2GTA


Conserved Protein Domain Family
NTP-PPase_BsYpjD
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cd11531: NTP-PPase_BsYpjD 
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Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs
This family includes a putative pyrophosphatase Ypjd from Bacillus subtilis (BsYpjD) and its homologs. Although its biological role has not been described in detail, BsYpjD shows significant sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, BsYpjD contains a single MazG-like domain.
Links
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Statistics
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PSSM-Id: 212138
Aligned: 20 rows
Threshold Bit Score: 102.001
Created: 29-Aug-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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metal bindinghomodimer
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E E DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Most superfamily members require the divalent ion, such as Mg2+, for enzyme activity.
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED.
  • Structure:2GTA: Bacillus subtilis putative pyrophosphatase Ypjd binds Na ion; contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      #  #                         #  #                 
2GTA_A         7 KDIQAEVDRYIgqfkeGYFSPLAXXARLTEELGELAREVNHRygekpkkateddkSXEEEIGDVLFVLVCLANSLdISLE 86  Bacillus subtilis
YP_359910      4 KEVQELTDKWVsqfkeGYFPPMSLVVRLAEEVGELAREVNHRfgekkkkpeelsgSIEEELGDILFIIACFANSLgYDLS 83  Carboxydothermu...
NP_579781      1 MELQKEVDKLIkr-mgGYWTPSQMLTALVEEVGELADIILSFegvkg---qkdysKLEEEIGDVLFALICIANYFkIDVE 76  Pyrococcus furi...
ZP_04389885    4 NEWQKSVDEWIhtygvRYFDELTNMAILAEETGEVARIMARRygeqsvkegatlgDLGDELADLIWVATCIANQTgIDLE 83  Porphyromonas e...
Q8A2P1         4 EEAQKEVDKWIktygvRYFSELTNMAVLTEEVGELARVMARKygdqsf-kegekdNLDEEIADILWVLLCIANQTgVDIT 82  Bacteroides the...
NP_691740      5 HIYQSNIDEHIqk-lgGYWRSISALARLQEEIGELAEIIIEEnpn--------vnELKEEIADIYIISTCLANQYlEKLQ 75  Oceanobacillus ...
YP_002885136   4 REVQQKIDTMIlh-lgGYWKPLSGLARLLEEVGEVGGALRREaq----------dELKEELLDVLVISTCLANQYaIALQ 72  Exiguobacterium...
NP_866880     24 ADAQTQVDQWIqtigvRYFDEMTNLAQLVEEVGEVARILSRTkgeqstksgavlgELSDELADVMFVVICLANQSgIDLT 103 Rhodopirellula ...
YP_003157545   4 NQLQEDVDAWVktigvRYFSELTNLGILMEEVGEVARIMTRRygdqsf-keneknDLGDELADVLFVLTCIANQTgVDLT 82  Desulfomicrobiu...
ADG82814       4 KDMQKEVHEWIsqfeeGYWHPLSMLARMTEEVGELAREINHRygqkpkkdsepegSIALELADILFIIICLANSLnLDLE 83  Thermincola sp. JR

Feature 1                      
2GTA_A        87 EAHDRVXHKFNTRD 100 Bacillus subtilis
YP_359910     84 EIFKATMDKYYKRD 97  Carboxydothermus hydrogenoformans Z-2901
NP_579781     77 EALKKTLVKYSTRD 90  Pyrococcus furiosus DSM 3638
ZP_04389885   84 AALHANLEKKTQRD 97  Porphyromonas endodontalis ATCC 35406
Q8A2P1        83 KAFRESLEKKTKRD 96  Bacteroides thetaiotaomicron
NP_691740     76 DVYKKISIPTNTLE 89  Oceanobacillus iheyensis HTE831
YP_002885136  73 QPVAEGSESKEKLY 86  Exiguobacterium sp. AT1b
NP_866880    104 DALRRNLDKKTKRD 117 Rhodopirellula baltica SH 1
YP_003157545  83 ESMRRNLEKKTLRD 96  Desulfomicrobium baculatum DSM 4028
ADG82814      84 SAFKAMMQKYRVRD 97  Thermincola sp. JR

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