3CYV,4ZR8,6W2O


Conserved Protein Domain Family
HemE

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COG0407: HemE 
Uroporphyrinogen-III decarboxylase HemE [Coenzyme transport and metabolism]
Uroporphyrinogen-III decarboxylase HemE is part of the Pathway/BioSystem: Heme biosynthesis
Statistics
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PSSM-Id: 440176
Aligned: 750 rows
Threshold Bit Score: 127.26
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3CYV_A         1 MTelK--NDRYLRALLRQPVDVTPVW--------MmrQAGRYLPEYkatraqagdfmslCKNAELACEVTLQPLRRYPLD 70 
WP_025414287   1 MR--PeqWEAYKRAARLEPQDKIPMAmivds-pwipgYVGVPHMDY-------------YLDPDAWFNANVKVIRDF-PD 63 
YP_429299      1 MN--LsqWSIIKKCVNMEELIQVPVGlivds-pwipgYVGISTMDY-------------FTIPEKWLEANIKIIKDF-PE 63 
WP_085754596   1 MK--EiqWKKLLETINGTKCETIPPGfiids-pwlpgWFGISTIDY-------------FSNDELWFEANKRAVETF-PD 63 
WP_052881300   1 MT--DhqWELLCRIVAGEAVETPPVGfiids-pwlpgWHGVSTLSY-------------YASDRAWLEANLNAVESF-PE 63 
WP_012548586   1 MR--EkdWQILLDCANLKEPKEIPIAlivds-pwipgYLGIPHMQF-------------YFIPDIWLEAYREIKKRF-PE 63 
WP_012377136   1 MK--PaqWETFKKAARLEKLDQIPMAmiids-pwipgYVGVSHMDF-------------FLNPEVWFQSHWKIHQEY-PD 63 
WP_015774279   1 MT--G--MERVLCALHGQPSDRRAFTlalslygsR--LSGCKAREY-------------YSAPGRYLEGQREVVRFIDPD 61 
WP_011684423   1 ML--PdqWETFKRAARREKMDRIPMAlivds-pwipgYLGIKHMDY-------------YLDPELWFESNLKIMREF-PD 63 
WP_014856759   1 MT--DnqWEILKKVIGGEKAEPLPVGfiids-pwlpnWYGIKIVEY-------------FASEELWFAANLKAINQF-PE 63 
3CYV_A        71 AAI-----LFSDILTVPDAMGLGLYFEAGEGPRFtS-PVTCKADV----DKLpIPDp--eDe-LGYVMnAVRTI---RHE 134
WP_025414287  64 VIMipswwMEYGMAAEPSILGAKIKFWDNNTPSE-YhTLYRLEDI----DEFpEYEve-aDgfAALTLhRYKMAlpkIRA 137
YP_429299     64 IIFlpgfwVEYGMATEPSGFGCKINFYPDRTPTI-NhIINSPEEA----EDIfVPNpq-tDglMPFVLnIYRNIepkVKD 137
WP_085754596  64 VMFlpgfwSEYGMCTEPSAFGAKCSFKKNDLPHA-EkIISSVGDI----DSLtLPKte-tDglASFVLnRIRLNrkkIES 137
WP_052881300  64 VMFipgfwSEFGMCTEPSAFGAKCSWETDALPHA-HrVITEAARA----GEIaKPDvr-rDglLPFVIeRLAGAqpaMRE 137
WP_012548586  64 VIFipdfwVEFGMAQEPSGFGAKIIFKPDATPNI-EpILKSADDLpdfvNNLkKPNpk-tDgfMPIVLeYYRYIepkVKE 141
WP_012377136  64 IIFvpgwwMEYGMAAEPSVMGSKIKFWQDNTPSE-YpMLFNIEDV----EKLpEYEve-nDafMALTLqRIRMQkqrVFG 137
WP_015774279  62 IVF-----SPFALPFEALAYGGEGIWLDNFPPNVrKpPFRGQEEA----QSLg--EgllrdegVAYLVeSTRLL---AAE 127
WP_011684423  64 IIFipswwMEYGMAAEPSILGAKIKFWQDNTPSE-YhTLYRLEDI----DNFpEYEvd-aDafAALTLhRIKMIkprIED 137
WP_014856759  64 VMFlpgfwSEYGMCTEPSAFGARSSFPPNEFPHA-HkLINSADEI----ESLhQPNpe-tDglLPLMLnRLKLLqsrIEE 137
3CYV_A       135 LkgEVPLIGFSGSPWTLATYMvEGgsskaFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQiKA---GAQAVMIfdTWG 211
WP_025414287 138 MgeIIPF-VTARGPMCTAGFV-RS-----TSNLMIELVEKPDEVHRLLDLCTRVVIDWLKAQhKVigdTVEGIFIldDIV 210
YP_429299    138 LgrCIKV-VAARGPLTIASHL-MG-----VTNFLIGLKTDPANTHKLLKKTTTLAKNWLEAQaEVl-sEVEGIMVldDIV 209
WP_085754596 138 LghSIRF-ACARGPLNIASFL-MG-----TTEFLIALRTDPDKAHKLLGIITEYTENWLRLQkQEf-dTIDGILIldDIV 209
WP_052881300 138 AghEIRF-AVSRGPLNIASFL-MG-----TTEFLLALYTEREACEALLKTITDFVVDWIGYQkERf-dTIDAVLVldDIV 209
WP_012548586 142 MgeKIKI-VAARGPFAIASHL-MG-----VTEFLVSVKLYPEEAKKLLEVVTSLVIDFLTAQiEVl-hDVEGILVldDIV 213
WP_012377136 138 TgeIMPI-VTSRGPMCTAGFA-RG-----TTELMIDLVEKPEWAHKLLDLCTRLIIDWLKAQeKAigrDVEGIFLldDIV 210
WP_015774279 128 WgsAKPVCAVATAPVDLPAML-LG-----IETWLEILLFDQERAARLMDLATDHFLRLTGAFfAA---GAAFVAIpvMFA 198
WP_011684423 138 LgyILPM-VTARGPLCTAGFV-RG-----TTHFMIDIVEDPKGAHRLIDLCTRVVIDWLKAQqAVmgdKVEGIFIldDIV 210
WP_014856759 138 NghKIRF-AVARGPLNIASYL-MG-----TTEFLTTMMMTPGKAHVLIRKITDFLKDWLDLQrKTf-pSIDGIFLldDII 209
3CYV_A       212 --GVLTGRDYQQFSLYYMHKIVDGLlrenDGRRVPvTL-FTKGGgQWLEAMAET--G---CDaLGLDwTTDIADARRRVG 283
WP_025414287 211 --GFVNEEHYLEFCHPYLKRICDAF----PKDWVK-LYhNDAEVdACLDHLPDA--G---FNvLNWGkQKDIREVKQRVG 278
YP_429299    210 --GFLSQDDYLEFAHPYLKEIFDAF----PQ-CIK-MYhNDSDNiVCFSYLQDL--S---INiFNFThLQDIAKVRQLVG 276
WP_085754596 210 --GFCGEPDFQEFASRYLKRLFSSF----DC-SVR-FFhNDADAkGCSPHLAEV--G---VNmFNFSfLHSIQELRQWTG 276
WP_052881300 210 --GFVGEEDYLQFAHPYLERIFQSF----PF-SVK-AFhNDAKGlVCAPHLSGA--G---INlFNFAfEHGLDEMRALCG 276
WP_012548586 214 --GFFSEEDYLEFAHPYLKKIFSSF----DY-PIK-IYhNDTNNnVYYKYLPDL--G---INiFNFThLQNIKDVYNLTQ 280
WP_012377136 211 --GFVNEEHYQEFCHPYLKRICDAF----PKDWVK-IYhNDAEVqACLDYLPDV--G---FNvLNWGkQTDIAEVKERVG 278
WP_015774279 199 nlRIVTPALLEKTILPELTRAFAQA----Q--G-PlVYhH-GGN-RILDHL-QLcsGlpnVAgFLLDpRDDLSQAREILG 268
WP_011684423 211 --GFINEEHYLEFAHPYLKRICDAF----PDNWVK-LYhNDAEVdACLDHLPDA--G---FNvLNWGkQRHITEVKRRVG 278
WP_014856759 210 --GFMGEPEFKEFGLPYFKELFNT-----DV-SVK-FLhNDAPCkVSAPFLNEM--G---VNmFNMGiDVSLTELKELTE 275
3CYV_A       284 NKVALQGNMDPs--MlyAPPARIEEEVATILAGF-G-HGEGHVFNLG-HGIHQDVPPEHAGVFVEAVHRLS 349
WP_025414287 279 DRMCLMGNVNPlevAvrGTPDEVKEATLEVLEGGtGpDGSGMILSVG-GGVSPGMPYENWIAMQDALAEFN 348
YP_429299    277 NKICLLGNIPPldvLtnGTPDMVAEAAVNCLNQH-G-NKAGIILSAG-GGTSPGTPGRNIHALIKATANY- 343
WP_085754596 277 GEITLFGNIPPrdvLasGTPEQVAESVKSNFSGL-E-NTSRIIASAG-GGMPDGVSTENIRSFTDALGDIS 344
WP_052881300 277 EEVTLWGNLPPrdtLaaQSPDEVRAAAADMVRGC-T-DPRRVLFSCG-GGMPPDVRSEQLRAFVEGCRQEG 344
WP_012548586 281 GKICLMGNIPPldvLvnGSKEDVKRSVERVLRDY-G-MKRGIILSAG-GGVSPGTPGENIRAMIDALKDFN 348
WP_012377136 279 KRMCLMGNVNPlevGvrGTPEEVRAATLDVLEKG-GsEGRGMILSVG-GGTSPGMPRANILAMQAALKEFN 347
WP_015774279 269 PQRLMLGNVNGp-gLarMQPDKAYAFVSTLLADR-A-SDRNFVLASShADIPYDTSPDTLLAVRKAVMDAG 336
WP_011684423 279 DRMCLMGNVNPleiAvrGTPEEVKDETLEVLEGA-G--GEGIILSVG-GGVSPGMPRENILAMLEALQEFN 345
WP_014856759 276 NKITLVGNLPPrdvLaaASPGEVAEATKKMLDDL-I-DKSRLIVSCG-GGMPPGVKTENIVAFVDTVKNYK 343
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