Conserved Protein Domain Family
MAGE

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pfam01454: MAGE (this model, PSSM-Id:396164 is obsolete and has been replaced by 426270)
MAGE family
The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.
Statistics
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PSSM-Id: 396164
Aligned: 99 rows
Threshold Bit Score: 71.1327
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE06932     127 LVRYA-LACEPRRVPIRRQAVKEHVLDN-------EG-KHFRVVFPIAQTQLREIFGMELVEWPARD--EttMSVRERR- 194 Ophiostoma pice...
CCK70997      22 VVRFLlSNAEASNGIVTKSRLQV-VVRTvseqlnnDRkIPMRVIIEHVNGILWDVYGFRLLGIPPRGesStaQPALAD-- 98  Kazachstania na...
Q6FSE8        24 LVGFIlSSTEQGNSVLGRAKLQK-AIKQyasn-envVrCPMSDVLLKVNQILDDTYGFELIGVSTNKttSqaDQSGRS-- 99  [Candida] glabrata
XP_002619647  49 LLRMV-MTRSARNQKIRREHFTA-ILHKh------NVkGNTKAIISQVDAELKEVFGLKLDQS----------------- 103 Clavispora lusi...
XP_007372871  44 VIRLV-LTRESKGQLIRREHINQ-IINDrk-------nRSYDVVLKEVTVALEEAYGLTLVETPIIKkkGdtSKAKKVLk 114 Spathaspora pas...
XP_002545705  63 VVRLA-LAKELNGKKLRTDHIAK-AIKHn-----fGRkVTGNVLIKEANKILQEVYGLSLEDVSSSTdkQktKPESDQPa 135 Candida tropica...
EMG48242      60 VVRLF-LTRELLGKPSKPDVIRK-FVKHn-----lGRkFTTDMLIQQADVVLKDVYGLAIQETPNLNnaKkqDQQQQQPq 132 Candida maltosa...
CCE41206      84 IVKLI-LTKDARGQNFQKQHINQYLTNKr---------FKSDSLLDDAIAILENVYGLTLVDAPTAKqeKkfNASHGDQr 153 Candida parapsi...
Q6BHM0        43 VIRYV-MSRELKSQIIRREHITQ-LYSNr--------rINYDALITRVKLTLKEVYGLTLVVVPPKRgdKknKSSHSNG- 111 Debaryomyces ha...
XP_001384110  11 VVRLI-LGRELKSQFIRREKISSEVNTKr---------HGLDLIIKRVNAELEKVYGLTLVETPPEKksRvtKTTNVKV- 79  Scheffersomyces...
EPE06932     195 ---------KALKTKkqqpagpqgtqrkaaaaPPVQRMDRYALLSTLPETYReAVFAPIPVENSARNPPASDAA------ 259 Ophiostoma pice...
CCK70997      99 ----------P------------------------SKADHFLLVNKLPW----------RKHFDEFKLSQVSSTydkliv 134 Kazachstania na...
Q6FSE8       100 ----------TPIAIads-----------tksIKSSDINYFVLRNKLKP----------ITAVENFKIELAKEAyetfls 148 [Candida] glabrata
XP_002619647 104 -------------------------------------TNDIVLVSNLQKDTKlLLQKLVENGDGSEFKGNPYdtfyfmnk 146 Clavispora lusi...
XP_007372871 115 ------------------------------------pKQPYAVVNCLTPEARnLLGDIWEKSLGT-FTKNDDLGqskfyv 157 Spathaspora pas...
XP_002545705 136 tkmr-----------------------------ktsgKGPYVMVSTLSVQSRnILGELWNKDLRI-SFKKPDLTskgffl 185 Candida tropica...
EMG48242     133 qtqeqqpkkPRKA---------------------AGERNAFIVVSDLSPQARnVLGELWQRDLAR-VTKKTDINtskffl 190 Candida maltosa...
CCE41206     154 nvidtsnanGGVNGGngd-----------kitKKTPPRNRFFLVSNLSQPAQqVLGDLWMTTVNS-SLDKTKIGdtrffl 221 Candida parapsi...
Q6BHM0       112 -------------------------------------KQQLMLTNCLSPEGRiVLQEIWLTDSEAGIPNNRNSGdnqyfl 154 Debaryomyces ha...
XP_001384110  80 -------------------------------------KQPFAIVSCLEPKSKkVLGELWQTSTNVNPEADAHgskyfvpk 122 Scheffersomyces...
EPE06932     260 -------------------------------------YMGFCTLVVSLITLSGGSMPHGDLEKYLGLLHGTSH-HiV--- 298 Ophiostoma pice...
CCK70997     135 dgeyvggemsl---------sdataagtklgvdedlvCKGLTAVALSIILFSRNNIVQRELLHHLSEFGIPIDgT-Ripi 204 Kazachstania na...
Q6FSE8       149 kelgenedynsdgeniipqsqinatlssdyeikdnlvLKGILSVMLCIILFSKNNLLERDLYEELKKFGISENnpip--- 225 [Candida] glabrata
XP_002619647 147 ekr-----------------------nettvsmsdsiFGGIIMLLIGLVIVNENRIRESDLLDGLSQFGFSENlN-Ivvp 202 Clavispora lusi...
XP_007372871 158 prysk---------------------sklptsnyelvKNGILLVIVSLIILSENHISESELFRNLRKFGISTNlN-Vkns 215 Spathaspora pas...
XP_002545705 186 plyek---------------------tpapgshydlvKTGIMLLIISMIILNENHIQETILLTKLKKFGISDNlN-Qkns 243 Candida tropica...
EMG48242     191 pkynk---------------------scipgshhqlvKDGIMLVIISIIILNENHIQEDALLKSLRKVGLPPSlN-Vkns 248 Candida maltosa...
CCE41206     222 pkfkq---------------------silpksnsdlvKTGIMMLVTTLVILSENHIMESQLIRSLRKFGISDNnA-Mkns 279 Candida parapsi...
Q6BHM0       155 pkynk---------------------tsslgsntdmvKTGVTLLIMSLLIISENHMSEYELVNGLKRFGLSDHpN-Fkns 212 Debaryomyces ha...
XP_001384110 123 ykk-----------------------tegplsnielvRTGIMLYIVSMLILAENYLSEDDLERGMERMGISKDsN-Krns 178 Scheffersomyces...
EPE06932     299 ----RADEdfmkpmaammgdhvddddggaggtsqtqdgdsviqggTLQHLVRQGYVVRVVEeataggssvHGGAKVTWHV 374 Ophiostoma pice...
CCK70997     205 -lewSIDE-------------------------------------FLRWLERREYVVRAQDkt------dLEGSSTLYRT 240 Kazachstania na...
Q6FSE8       226 lldmSIDS-------------------------------------VLRIFVNQQYIDKRDQnt------eTGNVITTYHI 262 [Candida] glabrata
XP_002619647 203 nlnkTTQE-------------------------------------VLTEATKKEYLQKLVAqa-----hgGEPAIVSYAL 240 Clavispora lusi...
XP_007372871 216 slnmNIQE-------------------------------------LLNDLIRREYLNKNITkg-----riESENVVEYTL 253 Spathaspora pas...
XP_002545705 244 ninmNSKD-------------------------------------LLNDLTDKEYLSRKKLkg-----rtESEDIHDYSL 281 Candida tropica...
EMG48242     249 nlnmNTVE-------------------------------------LIKELKDHDYLSENVIkg-----ssESENIIDYSL 286 Candida maltosa...
CCE41206     280 ninmNWED-------------------------------------VLKELVSREYLTKLQLad------sEKDKIYAISL 316 Candida parapsi...
Q6BHM0       213 sfnaSLPD-------------------------------------LINELVKKEYLDKEVQkd------sNNVENVDYKL 249 Debaryomyces ha...
XP_001384110 179 nlgmNLQE-------------------------------------LVSDLIKKDYINKEVSkg-----tvESENRVIYSL 216 Scheffersomyces...
EPE06932     375 GPRGRLEIGPA 385 Ophiostoma piceae UAMH 11346
CCK70997     241 GRRTQTEFPlp 251 Kazachstania naganishii CBS 8797
Q6FSE8       263 GRRTKYEFDFD 273 [Candida] glabrata
XP_002619647 241 GKRTLREFDAh 251 Clavispora lusitaniae ATCC 42720
XP_007372871 254 GRRSLIEFPPQ 264 Spathaspora passalidarum NRRL Y-27907
XP_002545705 282 GKRSLAEFTPQ 292 Candida tropicalis MYA-3404
EMG48242     287 GKRSLVEFTPH 297 Candida maltosa Xu316
CCE41206     317 GRRSLAELEPT 327 Candida parapsilosis
Q6BHM0       250 GRRSLVEFTPL 260 Debaryomyces hansenii
XP_001384110 217 GRRSLVEFPPQ 227 Scheffersomyces stipitis CBS 6054
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