1A6Q


Conserved Protein Domain Family
PP2Cc
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cd00143: PP2Cc 
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Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.
Links
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Statistics
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PSSM-Id: 238083
Aligned: 137 rows
Threshold Bit Score: 83.1446
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Active site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Active site [active site]
Evidence:
  • Citation:PMID 9003755
  • Comment:A binuclear Mn2- ion site that coordinates a phosphate ion forms the catalytic site of PP2C located within the channel of the beta-sandwich.
  • Structure:Invariant metal-coordinating residues
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #    ##                                 ###                          
1A6Q       22 LRYGLSSMQGWRv-eMEDAHTAVIglpsg------------leswSFFAVYDGHAGs----QVAKYCCEHLLDHItnnqd 84  human
2499729     8 LFASLSKKGPVRk-eNQDFSVVTFnrf----------------gqLMSLVCDGLGGy----KGGKMASALVSEVFtksft 66  Mycoplasma pneumoniae
NP_326517   2 DIFKLTDTGTVRe-eNQDRAAFFQne-----------------ktAFLILCDGMGGh----FGGSLASSITVKEFeklfs 59  Mycoplasma pulmonis
NP_520279   3 FSVYQESKKGSRr-vNQDRMGYCFtr-----------------daMMMVLCDGLGGh----SLGEVAAQQALQTMarqfq 60  Ralstonia solanace...
AAF36762    4 IYASSTHVGIVRe-eNQDAVFVGTnqy----------------hnIIALVCDGLGGy----KGGAIASTLTRDLIrdnfl 62  Mycoplasma gallise...
7445196     4 RTAYITNTGKVRp-kNEDALLVDGklfretsmntpqveefevyefTPFAVADGLGGh----ACGEKASGLVLEVLkeekp 78  Aquifex aeolicus
NP_078048   2 NFGFISDIGSQRk-hNDDCALVIQnqy----------------qqTLLIVCDGLGGy----KGGAAASHITLETIkdnfl 60  Ureaplasma urealyt...
NP_285657 378 AARTTVGLNPDRp-aNEDSYGYWQyqmead---------aeetlvLRACVCDGMGGm----AAGEVASQAAVQAFlnsd- 442 Deinococcus radiod...
CAB71205  215 GPIAAVSDRGLRhhrNEDAFSVGCtalpd------------garaQVAIVCDGVSSatrpdDASLAASRAAGESLlgalp 282 Streptomyces coeli...
7509173    79 DMLNGPSTVLDKgvfGDDAWFISRfk-----------------ntFVVGVADGVGGw----RKYGIDPSAFSRRLmkece 137 Caenorhabditis ele...

Feature 1                                                                                     
1A6Q       85 fkgsagapsvenvkngIRTGFLEIDEHMRvmsekk----------hgadrSGSTAVGVLIsp--qhTYFINCGDSRGLLC 152 human
2499729    67 vfdfh-sqteravkqwFEITLIEARRTLEqyfqtikr------nqvqfarMATTLVLSIIsk--qnIWTFWVGDSRAYLI 137 Mycoplasma pneumoniae
NP_326517  60 egip---snrktlyewFEFGLKRAREKMKfeagdd----------vakndMGTTVTAALVfkqdkqIYIFNVGDSRTYVY 126 Mycoplasma pulmonis
NP_520279  61 rhar---pmirnphdfLHESIMLAHREIHryaetn----------glpdaPRTTIVCVLAqr--gsLHWAHAGDSRMYLM 125 Ralstonia solanace...
AAF36762   63 stnfn-klsdekmeewFKKVLLKCKKQIAkyideydkqfqkehdnvslkqMATTIVLSIIan--ekIYTFWVGDSRAYLI 139 Mycoplasma gallise...
7445196    79 -----------ekpeyIKEIILKAKKRLDeyineg---------nefcygFGTALAGVYLsk--drAIVFNVGDCRVYRF 136 Aquifex aeolicus
NP_078048  61 ttdfs-eydkqqiqkwYIKVIKLAQVEIDrtvlld----------kdvynMGTTVVASIVvn--dfSYTLNIGDSRAYLL 127 Ureaplasma urealyt...
NP_285657 443 -------------ktdLPGQVWDANAAVLtamn--------------grdGGCTISGVELrg--tkLQLGHVGDTRAYLR 493 Deinococcus radiod...
CAB71205  283 rgthpqqamheailaaSHAVNALADEPATareqa-----------phqnaPACTLVGAVVta--glLVVGWVGDSRVYWV 349 Streptomyces coeli...
7509173   138 krvqkgdfdpqkpeslLDYAFRASAEAPRp-------------------vGSSTACVLVVhq--ekLYSANLGDSGFMVV 196 Caenorhabditis ele...

Feature 1                                                                                     
1A6Q      153 Rnr---kVHFFTQDHKPsn-plEKERIqnaggsvm-iqrvngsLAVSRALGDfdykcvhgkgpteqlvSPEPEVHDIers 227 human
2499729   138 Nsy---qSLQITEDHNLyn--qLLQMHatpdvi----asykdkLLALTATVSkdq-----------erQLKYSFRCDvv- 196 Mycoplasma pneumoniae
NP_326517 127 Ng----lLHQVTIDHNLm---nHYIRNsnldptq--aasmpgaSALTSALGPkk------------ktSLEVFEINEds- 184 Mycoplasma pulmonis
NP_520279 126 Rk-----GELVTRTRDHs---kIENLLqqervlpmqvanhperNKIYNCLGSp--------------nLPLIDIGGPtsl 183 Ralstonia solanace...
AAF36762  140 Akd--ktVNQITNDHNLy---nYLKKInasdvtf--kanekelLALTNIVSRdt-------------sKVEFDTSFDfin 199 Mycoplasma gallise...
7445196   137 Rdg---nLELLTEDHTYlfqyyKEGRIsyeelr----lhperhILESAILGGyp-------------dLPEVFVREEev- 195 Aquifex aeolicus
NP_078048 128 Sne---qFLQISRDHNLlq--vLQERKanpevyk---kheknlFSLTQFVGRts------------niFLSYDLFVNkl- 186 Ureaplasma urealyt...
NP_285657 494 Mdg---eVRQLTQDHSFvaamvASGQMtpeeaq-----vsperNKVLRSLGSl--------------rQPQPDYVQTlae 551 Deinococcus radiod...
CAB71205  350 PadratpPARLTEDDSWaa-qmVAAGLmneaea----yaderaHAITGWLGAda-------------yELEPHTASFkp- 410 Streptomyces coeli...
7509173   197 Rn-----GKIVSKSREQv---hYFNAPfqlt---------lppEGYQGFIGDk---------------ADMADKDEMav- 243 Caenorhabditis ele...

Feature 1                   #                                                                 
1A6Q      228 ---eedDQFIILACDGIWDvmgNEELCDFVrsrlevtddlekVCNEVVDTCLykg-----------------------sr 281 human
2499729   197 ----naWDFLLLCSDGLYNfldPNCFYEVItsap----nlkkAVTQLAKLSLdna-----------------------sn 245 Mycoplasma pneumoniae
NP_326517 185 -----kVEYLILTSDGIHDflpRNTIERIVgkenv---slewKTKELIKEALigr-----------------------st 233 Mycoplasma pulmonis
NP_520279 184 ----epGDVALLCSDGLWGsvaEDELVDTCtsfs-----vtqAIPELIARALrnagd-------------------tadn 235 Ralstonia solanace...
AAF36762  200 ----kgDEYLLLSSDGFYNfvmPEQFHDLLsltd----dmqkVADNLIQNGMnam-----------------------sn 248 Mycoplasma gallise...
7445196   196 ----kkGDTFLICSDGLWEalsFREKVSCLsked-----iklRANCLFELAYqd------------------------gk 242 Aquifex aeolicus
NP_078048 187 ----npNEIIVLTSDGFHNyfeLNTLYEKLikstq--etkneLLQQLIRQAIing-----------------------sn 237 Ureaplasma urealyt...
NP_285657 552 plelpvGSRVLIVTDGVWGevePATLNELLlges----dpqaLADRLVQLSLdag-----------------------ap 604 Deinococcus radiod...
CAB71205  411 ----drAGVVVVCTDGLWNyaeSAEEMAEAmppdaa-drplhAARVLVGHALdgg-----------------------gh 462 Streptomyces coeli...
7509173   244 ----kkGDIILLATDGVWDnlsEQQVLDQLkaldagksnvqeVCNALALTARrlafdskhnspfamkarehgflapggkp 319 Caenorhabditis ele...

Feature 1     #         
1A6Q      282 DNMSVILICF 291 human
2499729   246 DNITLNLINL 255 Mycoplasma pneumoniae
NP_326517 234 DNLTVIIMDL 243 Mycoplasma pulmonis
NP_520279 236 TTAIAMMWEL 245 Ralstonia solanacearum
AAF36762  249 DNLSVVVVKL 258 Mycoplasma gallisepticum
7445196   243 DNISFILLEC 252 Aquifex aeolicus
NP_078048 238 DNLSLAFLIF 247 Ureaplasma urealyticum
NP_285657 605 DNATALVIER 614 Deinococcus radiodurans
CAB71205  463 DNVTVALLPF 472 Streptomyces coelicolor A3(2)
7509173   320 DDITLVLLLI 329 Caenorhabditis elegans

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