2GJN,2GJL


Conserved Protein Domain Family
NPD_like
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cd04730: NPD_like 
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2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.
Links
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Statistics
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PSSM-Id: 240081
Aligned: 184 rows
Threshold Bit Score: 97.9392
Created: 13-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:FMN binding site [chemical binding site]
Evidence:
  • Structure:2GJN; Pseudomonas aeruginosa binds 2-nitropropane dioxygenase; contacts at 3.5 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               ##                                                                      
2GJN_A       14 VEHPIMQGGMqwv-graEMAAAVAn-----aGGLATLSAltq-------------------------------------p 50  Pseudomonas aeru...
AAM71644     14 EYIPIVIGGMgvnistsELALSAEr-----lGGIGHISDaevmfvcdqlfgtsyvadkrqmyasnvnnrdkssvhfdleq 88  Chlorobium tepid...
BAD40318     13 ARYCIVQGGMsvrialhRLAAAVAe-----cGGVGTIGGmgi-------------------------------------- 49  Symbiobacterium ...
CAI07603     15 EYVPIMIGGMgvdistsDLSLEAAr-----lGGIGHISDamiptvsdrrydtkytrdklkiykynvantdksevqfdlgl 89  Azoarcus sp. EbN1
AAV89541     14 EVWPLIEGGKgiaasdhMSAGAWAa-----aNGIGTISAvnadsydengriipqi------------yhsktrperhqel 76  Zymomonas mobili...
ZP_00741295  13 PKVPILQGGMgvgislsKLASAVAn-----aGGIGIISGtgi-------------------------------------- 49  Bacillus thuring...
YP_463466    32 GKRLLVQGGMgih-asdGLAGKVArhrgdrlVGVGTISAvlk-------------------------------------- 72  Anaeromyxobacter...
YP_518891    13 AKMPVIQGGMavrismaPLAAAVAe-----eGGIGLIAGsgl-------------------------------------- 49  Desulfitobacteri...
ZP_01290234  13 APIPLVQGGMsvrvstsALAIPVAq-----cGGIGTIGGsgi-------------------------------------- 49  delta proteobact...
ABF84825     15 IKFPIFQGGMgvgiswdELAGNVAk-----eGALGVISAvgtgyyknmrfveri--------------vakkpfealnfy 75  Helicobacter pyl...

Feature 1                                    #                                #                 
2GJN_A       51 spEALAAEIARCRelt-----drpFGVNLTLLptqk--pvpYAEYRAAIIEag---irVVETAGndPGEHIAEFRrh--- 117 Pseudomonas aeru...
AAM71644     89 laEAQKRFVSHTIsqkt---gngaIFMNCMEKltmnnsaatLKVRMEAAMEag---idGITLAAglHLRSLDLISeherf 162 Chlorobium tepid...
BAD40318     50 ppGELRREIRAAKalt-----dgvVGVNLMYAgy------lFDRLLDVCIEer---vdYVAIGAgfARGPFKKLHea--- 112 Symbiobacterium ...
CAI07603     90 laEATERHVRHTMerkh---gnglIFINCMEKltmngpkdtLRVRLRSALDag---idGITLAAglHLGSFALIEdhprf 163 Azoarcus sp. EbN1
AAV89541     77 vqYAINGAIDQVKrahdiasgkgaININILWEmg------gSQTILKEVLEqtkglvtGITCGAgmPYKLSEIAAhy--- 147 Zymomonas mobili...
ZP_00741295  50 siDEMRMHIRKAKekir---ntgyIGVNVLFAmn------dFAEKMKAAIEek---vdFIISGAgiSRDMYTWGKna--- 114 Bacillus thuring...
YP_463466    73 tpEQLRAEIRRARaeap----ggfVGVNLMAAink----ddFEALARVSIEek---vsFLVQGAgiSREIVRWCReg--- 138 Anaeromyxobacter...
YP_518891    50 svEELKQEIREARkrt-----kgiIGVNIMFAvr------eFAQLVKAAFDek---idLLVSGAgfSRDMFTWGQea--- 112 Desulfitobacteri...
ZP_01290234  50 pvDELKADIRKAKsat-----dgvIAVNIMFAmk------dFYELVMASIEag---vdMIVTGAgfSRDIFKIGQet--- 112 delta proteobact...
ABF84825     76 skKALNEIFANARkicg----nkpLGANILYAin------dYGRVLRDACEag---anIIITGAglPTNMPEFAKdf--- 139 Helicobacter pyl...

Feature 1              #                           #    ##                                      
2GJN_A      118 -gVKVIHKCTav----rHALKAERlg---vDAVSIDGf-ECAGHPgedd-------ipgLVLLPAAANrl-------rVP 174 Pseudomonas aeru...
AAM71644    163 rdVKLGIVISsvralsiFLKRAMRlqr-ppDYIVVEGp-LAGGHLgfgpdd--wqsqslQSIVAETLAflkk--enldIP 236 Chlorobium tepid...
BAD40318    113 -gIPGFCIISsv----kAARIVARtp--gvAGVVVESg-QAGGHLgpedp-----eistWELFPPVRAalre--agfaGP 177 Symbiobacterium ...
CAI07603    164 rdVKLGIIVSslralllFLRKSARtnr-lpDYVVVEGp-LAGGHLgfgmdw---aqydlHAIMAEIQDylka--enldIP 236 Azoarcus sp. EbN1
AAV89541    148 -qVYYLPIVSsarafnaLWKRAYSkapeflAAVVYEDpwRAGGHNglsnaedpaspqppYERVYALRKvmravgipdsIP 226 Zymomonas mobili...
ZP_00741295 115 -gIPVISIVSsa----kLARLSERlg---aAAVVVEGh-EAGGHLgtd--------rplFDILPEVVAav-------eIP 170 Bacillus thuring...
YP_463466   139 -gVPFCGIVSsg----rLAAMYEKwg---aDFVVAEGa-EAGGHIgdig-------hplPTLVDEVIAat-------sLP 195 Anaeromyxobacter...
YP_518891   113 -gIPVVPIVSsa----kLARLSEKlg---aAAVIVEGh-EAGGHLgte--------rpmREILPEVKEav-------kIP 168 Desulfitobacteri...
ZP_01290234 113 -nTPIVSIVSsp----sFARLAEKlg---aAAIVVEAk-EAGGHLgtd--------qalREIFPEVRKvv------kkVP 169 delta proteobact...
ABF84825    140 rdVALIPIISsakalkiLCKRWSDrykripDAFIVEGp-LSGGHQgfkyedcfkeefrlENLVPKVVEaske---wgnIP 215 Helicobacter pyl...

Feature 1          ###                      ####                                                
2GJN_A      175 IIASGGFad---grGLVAALa-lGADAINMGTRFLATrecpihPAVKAAIRAade-rsTDLIMRslr-ntARVArnaisq 248 Pseudomonas aeru...
AAM71644    237 IIPAGGIft---gtDAVEYLq-aGAAAVQVATRFTIAresglpDEVKQHYINaspedvEVNLSSptg-ypMRMLkqsptl 311 Chlorobium tepid...
BAD40318    178 IIAAGGLlt---rqDVLRALa-mGADGVQMGIRFAMTeesaasAEMKARWLAatg-sqVTDWSPtg--ykSRAIvphipf 250 Symbiobacterium ...
CAI07603    237 LIPAGGIft---gsDAVSFLd-aGAAAVQVATRFTVShecglpPEVQQHYFSade-edIEVNNTsptgypMRMLksspsi 311 Azoarcus sp. EbN1
AAV89541    227 IVMAGGVwhleewnDWIDNPe-lGTIAFQFGTRPLVTqespisLPWKKRLMQldegdvLLHRFSptg-fySSAIknrflk 304 Zymomonas mobili...
ZP_00741295 171 VIAAGGImt---gkDIAHALk-mGASGVQMGTRFVASnecdapLSFKEKYINarl-edTILVKTtvg-lqGRAVknnftk 244 Bacillus thuring...
YP_463466   196 VIAAGGVda----sDVSRFLa-aGAAGVQMATRFLACsdgdvhPAFKQMHLAkreddvVIITSCvkg-mkARAVrnafte 269 Anaeromyxobacter...
YP_518891   169 VIGAGGVmd---gqDVAEVLr-lGADGVQMGTRFALStessaaPEWKQHLLDaqa-edMVIVHSpvg-lpGRGIrnpfte 242 Desulfitobacteri...
ZP_01290234 170 LIAAGGItn---gyEMAEMMehyGADGVQIATRFVLThecsvdDNFKQTMLKasa-ddVTLVRSpvg-lpGRALktpfvd 244 delta proteobact...
ABF84825    216 IIAAGGIwd---rkDIDTMLs-lGASGVQMATRFLGTkec-daKVYADLLPTlkk-edILLIKSpvg-ypARAIntgvik 288 Helicobacter pyl...

Feature 1                                                                                   
2GJN_A      249 evlaiearggagyad------------------------------iaalvsgqrgrqvyqqgdtdlGIWSAGMVQG 294 Pseudomonas aeruginosa
AAM71644    312 yysrkpnceglgylldnngqcsyid----------dyyealesrnpaegrfvvknhtclctgmaryDCWTCGHTVS 377 Chlorobium tepidum TLS
BAD40318    251 ealprtrenggtysctnclkh-------------------clhrdegrshciwnalsnaqkgrvenGLIFCGGRVG 307 Symbiobacterium ther...
CAI07603    312 gagnrpnceaygylldangncayit-----------aynrelaahpdarrlrvmdktclcthmrnfDCWTCGHYTY 376 Azoarcus sp. EbN1
AAV89541    305 n----------------------------------------------------------leerserQIAFSGKEAG 322 Zymomonas mobilis su...
ZP_00741295 245 liadnnkkikikkcincl-------------------------kncsyrfctldslitsmdgdcenGLVFAGARVN 295 Bacillus thuringiens...
YP_463466   270 rlargeavpprsklwwfgkdgyrgrrgsciqclgeglckarasgfkesfcitdalleaavhgdteaGLFYTGQSIT 345 Anaeromyxobacter deh...
YP_518891   243 alaagknvrrigcdqcl--------------------------khcernfcimerlikaqqgdmkeGLVFSGAHYS 292 Desulfitobacterium h...
ZP_01290234 245 klaakvemkakecrwkcl-------------------------kkcdhfyciserlqkayqgdledGLFFTGENVW 295 delta proteobacteriu...
ABF84825    289 rieegnapkiacvsnc-----------------------------vapcnrgeeakkvgyciadglGRSYLGNREE 335 Helicobacter pylori ...

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