2A5S,4JWY,3OEK


Conserved Protein Domain Family
PBP2_iGluR_NMDA_Nr2
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cd13718: PBP2_iGluR_NMDA_Nr2 
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The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily.
This group contains the ligand-binding domain of the NR2 subunit of NMDA receptor family. The ionotropic N-methyl-d-asparate (NMDA) subtype of glutamate receptors serves critical functions in neuronal development, functioning, and degeneration in the mammalian central nervous system. The functional NMDA receptor is a heterotetramer composed of two NR1 and two NR2 (A, B, C, and D) or of NR3 (A and B) subunits. The receptor controls a cation channel that is highly permeable to monovalent ions and calcium and exhibits voltage-dependent inhibition by magnesium. Dual agonists, glutamate and glycine, are required for efficient activation of the NMDA receptor. Among NMDA receptor subtypes, the NR2B subunit containing receptors appear particularly important for pain perception; thus NR2B-selective antagonists may be useful in the treatment of chronic pain.
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Statistics
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PSSM-Id: 270436
Aligned: 41 rows
Threshold Bit Score: 446.784
Created: 19-Sep-2007
Updated: 17-Oct-2022
Structure
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Drawing:
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peptide bindingputative dimer
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:2A5S; Rattus norvegicus Nr2a ligand-binding core in complex with glutamate, contacts at 4 A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
2A5S_A          4 DNHLSIVTLEEAPFVIVEDIDPltet-cvrNTVPCRKFvkinnst-------negmnvkKCCKGFCIDILKKLSRTVKFT 75   Norway rat
NP_001162636  360 KFHLKITFLEEAPYINLSPADPvsgkclmdRGVLCRVAadhemaadidvgqahrnesfyQCCSGFCIDLLEKFAEELGFT 439  fruit fly
EFX89157      409 KFHLKVAFLEEPPFISIVPPDPvsgrcpvsHGVPCHVGnhvplngetd-pglfparnvtQCCSGFCIDLLEKFSDDLGFT 487  common water ...
CAA19838      318 KFHLKITFLEEAPYINLSPADPvsgkclmdRGVLCRVAadhemaadidvgqahrnesfyQCCSGFCIDLLEKFAEELGFT 397  fruit fly
AAM46167      260 KFHLKITFLEEAPYINLSPADPvsgkclmdRGVLCRVAadhemaadidvgqahrnesfyQCCSGFCIDLLEKFAEELGFT 339  fruit fly
AAT40462      502 KFHLKITFLEEAPYINLSPADPvsgkclmdRGVLCRVAadhemaadidvgqahrnesfyQCCSGFCIDLLEKFAEELGFT 581  fruit fly
NP_001014714  502 KFHLKITFLEEAPYINLSPADPvsgkclmdRGVLCRVAadhemaadidvgqahrnesfyQCCSGFCIDLLEKFAEELGFT 581  fruit fly
XP_971730     428 KFHLKITFLEEPPYISLAPPDPvtgkcsmdRGVLCRIAsdaditevdt-tlahrngsfyQCCSGFCIDLLQKFSEELGFT 506  red flour beetle
EEC08525      331 KFNLKVTFMEERPFLNIGQPDNetgecesgRAVKCRVVpeamlqgind-taarknstyyKCCLGFCIDLLQKFAQDLGFT 409  black-legged ...
XP_002435695  331 KFNLKVTFMEERPFLNIGQPDNetgecesgRAVKCRVVpeamlqgind-taarknstyyKCCLGFCIDLLQKFAQDLGFT 409  black-legged ...

Feature 1                                             ###    #                                    
2A5S_A         76 YDLYLVTngkhgkkvnNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRGT------------- 142  Norway rat
NP_001162636  440 YELVRVEdgkwgtlenGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTgiisptaflepfd 519  fruit fly
EFX89157      488 YELIRVDdpkfgthvhGRWNGLMGALANRRVDMVMTSLTVNAEREHVADFTIPFMETGIAILVAKRTgiisptaflepfd 567  common water ...
CAA19838      398 YELVRVEdgkwgtlenGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTgiisptaflepfd 477  fruit fly
AAM46167      340 YELVRVEdgkwgtlenGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTgiisptaflepfd 419  fruit fly
AAT40462      582 YELVRVEdgkwgtlenGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTgiisptaflepfd 661  fruit fly
NP_001014714  582 YELVRVEdgkwgtlenGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTgiisptaflepfd 661  fruit fly
XP_971730     507 YELVRVEdgrwgtnenGKWNGLIADLVNRKTDMVLTSLMINAEREAVVDFSVPFMETGIAIVVAKRTgiisptaflepfd 586  red flour beetle
EEC08525      410 YDIHRVEdgtwgvkdnGTWNGLIAELLDKKADIVVTSIKINSDRQMAVDFTVPFLETGIAIVVAKRTgiispkaflepfd 489  black-legged ...
XP_002435695  410 YDIHRVEdgtwgvkdnGTWNGLIAELLDKKADIVVTSIKINSDRQMAVDFTVPFLETGIAIVVAKRTgiispkaflepfd 489  black-legged ...

Feature 1                                                                                         
2A5S_A            --------------------------------------------------------------------------------      Norway rat
NP_001162636  520 taswmlvgivaiqaatfmiflfewlspsgydmklylqntnvtpyrfs--lfrtywlvwavlfqaavhvdsprgftsrfmt 597  fruit fly
EFX89157      568 taswllvgvvaiqvaalaiflfewlspsgynmqvslsaptnqrfsl----frtywlvwailfqasvnidcpkgftsrfis 643  common water ...
CAA19838      478 taswmlvgivaiqaatfmiflfewlspsgydmklylqntnvtpyrfs--lfrtywlvwavlfqaavhvdsprgftsrfmt 555  fruit fly
AAM46167      420 taswmlvgivaiqaatfmiflfewlspsgydmklylqntnvtpyrfs--lfrtywlvwavlfqaavhvdsprgftsrfmt 497  fruit fly
AAT40462      662 taswmlvgivaiqaatfmiflfewlspsgydmklylqntnvtpyrfs--lfrtywlvwavlfqaavhvdsprgftsrfmt 739  fruit fly
NP_001014714  662 taswmlvgivaiqaatfmiflfewlspsgydmklylqntnvtpyrfs--lfrtywlvwavlfqaavhvdsprgftsrfmt 739  fruit fly
XP_971730     587 taswmlvgvvaiqaatftiflfewlspsgfnmrlslnqsndtshrfs--lfrtywlvwavlfqaavhvdsprgftarfmt 664  red flour beetle
EEC08525      490 tvswllillvsiqvaafsifvfewmspsgydmritppreislfaehrfslfrtywlvwailfgaavnvdcprgytarfms 569  black-legged ...
XP_002435695  490 tvswllillvsiqvaafsifvfewmspsgydmritppreislfaehrfslfrtywlvwailfgaavnvdcprgytarfms 569  black-legged ...

Feature 1                                                                 ###                     
2A5S_A        143 -----------------------------QVTGLSDKkfqrphdysppFRFGTVPNGSTERNIRnNYPYMHQYMtRFNQR 193  Norway rat
NP_001162636  598 nvwalfavvflaiytanlaafmitreefhEFSGLNDSrlvhpfshkpsFKFGTIPYSHTDSTIHkYFNVMHNYMrQYNKT 677  fruit fly
EFX89157      644 nvwatfavvflaiytanlaafmitreefyDLSGVEDPrlmspksheppFRFGTVSNTHTEATILrHYKEMHYHMrNYNLN 723  common water ...
CAA19838      556 nvwalfavvflaiytanlaafmitreefhEFSGLNDSrlvhpfshkpsFKFGTIPYSHTDSTIHkYFNVMHNYMrQYNKT 635  fruit fly
AAM46167      498 nvwalfavvflaiytanlaafmitreefhEFSGLNDSrlvhpfshkpsFKFGTIPYSHTDSTIHkYFNVMHNYMrQYNKT 577  fruit fly
AAT40462      740 nvwalfavvflaiytanlaafmitreefhEFSGLNDSrlvhpfshkpsFKFGTIPYSHTDSTIHkYFNVMHNYMrQYNKT 819  fruit fly
NP_001014714  740 nvwalfavvflaiytanlaafmitreefhEFSGLNDSrlvhpfshkpsFKFGTIPYSHTDSTIHkYFNVMHNYMrQYNKT 819  fruit fly
XP_971730     665 nvwamfavvflaiytanlaafmitreeffEFSGLDDHrlsrpysqkplIKFGTIPWSHTDSTIAkYFKEMHAYMrQFNKS 744  red flour beetle
EEC08525      570 nvwamfavvflaiytanlaafmitreeyyNLAGIEDNrlqnpqqtdppFRFGTIPRGNTEAVLKqNKPQLYAYMrPFNRS 649  black-legged ...
XP_002435695  570 nvwamfavvflaiytanlaafmitreeyyNLAGIEDNrlqnpqqtdppFRFGTIPRGNTEAVLKqNKPQLYAYMrPFNRS 649  black-legged ...

Feature 1                           ##                                                            
2A5S_A        194 GVEDALVSLKTGklDAFIYDAAVLNYKAGRdegCKLVTIGsgyiFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEEL 273  Norway rat
NP_001162636  678 SVADGVAAVLNGnlDSFIYDGTVLDYLVAQdedCRLMTVGs--wYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERL 755  fruit fly
EFX89157      724 EIRAGIEAVKRGelDAFLYDGAVLDYLVAQdeeCRLLTVGs--wYAMTGYGVAFPRGSKYVAPFNEKLLEYIENGDVDRL 801  common water ...
CAA19838      636 SVADGVAAVLNGnlDSFIYDGTVLDYLVAQdedCRLMTVGs--wYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERL 713  fruit fly
AAM46167      578 SVADGVAAVLNGnlDSFIYDGTVLDYLVAQdedCRLMTVGs--wYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERL 655  fruit fly
AAT40462      820 SVADGVAAVLNGnlDSFIYDGTVLDYLVAQdedCRLMTVGs--wYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERL 897  fruit fly
NP_001014714  820 SVADGVAAVLNGnlDSFIYDGTVLDYLVAQdedCRLMTVGs--wYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERL 897  fruit fly
XP_971730     745 TVHEGVDAVLSAemDAFIYDGTVLDYLTSQdedCRLLTVGs--wYAMTGYGLAFPRNSKYLKMFNKRLLDFRENGDLERL 822  red flour beetle
EEC08525      650 TVTEGIRDVKRGelDAFVYDATVLDYLVGQddeCRLLTVGs--wYAMTGYGFALPKKSKYLAMFNRQMVEYRERGDLERL 727  black-legged ...
XP_002435695  650 TVTEGIRDVKRGelDAFVYDATVLDYLVGQddeCRLLTVGs--wYAMTGYGFALPKKSKYLAMFNRQMVEYRERGDLERL 727  black-legged ...

Feature 1                    
2A5S_A        274 ETLWLTGICHN 284  Norway rat
NP_001162636  756 RRYWMTGTCRP 766  fruit fly
EFX89157      802 RRFWLTGVCKP 812  common water flea
CAA19838      714 RRYWMTGTCRP 724  fruit fly
AAM46167      656 RRYWMTGTCRP 666  fruit fly
AAT40462      898 RRYWMTGTCRP 908  fruit fly
NP_001014714  898 RRYWMTGTCRP 908  fruit fly
XP_971730     823 RRYWMTGVCKP 833  red flour beetle
EEC08525      728 QRFWLQGACKP 738  black-legged tick
XP_002435695  728 QRFWLQGACKP 738  black-legged tick

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