Conserved Protein Domain Family
BrxC_BrxD
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pfam10923: BrxC_BrxD 
BREX system ATP-binding protein BrxC/D
This is the ATP-binding domain found in proteins that are associated with Bacteriophage Exclusion (BREX) system, a defense system that allows bacteriophage adsorption but blocks phage DNA replication. This domain is found in the ATP-binding proteins BrxC/pglY (due to its homology with pglY from Pgl system) and BrxD.
Links
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Statistics
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PSSM-Id: 431535
Aligned: 73 rows
Threshold Bit Score: 404.979
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CDC63624       16 PRRVLASLLASVSAGVVPREGAPYIAIGRQDEIAALLSDLNQVNEGGGAMRFLIGRYGSGKSFLIQLIRGYALERDFLTA 95 
BAK35873        8 SPRRRREVLDALRRGTVPAQGLDLLAVGLRPFESTLSDELTTVAGGGSVFKAVRGEYGSGKTFFARYLSELALRRGFAAA 87 
Q2J8S8          4 SEQRRREVIDALRRGTVPRQGLDVLAVGLDRFTTAIEEDLDRLAGGQATFRAIRGDYGAGKTFFTRWLAERAKARGFATA 83  Frankia casuar...
WP_015099260    5 SPARRRAVLAALRRGTVPESGLDLFAVGLDRLAPTLDEELSACASGAAEFKAVRGEYGAGKTFLARWLAERAKAAGMAVS 84  Saccharothrix ...
WP_012894230    6 SRARRQQIIAALGRGTVPQNGLDLFAVGMEGFEKVLDEELAVAASGRGGFKAIRGEYGSGKTFFARWLAERAKRMRMATS 85  Streptosporang...
WP_012851858    8 SPARRRKVIDALGRGTVPERDLDLFAVGMERFAR-LDEELAAVTRGGWKFKAVQGEYGSGKTFFSRWLAQRARDKNMASS 86  Thermomonospor...
WP_015158636    4 SEKDTEHILERLRSGTVPERGLEAFAVGIDKQQTEIRRQLSLAASGEGVFKFLRGGYGCGKTFMSRLAVLEAQEQGFATS 83  Chamaesiphon m...
WP_012826408    5 tERDIRHVIESLRSGLVPERGIDAFAVGVDKERGELQRQLDLAASGEGAIKFLRGGYGCGKTFMARLALLDAQARGFATS 84  Haliangium och...
WP_014777943    5 tRKDVEHVFESLRKGLVPERGIDAFGVGCEKPRGELHRQLDLAGNGEGTIKFLRGGYGCGKTFMARLALLDAQARGFATS 84  Thiocystis vio...
jgi:Plim_3078   5 tgRDVEHIFESLRKGLVPERGIDTFAVGIEKQRNELHRQLELVGSHEGSIKFLRGGYGCGKTFMARLALLDAQARGFATS 84 

CDC63624       96 DCDLS-PERRLYgaggSGVATYRELMKNLASKASPDGgALRKIIARWITALQTNLTGQGI--SPDSAAFDDALNRTVTAE 172
BAK35873       88 EVQISeTETPLH----RLETVYRRIVESLRTLSVPPS-AFRSVLDSWLFTVESDVEESG-------EGSVASVDRVLEQR 155
Q2J8S8         84 EIAISeNETPLH----RLETVYRRLAERLATAEFAPS-ALRPIVDSWFFALEEDVLAGGEvvENE---LARRVDELLEQR 155 Frankia casuar...
WP_015099260   85 EVQISeTETPLH----RLETVYRRLCENLTTAAAPPS-AFRAVLDSWLFALEEDVLAEGEvdASDAQRLGSAVDDLLELR 159 Saccharothrix ...
WP_012894230   86 EIQISdTQTPLH----KLETVYRALIGGLSTASSPPS-ALREIVDSWLLTLEDDVSAAAGiaKDNRRAMVPAVDELIESR 160 Streptosporang...
WP_012851858   87 EVQIS-QDVPLH----KLNVIYQRLIKNLTIAETSEG-AFRALVEDWLLNLEDEVCAAEGldPADRDRVEAAVNKRIDVR 160 Thermomonospor...
WP_015158636   84 FVVVSdNDLHFY----KFDDVYRKVVQELGTSSCPRG-ALSDIIDRWIAKVEDALIAGGA--DEESEGFDAQVQQRMEEE 156 Chamaesiphon m...
WP_012826408   85 FVVVSdNDLRFH----RFDDVYRKVVGELATASCPRG-ALGDILDRWIGGIEAGMIAAGA--DEDTDDFDQQVRKRIDDD 157 Haliangium och...
WP_014777943   85 FVVVSdNDLRFH----RFDDIYRKVLAELSTTACPRG-ALGDILDRWIGRIEAALIAVGE--DEQAADFDDRVRQRLDED 157 Thiocystis vio...
jgi:Plim_3078  85 FVVVSdNDLHFH----RFDDVYRKVMTELGTASCPRG-ALGDILDRWIGAVEETLVNAGV--DDTADDFDERVRKRLNED 157

CDC63624      173 LREMEFLVGGFDFAQVISAYYRAYRQAdaeSDARMSACLRWLRGEYTTKTEARKEIGipVSTIIDDENWYDFLKLWAALA 252
BAK35873      156 LTAVR--NTTPAFAQALRAYRAAVSGG---DQSTADSLIAWLGGQPHVAAAAKRSAG--IRGDLDHFGAMGALQGLLLVL 228
Q2J8S8        156 LAAVG--RVAPSFSAALRAYRRATAAG---ETAAAEGLIAWLGGQPHVAAAVKRAGG--VRGDLDHDGALGFLQGLLAVL 228 Frankia casuar...
WP_015099260  160 LGGLA--RTTPGYATGLRGYRRAVAEG---NTDTADGLAAWLAGQPHVASSAKRAAA--VKGDIDHFQALGFLQGLLTVL 232 Saccharothrix ...
WP_012894230  161 LAEAA--QTAPAFATALRFYRRARLAG---DQAIADGLLAWVGGEPNVAAAVLRYAN--IKGKLDSGNALGFLQGLLVVL 233 Streptosporang...
WP_012851858  161 LKEVA--DSAPSLATALRAYRKARMAG---DSGTAMQLLSWVSGDEHVAASVKRQAG--LKGEVNADTAFGFLRGLLIIL 233 Thermomonospor...
WP_015158636  157 LASLTAGKAPEDMARVLRAIFQLKQQG---EVAEASALLAWLSGSENVSASAKKVAG--IKGDIGSREALDYLQGILEIT 231 Chamaesiphon m...
WP_012826408  158 LMSLTGGQVPADFVRVVQTVFDLKQRG---EVAEAGALISWLSGSGNVSAGAKKRAG--IKGDIGSRDALDYLRGVLAIV 232 Haliangium och...
WP_014777943  158 LSSLTGGQAPQDFIRVVQRVFDLKQAG---DSSSAGALLSWLCGSGNVASSIKQTAG--VKGDIGSRDALDYLRGVLEIV 232 Thiocystis vio...
jgi:Plim_3078 158 LVSLTGGNAPEDFIRVIQTIFDLKQDG---NVVDAGALISWLCGSGNVAASAKKVAQ--VKGDIGSRDALHYLRGVLEIV 232

CDC63624      253 RRMGYRGLVVFIDECVNLYKIvHRTSRENNYEKILSMFNDTLQGRARGLEIVFAGTPQFLeDPRRGLFSYEALRSRLCDS 332
BAK35873      229 RDAGHPGLVVVLDEVETLQRV-RGDVRDKALNALRQLIDEMDAGRYPGLYLMITGTPAFF-EGPSGLSRLPPLAQRLHAD 306
Q2J8S8        229 TDSGHAGLVVVLDEVETLQRV-RGDMRDKALNALRQLIDDVDAGRFPGLMLVITGTPAFF-DGPQGAQRLAPLAQRLHVD 306 Frankia casuar...
WP_015099260  233 RDAGHPGLLLVLDEVETLQRV-RSDARAKALNALRQLIDEIDKGRFPGLYLMVTGTPAFF-DGRQGVQLLQPLADRLHTD 310 Saccharothrix ...
WP_012894230  234 RDCGHPGLLVVLDEIETLQRM-RSDIRERSLNTLRQLIDEIDKGRFPGLYLVITGTPAFY-DGQQGVQRLTPLAQRLATD 311 Streptosporang...
WP_012851858  234 RDCGHTGLLLVLDELETIQRL-RADVRDKSLGALRHLIDEIDRGSFPGLFLLITGTPAFF-TGPTGVPQLPPLAQRLDVD 311 Thermomonospor...
WP_015158636  232 KAAGYKGLVIAIDEAETILRM-RHDVRGKSLNGIRQICDA--ADRYRGLLWLFTGTSEFF-DTQRGVAGLQPLYERIK-- 305 Chamaesiphon m...
WP_012826408  233 KKAGYKGLVIVIDEAETILRM-RKDSRHKSLNGIRQIADA--AGSYHGLLWMFTGTPEFF-DERRGVAGLAPLHERVR-- 306 Haliangium och...
WP_014777943  233 KAAGYAGLVIVIDEAETILRM-RADSRHKSLNGIRQIADA--AGSYPGLVWLFTGTPEFF-DSRHGVAGLTPLHERIR-- 306 Thiocystis vio...
jgi:Plim_3078 233 KAAGYKGLVIVIDEAETILRM-RKDSRHKSLNGIRQIADA--ASSYPGLLWLFTGTAEFF-DTRHGVAGLTPLHDRIR-- 306

CDC63624      333 rFALEg-FKNLIGPVIRLRRLSDDELLALITRITQLYAQY---YNWDPsaHLTPEDQVTFLRLCLSRAGADSMITPREML 408
BAK35873      307 -FTAErrFDNPRAVQIRLAGFTRGSLVELGVRVRDLYAEGs-dHADRVraLVDDAYLGVLADAVAGSLGGSIGVAPRVFL 384
Q2J8S8        307 -FLPDqaFDNPRAVQLRLPGFNRDSLLELGGRIRELYSSGh-gDPERFatAVDEGYLAEFAQAVVGQFGGRVGVAPRIFV 384 Frankia casuar...
WP_015099260  311 -FGTDnrFDNARAPQVRLTGFTLDRLVELGSRVRSLYANGs-pAAQRIlqLVDDAYLRDFAASVAGRLGGKVGVAPRVFL 388 Saccharothrix ...
WP_012894230  312 -FDTDprFDTARAVQIRLTGFDTDKLVQLGCAVRDLYAGGn-pAEARIrsLVDDGYIKDLSATVAGRLG--VGTAPRTFL 387 Streptosporang...
WP_012851858  312 -FDTDprFDSMQSHRLRLTGFDLDKLVELGRRVRDLYAEGepqARERInqLVDDAYIKDLATSVAGKLS--VGTSPRVFL 388 Thermomonospor...
WP_015158636  306 -FQDEggFVSTRQPQLELKPFDANRLKEVALKLREIYPAV---DRHRLmnKVTVDFIDRLVAKTTQGFQGDVGVVPRQFL 381 Chamaesiphon m...
WP_012826408  307 -FIKQggFASRRQPQLELHPFDSQRLSAVALLLRGLYLRVa-eEPARVdeRITEAFIGRMVEEVTKGFRGDVGVVPRQFL 384 Haliangium och...
WP_014777943  307 -FLQQgrFASLRQAQLALAPFDAERLRAVALRLREIYPAQ---DRARLetCISTTFVDRLVTEVTRGFKGDVGVVPRQFL 382 Thiocystis vio...
jgi:Plim_3078 307 -FISSggFASLRQAQLELKPFDTERLKAVALRLREIYPGQ---DRSRLesAVSQEFIERLVANVTAGFKGDVGIVPRQFL 382

CDC63624      409 RDYM-TVLNILMQNPNAAFADVVGS 432
BAK35873      385 KKLVgDVLDRVDQFEDFDPRQHYRL 409
Q2J8S8        385 KKLV-DVLDRVDQHPAFDPRRAYVP 408 Frankia casuarinae
WP_015099260  389 RKLVlNVFDTIELHPDFDPRSDYTV 413 Saccharothrix espanaensis
WP_012894230  388 RKLVaDVLHRVADHEDFDPRRHYRL 412 Streptosporangium roseum
WP_012851858  389 RSLVsDVLFKVAEHPDFNPRVHYAR 413 Thermomonospora curvata
WP_015158636  382 RQFV-NVLDLTDENEDYDPMVVagf 405 Chamaesiphon minutus
WP_012826408  385 REFV-SQMDRVDEFEECDPMRDWNf 408 Haliangium ochraceum
WP_014777943  383 RELV-NQLDLVEEHADYDPMTEYGF 406 Thiocystis violascens
jgi:Plim_3078 383 REFV-TQMDLVEENKDYSPAEQYGF 406
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