Conserved Protein Domain Family
DUF4460

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pfam14687: DUF4460 
Domain of unknown function (DUF4460)
This domain family is found in eukaryotes, and is typically between 103 and 119 amino acids in length. There is a conserved HPD sequence motif. There are two completely conserved residues (N and F) that may be functionally important.
Statistics
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PSSM-Id: 464262
Aligned: 31 rows
Threshold Bit Score: 82.7575
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001616560  64 YQSSIFRKSVRKLILFFYKEIHPDLTQELPEELkKVNSESLSVLNSYIDILSSSERSqgNIFLEKKIVFFKVFE------ 137
Q8I5W1        31 YEANITKRSIRKLLHFFYKQVHPDLTSTLPEELkKKNSESLSILNSYIDILSTPEKNeeNIFIERNIVFFKVFE------ 104 Plasmodium falc...
XP_004367091  96 KKNTSKIKAIRSTLKKFFLKVHPDLFYQYPDVK-KTNDKSLRILQSFLEEIKNE-----KMTTRSYSLQFYYLDse---s 166
XP_003293187  87 SSSNNNDKSNKLILKKFFLKVHPDIFYQFPKIK-NNNDESLRLFLGFLGEVKSE-----KILKKEYNLKFYYQDe----- 155
Q54N93        78 EKQQEINKNNKIALKKFFLKVHPDLFFQFPNIK-KTNDKSLSLLHSFLEEIKTE-----RLSRKQYDLQFYYLDn----- 146 Dictyostelium d...
EFA78338      88 NSHSKPIPNARSVLKKFFLKVHPDLFYQYPKLK-NINDKSLRVLQSFLEEVKSE-----KVSSRSYKLEFYYLDar---s 158
EFA82255      42 NNNGENVVKLRNVLKQFYQLVHPDTLANYPSEK-KVNSHNMKIIMGVIDQYKKRPVPdpSTKPVAHPLTFFMIDk----y 116
EGG22642      41 DREKNELPKLKNILKQFYLKIHPDTLSAHPEEK-KVNSHNMKIIMGIIDAFKRRPVPdpNTQQIPHALSFFIPD------ 113
Q54XH7        43 TTNGEEKPKLRHVLKKFYLMIHPDTLTQYPNEK-HVNSNSMKALMSIVDEYKKRPTPdsQTKRNVQKLTFYVPEdkisge 121 Dictyostelium d...
EGC34535      41 STNNDSKPKLRNILKRFYLMVHPDTLTSYPKEK-SVNSHNMKLFMSIFDQYKKRPSPdpNTKPIVHNLSFYIPEn----d 115
XP_001616560 138 NSQNKIIKGRYKNVVIklQTLPnNLSTqqkeeiTAKLIYDIRHSLEK 184
Q8I5W1       105 NKENKIIQGRYKHLVIklHTLSnNLTEnekekiIVKLIYDIKQAIGG 151 Plasmodium falciparum 3D7
XP_004367091 167 AGATEQSQIPHISVSF--DIDSsNPR----------KLQTFLRNAEK 201
XP_003293187 156 NLYANEDEVPSVSVQF--DVERsASSD------SFENLVYLLRDAQI 194
Q54N93       147 NIYDNENDIPFFNIKFsvNISSsSSSN------SFDKIAYHLQDAQE 187 Dictyostelium discoideum AX4
EFA78338     159 ATTTNEDDIPYVEISF--DIDNsTPR----------KLNTMIKKAEQ 193
EFA82255     117 AETRPNELAPLKRVDI--EVIE-NSRNpn---qVPDQLSKLFGMCHL 157
EGG22642     114 --ELEEGKDVLKRVDI--EMIE-NCRNpn---hVPDQLSKLFGYCNL 152
Q54XH7       122 EAPTSIGDRKFKIIES--EFCQ-YSNNpn---hIPNQIRLLFEQCKL 162 Dictyostelium discoideum AX4
EGC34535     116 VETTKPIPGKFKMIDI--ELIQ-NCNNps---hIPNQIRLLFEKCSL 156
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