4FR4


Conserved Protein Domain Family
STKc_Yank1
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cd05578: STKc_Yank1 
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Catalytic domain of the Serine/Threonine Kinase, Yank1
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily contains uncharacterized STKs with similarity to the human protein designated as Yank1 or STK32A. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Links
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Statistics
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PSSM-Id: 270730
Aligned: 18 rows
Threshold Bit Score: 367.352
Created: 4-Aug-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #####   #            # #                               #                #
4FR4_A        16 HFEILRAIGKGSFGKVCIVQKndtKKMYAMKYMNKQKCverneVRNVFKELQIMQGLeHPFLVNLWYSFQDeeDMFMVVD 95  human
CAA19590      29 QFKIRNVIGKGSWSTVFVVKHrqtKQRFALKCINKKKHde-hkIKKLRNEVLLLQSLnHPLLCKFYSEFEDetKIYLVTD 107 fission yeast
XP_568881     21 HFYLLRSVGKGAFGKVRVVQHkhtKTLFALKYINKQKCvkmraVANIVQERRLLEEIdHPFVVNLRYAFQDdeNCFFVLD 100 Cryptococcus ne...
NP_499294     27 HFSVIRSIGRGAFGKVCIVQErktKKYFALKYMNKRRCiekgvAANVIRELTLLSKMsHPFIVNLWYTFQDgdYMYMVSD 106 nematode
XP_503305     63 NYELLQVVGSGAFSKVRVVRQmttNNVYALKYSVREDIvklgrTQLMLNERRILLRLqHPFLCNLHQTFCDseYLYTLLD 142 Yarrowia lipoly...
AAK69536      18 HFRLLRVVGRGAFGKVRIVERrdtGLTFALKYIRKGDVirtesVRNILRERRMLEQLnYQFICNLRYSFQDieYMYLVVD 97  grass mildew
EAR95457      57 GYIFNQVIGKGGFGKVWNVQKrknKEVLAMKIMSKVKIlskksVNSVLNERKILSHLnHPLIVNMHNSFQDreNLYLTMD 136 Tetrahymena the...
CAK86778     219 HFIYNYVIGKGGFGKVWKVELkknRQMFAMKEMMKSKIiakrsINSVMNEKELLSQLrHPFLVNMCYAFQDrdNLYLIMD 298 Paramecium tetr...
ELU01456      22 HFQILRAIGKGSFGKVCIVQKkdtKKMFAMKYMNKNMCikkdaIRNVFREVELLQNLdHPFLVNLWFTFQDdeDMFMVVD 101 Capitella sp. I...
XP_002603827  18 HFQILRSIGKGSFGKVCIVRKkdnKQMYAMKYMSKAAClekdaSHHVLRELEILQKLeHPFLVNLWFSFQDeeDMFIVVD 97  Florida lancelet

Feature 1        ##   #                                       # # ## #         ##                
4FR4_A        96 LLlGGDLRYHLQQn-vHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDehGHVHITDFNIAAMLPRet----- 169 human
CAA19590     108 LMlGGDLRYHISQr--KFNESVIRIWMVELVSALIYIHSKGVLHRDVKPDNILLDekGHCKLADFNVAAKVHTssspsks 185 fission yeast
XP_568881    101 LMlGGDLRFHLDRa-gAMSEEIVRFYVAEIALAIDYLHSKRIVHRDLKPDNILLDekGHAHITDFNIAVHFSDrr----- 174 Cryptococcus ne...
NP_499294    107 LLlGGDLRYHLSQq-gKFAEDRAKLYLCEICLAVEYLHEMKIVHRDIKPENILLDeqGHAHLTDLNLATQLEDdq----- 180 nematode
XP_503305    143 LMtGGDLRWHIERk--TFSEATIRFWVVEVACAVAYLHEKGVVHRDIKPDNIMLDelGHARLGDFNVACMLPYge----- 215 Yarrowia lipoly...
AAK69536      98 LMnGGDLRFHISRk--VFTEEAVRFWISELGLAIRYIHSQGIIHRDIKPDNVLLDaeGHVHLADFNVASDFTPgk----- 170 grass mildew
EAR95457     137 FIgGGDLRYHLIHqtePFSETQAQFIACCIVSALEYIHSQNILHRDIKPENLIFDesGYLKVTDFGISRIWKPd------ 210 Tetrahymena the...
CAK86778     299 LLtGGDLRYHIGKm-kRFKEHQTKFFIACIVSGLEYLHNNNIIHRDIKPENIVLDkrGYARITDLGIARKVRPd------ 371 Paramecium tetr...
ELU01456     102 LLlGGDLRYHIQQd-vKFDEARVKLYICEIALALEYLQKNRIVHRDIKPDNILLDenGHVHITDFNIATELLDgq----- 175 Capitella sp. I...
XP_002603827  98 LLlGGDLRYHMGQd-vNFTEDIVKFYICELVLALDYLQSKNILHRDLKPDNILLDeqGHAHLTDFNVATVLREne----- 171 Florida lancelet

Feature 1                                                                                        
4FR4_A       170 -qITTMAGTKPYMAPEMFSSrkga--gysFAVDWWSLGVTAYELLRGRRPYHIRSst-sSKEIVHTFEt----TVVTYPS 241 human
CAA19590     186 nmTVGRVGTPVYMAPETLIHav-----syKESDWWSLGITFYECLFQVRPFPNHLl---INWIRASEEekassADRLSSA 257 fission yeast
XP_568881    175 -lLTGVAGSMAYMAPEVLTKrg-----ysAPVDFWSLGILAYELLFGKRPFRGRT----NSGLTNSIL-----NEPLSWP 239 Cryptococcus ne...
NP_499294    181 -lATSYSGTRPYMAPEIYATyleiedgydSRVDWWALGVCFYEMLRGRTPFEFSSrtkpEEAYVAFRE-----SSIPYPA 254 nematode
XP_503305    216 ykTDSGCGTIGYMAPEVVRAky------nHLVDWWSLGAVFYECLYGTVPYRYHS----TDEYRRMKLk---eHSNLFPV 282 Yarrowia lipoly...
AAK69536     171 -lLTSKSGTLAYLAPEVYKGkg-----ysSSVDWWSLGVLFYECIYNKRPFEKISs---SDLQEQILK-----ADPKFPV 236 grass mildew
EAR95457     211 -nSNETSGTPGYIAPEILMRqn-----ygVAVDYYALGIIMYEMAMGKRPYKAKDrkelREQILAKQVq---iKREEIPK 281 Tetrahymena the...
CAK86778     372 -nSQDTSGTPGYMAPEVMCRqn-----hgIAVDYFALGVIAYEFMIGKRPYNGKSrkeiRDQILAKQAs---iKKEDLPN 442 Paramecium tetr...
ELU01456     176 -lATSLSGTKPYMAPEVFACaldncvgytYAVDWWSLGVCIYEMLRAKRPYEIHSat-tANEVTQLFAs----HSVSYPL 249 Capitella sp. I...
XP_002603827 172 -lATSLSGTKPYMAPEVYMCalemcrgysYSVDWWSLGVVAYEMLRRKRPYHIHTvt-sLQEVVHQFEt----TGVHFSS 245 Florida lancelet

Feature 1                                                          
4FR4_A       242 AWs----------QEMVSLLKKLLEPNPDQRFSq------lSDVQNFPYM 275 human
CAA19590     258 LHisrdkklttisKDARSAVMAFLEMDIKKRLGhs-----sKKLQTHPFF 302 fission yeast
XP_568881    240 EDapg-----rcsSDGMHAIRGFLERDPNKRLGyrpggggmDDIKNHPWF 284 Cryptococcus neoformans var. neoformans JEC21
NP_499294    255 HWp----------TDLIQFINSMLKFDKEKRLVg------lEAIKKHSYT 288 nematode
XP_503305    283 TQpq-------vsMAAIEALDLLLTVEAQYRLHd------vDQLLQLSYF 319 Yarrowia lipolytica CLIB122
AAK69536     237 TDpp-------vsIVCMHAISSALEQDPNKRMGctkd-egfSSFTDNPFF 278 grass mildew
EAR95457     282 GWs----------LEAIDFINRLIQRKPSNRLGvn----gpQEVKDHVWI 317 Tetrahymena thermophila SB210
CAK86778     443 GWs----------IEAMDFVNKLLQRKPQNRLGfn----gpSDVKNHPWL 478 Paramecium tetraurelia
ELU01456     250 SWd----------EDMRDLLRQLLCVDAKNRISt------lEGMKAHPFL 283 Capitella sp. I Grassle & Grassle, 1976
XP_002603827 246 QWs----------KDTCNLLRKLLTVDIDQRLCs------lSEMKQHPAM 279 Florida lancelet

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