1MM8


Conserved Protein Domain Family
DDE_Tnp_1
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pfam01609: DDE_Tnp_1 
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Transposase DDE domain
Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.
Links
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Statistics
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PSSM-Id: 376573
Aligned: 92 rows
Threshold Bit Score: 43.7703
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1MM8_A   128 WWVHSVLLLEATTFRTVGLL-HQEWW-----MrpddpadAD-EKESGKWL--AAAATSRLRmGSMMSNVIA-VCDReADI 197
Q44285   103 HQGKPIIAFDGKVLRGSFRG----------------------NAK--DAL--QLVTAYDTEnGLVLSQKAT-PNKK-GEI 154 Aeromonas salmonicida
O07439    76 PSGLVPIELDGKNAAWCFTR-------------------------QSDTT--HLVSVFAHRaRLVLGQLAV-AEKS-NEI 126 Mycobacterium ulcerans
Q490H4   102 DAVHQLISVDGKTIRG------------------------N-RGKNQKPV--HIVTAYDGGhHLSLGQVAV-EEKS-NEI 152 Streptococcus pyoge...
Q7BWB3   105 ATSGKHICIDGKTMRGVKKL-----------S-------FD-TQS-------HVVSAFSPQdMCSLAQLYI-DRKT-NEI 156 Porphyromonas gingi...
Q57520   101 LTDGEVIAIDGKTLRG---------------S-------YD-RSKGKGTI--HMVNAFATAnGMSIGQLKV-DSKS-NEI 153 Vibrio cholerae
Q9R793   101 LTDGEVIAIDGKTLRG---------------S-------YD-RSKGKGTI--HMVNAFATAnGMSIGQQKV-DSKS-NEI 153 Vibrio anguillarum
AFR44080 124 WWVHSVLLLEATTFRTVGLL-HQEWWmrpddP-------AD-ADEKESGKwlAAAATSRLRmGSMMSNVIAvCDRE-ADI 193
Q45620   108 RFPKPLRVVDSTTVTVGKNRlPWAPY----------------HGE-RAGV--KLHVAYSPEfSLPADVVET-TGLR-HDG 166 Geobacillus stearot...
P55729    82 EGRAMLRLIDSTPIPLGKLC-----------G-------WAkSNGRIRGM--KMHVVYDPDsDCPRLLDIT-DANV-NDA 139 Sinorhizobium fredi...

1MM8_A   198 HAYLQdklaHNERFVvrsKHPRKDVESG-LY-LYDHLKNQP-ELGGYqisipqkgvvdkr-----------gkrknrpar 263
Q44285   155 ETVKDm--lDILEL----KGAVVTLDAL-HC-QRETLEKIS-EKKAHvvvqvknnqpklyravqsqfqslfdaqkekivv 225 Aeromonas salmonicida
O07439   127 PCVRAl--lTLLPD----NLRWLVTVDA-MHtQVVTAKLICaTLKSHylmivksnqakilari-----talpwaevpaaa 194 Mycobacterium ulcerans
Q490H4   153 VAIPQl--lRTIDI----RKSIVTIDA--MGtQTAIVDTII-KGKADyclavkgnqetly----------ddialyfsdv 213 Streptococcus pyoge...
Q7BWB3   157 PAIHQl--lDLLDL----NGAVVSIDA--IGtQTAIAEQII-DKGGNyvlcvkanqslslqeieayfcplfqkhilldeq 227 Porphyromonas gingi...
Q57520   154 TAIPKl--lDLLDV----KGCLITIDA--MGcQKKIAQKIR-DKEADyllavkgnqgml-------------eqafddyf 211 Vibrio cholerae
Q9R793   154 TAIPKl--lDLLEV----KGCLVTIDA--MGcQKKIAQKIL-DKEADyllavkgnqgml-------------eqafddyf 211 Vibrio anguillarum
AFR44080 194 HAYLQdklaHNERFVvrsKHPRKDVESGlYL--YDHLKNQP-ELGGYqisipqkgvvdkr-----------gkrknrpar 259
Q45620   167 PVGEQl--tN--------AQQVLVEDRA-YF-KIERLDRFV-EQHQLfvirmkdnielhqkks-----lnrlsstsssvq 228 Geobacillus stearot...
P55729   140 QIGRTi--aIE-------SGATYIFDKG-YC-HYGWWTAIA-EAKAFfvtrpksnm-------------------glkvv 188 Sinorhizobium fredi...

1MM8_A   264 kasLSLRSGRITLKQGNITLNAvlaeeinppkgetplkwl----------------------------lltsepveslaq 315
Q44285   226 ehkESGHGRQEERYVFQLKAKLppestekwptirsiiaverhrsa-----------------ngkgtvdtsyyvsslspk 288 Aeromonas salmonicida
O07439   195 tddSRGHGRVKTRTLQIITAARgigfpyakqiiritrerlitatdq----------------rsvevvyaicslpfehar 258 Mycobacterium ulcerans
Q490H4   214 nllEELQENAQYYQTVEKSRGQievreywvssdikwlcqnhpkwhklrgigm---trntidkdgqlsqenryfifsfkpd 290 Streptococcus pyoge...
Q7BWB3   228 telSHGRIETRRYESILNPLEIeanevltrwkglrsihkvvrkrrd---------------kksdktseevayyissltd 292 Porphyromonas gingi...
Q57520   212 rmdMLQDFDGSSYSTQEKSHGRietrvalvnrdlsvlgdiehewpglksmgivasirqesavateqdvsiryyicskele 291 Vibrio cholerae
Q9R793   212 rmdMLQDFDGSSYSTQEKSHGRtetrvalvnrdlsvlgdiehewpelksmgivasirqesavateqdvsiryyicskele 291 Vibrio anguillarum
AFR44080 260 kasLSLRSGRITLKQGNITLNAvlaeeinppkgetplkwl----------------------------lltsepveslaq 311
Q45620   229 tdfTCQLGTKQCRSTKRHRVVIfrdangrdirvv---------------------------------------tnlfhas 269 Geobacillus stearot...
P55729   189 rqrRIKVAEGDGFTVIDDATVRlaskgdsklpiplrrltvkra----------------------dgdtitlltndrkrp 246 Sinorhizobium fredi...

1MM8_A   316 alrviDIYTHRWRIEEFHKAWKTG-AGAERQRMEKPDNLERMVSILSFVAV 365
Q44285   289 hkllgHYIRQHWRIENSQHYILDVvFNEDASRIAMEDAVENMALFRRFVLN 339 Aeromonas salmonicida
O07439   259 ptaimTWMRQHCGIENSLHWIRDVtFDEDRHRLHTGNGAQVLATRRNTAIN 309 Mycobacterium ulcerans
Q490H4   291 vltfaNCVRGHWQIES-MHWLLDVvYHEDHHQTLDKRAAFNLNLIRKMCLY 340 Streptococcus pyogenes serotype M1
Q7BWB3   293 vsslkQAIRGHWAIENKLHHCLDVyFGHDASHKRTRNVAQIMDIIQKINLL 343 Porphyromonas gingivalis
Q57520   292 aqtllEATRSHWGVE-VMHWSLDTaFCEDNSRIRADDRAEAFARIRQICLN 341 Vibrio cholerae
Q9R793   292 aqtllEATRSHWGVE-AMHWSLDTaFSEDNSRIRADDRAEALARIRQMCLN 341 Vibrio anguillarum
AFR44080 312 alrviDIYTHRWRIEEFHKAWKTG-AGAERQRMEEPDNLERMVSILSFVAV 361
Q45620   270 aetiaDMYQQRWAVEVFFRWVKQY-LNVPTLFGTTENAVYNQLFAAFIAYV 319 Geobacillus stearothermophilus
P55729   247 avaiaALYKGRWQIELLFRWIKQH-LKIRSFLGNNDNAVRLQLFAAMIAYA 296 Sinorhizobium fredii NGR234
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