Conserved Protein Domain Family
PNMA

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pfam14893: PNMA 
PNMA
The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis.
Statistics
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PSSM-Id: 464357
Aligned: 22 rows
Threshold Bit Score: 341.626
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006108514   1 MTMTLLEDWCRGMDVDIHRALLVTGIPQDCGPEEMEETLSRVLsPLGPYRVLNRIFVREENAKAALLEVGEGVSLRAVPR 80 
EFB27002       1 MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAM-PQVRYRVLGRMFWREENAKAALLELTGAVDYAAIPR 79 
Q80VM8         5 VAMTLLEDWCRGMGMDIHRSLLVTGIPEYCSHAEIEETLNGVLlPLGTYRVLNKIFLRQENVKAALVEVSEGVNLSSIPR 84  house mouse
XP_003464736   5 TAMNLLEDWCRGMEVDVHRSLLVTGIPEDCGQAELEETLNGVLaPLGTYRVLNKIFLREENVKAALIEVGEGVNLSAVPR 84 
Q5R6R8         5 MAMNLLEDWCRGMEVDIHRSLLVTGIPEDCGQAEIEETLNGVLaPLGPYRVLNKIFVREENVKAALIEVGEGVNLSTIPR 84  Sumatran orangutan
XP_014584920   1 MAMNLLEDWCRGMEVDIHRSLLVTGIPEDCGQAEIEETLNGVLsPLGQYLVLNKIFLREENAKAVLIEVSEGVNLRAIPR 80 
XP_004754851   1 MTLRLLEDWCRGMDVDPRRAVLVAGIPPTCTVAEIEEALRAGLaPLGECRLLGRMFRRDENRNVALVGLTEETSHAVVPK 80 
XP_510137      1 MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEIEEALQAGLaPLGEYRLLGRMFRRDENRKVALVGLTAETSHALVPK 80 
Q5BJV6         1 MTLRLLEDWCRGMDMNPRKALLVAGIPPTCGVADIEEALQVGLaPLGEHRLLGRMFRRDENKNVALVGLTVETGSALVPK 80  Norway rat
XP_008530705   1 MALALLEDWCRIMSVDDQKSLMVMGIPVDCDEAEIQEVLQETLkSLGRYRLLGKIFRKQENANAVLLELMEDIDVSVIPS 80 
XP_006108514  81 EFPGRGGAWRVVCRNPTQDAEFLKNLNEFLDAEGRTWEDVVRLLHLNDAPAprnrnqnpPPGSWVEALGALLGTVMQVI- 159
EFB27002      80 EMPGKGGVWKVVFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFQNPAPt------pGPDMPAEMLNYILDSVIQPLv 153
Q80VM8        85 EFPGRGGVWRVVCRDPTQDDDFLKNLNEFLDGEGRTWEDMVRLLKLNPNPPlpn--snqPPPNWAEALGLLLGAVVQVI- 161 house mouse
XP_003464736  85 EFAGRGGIWKVACRDPTQDAEFLKNLNEFLDAEGRTWEDVIRLLQLNHPPPpqs--anqASENWGEALGVLLGAVVQVI- 161
Q5R6R8        85 EFPGRGGVWRVVCRDPTQDAEFLKNLNEFLDAEGRTWEDVVRLLQLNHPTLsqn--qhqPPENWAEALGVLLGAVVQII- 161 Sumatran orangutan
XP_014584920  81 EFPGRGGVWRVVCRDPTQDAEFLKNLNEFLDTEGRTWEDVVHLLQLNHPPApqn--rdqPPESWAEALGVLLGATVQVV- 157
XP_004754851  81 EIPGKGGVWRVIFKPPGLDNELLSRLNEFLEGEGTRLGELTRARAYGNDPSdlg--qnmIPEVQAPMLARALEEALQPVl 158
XP_510137     81 EIPGKGGIWRVIFKPPDPDNTFLSRLNEFLAGEGMTVGELTRALGHENGSLdpe--qgmVPEMWAPMLAQAL-EALQPAl 157
Q5BJV6        81 EIPAKGGVWRVIFKPPDADSDFLCRLNEFLKGEGMTMGELTRVLGNRNDPLcldq-nvmIPEIRAPMLAQALDEALKPTl 159 Norway rat
XP_008530705  81 EVQGRGGIWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGMFRALGHEGVSPaav--pcvSPELLAHLLGQAIAHAPQPLl 158
XP_006108514 160 ---------LHLDSELRNQEEA-------RAQEAEEAYAlAMAASAAGRKGPKEPGRAARACSVLTMGNPgswdDVEDEg 223
EFB27002     154 esiwykkltLFSGRDIPGPGEEtfdpwleHTNEVIEEWQ-VSDVEKRRRLMESLRGPAADVIRILKTNNP----SITTA- 227
Q80VM8       162 ---------FYMDAAIRSRDEEa------RAEEAAEAELmEAWASTARKRVKKEPGLGVEVGSAFKMEDRnywkNTEDHg 226 house mouse
XP_003464736 162 ---------LCRDAEIRSREEA-------RAQEAAEAEEgAAWALAAGKKVKKEPRLATEVGLALKMESPtrwkGMEDQg 225
Q5R6R8       162 ---------FCMDAEIRSREEA-------RAQEAAEFEEmAAWALAAGKKVKKEPGLAAEVGSALKAETPnnwnATEDQh 225 Sumatran orangutan
XP_014584920 158 ---------FYMDAEMRRREEA-------RAQEAAEAGVvAVLASAAGRKIKKEPGQAAEVSSALKMENPdswhDMGDEg 221
XP_004754851 159 qylkykklrVFSGSNPPEPGEEefeswlfHTTEMMKTWR-VSDMEKRRRLLESLRGPAFDVIRVLKTDNP----FITVA- 232
XP_510137    158 qclkykklrVFSGRESPEPGEEefgrwmfHTTQMIKAWQ-VPDVEKRRRLLESLRGPALDVIRVLKINNP----LITVD- 231
Q5BJV6       160 qylrykklsVFSGRDPPGPGEEefeswmfHTSQVMKTWQ-VSDVEKRRRLMESLRGPAFEIIRVLKINNP----FITVA- 233 Norway rat
XP_008530705 159 pmry-rklrVFSGSAVPAPEEEpfeiwleQATEIVKEWP-VAEAEKKRWLMESLRGPALDLMHIVQADNP----SISVE- 231
XP_006108514 224 DPPKPLVRKARAKTRSrrrKQKKsprqepvpwkkptgh---hsnspassegpeaddGENGEVPEYPRSSRKPRAKPEAAA 300
EFB27002     228 ECLKALEQVFGSVESS---RDAQ---------------------------------VRFLNTYQNPGEKLSAYVIRLEPL 271
Q80VM8       227 DPPKPLVRRPGGKIRSrrrKQKKnlkqepicwrksqgsn--ynsnynkvnleageaAQSSEIPESVKSNKKPFVKQEETV 304 house mouse
XP_003464736 226 DPPKLIVRRAGAKARS---RRKKqkktpkqepvlwkkpkgshgsssaylegfgvgdVERMEIREFGKSLRKQ-AEQEEPP 301
Q5R6R8       226 DPPKPLVRRAGAKSRSrrkKQKKnpkqeavpwkkpkgi---nssstanledpevgdAESMAISEPIKGSRKPCVKQEELA 302 Sumatran orangutan
XP_014584920 222 DPPKPFFHKAGAKTGS---RRKKqknhpqqepgpwkkakgncsnssaslegpeagdAENMEISEYIRSKKKPCVKQEESA 298
XP_004754851 233 ECLQALEQVFGVIDNP---RELQ---------------------------------IKYLTTYQKDEEKLSAYVLRLEPL 276
XP_510137    232 ECLQALEEVFGVTDNP---RELQ---------------------------------VKYLTTYQKDEEKLSAYVLRLEPL 275
Q5BJV6       234 ECLKTLETIFGIIDNP---RALQ---------------------------------VRYLTTYQKSGEKLSAYVLRLEPL 277 Norway rat
XP_008530705 232 ECLEAFKQVFGSLESR---RTSQ---------------------------------VKYLKTYQEEGEKVSAYVLRLETL 275
XP_006108514 301 GKKPVEKcpwkaprhapqDARAEAAGPEVASESDQDDGPEEPPKKKAMGWASAKS---PGCMRRR 362
EFB27002     272 LQKVVEK-----------GAIDKDNVNQARLEQVIAGANHSGAIRRQLWLTGAAEgpaPNLFQLL 325
Q80VM8       305 WKK---KrvwrdpsdlprSALPAADSPGNLEDSDQDGGPENPAKKKAMTWASNKI---PVPTRKK 363 house mouse
XP_003464736 302 LRKPMGTsawkvprepspDTLGGAESPEGTSKSDQGGGQGRPLKKKATGWASGKS---LGPVRKK 363
Q5R6R8       303 LKKPMAKcawkgpreppqDAQAEAESPGGASESDQDGGHESPPKKKAMAWVSAKN---PAPMRKK 364 Sumatran orangutan
XP_014584920 299 WKKPVGKcvwkapsnpppGARSAAASPGVASESEQAGGREGPPKKKAVGWASAKR---PAPTKKN 360
XP_004754851 277 LQKLVER-----------GVIEKDVVNQARLDQILAGA-VCRTLRRKLAL--PQGgpaPGLLQLL 327
XP_510137    276 LQKLVQR-----------GAIERDAVNQARLDQVIAGA-VHKTIRRELNL--PEDgpaPGFLQLL 326
Q5BJV6       278 LQKLVQK-----------GAIEKEVVNQARLDQVIAGA-IHKSVRRELGL--PEGspaPGLLQLL 328 Norway rat
XP_008530705 276 LRRAVEK-----------RAIPRNIADQVRLEQVMAGASLSEILWCRLRELKDQGp-pPSFLELM 328
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