Conserved Protein Domain Family
TMEM132

?
pfam16070: TMEM132 
Transmembrane protein family 132
This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.
Statistics
?
PSSM-Id: 465003
Aligned: 47 rows
Threshold Bit Score: 198.664
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EFN86171        88 EVMNTAVLTGRQVSQ--GMKVFIVSQAG-----TVADVTLQSSCHSEDESVLKVSSSCSSVYVDGSEARGSSNASV---- 156  
XP_002594816   391 QLLNTAVLNGLHVST--PLRVLAVMRSG-----KVIDISDKATCTSPGTDVIKVMHDCSMVYLDGTEMRGSQHATI---- 459  
XP_025016428   519 sMINTAILTGKQVAQ--SLRVFAVSQAG-----RIGDVTLQASCTSTDESVLKVSPSCTSIYLDGSEIRGSSNATI---- 587  
EFX85492       549 DLVNTAILTSRQVSE--PLRVFMVTQAG-----KVADVTLQATCSSADESVLKVSSSCTSVYLDGSEVRGSTNATL---- 617  
EFP09182       300 ELMNLAVISGLQVTS--SLRIFTVSIGS-----KAEDVTSQSHCISSDANIIKVSPTCSSVYLDGSESNGSSDAQV---- 368  
EFO25867       352 NLVNTAVLSGKQAAV--PMKIFSVTEGG-----NLDDVTSSSYCLSAESRVLKVSPTCSSIYVDGSELRGMSKVKV---- 420  
XP_004992680   797 vLLNTAALNPDNAALqhPLTVSAYSASGs---gTTLSPSTSLVCSSSAPEALQVDASCGYVHFTGAETAGSDSAQV---- 869  
XP_004990690  7537 fvetTCIVNGGEQTF--PLRIVTSDAAGdmqlvTGTTGTPGLSCSSRHPHVWDVSSDCSSVVLAGDETSGMTGASIavs- 7613 
XP_001750073  8018 ELVNTAILSGRPVTS--GVTLVSALANGtl--vLQDPTAAAVSCVAGNTTVLNVREDCSELLLSGAESHGQAEASVifal 8093 
EGD82877      1259 ELVNTAVLSGSEETS--ALSVRAVSSWRpgqfaVVSAGSPGLACMSLNTSVLLADADCGRVRVTGAESGGSPSVGV---- 1332 
EFN86171       157 -----LVKYGT--YTGLAKFIVWMPEF-PLEVTV------GDTRLSQIKGWKI------Peqqtsstkskrslnatglde 216  
XP_002594816   460 -----IVSYAD--VFTELNFTVWMPEL-PLTVEL------SDTRLSQIKGWKV------A-------------------- 499  
XP_025016428   588 -----SIKYGT--YTGQANFVVWMPKL-PLEVRV------SDSKLSQIKGWKI------Phlkregrrs----yhnqnsi 643  
EFX85492       618 -----VARYGN--VESTSSLTVWVPEM-PLDIQL------DDVKLNQISGWKV--------------------------- 656  
EFP09182       369 -----YAHFLR--YTTAFSFRVWYPKL-PLKIWT------SSSTLSTIKNWKVgfwrdlP-------------------- 414  
EFO25867       421 -----HVHFKT--MTTSIEVTVWYPRL-PITVWL------SDPVLNAIKDWQIavwkwlP-------------------- 466  
XP_004992680   870 -----VVQHATlpLNTTLRYKVWHPAAfRIAIDVqgsssgSDVVLRRIGGTAL--------------------------- 917  
XP_004990690  7614 --vrdAVSNTT--ANGDCLGEVWAPQL-PIELQA------DNPMLARVAGWQW--------------------------- 7655 
XP_001750073  8094 arndsAV------LLAEAHARVWAPTL-PVELEV------DDTTLRRVANWSW--------------------------- 8133 
EGD82877      1333 -----SVEYGG--QSARVWVRVWYPEE-PVQVVL------DRDVVRRVARWQR--------------------------- 1371 
EFN86171       217 aAVTARAkkRSAMELEDSIEDdtsmdvedsdmmpdedeqeeryrggggdhgwdnsiersPPTTCRLR----FQQSPVEVH 292  
XP_002594816   500 -LVSDNNynRYSATEGKAR------------------------------------------AACRLR----YQHATVQVF 532  
XP_025016428   644 yGHSNHKsrRSSAKNSPNDKIdys--------------------------------stdNDIGCRLR----HQQAYIQVF 687  
EFX85492       657 ---------MATSAASGASA-----------------------------------------NQCRLR----YQQSSFEVF 682  
EFP09182       415 -LGGGVKrsRAARQ-----------------------------------------------FACVNR----FQHGHVKVL 442  
EFO25867       467 -----SRrkREARQ-----------------------------------------------FGCINK----YQQAEIRIL 490  
XP_004992680   918 -----------------------------------------------------------------------YQHVGYTIE 926  
XP_004990690  7656 --------------------Fd------------------------------------eDASTCRDK----FQDTRIHAF 7675 
XP_001750073  8134 --------------------Fd------------------------------------tDASICRPK----YQNTRLRAF 8153 
EGD82877      1372 --------------------Dag----------------------------------hdASDGCVSLgtsqFQRARVSVV 1397 
EFN86171       293 ARFSATDHD--SGRTSFFVN-RR-----TWLRVTD-----LVTAVL---RISDPRIATlLq--GR-IVQGRSVGRTEVQV 353  
XP_002594816   533 TRFYTPEDDl-AGENRFLLG-DR------YLQITE-----LVSSFI---RVADESIAS-Lk--GR-TVNAKVPGTTEIQV 592  
XP_025016428   688 SRFFSTDHN--SGRESYLLN-RK-----VLAQVTK-----LVTPFL---RVTDSRVAI-Ir--SN-IIEGISSGRTEIQI 747  
EFX85492       683 ARFYAEDHD--SGRVSYLIS-RK-----TYLLITD-----LVRKVM---RVADPRVAS-LkmtSG-FIEGLKPGKTEVQV 744  
EFP09182       443 ASLWIE--DqkTGDQLYLSShKS-----ILFDVTN-----IVHNTL---QISNRTVANvKfheGRaVIIGENMGLAKLVV 507  
EFO25867       491 ASYYVG--DkeTGERIYLSGdRD-----ILFDVTS-----LTMNHV---HSSNIAVAVvLprqDRiFVVAHRPGSARITV 555  
XP_004992680   927 ADWSSATA----------MTsGGaddwlNSTDVTEevwplLQGQHVgggSGDGNVIVTpLsitTN------TSGTFRLCI 990  
XP_004990690  7676 AMFSRMES-----------GaGA-----VRVRVTKdvsgvLQALDA---TGAAQSTA--IqmqGN-VARGFRLGSAVVAV 7733 
XP_001750073  8154 ATFS--------------YGaQA-----YRARVSS-----LVVLGA---SSSNTSVAR-VesdGQ--VSAWRPGNITIAI 8203 
EGD82877      1398 GRFRSGDA----------------------VSAALslgglLGQSQL---AVVNQSVARvDpvvSG-HVQGVGAGQTVVRV 1451 
EFN86171       354 LSPI-TG-RVIGAKEVRVGNDRV-SVTRLSVTVVSG-----------LQLSISPD-TAIENGYVA-ETSVTRRLTAQYQE 417  
XP_002594816   593 ISPL-NG-RLMGAQELMVADDKV-TIKSIKAIVVAG-----------ITMSLMPEpSSGGKIFSA-TTTAQQTMTGQYQR 657  
XP_025016428   748 VSPI-TN-QILGSTEIHVGNDKE-MITQLEVNLVTG-----------LSLSITPE-SSLTNVWKI-TANISSKLVNQYQE 811  
EFX85492       745 LSPM-SG-HVIAARELRVLADKV-DVSRLSVRLIAG-----------LSLSLSPD-PDLDSCFVA-QVEASDRLHSRYQE 808  
EFP09182       508 RNAK-KS-LDLVTENISVRNEEV-TTTGLSARPICD-----------TNFRILPI-LFSPAFFKI-EIYHSKTLTKLYQQ 571  
EFO25867       556 RSNT-PN-IDYGSAPIVVTEDAV-SIRRFAVEGVAD-----------IALDIERI-PRRAHEYVV-STFVQNTLTYKYQH 619  
XP_004992680   991 SHPLrTP-SCLGARDIEATDSEPaTPVAISATVVAS-------------VTAATT-TSSADTYTRvSSSFTSVLTADQQS 1055 
XP_004990690  7734 INPAvPE-RTIGNTTVEAVGSV--PVPSLGGSTVASllvdelelivfTDMTVKPLySPFTGLASAsVVSISQALDQEQEV 7810 
XP_001750073  8204 DHAQrQG-RDLGSVTLTVLEED--------ASSALGllvsrlelhafTNLTAAPLaSPLVDLDSSsVVFVHQVFDVEDRV 8274 
EGD82877      1452 LSAAvSGsRVIGEAMLEAQDSYV-GIVGLDVVVASAv---------rVSGGMSELgNDPGSSAEAtVVVERDVLDFEGQR 1521 
EFN86171       418 GLLDIDVEFADGSRTPLR--------EIAVSDYHLLVESLDKEVVVFAPMV----ASHHPRVIAIGEG-RGDLLRVSLQL 484  
XP_002594816   658 GVLDVSVSFSDGSAFWLR--------EIEDNEYSIKVSSLNPRVVALSPSK----THTIPRVIATGHG-KGDLLEVELRI 724  
XP_025016428   812 GLLNIKVHFSDDTVTSLA--------DINDSDYQLSINTLDNGGIAYAPLI----GQPYPRVIVIGQG--NSQLHVSLEV 877  
EFX85492       809 AILDLTVHFSDGSASPLR--------LTDRSHYNLVVESHNTSILALTSPA----RANIPRVLALGEG-RATL---SVTF 872  
EFP09182       572 CSIFASVSYSDATWEPLN--------DLDSSYFEMSAHSDNERALAVSHHA------SKVHVIAIDEHwPLPSVEIALQS 637  
EFO25867       620 ATLVCRLYFSDEQVLELT--------DIPSEQYVLRGWSSDEQAIALNHGP----GGHNIELIVLQNA-KNVIISVSLHS 686  
XP_004992680  1056 ASVVVHAIFSDGSTRVLD-----------PALHNTTVTTGSPALIATNINAa--sSNSHPFV--TTLGgGSVAVGLTWYV 1120 
XP_004990690  7811 GSVAAFARFQDGSRMVVG----------PETGLRLSVDQANRGVIAVPSTGdlvfDNRHVLA--QGSG-SGNLLSATWTV 7877 
XP_001750073  8275 GAVAAYAVFEDGARMELS------------PEQGLRLNSLDPAVLAVSATGvssyDHAHVVA--KGAG-SGPLLQGTWL- 8338 
EGD82877      1522 ASVFVSAVFEDLTRMELGvgrevrlrTLAPGTVRVVGNGAEPGVIVVPGRA-----------VD---G-SGELIEAIWQG 1586 
EFN86171       485 ADSCRL 490  
XP_002594816   725 PEGCMR 730  
XP_025016428   878 SDQCQR 883  
EFX85492       873 SSACTt 878  
EFP09182       638 SSQCAS 643  
EFO25867       687 PVQCSE 692  
XP_004992680  1121 SDtttv 1126 
XP_004990690  7878 LCESPN 7883 
XP_001750073  8339 -AECAN 8343 
EGD82877      1587 GNANAe 1592 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap