4HHB,1OUT,1SI4,1HBR,3BCQ,1GCW,1CG5,1PBX,1FDH,5JGG


Conserved Protein Domain Family
Hb-beta-like

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cd08925: Hb-beta-like 
Click on image for an interactive view with Cn3D
Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits
Hb is the oxygen transport protein of erythrocytes. It is an allosterically modulated heterotetramer. Hemoglobin A (HbA) is the most common Hb in adult humans, and is formed from two alpha-chains and two beta-chains (alpha2beta2). An equilibrium exists between deoxygenated/unliganded/T(tense state) Hb having low oxygen affinity, and oxygenated /liganded/R(relaxed state) Hb having a high oxygen affinity. Various endogenous heterotropic effectors bind Hb to modulate its oxygen affinity and cooperative behavior, e.g. hydrogen ions, chloride ions, carbon dioxide and 2,3-bisphosphoglycerate. Hb is also an allosterically regulated nitrite reductase; the plasma nitrite anion may be activated by hemoglobin in areas of hypoxia to bring about vasodilation. Other Hb types are: HbA2 (alpha2delta2) which in normal individuals, is naturally expressed at a low level; Hb Portland-1 (zeta2gamma2), Hb Gower-1 (zeta2epsilon2), and Hb Gower-2 (alpha2epsilon2), which are Hbs present during the embryonic period; and fetal hemoglobin (HbF, alpha2gamma2), the primary hemoglobin throughout most of gestation. These Hbs types have differences in O2 affinity and in their interactions with allosteric effectors.
Statistics
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PSSM-Id: 381262
Aligned: 26 rows
Threshold Bit Score: 185.15
Created: 14-Jun-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingtetramer
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:1SI4: Human HbA2, delta subunit binds cyanide ion/heme; contacts at 4A
  • Structure:1FDH: Human HbF, gamma subunit binds heme; contacts at 4A
  • Citation:PMID 881729
  • Structure:4HHB: Human deoxyhemoglobin beta subunit binds heme; contacts at 4A
  • Citation:PMID 5528692
  • Structure:1CG5: Dasyatis akajei deoxyhemoglobin beta subunit binds heme, contacts at 4A
  • Structure:1HBR: Gallus gallus R-State form of hemoglobin D beta subunit binds heme; contacts at 4A
  • Citation:PMID 6644819

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                             #         ##                    #  ##  #                
4HHB_B      7 EKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLstpdavmgnpKVKAHGKKVLGAFSDGLAHLDNLKGTFA 86  human
1SI4_B      7 EKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFESFGDLsspdavmgnpKVKAHGKKVLGAFSDGLAHLDNLKGTFS 86  human
1GCW_B      7 ERDEISKTFQGTDMKTVVTQALDRMFKVYPWTNRYFQKRTDF----------RSSIHAGIVVGALQDAVKHMDDVKTLFK 76  Mustelus griseus
1CG5_B      7 QEHYIKGVWKDVDHKQITAKALERVFVVYPWTTRLFSKLQGLfsa----ndiGVQQHADKVQRALGEAIDDLKKVEINFQ 82  red stingray
P02138      7 EKQYIVSVFSKIDVDHVGANTLERVLIVFPWTKRYFNSFGDLsspgaikhnnKVSAHGRKVLAAIIECTRHFGNIKGHLA 86  South American lun...
P23741      7 ERATIETVYQKLHLDEVGREALTRLFIVYPWTTRYFKSFGDLssskaiasnpKVTEHGLKVMNKLTEAIHNLDHIKDLFH 86  coelacanth
P02143      7 ELHEITTTWKSIDKHSLGAKALARMFIVYPWTTRYFGNLKEFtac-----syGVKEHAKKVTGALGVAVTHLGDVKSQFT 81  Port Jackson shark
P07409      7 EKALVNAVWTKTDHQAVVAKALERLFVVYPWTKTYFVKFNGKfha----sdsTVQTHAGKVVSALTVAYNHIDDVKPHFV 82  spiny dogfish
BAA86391    7 ERKDIHEVWGKVKADKLGADALARVLIVNPWTRKHFSSFGDLstpeailhnpKIAAHGAKVVHSIIEASKHLDDLKGYYA 86  Noboribetsu salama...
P84217      7 KAAYITGIWSKLDKKVTTAHALERVFTVYPWTTRLFKSFNGHfka----gdsGVQGHAEKVVGALDTAVLHLHDIDAGYK 82  Eaton's skate
Feature 1      #   #   # #   ##  #                                   #    
4HHB_B     87 TLSELHCDkLHVDPENFRLLGNVLVCVLAHHFGKe-FTPPVQAAYQKVVAGVANALAHkY 145 human
1SI4_B     87 QLSELHCDkLHVDPENFRLLGNVLVCVLARNFGKe-FTPQMQAAYQKVVAGVANALAHkY 145 human
1GCW_B     77 DLSKKHADdLHVDPGSFHLLTDCIIVELAYLRKDc-FTPHIQGIWDKFFEVVIDAISKqY 135 Mustelus griseus
1CG5_B     83 NLSGKHQE-IGVDTQNFKLLGQTFMVELALHYKKt-FRPKEHAAAYKFFRLVAEALSSnY 140 red stingray
P02138     87 NLSHLHSEkLHVDPHNFRVLGQCLRIELAAALGFkeFTPERNAYFQKFMDVISHSLGReY 146 South American lungfish
P23741     87 KLSEKHFHeLHVDPQNFKLLSKCLIIVLATKLGKq-LTPDVQATWEKLLSVVVAALSReY 145 coelacanth
P02143     82 DLSKKHAEeLHVDVESFKLLAKCFVVELGILLKDk-FAPQTQAIWEKYFGVVVDAISKeY 140 Port Jackson shark
P07409     83 ELSKKHYEeLHVDPENFKLLANCLEVELGHALHKe-FTPEVQAAWSKFSNVVVDALSKgY 141 spiny dogfish
BAA86391   87 DLSNVHCLkLHVDPNNFHLLAGIIVVMLGITLREd-FTPHRQASVEKYLEAVCDALSHgY 145 Noboribetsu salamander
P84217     83 KLSEKHQL-IGVDTQNFKLLGQAFLVELAILFKEg-FTPELHEAAYKFFLAVAGGLSSqY 140 Eaton's skate

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