSWLVRLLAALAKEtqpvFHTTTLgtCA 302
XP_006850005 119 SVTH---EDVK-AE--LDVHLIGGYEDapyehs-----gtnserSDGYSWGLCPKIIEALQDSATI----FHLQTL--CL 181
EFH56370     128 LVLE---DDVD-AE--LDVHMVGGYEDvdiknadg--sggdyakPEGYSFPLCCKLVETLQKRREN----FHIQTL--FI 193
XP_010659556 126 LVHN---HGFD-AE--LDVHLIGGFDDsspkqashktrskrqekWDGYSLPLCIKIIDALWRSREN----FHIQTL--CV 193
XP_006359165 125 FVVN---QSSD-AM--LDVHLIGGFDDaspenvng--iteshgkLEGYSFPLCKKIVDSLAKSNMK----FQIHTL--HV 190
4_pfamImport  77 SIENIRTPEGA-QGydLDLHIIGGFDD-----------------DRKLSGKLSTDLLRTFQTLSSDrglkLYLRTF--CC 136
ESO05173     109 KFKQSSLVGPE-GR--FELHIVGGFHE-----------------QRNFSKKLSLEVISCLLAREEE----LHLMTY--CV 162
XP_009386019 119 SIADNDEDSDE-AS--FDVHLIGGFDDgpkrhpinatvserkqkKEGFSLPLCSKLIEALHNSQQK----FHLQTL--CV 189
6A0E_A       162 T-ELNDREE-N---ENHFPVIYGIAVNIKTAEIYRASF--QDRGPEEQLRAARTLA-GG-------PMISIYDAETEQLR 226
XP_002109751 163 G-EINDTVRdD---GEHMPIIYGAGIDIQSGVISWASF--SDKGPDEIIRHSRLSW-GYc-----nKMTNLYDTATCEVH 230
XP_002178407 303 VtSLNHCND-S---KYPSPIGRGLAMEMESGRVFLASCdtAVAGPNTVLRSVRLWApqa-----qpRLHVIHEAHRDGII 373
XP_006850005 182 L-RHNTQYs-D---GVALPIIRGFVVEPATGTMAPAIFdsSSRCPDEVLRRVRITV-SSedvywtgKLLETYDTDHDRFQ 255
EFH56370     194 L-GHNTKLDaQ---ANTCPIFNGCLVNTSTGAIFPASFdrTSRCPDEIVRRIRVSS-SFldsswkgKLLDTYDTKTDRFI 268
XP_010659556 194 L-GHNTRRDsE---GNGYPIFNGFLAETSTGRILPASFdrTTRCPEEIVRRIRVSV-SYedpswdgRLLETYDTRTDQFK 268
XP_006359165 191 L-GHNTRRDtE---GNAYPIFTGFLAETATGSIIPANFdaTTRCPDEVVRRIRVSA-SFedpswkgRLLETYDTQTDQFV 265
4_pfamImport 137 S-PFNTCVVtKhgvEINSPVIFGVVVTVGDGKIYGADFaeDARGPVRAMRAARGVH-GRk------QMFNVYDYVKERFI 208
ESO05173     163 C-DENDEVR-D---GIHFPIITGLAYNTRTRAIFPAEF--TYKGPDNDIRSASGFAlKQ-------KMLDIY--VNKCLV 226
XP_009386019 190 L-RHNTKLDsC---GNACPIVSGFLVDTSSDSIMPASFdrSSRGPDEIVRRIRVSL-SSddsnwkgRLLDTYDTCHDRFE 264
6A0E_A       227 IGPYSWTPFPH--VDFWLHQDDKQILENLSTSPLAEPPHFVEHIRSTLMFLKKHPSPAHTlFSGNKALLYKKnE-DGLWE 303
XP_002109751 231 IKPFAYRQYRKemYIYYLRMSDQEFLKNMSTSPKVEPSYFVDKAKEILLFMLSSPRSD-TlFPNGIPRRYRChQ--GKWI 307
XP_002178407 374 IRPFAYKPFAD--IGTLLALPDDLLLTYTSTSPDCEQDDFCGALRETLRFLQTVPAASVFgPDLGQPLVYRR---TGRLG 448
XP_006850005 256 IAPVSWHQEWKftASLLLQHSDSQMLIRCSTSPYAEAPDFVKSMRMTFSYLVRYPDWQTS-FPNRQPRVFKR-IdNGGWE 333
EFH56370     269 IAPCRWTMRLVeyVWELNQLTDEEILINCSTSPSAEGPDFVDNSRRIWEYLLKHPDWSKT-FPKRQPRVFER-TvDGHWK 346
XP_010659556 269 IAPCTWTMRQLhiAMTLQHLSDSEILQTCSTSPSAEAPDFLDNIRRCWDYLIHRPDWRET-FPMKQPRVFKR-Ta-GGWA 345
XP_006359165 266 IAPCTWDMRKMhiALMLQNLSDQEILLTCSTSPSAEAPDFVDNQRRQWDYLIQHPDWSET-FPFKKPRIFQR-TeDKSWV 343
4_pfamImport 209 VPPFTYQPLPF--IEEWIEQSDSFIKENMSTSPDVEPAFFAPDTRESLRFIATHPNPMHSiFKSNLPLFYKLd--GGLWK 284
ESO05173     227 VGPFDWSVICNvnVD---ELDEASIRQNFSTSPEQESKYFVEHIRSTFRILMDHPQSLNSlFKNGQARKYKWnAsKLIWD 303
XP_009386019 265 IAPCTWMSEWKsyASSLQQLSDSEFLLRCSTSPYAEAPDFVESQRRKWNYLIENPDWRHT-FTGKKPRIFQR-TdDGGWS 342
6A0E_A       304 K 304
XP_002109751 308 R 308
XP_002178407 449 N 449
XP_006850005 334 Q 334
EFH56370     347 R 347
XP_010659556 346 R 346
XP_006359165 344 R 344
4_pfamImport 285 Q 285
ESO05173     304 R 304
XP_009386019 343 K 343
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