Conserved Protein Domain Family
G6S_like

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cd16031: G6S_like 
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS)
N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Statistics
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PSSM-Id: 293755
Aligned: 80 rows
Threshold Bit Score: 486.651
Created: 12-Dec-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activemetal bindingputative
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  ##                                      #                             
NP_813567     51 KRPNIIFMMTDDHTTQAMSCYggnliQTPNMDRIANEGIRFDNCYAVNALSGPSRACILTGKFSHENGFTDNast---fn 127 Bacteroides the...
NP_866612     50 SRPNFLFVLTDDQSYGMMGCDgneltRTPNIDQLAREGIFFDRAYVTSAICTPSRISIFLSQYERKHGVNFNsgtsvape 129 Rhodopirellula ...
WP_018474051  29 KRPNIIYLMADDQSTYSVGIYgnkevMTPNMDKLGMDGLIFDRHYNTTAICMASRATVLTGMYEYKTGTNFFhgdm-hpe 107 Echinicola paci...
WP_020149404  13 DRPNIIFLFADDQAYDTLGCYgnpdvKTPHIDRIGQSGLIFDRHYNTTAICMASRANVMTGLLEYRTGCNFMhgpm-aqs 91  Verrucomicrobia...
EDM28635      20 DRPNIIMLLTDDQRYDTLGCMgndqvKTPHIDKLSERGVTFDSHYTNTPICLGSRASTMTGMYEYTNGCNFShgflsqel 99  Lentisphaera ar...
WP_013041986  31 ARPNIIFILTDDHRADHVGFMgndvvQTPNLDQLASEATVFDNAYVNSAICTPSRACYMLGQYERKHGINFNsgtsmsre 110 Coraliomargarit...
EPR73196      21 DKPNIIFLLSDDQTNIATGCYgndqvVTPNMDALAKEGVLFENHYNTTAICMASRAVILTGMYEYKAGCNFDhgpl-rke 99  Winogradskyella...
WP_010585582  33 VRPNIVFLMTDDQAAGAVGCYgnreiITPHLDNLARDGVRFSNHYATTSICTASRCSVLTGLYEYRHGCNFDhgdl-rrq 111 Schlesneria pal...
WP_010135339  23 EKPNIIFVLTDDQSYGMMGCTgneivQTPNLDQLAKDGVLFTNAHVTSAICTPSRISILLSQYERKHGVNFNsgtsvsdq 102 Flavobacteriace...
EDM29647      20 ERPNIIFLLADDMRWDSLGHLdifevKTPTLDKLAEKGVRFTRNYNTTAICMASRAQIMTGLYEFSTGSNFLhgnl-awq 98  Lentisphaera ar...
Feature 1                             # #                                                        
NP_813567    128 gDQQTFPKLLQQAGYQTAMIGKWHLis----------------epQGFDHWSILSGQHEQgdyydpdfw----------- 180 Bacteroides the...
NP_866612    130 aWAKSYPVVMRDNGYYTGYVGKNHApigkdgy-------nsglmeESFDYFYAGHGHIRFypkavhkifegaey---dtq 199 Rhodopirellula ...
WP_018474051 108 vWEKSYPVLLREAGYLTAFAGKFGIkvdsk-----------giceEDFDIWGGAPGQSSYttlenesm------------ 164 Echinicola paci...
WP_020149404  92 iWEQSYPKRLRSSGYRTAFGGKFGFaivedprkggsdnkyehlplTDFDFWVGGLGQTHYvtaknkyl------------ 159 Verrucomicrobia...
EDM28635     100 wDEMSYPVILRNNGYFTGFIGKFGFpvnaknyh-----eyenlpiDSFDRWYGWTGQGYFdtsknkym------------ 162 Lentisphaera ar...
WP_013041986 111 aWEQSYPYILRDSGYFTGYIGKNHLpigekgy-------ytgfmdRTFDYWYAGHHHIGFypkekhaifdnaaqdtqtev 183 Coraliomargarit...
EPR73196     100 kFAKSYPVLLREQGYYTGFAGKFGLavsdegnstr-hnswdalpvDDFDNWAGGLGQTSYktannkym------------ 166 Winogradskyella...
WP_010585582 112 fFAASYPAKLRASGYYTGFAGKIGFelkgep---------faalqQEFDEWAAGPGQTEYetiknqsl------------ 170 Schlesneria pal...
WP_010135339 103 aWSKSYPMVMRDAGYYTGWIGKNHApvgkggy-------tsgvmeKSFDYWYAGHGHIRFypkevhkifndaia--htqp 173 Flavobacteriace...
EDM29647      99 kWENSYPMMLRENGYYTGFAGKFGFhlndeegkal-kggaterviNSFDWWSGWMGQGSYqmnenreare---------- 167 Lentisphaera ar...
Feature 1                                                    #                                   
NP_813567    181 -edgkhivekGYATDIITDKAINFLENRDKn-KPFCMMYHQKAPHRNWMPAPRHl----------gIFNNTIFPEPANlf 248 Bacteroides the...
NP_866612    200 veivnegaedFLSYEHRLDGAVRFLEERPAd-KPFCLSICLNLPHSAGTGSMQQresdd--diyksLYRDIEIPLPKH-- 274 Rhodopirellula ...
WP_018474051 165 ---agyaekyPHSTLSYGAFGQDVIRAAAKqnKPFSLSISFKAPHKPADPDPMFd----------aIYQDKVFTKPGNfg 231 Echinicola paci...
WP_020149404 160 ---apyaenyPHSTRAYGAAGVDFISESVKadQPFCLTLFFKAPHRPTTPDPVFd----------hVYRETHFRKLPNyg 226 Verrucomicrobia...
EDM28635     163 ---vkfakeyPHVTLATAEAACEFIDEAQKqdKPFCLSLSFKASHKPFSPDPAYd----------dVYKDTVWKKRANyd 229 Lentisphaera ar...
WP_013041986 184 laegiqafldPDSNEAFMKNAVSFLQTRPDg-KPFCLSIALNLPHGSSTGTMQMretddelyrtgyRELQDSMPLPPH-- 260 Coraliomargarit...
EPR73196     167 ---akyaekyPHSTRAYAAWAEDFIIEAKEsgKPFSMSISFKAPHMPFSPDQYFd----------yVYEGKTYKKPDNyg 233 Winogradskyella...
WP_010585582 171 ---akyasqyPHCTRAYAAWAKDFLKAAKQtgRPFCMNISFKAPHLPFRPDPIDsq--------lyEHKTKFARHPNDgv 239 Schlesneria pal...
WP_010135339 174 eiineaaddfLDPNARKLKGAVKFLEVRPKd-RPFLLSINFNLPHGAGTSSMKLrktdd--eiyrtMYRDLDIPLPNN-- 248 Flavobacteriace...
EDM29647     168 -yksvygdkaEHTTYALGLMGRDFIKKAKAsgKPFCLSISFKAPHTPLATDPRYd----------aLYEGVKFTKPADfn 236 Lentisphaera ar...
Feature 1                                                                                        
NP_813567    249 ----ddYEGRGKAAREqdmsiehtltndwdlklltreemlkdttnrlysvykrmpsevqdkwdsayaqriaeyrkgdlkg 324 Bacteroides the...
NP_866612    275 ------YVAKDDIKTPrlpadvlrasdr-----------------------------------------------qtgyn 301 Rhodopirellula ...
WP_018474051 232 reyakyLSEQSKGGRQyprfte---------------------------------------------------------- 253 Echinicola paci...
WP_020149404 227 reagrhLAPQSKMGRQyprfeew--------------------------------------------------------- 249 Verrucomicrobia...
EDM28635     230 e---ggARKLPPQAKLgrqylti--------------------------------------------------------- 249 Lentisphaera ar...
WP_013041986 261 ------YTPKQAIQEPklpadvlltqlr-----------------------------------------------qdnyt 287 Coraliomargarit...
EPR73196     234 aenathLAPQAKTGRQyndytf---------------------------------------------------------- 255 Winogradskyella...
WP_010585582 240 en-grhLSPQALTSRAakeyr----------------------------------------------------------- 259 Schlesneria pal...
WP_010135339 249 ------YIAKKDIKAPklpadllrakdr-----------------------------------------------qtgyn 275 Flavobacteriace...
EDM29647     237 -----eVDSLPEQAKSgrpmsk---------------------------------------------------------- 253 Lentisphaera ar...
Feature 1                                                        ##                              
NP_813567    325 kaliswKYQQYMRDYLATVLAVDENIGRLLNYLEKIGELDNTIIVYTSDQGFFLGEHGWfDKRFMYEECQRMPLIIRYPK 404 Bacteroides the...
NP_866612    302 fvdtpeLLKERIIRQMQSLTGIDRLIGNLRTKLETEGVDDNTIIIFCSDHGLFMGQHGLgGKALCYEQTTHVPLIVYDPE 381 Rhodopirellula ...
WP_018474051 254 -whydtDYDREMRKYHQQVYAIDVAIGMIREELERQGMDKNTVIIYTSDNGYISGSHGYaSKVLPMEESSRVPLMIYDPR 332 Echinicola paci...
WP_020149404 250 gyhteeSYQSALRTYHQQIHGIDVAVGMLMQALENQGVADNTVIIYSSDNGFFNGSHGLgSKVLPYEEGARVPLMILDPR 329 Verrucomicrobia...
EDM28635     250 ddfapeKYQESMRKYNQLIYGIDQAVGKIVEKLDQTGLSKNTVIIYATDNGYSCGSHGFgGKVLPYEGPARGPMIIMDPR 329 Lentisphaera ar...
WP_013041986 288 wvdtpeTVRERTIRTYEAITGIDRMIGQLRATLEKQGLADNTILIFSSDHGLFFGEHGLgGKSLCYEVTLKVPFLIYDPR 367 Coraliomargarit...
EPR73196     256 wrdseeSYQKTIKNYNQLIHGVDYALGMIRKMLEEQGVADNTIIIFTSDNGYSCGAHNMgGKVLPYEEASKSPLIIYDPR 335 Winogradskyella...
WP_010585582 260 --qwitNFDETCKSYYALISGVDAAVGMIREALEQEGFAENTVIIFTSDNGYNCGAHGFgDKVLPYEEASRIPLIIYDPR 337 Schlesneria pal...
WP_010135339 276 yvdnpkDVRERIIRQYQAMTGIDRMVGNLRAKLKELKLDKNTYIIFTSDHGLFMGEQGLgGKALCYEKTTHVPMIVYSPK 355 Flavobacteriace...
EDM29647     254 gkswikSYDDTMKKYHTMIYGMDKAIAMIMEELKEQALDHNTIIIFTSDNGHHNGSKGLgGKLYAYEVGSLAPAIIYDPR 333 Lentisphaera ar...
Feature 1                                                                                        
NP_813567    405 a--iKAGSTSSAISMNVDFAPTFLDFAGVEVPSdIQGASLKPVLENegkt--padWRKAAYYHYYeypaehsVKRHYGIR 480 Bacteroides the...
NP_866612    382 lptvLKGARCNELVQTIDIAATMLDLADIETPAtFQGKSMRPLLSGdggairdhvFTENLWVTHFg------NPRIEAVQ 455 Rhodopirellula ...
WP_018474051 333 sksaGKKFRSQSLTGNIDFAPTILDLAGLPVPKnMDGASLVPLIENpkk----evHDQMAFMNVFgp----iMTHSLTCL 404 Echinicola paci...
WP_020149404 330 vpesLRGRRTSAVSGNIDITATIMDLAGIGHTHaMDGRSLMPMVRGkak----rvRDRLPLIQVWgt----aGTLAMGVV 401 Verrucomicrobia...
EDM28635     330 s--dQTGKRSKGVSGNVDIHPTICDLAGIAIPAkVDGKSLLPVLKDsei----rvRKAMPVFNFWgs----aATHEMTMV 399 Lentisphaera ar...
WP_013041986 368 l---PQGERLNNLVMSIDVAPTILSMAGVDIPDsMQGADITPLLRGek-----vnWRDAAFGENLwsn-ifgNPRCETVR 438 Coraliomargarit...
EPR73196     336 tpikERGVRREEITANIDMAPTILRYAGIEPPAnMDGEDLRLLIEKpkk----fkRETVALTNMWgn----dEIQAMGVV 407 Winogradskyella...
WP_010585582 338 rpklQTNHVCAALTANVDMAPTILALAHVPSPSdIDGINLAPLLGNpdg----nvRDVLPLFSFWgi----pSAQSMAIV 409 Schlesneria pal...
WP_010135339 356 lkrkYRGQKNDALVQSIDVAATMLAIGGVVKPKeFQGKNLLPLLTNpkasvrthvFTENLWSTHFg------NPKCEAVQ 429 Flavobacteriace...
EDM29647     334 hdtgTQFKTIDALSGNIDFHPTILDYAGVAKAApNHGKSLASLIKGetd----riHDAILLINVWgi----aSAQSLGVV 405 Lentisphaera ar...
Feature 1                                                                                        
NP_813567    481 TQDFKLIHFYndi----------------------------------------------deWEMYDMKADPREMNNIFGK 514 Bacteroides the...
NP_866612    456 DKRWKYIRYYrndrvsasvkiqvaedlgmksslmlygvhdneiavyrnhaeaslrgeepihEELFDLESDPDELNNLIDD 535 Rhodopirellula ...
WP_018474051 405 TSQWKYTYWWykdek------------------------------------------mdpvEELFDVKNDPLELKNYASD 442 Echinicola paci...
WP_020149404 402 TEQYKYIFWPygeg-------------------------------------------idphEELFDIQFDPYEMRNLAVM 438 Verrucomicrobia...
EDM28635     400 TEDYKYIYWYfegdg------------------------------------------mvaaEELYHRHKDSAEMNNLVNN 437 Lentisphaera ar...
WP_013041986 439 TAEYRYIRYFkndnlqnrlntkpqdlyivpe---------ymaedyrvhltstikgeavvyEELFHTAKDPYEAVNLAND 509 Coraliomargarit...
EPR73196     408 SKDWKYIFWNyeddn------------------------------------------mdttEELYHIGKDRLEMTNKVND 445 Winogradskyella...
WP_010585582 410 TPEWKYIYWYygdq-------------------------------------------mqptEELFHLTHDRLEMANLASS 446 Schlesneria pal...
WP_010135339 430 NQEWKYIRYYknttrsatqeiksakligmlinkmlyavhdpdiayyrhlsdsslegeqpvyEELYDLKNDPNELHNLINS 509 Flavobacteriace...
EDM29647     406 TDDYKYINWFygagd------------------------------------------ftptEELFNLTKDQFEQNTLAAN 443 Lentisphaera ar...
Feature 1                         
NP_813567    515 AeyakkqkELMQLLEET 531 Bacteroides thetaiotaomicron VPI-5482
NP_866612    536 P-------EVKTQLETL 545 Rhodopirellula baltica SH 1
WP_018474051 443 P-------QFKSELEMM 452 Echinicola pacifica
WP_020149404 439 QenhpalqSMKNHYNEE 455 Verrucomicrobia bacterium SCGC AAA164-E04
EDM28635     438 P-------EMALKLEEM 447 Lentisphaera araneosa HTCC2155
WP_013041986 510 PayadvlkALRAKCSEL 526 Coraliomargarita akajimensis
EPR73196     446 P-------SAEKQLQKM 455 Winogradskyella psychrotolerans RS-3
WP_010585582 447 Pqh----tNLRTSLRLA 459 Schlesneria paludicola
WP_010135339 510 Kkh----tTVLNELKAV 522 Flavobacteriaceae bacterium S85
EDM29647     444 P-------EAKPQLEEM 453 Lentisphaera araneosa HTCC2155

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