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?cl00500: ACPS Superfamily (this model, PSSM-Id:412412 is obsolete and has been replaced by 444941)
4'-phosphopantetheinyl transferase superfamily Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pfam00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP. This superfamily consists of two subtypes: The ACPS type and the Sfp type. The structure of the Sfp type is known, which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",