6TX2,6X0L,6TX1


Conserved Protein Domain Family
DUF2228

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pfam10228: DUF2228 
Uncharacterized conserved protein (DUF2228)
This is a family of conserved proteins of approximately 700 residues found from worms to humans.
Statistics
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PSSM-Id: 463010
Aligned: 39 rows
Threshold Bit Score: 261.002
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6TX2_A         49 GLQLVGPYDILAGKHKtK--KKSTGLNFNLHWRFYY--DPPEFQTIIIGDNK-TQYHMGYFRDSPDEFPVYVGINEAKKN 123 
XP_008192479  229 NLELVGPFDVLAGKFK-R--VKRPPEDYLRHWRFYY--DTPELLTVLKGDDS-TGYHIGYFYDSPNEPPQVLVSNHGTKD 302 
XP_011062524  191 RLKLVGPYDILDGKIK-IssSENDKEKYLIHWRYYY--DPPEFQTIVKCDDK-EGLHFGYWRDDAVEKPVFIAKNQANVN 266 
5_pfamImport    1 NLELVGPFDVLNGAIM-----KCTKETALRHYRYFY--DPPEFQTLLKGDEK-EQLHYGYFRDDPKEFPCCVARNKAAVS 72  
XP_015782073   53 DLLLVGPFDVIDGKLKdEvlDSADPASILCYYRFFY--DVPEFQTVLRDTK--SNFHIGYFRDSPSEMPSMVVSNDPDKS 128 
EGD81361       48 GIDLVGPCQVLHSVDK------PQTKDLHCWHRHVYnfDPPECMTVAVRHA--TKEHWCYFRDDPSETPVMVVHNKASDG 119 
EGT37142       64 NMKLVGPFRKLMENSD------VTGTDLIMLDREKT--DLPEMQTFM----LtTFGRYAFWRDTPSEKNPVIVFVDLKTI 131 
EFO93194       63 DIVFFGPFRKLKENSD------VNGVELIMLDREQS--DLPEMQTFM----KcGTGRYSFWRDEPSERNPVVMFLDQHTC 130 
XP_002634233   64 NMSFIGPFRVLREGVE------VNGVELIMTDRDET--DLPEMQTFL----KcSHGKFSFWRDTPSEKNPVIVFSDIQGI 131 
O62291         66 SVTLVGPFRKLRGESD------ADGTDLIMLDREMT--DLPEMQTFM----KcSHGRYAFWRDKPNDKKPVIVFMDLKTI 133  Caenorhabditi...
6TX2_A        124 CIIVPNGDNVFAAVKLFLTKKLKEITD-----KKKINLLKNIDEKLTEAARELGYSleqRTVKMKQRdKKVVTKTFHGAG 198 
XP_008192479  303 GVFTKMGDNIFAAVCSYLGELQQSGDP------FKKMHVGKFLTQLKTKAQKLHLStsaHSEKIKKRgNKIVAKTFNKIG 376 
XP_011062524  267 GIFEPVAENIFGAVDAYLQNKVKTANP------FEKTSIIRLHSQLKNFAKQHNITldkNTADMRAReKRVVARTFHKAG 340 
5_pfamImport   73 PAISCVAGNLFGTVNVHAEEVKGTADI------FRKMQIQKIQSALVKWAKQKKFTldtVTASIKARrSKVVAKTFNGIG 146 
XP_015782073  129 CIINPLGDNIFSGLLAFCEDLKRRRSEk----DDKKANAEKLSLKIKAYAEKNDIPl--VNNNMKERkKKVVAKTFHGAG 202 
EGD81361      120 GVYGDAGDSILALLVAECKAA------------DRKRDASELRQKLQDLAKKYNIPl-tLGKAKRKRkAKVNAPTFSGIG 186 
EGT37142      132 PELSMVGNTVEHAIHHFCGLFAKCQDNgkeakAAASNILEILGDA--KMKKE-------TTRAIKKRqSISVGG-LLGPG 201 
EFO93194      131 PEVTVVGNKVEHAIHHLCMRVSKYQDNtkeikEAISTILDILGDN--AMKDE-------IARVIRNRkRETIVG-IVGPG 200 
XP_002634233  132 PVVTVVGNTVEHAIYGFCNKISKLQDNskevkSAIAEILGLLGAQ--KMEKE-------ANQVMKKRkKETITG-VLGPG 201 
O62291        134 PDLSVVGNEIRHAILDFCTRCSKCIDCsakskAANSKIQSFFTPS--KISSE-------VKEVLKHReKTTVRG-ISGPG 203  Caenorhabditi...
6TX2_A        199 LVVPVDk-ND----------VGYRELPETDA--DLKRICKTIVEAA-SDEERLKAFAPI-QEMMTFVQFANDECDYGMGL 263 
XP_008192479  377 LVVPYArkTQ----------LGYRELAMGDK--DLMVLLNKLNKAS--PEQKNKYLADL-QPVLTFANIALDECDFGTGV 441 
XP_011062524  341 IVVPYDkkTQ----------LGYRDLAATDN--DLQKILKQIEEAD-TPEDRKMPIAKL-DEIVRLATIAADECDFGTCL 406 
5_pfamImport  147 VVVPYDkkTD----------VGYRPLAVSDD--ELKQILKKIASAN-TNSEQDVAWSKL-QPVITAANIANDECDFGTSL 212 
XP_015782073  203 IVVPFE--ND----------VGYRPLPENEQ--NLKKLLKKIADMPeEDRQRSKAYESL-REIVNLTNLANDECDFGMAL 267 
EGD81361      187 ICVPFDedTE----------IGYRPLSVSDK--KLRSILDAIVKAK--RKNQTPDYSQL-DLLVQYANISNDEFDFGQAL 251 
EGT37142      202 IYLEQHsnGSp----------rYRRLLHSRHdpHIENLLRCLTNAK-VKSDEQAVIKLInEEIVGHVIICNDEGDFGNGL 270 
EFO93194      201 LLVGELprGGs----------rYRVMDDAQNp-NIESLLRCLKHVP-FPKQQDTVVDII-DSLMGDFTVYNDEGFYGNGL 267 
XP_002634233  202 LLVGDFpnTNks---------rYRVVSKES---NIENLLRCLSNTG--KQHQDAVIGEI-DELMNNVMMYNDEGFYGNGL 266 
O62291        204 MLIDVVptGNsgkknkknerTGYRDLSKNAYciNIEHLVRSLRLCQ-TKEQEEKVLDFV-YGLMNEINICNDEGDFGNGL 281  Caenorhabditi...
6TX2_A        264 ELGMDLFCYGSHYFHKVAGQLLPLAYNLLKRNLFAEI 300 
XP_008192479  442 KLGWELLFHGIDSLNATIAQFLGNSNRLLGREAFAKI 478 
XP_011062524  407 ELGHDLFSNGGIHVQTRALQMLSIAYTHLKRPQLLKI 443 
5_pfamImport  213 ELGLDMFAFGEESLHATIEQVLCTTYNLLQRNNFADI 249 
XP_015782073  268 ELGIDLFCFGEECYHRLVSFTLGTAYELLDRHQFGTI 304 
EGD81361      252 QLGLDLYAHSL-IFKTDALHLLAPTYALLQRDVFADI 287 
EGT37142      271 ELGHVMFLANHKAIEDDLKMILIPAYKFLKRSDFIEI 307 
EFO93194      268 ELGHLLFLANHKSVSNQALILLQTAYQLLKRNDFITI 304 
XP_002634233  267 ELGHVLFLSNQSSISNQVLLVLTTAYNLYGRTDFVNI 303 
O62291        282 ELGHILFLANMKAVADPMMITLHIAYKNLHRPDFAKI 318  Caenorhabditis elegans
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