Conserved Protein Domain Family
M28_nicalin_like

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cd03882: M28_nicalin_like 
M28 Zn-Peptidase Nicalin, Nicastrin-like protein
Peptidase M28 family, Nicalin (nicastrin-like protein) subfamily. Nicalin is distantly related to Nicastrin, a component of the Alzheimer's disease-associated gamma-secretase, and forms a complex with Nomo (nodal modulator) pM5. Similar to Nicastrin, Nicalin lacks the amino-acid conservation required for catalytically active aminopeptidases. Functional studies in zebrafish embryos and cultured human cells reveal that nicalin and Nomo collaborate to antagonize the Nodal/TGFbeta signaling pathway. Thus, nicastrin and nicalin are both associated with protein complexes involved in cell fate decisions during early embryonic development.
Statistics
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PSSM-Id: 349878
Aligned: 19 rows
Threshold Bit Score: 256.14
Created: 3-Jun-2005
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q969V3    127 FMEIEPEM----LAMETAVPVYFAVEDEALLsiykqtqa------asasqgsASAAEVLLRTATAN--GFQMVTSGvqsk 194 human
EAT42305  121 IHMLEQAM----MLQEISIPVYFSRYNPKMNeiindvtkttsanqkkssqerESAISEIMGSISAN--GYQIVVSGtght 194 yellow fever mosquito
CAB86911  138 LGQLEKLL----VHGNIPFPVYFAFENEETDaml----------------adVKKNDALGQQATATtgGYKLVISVsepr 197 thale cress
AAM29385  118 ITILEQSM----LTHTAAVPIYFAPYNKDLEkiiddityt----ttdspgqnQTALAQLVVTVSAN--RYHINVGGgsia 187 fruit fly
CAB04692  121 FIDLEAKL----LSAKTDLAVYVAPFNDDAVsilhdvn--------trsekaPTALQHLLQSLSGN--TISITSSDqspe 186 nematode
XP_646483 162 YDKIYTSN----LKIKIKVPIYFVKKEEYEEliky--------------ayhQISKDKIITPKQQN--DFKFLISLglpe 221 Dictyostelium disc...
EDL44717  225 ILFAQAFL----LNFKLNQPVYFVKNNQEVEriyqnyk--------gkfglfDLTRNVSIMPLSKNqhRNKIGAKNvfff 292 malaria parasite P...
CAJ05062  112 DTTNEDVLsfffSNTAANIPVYFLPNGTASKellrll----------svaaqRRATERVVLSVAKTrrLSELVENStl-- 179 Leishmania major
EDQ51058  127 LAELEQWL----VHNTFQYPVYFAYEDENLLkll----------------heVAASDAAGRPASATngGYKLVVSApeak 186 Physcomitrella pat...
NP_492553 121 FIDLEAKL----LSAKTDLAVYVAPFNDDAVsilhdvn--------trsekaPTALQHLLQSLSGN--TISITSSDqspe 186 Caenorhabditis ele...
Q969V3    195 a----vsdwlIASVEGRLTGlg-----------gEDLPTIVIVAHYDAFGVapwlsLGADSNGSGVSVLLELARLFSRLY 259 human
EAT42305  195 a----ikqskIPIIQGELTPtkhaik---tsdgeSKLPLIILTAHLDTFGL-----INGPLKNVDVAVLLTLVELFSKLH 262 yellow fever mosquito
CAB86911  198 k----iasptITNIQGWLPGlrae-------gdsSQLPTIAVVASYDTFGAapalsVGSDSNGSGVVALLEVARLFSVLY 266 thale cress
AAM29385  188 a----nknskIPIIHGELIPnqlalkptesvadgQKLPVILITANLKTFGI-----YNDYPVNADAAVLLVLMELFSKLH 258 fruit fly
CAB04692  187 l----ppsykPLNIVGRLSSg------------dRAAPTIAFVAHYDTQSAvpgvsPGADSNGSGIVALLELLAVLSKFY 250 nematode
XP_646483 222 iinnpnsynfQTTLKCKRSSln----------ssQPLKTIVILASYDSYSIip-alSGEINNHGNSIAIFELLRVFSMLY 290 Dictyostelium disc...
EDL44717  293 ls---kdnihISSVFNKSKNnet--------flfTKRKTIVIAMDYNVFSIisahpSHSTATNTQVIAMTELIKLFSQVY 361 malaria parasite P...
CAJ05062  180 ---------pSATIESHYVHkpkqar--skaasaAAAPQVLVTAHFDSLGV-----SPASRTSGGASGAVVAMELWRRLT 243 Leishmania major
EDQ51058  187 k----lttptITNIQGWLPGlrae-------gdsLMLPTIAIVASYDTFGAapalaSGSDSNGSGVAMLLELARLFSRLY 255 Physcomitrella pat...
NP_492553 187 l----ppsykPLNIVGRLSSg------------dRAAPTIAFVAHYDTQSAvpgvsPGADSNGSGIVALLELLAVLSKFY 250 Caenorhabditis ele...
Q969V3    260 TYkrt------haAYNLLFFASGGg-kFNYQGTKRWLEDNLDHtds--------sllQDNVAFVLCLDTVGRGSs----- 319 human
EAT42305  263 ASi---------pKYRLMFLVSESgslLNFQGMKKWLDSNLDEnv-----------qIQQAEFVICLDSISKALan---- 318 yellow fever mosquito
CAB86911  267 SNpkt------rgKYNLLFALTSGg-pYNYEGTQKWLKSLDQRm-------------RESIDYAICLNSVGSWDs----- 321 thale cress
AAM29385  259 YTssm------apKYRLRFLLSDAgvlLNFQGSKKWLEVDDNA--------------LQNVEFMLCLDTISESLsytt-- 316 fruit fly
CAB04692  251 DSpst------rpPYNILFIWTAAg-kLNYQGTRHWIDEYQKGfdsadyaksglsrkDDRVDLAICIEAIGRKTg----- 318 nematode
XP_646483 291 SNpnt-----qpiSFNLVFTLVGAs-sLNEFGVKRWIDQQSKSf-------------LNSIDHVLCIDSIGMKSystfkn 351 Dictyostelium disc...
EDL44717  362 KNe----------EVNYNILFFFT---NYYFGIDHFLDSVNVIf-------------RENIQFVLTLGSLNDED------ 409 malaria parasite P...
CAJ05062  244 STpyarqesvapyGVTVLFGSTSR---FNYAGTTSWISQHTDRe-------------LDQFRAVLCLDELLPPRetsk-- 305 Leishmania major
EDQ51058  256 ANpnt------rgRYNLLFGLTSGs-pYNYNGTSNWLRNFDQRl-------------RESMEYALCLNSLGSSSd----- 310 Physcomitrella pat...
NP_492553 251 DSpst------rpPYNILFIWTAAg-kLNYQGTRHWIDEYQKGfdsadyaksglsrkDDRVDLAICIEAIGRKTg----- 318 Caenorhabditis ele...
Q969V3    320 --------------------LHLHVSKPPrEGTLQHAFLRELETvaahqfpevRFSMV----HKRINLAeDVLAWEHERF 375 human
EAT42305  319 ------------------dnIFMHVSKPPkEGTPMNSFYKTLKAvaq---rygNITVEg--vHKKINLAdTLLAWEHERF 375 yellow fever mosquito
CAB86911  322 -------------------eLLIHVSKPP-DNAYIKQIFEGFSNvae----dlGFQVAl--kHKKINISnSRVAWEHEQF 375 thale cress
AAM29385  317 -----------------enaLYMHVSKPPkDKTSISNFFKLLKSsaek--ysnGLAVEg--vHKKINLAdTKLAWEHERF 375 fruit fly
CAB04692  319 -------------------gFFMHAGKTPsENSVAAQLLRRLNSisp----kkNIELV----TKKISLT-TVSAWEHEKF 370 nematode
XP_646483 352 nnddgdenenekelindenkLYLQISKSLtKSLKIKNLVGNYQFsakn--ddiNLTII----QKKIDISnPKINFKHEIF 425 Dictyostelium disc...
EDL44717  410 --------------------FIIHQNKKL-PPDHVLRFYDILKGvl-----mkNLHLEiqlsEEKIKTHsKHLPWLHEYF 463 malaria parasite P...
CAJ05062  306 ----------------dapdLYLHVQDVLmKRQHGQQVVEQVEAaakl--lgiSLKVV----SAKTNYQhYDLEFEHEAF 363 Leishmania major
EDQ51058  311 -------------------rMLLHVSKPP-ENAFIQQIFSEIESvak----dsDLTVEl--kHKKINISnSRVAWEHEQF 364 Physcomitrella pat...
NP_492553 319 -------------------gFFMHAGKTPsENSVAAQLLRRLNSisp----kkNIELV----TKKISLT-TVSAWEHEKF 370 Caenorhabditis ele...
Q969V3    376 AIRRLPAFTLSHle--sHRDGQRSSIMDVRsr------------vDSKTLTRNTRIIAEALTRVIYNL 429 human
EAT42305  376 SMKRMPAFTVSNlk--sHKDYLRNTIFDDEde-----------eeQLQKLETNVKILAETLASYIYNL 430 yellow fever mosquito
CAB86911  376 SRLRVTAATLSElstppELLENAGSLSDTRql------------vNEDAIIKGVKLVAESLAKHIYGH 431 thale cress
AAM29385  376 SIKRYPSFTLSSvk--sPRSPIRTTIFKNDes------------rLVEHTLNTTRIIAEALASFMYKV 429 fruit fly
CAB04692  371 NIKRMPAITLSTlp--sPSDPARNSILDLPsa------------lDEDELIDNIRLIGEAVLGYILDL 424 nematode
XP_646483 426 SRKHIDSMTITQk---qFSTPTTNGILSTNsk------------lSLPILKRNTKIIASSLLSYIYNI 478 Dictyostelium discoideum AX4
EDL44717  464 ELKNVDSFTLSTkg-eiLSFINKTPLIEQKi--------------KPDVVKAHIKNIFEALYVYIKSP 516 malaria parasite P. vivax
CAJ05062  364 ASRQVIAMTLST-----HRVHHNDQLFRDLrrppataadaavlakRADLVEAIVRIIAEAAPSVEGAT 426 Leishmania major
EDQ51058  365 SRQRITAVTLSHleeppELLQRTGGIADIRrs------------vNETVVLRNIKVVAESLARHIYGQ 420 Physcomitrella patens subsp. p...
NP_492553 371 NIKRMPAITLSTlp--sPSDPARNSILDLPsa------------lDEDELIDNIRLIGEAVLGYILDL 424 Caenorhabditis elegans
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