Conserved Protein Domain Family
TACC_C
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pfam05010: TACC_C 
Transforming acidic coiled-coil-containing protein (TACC), C-terminal
This entry represents a C-terminal domain found in the the proteins TACC 1, 2 and 3 (TACC1-3). TACC1 is found concentrated in the centrosomes of eukaryotes which may play a conserved role in organizing centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1). TACC 3 from Xenopus laevis, also known as maskin, associates XMAP215 and promotes efficient microtubule elongation during mitosis. Maskin is also found to bind CPEB and elF-4E. Interestingly, the functional homolog (Alp7) in Schizosaccharomyces pombe (not included in this entry) has been shown to be required for organization of bipolar spindles.
Links
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Statistics
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PSSM-Id: 461517
Aligned: 23 rows
Threshold Bit Score: 171.397
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006677647  489 FSQRNLDEQRQRlqknFENEFEV--------AQLEIQD--LTLSSQNLERENQKMKDTLKQWEQAVKLMITEKDKDKQQK 558 
XP_017826207  566 YSQKDLDTAVKA----AQEENQE-----------------LRSRCEELQRKNVELGVIMDRFEEVTYQVMEEVQKQKELA 624 
XP_012915487  578 YSQKDLDAVVET----TREENVL-----------------LRSQCETLRARNLEMGKIMDGFEGIVYQAMEEAQKQKELA 636 
XP_005208348  611 YSQKDLDSAVEA----TQKENEV-----------------LRGKCAALQERLLEMGKIMDSFEGTVYQVMEESQKQKELT 669 
EFN83265      794 EKQKKHEVDLEK----QKAT-----------FQEKINK--LQAQVAQEVKMKTQMSVVVEEYEKSISRLLTERERDRTNF 856 
Q95TU9       1089 HNYNDMDELEKK----IKNEVTRsediekklKEGELREeaLIKRITEKDKTNAKLNGVIEAYEKAIAELISEKEQQAQLH 1164 fruit fly
6_pfamImport    1 YDNLD---AINP----FQGSNMI----------------------------------LLSPAKPVVDHPPENIQEEPNVE 39  
XP_007247623  804 YSQKDMDAAMER----ARKQAEE--------KEEE-----LKAQIAKMTMDNEHMVLIVSEFETIIAQITAEHKQKEELV 866 
XP_005157032  737 YSQKDMDAALQK----ADRQSEE--------RQQE-----LKSQIEKLQLENQQMLFIMSEFETTITQITDEHKQKEALA 799 
XP_005208350  611 YSQKDLDSAVEA----TQKENEV-----------------LRGKCAALQERLLEMGKIMDSFEGtVYQVMEESQKQKELT 669  cattle

XP_006677647  559 QAEIDRLKEQLDLAYAERNESKKELDQMSLKYKQLRVDISDLKELDERQREQISELEQTVATGNQRFDSLRAHAETKLDE 638 
XP_017826207  625 KADIQKVLQEKDQLTADLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCAEDYLVRVTQAGQRYQALKAHAEEKLQL 704 
XP_012915487  637 KAEIQKILKEKEQLTADLSSMEKSFSDLFKRFEKQKEVIEGYRKNEELLKKCVEGYIARIEKEGQRYQALKAHAEEKLQL 716 
XP_005208348  670 KAEMQKVLKEKAQLTADLHSMEKSFSDLFKRFEKQKEVIEGYRTNEESLKKCVEDYIERVEKEAQKYQALKAQAEEKLRQ 749 
EFN83265      857 EQEKAKLQEELQAANHHLTNTEAAFNDVHQKYERLKGVVSVYKNNEAVLKESIQENVDTIKTLETRYDQLKDHAMAQLEK 936 
Q95TU9       1165 ERQLQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMDNLRLQEQRYDKMKNHAMQQLEI 1244 fruit fly
6_pfamImport   40 DLRQDDTLPFIPSVDNSLADVNISSTDSSVVIVTMNETVEG-QDNEEILKTRAQDYQERIKKEEQRYQILKAHAEGKIGQ 118 
XP_007247623  867 QAELSKVFQEKQQLAKDLNDMERSFSDVVKRLDRRKEVIDGFKKNEETLKQCAQSYLARLQKEEQRYQMLKTHAEEKIEQ 946 
XP_005157032  800 KMEMERVLEEKDQLAKDLNELERSFSSVVKRLDRCKEVIEGFKKNEETLKQYAKNCMDRLQKEEKRYQALKAHAEEKLEQ 879 
XP_005208350  670 KAEMQKvLKEKAQLTADLHSMEKSFSDLFKRFEKQKE-------NEESLKKCVEdyiERVEkEAQKYQALKAQAEEKLRQ 742  cattle

XP_006677647  639 ANVEIARVRASYEKEAAAMRAKLSRVEIQMQTLDCNLKTKVQENQELTKICDDLV 693 
XP_017826207  705 ANEEIAQVRSKAQAEALALQASLRKEQMRVQSLERTVEEKTKENEELTRICDDLI 759 
XP_012915487  717 ASEEIAQVRSKAQAESLAFQASLRKEQMRIHSLEKTVEQKTKENEELTRICDDLI 771 
XP_005208348  750 ASEEIAQVRSKAQTDALALQAVLRKEQMRVHSLEKVVEQKTKENDELTRICDDLI 804 
EFN83265      937 ANLELDGIRKQNEAETVKLHAMIRKAELKSNSLAELVEQKTKENKELAKILDEVI 991 
Q95TU9       1245 ANKKLDTYSREHADETKKLKALLKKEEISRVSMTEQLQQKSRENADLLKICEELI 1299 fruit fly
6_pfamImport  119 ANEEIAEVRSKYKAEFSALQAQLRREQLKVQSVEKRLDQKEKEAQELTKLCDDLI 173 
XP_007247623  947 ANKEIADVRSKLGTEISALQVQLRREQLKVQSLEKNLEQKVKEVEDVTKLCDELI 1001
XP_005157032  880 ANKAIAEVRTKQGAEVAALQVQLKREQLKVQSLEKDLEQKAKEVKDVTELCDELL 934 
XP_005208350  743 ASEEIAQvrsKAQTDALALQAVLRKEQMRVHSLEKVVEQKTKENDELTRICDDLI 797  cattle
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