4DGK


Conserved Protein Domain Family
crtI_fam

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TIGR02734: crtI_fam 
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phytoene desaturase
Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Statistics
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PSSM-Id: 274273
Aligned: 26 rows
Threshold Bit Score: 591.174
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4DGK_A     4 TTVIGAGFGGLALAIRLQAAGIPVLLLEQRDKPGGRAYVYEDQ---GFTFDAGPTVITDPSAIEELFALAGKQLKEYVEL 80  Pantoea ananatis
BAC17450  10 AVVIGAGVAGLATAALLARDGWDVTVVEKNADVGGRAGSLEIDgfdGFRWDTGPSWYLMPEAFDHFFALFGTKTEDHLDL 89  Corynebacterium eff...
CAE50400   5 AIVIGAGVAGLATAGLLAREGYHVRVFEKLDAPGGRAGQLTDS---GFRWDTGPSWYLMPEAYDHFFELMGTTTEQAYEL 81  Corynebacterium dip...
AAM94364   4 AVVIGGGIAGLATAALLARDGHEVRLFEARDELGGRAGRWRAN---GFLFDTGPSWYLMPEVFEHFYRLMGTTAAEELEL 80  Agromyces mediolanus
P54980    13 ALVIGSGLGGLAAAMRLGAKGWRVTVIDKLDVPGGRGSSITQE---GHRFDLGPTIVTVPQSLRDLWKTCGRDFDADVEL 89  Rhodobacter sphaero...
P54981    11 VVVVGAGLAGLAAALHLLGAGRRVTVVEREDVPGGRAGLLESG---GFRIDTGPTVLTMPDLVEDAFAAVGERMADRLEL 87  Streptomyces griseus
P54971    11 VVVVGAGLAGLAAALHLLGAGRSVTVVEQEGVPGGRAGLLETD---GFRVDTGPTVLTMPDLVEEAFAAVGEPMADRLEL 87  Streptomyces griseus
CAB53153  11 VVVVGAGLSGLACALHLLGAGRRVTVVERDAGPGGRSGRVRLG---GYELDTGPTVLTMPHLADEAFAAVGDSLRRRVEL 87  Streptomyces coelic...
BAC68733  12 VVVVGAGLAGLSAALHLLGAGRRVTVVERDLLPGGRAGRLVRG---GYLIDTGPTVLTMPDLADEAFAAVGDSLRDRVDL 88  Streptomyces avermi...
CAD78796  27 VVVVGAGPGGLASAMQLAAGGCDVTILERRGQVGGRTSAIEID---GFRFDCGPTFFLYPRVLDEIFHSTGRDLMEEVPM 103 Rhodopirellula balt...
4DGK_A    81 LPVTPFYRLCW-----ESGKVFNYDNDQTRLEAQIQQFNPRD-VEGYRQFLDYSRAVFKEGYLKLGTVPFLSFRDMLRA- 153 Pantoea ananatis
BAC17450  90 VDLTPGYRVFS-----GDTTTVDVPTGREEAAALFESIEPGA-GEKLLTYLDGAEDAYNIAIDRFLYNTFSELGPLLHKd 163 Corynebacterium eff...
CAE50400  82 VDLHPAYRLFP-----EGSPALDVDSGVGNVATLFDALHPGA-GKKVQRYLRNATDVYHLSLRHFLYTTFSNPRDFLRAd 155 Corynebacterium dip...
AAM94364  81 VRLDPGYRVYFegydeP----VDVRAEREASIALFESIEPGA-GAALARHLDSANETYRLAMTHFLYTDFAHPGALLAAp 155 Agromyces mediolanus
P54980    90 KPIDPFYEVRWp-----DGSHFTVRQSTEAMKAEVARLSPGD-VAGYEKFLKDSEKRYWFGYEDLGRRSMHKLWDLIKV- 162 Rhodobacter sphaero...
P54981    88 IRLAPAYRARFa-----DGSQLDVHTDGAAMEAAVEEFAGARqAVGYRRLRIWLERLYRVQMRRFIDTNFDSPLQLAHPd 162 Streptomyces griseus
P54971    88 IRLDPAYRARFa-----DGSQLDVHTDGAAMEAAVEQFAGARqAVGYRRLRIWLERLYRVQMRRFIDANFDSPFQLVHPd 162 Streptomyces griseus
CAB53153  88 TALDPAYRACFa-----DGSALDVHTDGEAMEAEVRRFAGPAqAAGYRDLRRWLERLYRAQMRRFIDTNFDSPLQLLHPd 162 Streptomyces coelic...
BAC68733  89 IPLHPAYRARFa-----DGSTLDVHTGAEAMEAEIERFAGAReAAGYRQLRDWLERLYRAQMRRFIDSNFDSPLQLLTPd 163 Streptomyces avermi...
CAD78796 104 ERLDPQYRLTFg-----GGGQLDCTPDMDEMDRQIAQFSPQD--VGQLKRYMDDNRIKLEKFRPILESPFHSALDVMKPs 176 Rhodopirellula balt...
4DGK_A   154 ---APQLAKLQAWRSVYSKVASYIEDEHLRQAFSFHSLLVGGNPFATSSIYTLIHALEREWGVWFPRGGTGALVQGMIKL 230 Pantoea ananatis
BAC17450 164 vlsRAGRLASLLTRSLESYVNSQFENPILRQILTYPAVFLSSRPEGTPSMYHLMSHTDLVQGVKYPIGGFTAVVTALHKL 243 Corynebacterium eff...
CAE50400 156 ilrRLPYLARLLSSSLDTWVRNRFPHPILRQILSYPAVFLSTQPTQAPALYSLMSHTDLVEGVHYPRGGFAAIMSAIEKI 235 Corynebacterium dip...
AAM94364 156 vrrRLGRLAKLLLEPLDRMVGRSFDDVrLRQILGYPAVFLGTSPERAPSMYHLMSRFDLADGVFYPMGGFGEIIASVARL 235 Agromyces mediolanus
P54980   163 ---LPTFGMMRADRSVYQHAALRVKDERLRMALSFHPLFIGGDPFnVTSMYILVSQLEKEFGVHYAIGGVAAIAAAMAKV 239 Rhodobacter sphaero...
P54981   163 ---LARLAALGGFGRLDARIGHFVSDERLRRVFSFQALYAGVPPArALAAYAVIAYMDTVAGVYFPRGGMHALPRAMADA 239 Streptomyces griseus
P54971   163 ---LARLAALGGFGRLDARIGHFVSDERLRRVFSFQALYAGVPPArALAAYAVIAYMDTVAGVYFPRGGMHALPRAMADA 239 Streptomyces griseus
CAB53153 163 ---LARLAALGGFGRLDGRIGRFLSDERLRRVFSFQALYAGVAPArALAAYAVIAYMDTVAGVWFPKGGMHALPRAMADA 239 Streptomyces coelic...
BAC68733 164 ---LARLAALGGFGRLDARIGRHLRDERLRRVFSFQALYAGVPPArALAAYAVIAYMDTVAGVYFPRGGMHALPRAMADA 240 Streptomyces avermi...
CAD78796 177 --lLGAAKHLHPFRTLGKELERYFSDPRLVIAFAFQSKYLGMSPFnCPSLFSILSFLEYEYGVFHPIGGCSRVSEKMAEI 254 Rhodopirellula balt...
4DGK_A   231 FQ--DLGGEVVLNARVSHMETTG-------NKieAVHLEDGRRFLTQAVASNADVVHTYRDLLSQHPaAVKQSNKLQTKR 301 Pantoea ananatis
BAC17450 244 ATehGVNFRLSTEAISINTTKVGgktittdVS--VLHDGELEKIPADIVISAGDLHHTENNLLPKKL-RTYPERYWSTRN 320 Corynebacterium eff...
CAE50400 236 DReaGVEFYYEHEVTDITIESGRac----gIT--AAGPHGTSTFNADVVVSAADLHHTETRLLPPHL-RSYPENYWSKRN 308 Corynebacterium dip...
AAM94364 236 ARraGAELVTGARVLGIETAGGRatgvrvqHHgpTGGTGTEEFLEAELVVSAADLHHTDAELLPPRA-RTRSEASWSRRD 314 Agromyces mediolanus
P54980   240 IE--GQGGSFRMNTEVDEILVEK-------GTatGVRLASGEVLRAGLVVSNADAGHTYMRLLRNHPrRRWTDAHVKSRR 310 Rhodobacter sphaero...
P54981   240 AS--DAGAVLRYGQRVTRLERSG-------DRvtAVVTDQ-EHIPCDAVVLTPDLPVSYRLLGRTPH-------RPLPLR 302 Streptomyces griseus
P54971   240 AA--DAGASFRYGQSVTRLERSG-------DRvtAVVTDQ-ERIACDAVVLTPDLPVSYRLLGRSPH-------RPLPLR 302 Streptomyces griseus
CAB53153 240 AA--TAGADLRWSAEVKALERSA-------GRvrAVHLASGERIACDAVVLTCELSTAYGLLGRAPR-------RPARLR 303 Streptomyces coelic...
BAC68733 241 AA--QAGAELRFGQDVTRLERAG-------DRitAVVTAY-DRIPCDAVVLTPDLPVTYRLLGRAPR-------RPLRIR 303 Streptomyces avermi...
CAD78796 255 AE--EMGVKIRLNEPVDSIEMEG--------RrvRALHTQADRYDADAFVVNADFADWMTKTVPNASrKRWSDEQIAKKK 324 Rhodopirellula balt...
4DGK_A   302 MSNSLFVLYfglN---HHHDQLAHHTVCFGPRYRELIDEIFN---HDGLAEDFSLYLHAP--CVTDsSLAPEGCGSYYVL 373 Pantoea ananatis
BAC17450 321 PGIGAVLVY---LgveGKLEQLDHHNLFFSEDWTDDFAVVFDgpqATRPSNASESIYVSMpsASED-GVAPEGHENLFIL 396 Corynebacterium eff...
CAE50400 309 PGLGTVLIM---LgvrGHLPELAHHNLLFSKDWDPDFAAVYSgphPSRPLGASQSIYISKtsATDS-DAAPEGHENLFIL 384 Corynebacterium dip...
AAM94364 315 PGPGAVLVM---LgvhGRLPELAHHTLCFTADWRTNFQRVFGsrpAIP---DPASFYVCRpsATDP-GVAPPGCENLFLL 387 Agromyces mediolanus
P54980   311 WSMGLFVWYfgtKgtkGMWPDVGHHTIVNAPRYKGLVEDIFL---KGKLAKDMSLYIHRP--SITDpTVAPEGDDTFYAL 385 Rhodobacter sphaero...
P54981   303 HSPSAVILH---TgtdRTWPDLAHHTISFGAAWKNTFHELTR---TGRLMSDPSLLITRP--TATDpSLAPPGKHLHYVL 374 Streptomyces griseus
P54971   303 HSPSAVILH---AgtdRTWPNLAHHTISFGAAWKSTFHELTR---TGELMSDPSLLITRP--TASDpSLAPPSKHLHYVL 374 Streptomyces griseus
CAB53153 304 HSPSAVILH---AgtdRTWPHLAHHTLSFGAAWERTFEELTR---TGELMSDPSLLITRP--TTHDpALAPPGRHLHYVL 375 Streptomyces coelic...
BAC68733 304 NSPSAVVLH---AgtdRTWPGLAHHTLSFGAAWGRTFDELTR---TGGLMSDPSLLITRP--TATDpGLAPPGRHLHYIL 375 Streptomyces avermi...
CAD78796 325 FSCSTYMLYlgiEg---LYEDLPHHSIHISSDYNRNLREIET---DHILSQDPSVYVQNAg--VTDpTLAPAGHSSLYVL 396 Rhodopirellula balt...
4DGK_A   374 APVP---HL------GTANLDWTVEGPKLRDRIFAYLEQHY-MPGLRSQLVTHRMFTPFDFRDQLNAYHGSAFSVEPVLT 443 Pantoea ananatis
BAC17450 397 VPTK---ATssighgDAYLPEASAAVEAIAEHAIDQIAAQAgIEDLRERIVVKRTLGPADFERRYHSWLGSALGPAHTLA 473 Corynebacterium eff...
CAE50400 385 VPVP---ANdalghgNTYHHTASPRVEEITRATIAQIATWTgISDLDERIVVTKTIGPADFSERYHAWSSGAIGPAHTLM 461 Corynebacterium dip...
AAM94364 388 VPVP---ADpti-gagGVDGRGDRAVEETADRAIATLAEWAgIPDLAERILVRRTIGPADFEDWFQSWRGSALGPGHTLR 463 Agromyces mediolanus
P54980   386 SPVPhlkQ--------AQPVDWQAVAEPYRESVLEVLEQS--MPGIGERIGPSLVFTPETFRDRYLSPWGAGFSIEPRIL 455 Rhodobacter sphaero...
P54981   375 APCPnteVG-------PGVREWRELGPRYRDELLAELERRE-MPGLGAAIEEEGLVTPVDWTA-QGHAAGTPFSVAHTFP 445 Streptomyces griseus
P54971   375 APCPnteVG-------PGVREWRELGPRYRDELLAELERRE-MPGLGSAIEVEGLVTPVDWTA-QGHAAGTPFSVAHTFP 445 Streptomyces griseus
CAB53153 376 APCPntdVG-------PDAVAWRDLGPRYRESLVGVLESRG-LEGFADSVQEELLVTPLDWDA-QGHAAGSPFSVSHTFA 446 Streptomyces coelic...
BAC68733 376 APCPntdIG-------PSAAAWGDLAPRYRDSLLTELEARG-LDGIGSAVEEECLVTPADWAA-QGHAAGTPFSAAHTFA 446 Streptomyces avermi...
CAD78796 397 VPVThd----------tENVDWSKEAAGFRELTLDKLGELG-LTDVRDRIRVEHQITPDDWQSDYSIYKGATFNLAHNLG 465 Rhodopirellula balt...
4DGK_A   444 QSAWFRPHNRDKTITNLYLVGAGTHPGAGIPGVIGSAKATAGLMLEDLIGG 494 Pantoea ananatis
BAC17450 474 QSAFLRGRNKSRKIDTLFYAGATTVPGVGIPMCLISAENILKRLHADTTPG 524 Corynebacterium efficiens YS-314
CAE50400 462 QSAFFRGKNMASKVKGLYYAGGTTVPGVGVPMCLISAENVITRIKAE---- 508 Corynebacterium diphtheriae
AAM94364 464 QSAMFRGRTASANVEGLYFAGATTIPGIGLPMCLISAELVAKAVRGEDAPG 514 Agromyces mediolanus
P54980   456 QSAWFRPHNISEEVANLFLVGAGTHPGAGVPGVIGSAEVMAKLAPDAPRAR 506 Rhodobacter sphaeroides 2.4.1
P54981   446 QTGPFRPRNLVRGTVNAVLAGCGTTPGVGVPTVLISGKLAAERITGPriar 496 Streptomyces griseus
P54971   446 QTGPFRPGNLVRGTVNAVLAGCGTTPGVGVPTVLISGKLAAQRITGPppfr 496 Streptomyces griseus
CAB53153 447 QTGPFRPRNLVRGLDNVVLAGCGTTPGVGVPTVLVSGKLAAARVTGGAGSR 497 Streptomyces coelicolor A3(2)
BAC68733 447 QTGPFRPRNLVRGTANAVLAGCGTTPGVGVPTVLLSGKLAAARVTGGtrrt 497 Streptomyces avermitilis MA-4680 = NBRC 14893
CAD78796 466 QMLHKRPRNRFEELDGVYLVGGGTHPGSGLPVIYESSRISSRLLLQDLGMD 516 Rhodopirellula baltica SH 1
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