Conserved Protein Domain Family
Ciart

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pfam15673: Ciart 
Circadian-associated transcriptional repressor
Circadian-associated transcriptional repressor (Ciart or Chrono) is a negative regulatory component of the circadian clock. It functions as a transcriptional repressor, modulating BMAL1-CLOCK activity. It also regulates metabolic pathways such as the glucocorticoid response triggered by behavioral stress.
Statistics
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PSSM-Id: 464794
Aligned: 4 rows
Threshold Bit Score: 504.845
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007485432 251 SGMKRSRDNEEETCHNIQNPRTEGDRLFAQKCKELQGFIRPLTDLLNGLKMGRYERGLSSFQQSVAMDRIQRIVGVLQKP 330
Q3TQ03        85 SEVKRSRDGEQETSLNTQGCTTEGDLLFAQKCKELQGFIRPLTDLLNGLKMGRFDRGLSSFQQSVAMDRIQRIVGVLQKP 164 house mouse
XP_003800456  89 SGVKRSRDGELETSQNIQGCTTEGDLLFAQKCKELQGYITPLTDLLNRLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKP 168
XP_010587958 159 SRVKRSRDGELESSLNIQGCTTEGDLLFAQKCKELQGFIRPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKP 238 African savanna...
XP_007485432 331 EMGERYLGTLLQVEGMLKTWFPHVASQRATPGDGKHRlLSKRLASSQANPTGPSADLARKNLNQIQLRHLdqgkeklhSQ 410
Q3TQ03       165 QMGERYLGTLLQVEGMLKTWFPHIAAQKSSSGGSRHQ-ISKHFPSHHGDPGAASPAPLLEKMGQTQLGHL--------VL 235 house mouse
XP_003800456 169 YMGERYLGTLLQVEGMLKTWFPHIAAQKSLLGHSRHQ-LTKHFPSHHSDSAASFPVSSLEKVDQSQLGHV--------VL 239
XP_010587958 239 QMGERYLGTLLQVEGMLKTWFPHIAAQRSLLGDNRHQ-LTKPLPSHHTNLAVSSPAPPMAKMNQTQLGHL--------VL 309 African savanna...
XP_007485432 411 EQELPQLLPEWPAMNLTWIHTTPICNPPLSSLGSAAfSHGLLGPGASFGFILFLQHGAQSFARSAPTTPVPYSAVSSVVC 490
Q3TQ03       236 KPKQPWHLTGWPAMNLTWIHSTPICNPPLSSQGSAS-GHSPIGTGASIGVILVLQKGGQPFTHSAPGTPVPPTPLSPVVP 314 house mouse
XP_003800456 240 KPEQPCHLTDWPALNLTWIHTTPICNPPLSSPGTISfSHGPLGTGTSIGVIFFLQHGVQPFTHSTPTTPVLPTTASPVIS 319
XP_010587958 310 KQKQPWHLTEWPAMDLTWIHTTPICNPPLSSPGTISlSHGPLGTATSIGVILFLQHGVQPFTHSAPATPVPPPTTSPVTP 389 African savanna...
XP_007485432 491 DGPKNISEEEPRCYSLPVSLSstpltSERSHSLSSPCLPTVTREKTPRMDE 541
Q3TQ03       315 GDLKKLPGEEPRCHSLPVTLP-----SDWSCILCPPVLPTTDREMTKGHPE 360 house mouse
XP_003800456 320 GDPKKLSREGPRCYSLPVTLP-----SDRSCPLSPPSLPIMAREMTVGHLE 365
XP_010587958 390 GDTKKLSGEGPHCHSxTVTLP-----SDWNCTLCSPGLPTVTREMTMGHLE 435 African savanna elephant
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