Conserved Protein Domain Family
Creb_binding
?
pfam09030: Creb_binding 
Creb binding
The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery.
Links
?
Statistics
?
PSSM-Id: 462659
Aligned: 15 rows
Threshold Bit Score: 76.4128
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_009297442 1907 QMAMAQQQSQVAQT------PQQaqMIQRALMQQQQQqqQQPRqiqaVMPPQqvQPQAPQQQGmQQRG------------ 1968
XP_014352799  945 QHQWGQGGMAQAQQ------LQA--GMQRPPMMQMPQ--QAQQ----MNMQP--QPGMGQVPGaPQAN------------ 996 
XP_007502632 2018 QPPWAPGGLSQPQQ------FQG--GMQRPAMMSGGQ--AGQP----MNMAP--QPGLGQVPAvGQPK------------ 2069
Q09472       1992 QPPWSQGGLPQPQQ------LQS--GMPRPAMMSVAQ--HGQP----LNMAP--QPGLGQV-G-ISPL------------ 2041 human
CAG06082      536 AAQNPQGLVPGQTP------QQPm-AMQRAMMTPGQQpqQPAR----MLIPQ--QPGARP----QTAQ------------ 586 
XP_014340859 1763 MPTMQPGQWQPAPL------SQPqsGMARPSIPMTAQ----QP----ASVLR--MPGV------QQPQ------------ 1808
XP_016853000 2062 MPGLGPGQWSSAAPmaqvapLQP--GMPRPVLPMPPQq-QPPQ----QQQPQ--AVGVPRMSG-AQSA------------ 2119
XP_005161827 1948 AQQTPQG-------------PQStlPIQRPAMPQQVA--QPRM----MVPTQ--GPRP------QAPQ------------ 1988
CAG04516     2152 LQPVQQGGGGQLQP------TNQqwAAGGPPMNPQQRpgMMGH----MAPQQ--QPAVTQspqqqmnqpqpqpgnrgmmp 2219 spotted green...
XP_022611225 2047 AQTQQPGLVPGQTP------QQAm-TMQRAMMPPGQQp-qGQR----MLIPQ--QPGARP----QTPQ------------ 2096 greater amber...

XP_009297442 1969 -------------------VtsnitpGALQDLLRTLKSPSSPQQQQQVLNILKSNPHLMAAFIKQRTAKYQANQPQ 2025
XP_014352799  997 -------------------R------GALQDLLQTLRSPSSPMQQQQVLNILRSNPQLMAAFIKQRAAKYQGGKSP 1047
XP_007502632 2070 -------------------Qgsl-pqAALQNLLRTLRSPSSPMQQQQVLNILHANPQLLAAFIKQRAAKYVTQNPQ 2125
Q09472       2042 -------------------KpgtvsqQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQ 2098 human
CAG06082      587 -------------------RpgtiapNALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYQANQPQ 643 
XP_014340859 1809 -------------------Rsi--spNALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYQASQPG 1863
XP_016853000 2120 -------------------PsrsiapNALHELLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVASQPQ 2176
XP_005161827 1989 -------------------RaagiapNALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYHASQPQ 2045
CAG04516     2220 glgvsggpvglpasiagaaasgnlpqGALQELLRTLRSPSSPAQQQQVLNILRSNPALMAAFIRQRAARYQGGQGG 2295 spotted green puf...
XP_022611225 2097 -------------------RpgaiapNALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYHANqpq 2153 greater amberjack
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap