Conserved Protein Domain Family
LIFR_D2
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pfam17971: LIFR_D2 
Leukemia inhibitory factor receptor D2 domain
This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.
Links
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Statistics
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PSSM-Id: 375455
Aligned: 12 rows
Threshold Bit Score: 169.939
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_017200181  125 NVSLIPETPEILNLSADFSTSTLSIKWNDKGSAIPHHSNVIWEIKVLRKKSMELVKLATHSTTLSGRDTFHHWNWTSDMP 204 
XP_010586411  127 NISLIPDTPEILNLTADFSTSALHIKWNDKGSAFPHHSNVTWQIEILRKKKMEIVTLMTHNTTLNGKDTLHHWSWTSDMP 206 
EDL75700      127 DVSLVPDTPEILSLSADFSTSTLQLKWNDKGSALPYPSNATWEVKVLQNPRTEPVALVSLNTVLSGKDKGHHWNWTSELP 206 
XP_003981497  131 NVSLIPDTPEILNLSADFSTSTLHLKWNDRGSIFPRHLNVIWEVKILRKENTEIIKLVTHNTTVNGKDTVHHWSWASDMP 210 
XP_023610786  130 NVSLIPDPPEILRLSANFSTSTLHLEWSDKGSAFPRHANVIWEIKVLRKENLELVKLETYNTTLNLKDTVLRWSWASDLP 209 
XP_003759984  127 NVSLVPATLQDFNLTADFSTSTLYLKWNDNGSVFPSHSSVIWEIIVQYKEKMEVATVATLNTTLIGKDSVHHWNWTSDIP 206 
XP_014353751  115 DITFISPTPQILGVTPDFPSNTLIVEWNV--SALELVTTFRFQIQILQTEKMKIIWTEDYSAVAAVPEQTFHWDWTSDIP 192 
1_pfamImport    1 DITFISPTPQILGVTPDFPSNTLIVEWNVSALELTEKMKIIWTVSDLGGGALVTAANTPHNTLAAVPEQTFHWDWTSDIP 80  
XP_006139538  118 NVSFIPLTPQILSLSPDFSTYTLYLEWNDSGSVFQYELDAHWQIQILRKETMETVTLVNYDSKLTGKDTILSWKWTSDIP 197 
KFM11522      103 DISFVPLTPRILSLTPDFSTSTLNLKWSDNGSIFPYGLDAFWQIQVLRKEAMEKVTQVTYYSKLTHEDIVLSWNWTSDMP 182 
XP_019351510  116 NVSFIPVTPQILSLTPDFSTEMLYLKWKDGGSAFPFDLDATWQIEVLRKETLERVAQVTYHSKLTSKDTIISWNWKSDMP 195 
KFO22074      130 NVSLIPDTPEILNLSADFSTSTLHLKWNDKGSVFPHHSNVIWEIKILRKDSMELVELVTYNTTLNGRDIVHHWSWTSDMP 209 

XP_017200181  205 LECVSHYVRLRSYIDDPHFSGHKEWSDWSPLKNI 238 
XP_010586411  207 LECVTHYVRMRCYIDDLHFSGHKEWSDWSPVKNI 240 
EDL75700      207 LQCATHSVSIRWHIDYPRFSGYKEWSEWSPLKNI 240 
XP_003981497  211 LECTTHSVAIRCYVDDPHFSGRKEWSDWSPLKNI 244 
XP_023610786  210 LECAAHSVGLRRYIDDVHFSGRKEWSDWSPLQSI 243 
XP_003759984  207 LECTPHYVKIRYYIDELHFFGQKEWSEWSPLRNI 240 
XP_014353751  193 LECTSHSVRIRSSVN-VYFPGPTNWSEWSPLKTV 225 
1_pfamImport   81 LECTSHSVRIRSSVN-VYFPGPTNWSEWSPLKTV 113 
XP_006139538  198 LECTSHYVKIRCYINESYFHGRKEWSEWSPVKTV 231 
KFM11522      183 LECTSHYVKIRCYFNVTQFVGPKDWSDWSPVEEV 216 
XP_019351510  196 LECVSHSVRIRCYINKMNYGGNKEWSEWSPVVTV 229 
KFO22074      210 LECATHHVRIRCYIDSPHFSGLKEWSDWSPVKNI 243
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