19552630 1 MLVDIAIENLGVIPAASAEFSSGLTVLTGETGAGKTMVVTGLRLLSGGRADASRVRTGSPQAVVEGRFVTQgvpcdiVER 80 Corynebacterium glu... 15895343 1 MLLQLNIKNFALIEDITINFEKGFNVLFGETGAGKSILIDAINYVLGGKSSRGFIRTGEKRTYVEAIFTIE------NDK 74 Clostridium acetobu... 11134703 1 MINRIFMKENLGFKKAELEISKGLTVFTGLSGAGKSVLFKGILSAFSLS-ESE-----AKIVEIEVDDKLD--------- 65 Campylobacter jejuni 19703613 6 MLRELKIENLAIIDELDIEFEKGFIVLTGETGAGKSIILSGINLLIGEKASVDMIRDGEENLVAQGVFDVD-------EE 78 Fusobacterium nucle... 11134383 8 QITRLKVRQNAVFEKLDLEFKDGLSAISGASGVGKSVLIASLLGAFGLK-ESN--ASNIE-VELIAPFLDT--------E 75 Helicobacter pylori 20139553 1 MFYSLSVKNFILIDELEIEFNKGLCVITGETGAGKSILLDAILFCLGYKTSNNIIKRGKDYAVVNIIFSLN-------EE 73 Rickettsia conorii 11134855 1 MFYSLSVKNFILIDELEIEFSKGLCVITGETGAGKSILLDAILFCLGYKTSNNIIKHGKDYTVVNIIFSLN-------EK 73 Rickettsia prowazekii 15927100 1 MLQTLSIKQFAIIEELEIQFSDGLTVLSGETGSGKSIIIDAIGQLIGMRASSDFVRHGEKKAVIEGIFDIDe-----SKD 75 Staphylococcus aure... 15675399 1 MLLEISIKNFAIIDEISLNFENGMTVLTGETGAGKSIIIDAMNMMLGARASTEVIRRGANKAEIEGFFSVDa----tPEL 76 Streptococcus pyoge... 11134437 1 MLGRLYIQNFFFIRDVEVEFERGLNVITGETGTGKSMTISAIEFLMGKQGDYP---EGTA---------VE--------- 59 Aquifex aeolicus
19552630 81 ATGIVSNAGGAADEngEFLAVRSVGANGRSKAHLGGRSVPAATLSEFSDELLT-IHGQNDQLRLLSPERQLEALDRFDPE 159 Corynebacterium glu... 15895343 75 TKAELENMDIEYED--CVIVSRETFKSGKSIAKINGKSVLVSVLKNVSETLID-IHGQHENQNLLDPLKHIMYLDDYCEE 151 Clostridium acetobu... 11134703 66 ----LESFGIESEE--ENVFK-LLKEKN-TKYFINNQSIAKKSLQNLSKTFIKyLSAKENNE--FGNEKFLNLLDALEMQ 135 Campylobacter jejuni 19703613 79 QKKKLEAMGIDIDGd-EIIIRRSYSRSGKARAFINNVRITLTDLKEIASTLVD-IVGQHSHQMLLNKNNHIKLLDSFLNK 156 Fusobacterium nucle... 11134383 76 EYGIFREDEHEP----LVIS--VIKKEK-TRYFLNQTSLSKNTLKALLKGLIKrLSNDRFSQNELNDILMLSLLDGYIQN 148 Helicobacter pylori 20139553 74 IKNFLVQNFIEPEE--LLFVKCLQKAEGRKNFFINNQVVTKALMQQLATYLFE-LHGQNNNISLLEANTQRDILDSYGNL 150 Rickettsia conorii 11134855 74 IKKFLIQNFIEPEE--LLLVKCLQKAEGRKSFFINNQIVTKTLIKQLANYLFE-LHGQNNNITLLEASTQRDILDSYGDL 150 Rickettsia prowazekii 15927100 76 AIHILKNMDIDVDEd-FLLVKREIFSSGKSLCKINNQTVTLQDLRKVMQELLD-IHGQHETQSLLKQKYHLTLLDNYAES 153 Staphylococcus aure... 15675399 77 VA-CLESSGIAMEE--ELIIRRDIFANGRSVSRINGQMVNLATLKQVGQFLVD-IHGQHDQEELMRPQLHQQILDAFGDK 152 Streptococcus pyoge... 11134437 60 ----LELLGEE-----EIILRREVKKG-RSRYYVNGKGASKSTVLELLEGKIS-LQGQNEFINLFREDFQRKLLDTFANL 128 Aquifex aeolicus
19552630 160 LAQLR----KNYNAKYLTWKSLDKDLQKRLSSRRELAQEVDRLQFAINEIEEVSPQPGEDAELVEQIRRLQDVDTLREQA 235 Corynebacterium glu... 15895343 152 SLISAk---KDYTITYESLKAIDEKIRDLKGKNGENGKLADFLKYQINEIDNSKLKIGEDNELQERYSIVSNSEALSKVF 228 Clostridium acetobu... 11134703 136 ENTNFvsflEDFKKDFNAYSQISNELNAILEEEKKVEELKELARAQIEKISSINPKIGEYEELLILKKKLSKKDKLEEAW 215 Campylobacter jejuni 19703613 157 DEKDIk---ENLASLLYQYREIDSKIEDIEREKRETLEKKEFYEYQLEEIEKLKLKDGEDELLEVEYKRVFNAEKIREKV 233 Fusobacterium nucle... 11134383 149 ENKAFspllGALEEKFTRLEKLEKERRLLEDKKRFQKDLEERLNFEKMKLERLDLKEDEYERLLEQKKLLSSKEKLNDKI 228 Helicobacter pylori 20139553 151 LDFR-----AELSKCYQAWQNTRKEMAEITLKQNSIEQEIDYLSFATEELTKLNIQTGEEEKLANLRKDLQNKDKDLQLI 225 Rickettsia conorii 11134855 151 LEFR-----VKLAKCYQIWQNTRKEIEEITVKQNVIEQEIDYLNFVTEELTKLNIQIGEEETLTNIRQDLQNKNKDLQLI 225 Rickettsia prowazekii 15927100 154 RYQDLl---DKYHQTFQNYKAKKQELEDLESADQALLQRLDLMKFQLEELSEAHLKEGEIEQLEIDIKRIQNSEKLSLAL 230 Staphylococcus aure... 15675399 153 AFEQLk---ENYQLIFDRYKSLRRQVIDKQKNEKEHKDRIDMLAFQIAEIEAAALSRGEDDRLNQERDRLMNHKQIADTL 229 Streptococcus pyoge... 11134437 129 NDKVK-----ELEKVYNSLRKKEQELFEFLRKKEELIQKKDYLEFRVREVEEIGISSEEYEELKNKANLINNLEKVKKAV 203 Aquifex aeolicus
19552630 236 -ATALAAIDGagslsdamggsggfDESQESASDQLGQAESALA-GSD-DS-KLKDIAVQLAEITSQLSQVSMELGGFLSD 311 Corynebacterium glu... 15895343 229 -SEACEVLYDg-------------SDNSKSAYDLIGYVVNKIKsIENnND-KISDIVKILEDSYYNLGEVVEEIKAIKSG 293 Clostridium acetobu... 11134703 216 -SKAERIF----------------E-----LEKVV---IEALN-LSEvD-------ASFFSECLNELRVICE--NQKMED 260 Campylobacter jejuni 19703613 234 -YESLEYLKN--------------DDD--SALSLITNSIRNIEyLGKyDE-RYTELAKRIENAYYELEDCANEIEDISKG 295 Fusobacterium nucle... 11134383 229 -ALALEVLEN---------------------THKITHALESVG----------HSAEFLKS-ALLEASALLEKEQAKLEE 275 Helicobacter pylori 20139553 226 -KDIIEQIN------------------NPEINTSINRAEKLLA-RQGnNE-RFEAIVTSLEEAYNNLEEARQELSNLLDS 284 Rickettsia conorii 11134855 226 -RDIIAQIN------------------NPEINISINRAEKLLA-RQRdND-RFKAIATSLEEAYNNLEVARQELSNLLDS 284 Rickettsia prowazekii 15927100 231 -NNAHMTLTD--------------EN---AITDRLYELSNHLLtINDiVPnKYDKLKEDIDQFYYILEDAKHELYDEMAN 292 Staphylococcus aure... 15675399 230 -TNAYVMLDN--------------DD--FSSLSNIRSSMNDLLsIEQfDS-EYKGMSTSISEAYYILEEVSKQLSDTIDQ 291 Streptococcus pyoge... 11134437 204 gESLYKLLEG--------------EN---SVYEILGEIRKNLAkVESySG-KFSELIEKIANLEEEVYELYNSLKEEMPE 265 Aquifex aeolicus
19552630 312 LPADPQALDDMLTRQQQLKLLTRKYAADIDGVIEWQRKAQIRLDSIDISSEALDKLKEDAKKAQASMMRAAKKLSAVRAK 391 Corynebacterium glu... 15895343 294 ISFDAGELDYINSRLFTIDSYKKKYGSTIQDILNYRDKLNTQYNEIVNSEEIVKELEGKRKSVYEKLLHKAKNIHKIRCD 373 Clostridium acetobu... 11134703 261 LDFD---VEALLDRIENLSYLIKRYES-IENALEVLKQKKYELEHYENLSFEKKELEKKFQELKQKLEEKAQILTQTRKK 336 Campylobacter jejuni 19703613 296 IDVTENDLDKIASRMNTLKRIKEKYKRTLPELIEYREDLKEKLSDIDSGDFKTKELKKELNKIKDEYDKIAEKLTNSRKE 375 Fusobacterium nucle... 11134383 276 CER--LDIEKVLERLGMLSGIIKDYGS-IMHAKERLGHVKNELHNLKEIDSHCETYHKEIERLKTECLKLCEEISGFRKE 352 Helicobacter pylori 20139553 285 FNYEEYNLEETEERLFLIKAISRKYNVPADALGVFLDKSLEQLSILKNKIANSNELKAQEVLLQKKYYELASNLSAKRLI 364 Rickettsia conorii 11134855 285 FTYEEYNLEETEERLFLIKAISRKYNVPANELGIFLDKSLEKLVILKNKIANSHKLQAQEVLLQEQYYKLANDLSARRLI 364 Rickettsia prowazekii 15927100 293 TEFDEQVLNEYESRMNLLNNLKRKYGKDISELIAYQEKLNNEINKIENYEQSTSQLREEINALYNQVIEVGQALSKQRRI 372 Staphylococcus aure... 15675399 292 LDFDGGRLQEIEFRLDILNSLTRKYGGNVNDVLDYYDNIVKEYQLLTGDDLSSGDLEAELKSLEKQLVAAASELSVSRHQ 371 Streptococcus pyoge... 11134437 266 ISEE--EVNEINEKLFRIQRLEEKYKKSFPEILKEVEEIKEELSNLNSVDFKEEELREEVEKLREEYDKLAEEVSRDRRK 343 Aquifex aeolicus
19552630 392 AATKLGTTVTEELQGLAMQKARFEVALTSIEA--CASGIDQVEFQLAANAFAQPRPLASSASGGELSRVMLALEVILAAG 469 Corynebacterium glu... 15895343 374 FAKKLEKSVKDQLDYVGLGKSTFSIEVDFNERyiSESGSDKVQFLISTNIGEPLRPLEKIVSGGELSRIMLSMKTVFVNK 453 Clostridium acetobu... 11134703 337 NLKKLEKCLNNYLKDLYMKDASLTLKENEk---iSILGKDEIMLDINLAH-------LKNLSSGELNRLRLAFIATECNI 406 Campylobacter jejuni 19703613 376 IAVKIENELLNELKFLNMEDAKLKVQINKLERm-TNEGYDDVEFFISTNVGQDLKPLNKIASGGEVSRVMLALKVIFSKV 454 Fusobacterium nucle... 11134383 353 YLAGFNALLSAKAKDLLLKSPSLVLEDAPm----SEKGAQKLVLNLQNSQ-------LETLSSGEYSRLRLAFMLLEMEF 421 Helicobacter pylori 20139553 365 VAKHLEESLHQELKQLKMAKAIFEIEINTKe--pTADGNDDIVFKASTNPGTAAAAINKIASGGELSRFMLALKTALFDK 442 Rickettsia conorii 11134855 365 AAKHLEESLNQELKQLKMEKANFKIEIKTAId-pTASGNDDIVFKASTNPGMKAEEINKIASGGELSRFMLALKTSLFDK 443 Rickettsia prowazekii 15927100 373 VARELRDHIVSEIQNLQMKDANLEISFKKLEEp-NIDGIEFVEFLISPNKGEPLKSLNKIASGGELSRIMLALKSIFVKS 451 Staphylococcus aure... 15675399 372 LAEQLEAEIKAELKELYMEKADFKVHFTTSKFn--RDGNESLEFYISTNPGEGFKPLVKVASGGELSRLMLAIKAAISRK 449 Streptococcus pyoge... 11134437 344 KAEDLEERIEEILKELNLERAKLKVEIKESEp--TKYGKDKIEFLFSSYG-KDFKPLEEVASGGELSRLFLALSLILPAS 420 Aquifex aeolicus
19552630 470 ---TTgtTLVFDEVDAGVGGRAAVEIGRRLARLATKNQVIVVTHLPQVAAYADTHLHVAKNVGEASVTSGVESLTFDRRV 546 Corynebacterium glu... 15895343 454 d-kIP--SVIFDEIDTGISGRIAERVADKMYAVSENHQVFCVTHLPQIACMSDTQFMVSKNIKNDKTYTDVRPLDKEGKA 530 Clostridium acetobu... 11134703 407 lnaGKg-ILFLDEIDANLSGKEAMSIAKVLEELSKFYQIFAISHLPQLSSKAHNHFLVEKNGE----ESKVKKLDQEERI 481 Campylobacter jejuni 19703613 455 d-nIP--ILIFDEIDTGIGGETVRKIALKLKEIGDNTQIISITHSAVIASKASQQFYIEKYVENSKTISRVKKLSAEERI 531 Fusobacterium nucle... 11134383 422 lkdFKg-VLVLDEMDSNLSGEESLAVSKALETLSSHSQIFAISHQVHIPALAKNHILVFKENH----KSLAKTLNNEERV 496 Helicobacter pylori 20139553 443 m-vKP--SIIFDEIDVGISGEVADKVGERLKKLSSVTQVIVITHQPQVAGKADLHIKIEKTQLEKETKVTVKALNLAERQ 519 Rickettsia conorii 11134855 444 m-iKP--SIIFDEIDVGIGGEAADKVGDRLKKLSSVTQVIVITHQPQVAGKADLHIKIEKTQLEQETKIKVKALNLAERQ 520 Rickettsia prowazekii 15927100 452 r-gQT--AILFDEVDSGVSGQAAQKMAEKMRDIAEYIQVICISHLPQVASMSDHHLLISKSSKDDRTTTQVQELIGDDKV 528 Staphylococcus aure... 15675399 450 e-dKT--SIVFDEVDTGVSGRVAQAIAQKIYKIGRHGQVLAISHLPQVIAIADYQYFISKESKEESTVSKVRLLTPEERV 526 Streptococcus pyoge... 11134437 421 ---ET---YVFDEVDAGISGETSFKVAKFLKELSKKMQVIVITHSAPLCAAGDKNFKTEKKFLGDIPYIVVRELSEEEKV 494 Aquifex aeolicus
19552630 547 EELSRMLAGLDDTATGRAHATELLERAQR 575 Corynebacterium glutamicum ATCC 13032 15895343 531 NALAMMIGGSEVTKITMDHAKEMILIAQK 559 Clostridium acetobutylicum 11134703 482 KELARMVSGELVSDEAIEFAKTLFKN--- 507 Campylobacter jejuni 19703613 532 KEIGRMLVGEKINNEVLEIANKMLNEV-- 558 Fusobacterium nucleatum subsp. nucleatum ATCC 25586 11134383 497 LEIARMIGGSENIESAISFAKEKLKAQE- 524 Helicobacter pylori 20139553 520 EELARMISGKTITKASLKAAKELLHL--- 545 Rickettsia conorii 11134855 521 RELARMISGKTITDASLKVAKELLYPVAC 549 Rickettsia prowazekii 15927100 529 DEIARMISGASVTDLTRENAREMIQHNQR 557 Staphylococcus aureus subsp. aureus N315 15675399 527 EEIASMIAGTDMTQAALTQARELLAKH-- 553 Streptococcus pyogenes M1 GAS 11134437 495 EEVARLMGM--KSEKTLEGAKELVEAFK- 520 Aquifex aeolicus
Jiyao W et al.(2023). "The conserved domain database in 2023.",