1STF,1GD4,1MOL,1EQK,1CEW


Conserved Protein Domain Family
CY

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cd00042: CY 
Click on image for an interactive view with Cn3D
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.
Statistics
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PSSM-Id: 238002
Aligned: 52 rows
Threshold Bit Score: 37.0684
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:putative proteinase inhibition site
Evidence:
  • Comment:n-terminal Gly is essential for binding to proteinase target
  • Citation:PMID 2347312
  • Structure:1STF1, bound to papain

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     #                                                     ###     #                 
1STF_I      4 GAPsaTQP-AT---AETQHIADQVRSQLEEKynkk-------fpvfKAV-SFKSQVVa----GTNYFIKVHVgd------ 61  human
399335     16 AYAq-PQCvGCp-sEVKGDKLKQSEETLNKSlsklaagdgptyklvKIN-SATTQVVs----GSKDVINADLkden---- 84  Sarcophaga peregrina
2071985    11 VVAlaVVScEAlrqLRYEEIVDRAIEAYNQGrqgr--------plfRLL-SATPPSSqnpatNIPLQFRIKEtectstqe 81  house mouse
112910    148 DCPl-LAP-LNd--TRVVHAAKAALAAFNAQnng---------snfQLEeISRAQLVpl-ppSTYVEFTVSGtdcvakea 213 human
112909    148 DCPl-LAP-LNd--SRVVHAVEVALATFNAEsng---------sylQLVeISRAQFVpl-pvSVSVEFAVAAtdciakev 213 cow
231466    148 RCPl-LTP-FNd--TNVVHTVNTALAAFNTQnng---------tyfKLVeISRAQNVpl-pvSTLVEFVIAAtdctakev 213 house mouse
6226846    32 QNYfgSIN-ISn--ANVKQCVWFAMKEYNKEsedky-----vflvdKIL-HAKLQITd----RMEYQIDVQIsrsnckkp 98  house mouse
231466     24 GLGfrELA-CDd--PEAEQVALLAVDYLNNHllq---------gfkQVL-NQIDKVKvwsrrPFGVVYEMEVdtlettch 90  house mouse
266314      1 DQVrgDLE-CDd--KEAKNWADDAVRYINEHklh---------ghkQAL-NVIKNICvvpwnGDLVAVFLELnlletech 67  Protobothrops flav...
112720     32 GMEifEKNfIDk--NKLKDVYDVFKYLYNTHsadty------lsniKNE-SFTMNIW-----GFGEIEMVKTkcrkidsd 97  Norway rat
Feature 1                                                   
1STF_I     62 --------------------eDFVHLRVFQSlphenkpLTLSNYQT 87  human
399335     85 ------------------dktKTCDITIWSQpwl--enGIEVTFNC 110 Sarcophaga peregrina
2071985    82 rqp-------kdcdfledgeeRNCTGKFFRRr-----qSTSLTLTC 115 house mouse
112910    214 tea-------akcnllaekqyGFCKATLSEKl-----gGAEVAVTC 247 human
112909    214 vdp-------tkcnllaekqyGFCKGSVIQKal----gGEDVRVTC 248 cow
231466    214 tdp-------akcnllaekqhGFCKANLMHNl-----gGEEVSVAC 247 house mouse
6226846    99 lnnte---ncipqkkpelekkMSCSFLVGALpwn--geFNLLSKEC 139 house mouse
231466     91 aldptplancsvrqltehaveGDCDFHILKQdg----qFRVMHTQC 132 house mouse
266314     68 vldptpvekctvrqqhnhaveMDCDAKIMFNve---tfKRDVFVKC 110 Protobothrops flavoviridis
112720     98 fykcs----fqrefynlkrtpGETMYYISLPgsv--rcRKLLSKLD 137 Norway rat

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