Conserved Protein Domain Family
PRK08074

?
PRK08074: PRK08074 
bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated
Statistics
?
PSSM-Id: 236148
Aligned: 46 rows
Threshold Bit Score: 1381.59
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
15614254    1 MNNRFVVIDIETTGQSVAQGDRIIEIGAVVIEDEEAVESFCTLVNPERSIPPFIEELTGISDEMVKGAPTFHQCIPELMS 80  
16079297    2 NKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKYINPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQ 81  
52786119    2 NNQRYVVIDVETTGNSPKKGDRIIQIAAVVIENGQITERFSKYVNPNQPIPAFIEQLTGISNEMVENEEPFSAIAEDIFE 81  
52080748    2 NNQRYVVIDVETTGNSPKKGDRIIQIAAVVIENGQITERFSKYVNPNQPIPAFIEQLTGISNEMVENEEPFSAIAEDIFE 81  
16803938    2 KQKRYIVVDLETTGNQASREDRIIQFAACFVESGKRLETYTTFLNPEKPIPAFIQELTGISPKDVKNAPLFEDVAPIIAN 81  
154686487   2 NKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKYINPNQAIPPFIEQLTGISSGMVENELPFEAVAEEIFH 81  
217963949   2 KQKRYIVVDLETTGNQASREDRIIQFAACFVESGKRLETYTTFLNPEKPIPAFIQELTGISPKDVKNAPLFEDVAPIIAG 81  
289435248   2 KQKRYIVVDLETTGNQASREDRIIQFAACFVESGKRLETYATFLNPEKPIPAFIQELTGISPKDVKDAPLFEDVAPIIAG 81  
284995486   2 KQKRYIVVDLETTGNQASREDRIIQFAACFVESGKRLETYTTFLNPEKPIPAFIQELTGISPKDVKNAPLFEDVAPIIAN 81  
284802344   2 KQKRYIVVDLETTGNQASREDRIIQFAACFVESGKRLETYTTFLNPEKPIPAFIQELTGISPKDVKNAPLFEDVAPIIAN 81  
15614254   81 MLEGGVFVAHNVHFDLSFLQKLLEHEGYGPLLVPIIDTVELSRILLPTEESYKLSALTEQLGLEHENPHRADSDAKVTAD 160 
16079297   82 LLDGAYFVAHNIHFDLGFVKYELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTGL 161 
52786119   82 LLHDSCFIAHNIHFDLAFVKHELQLAGFGEIECSVLDTVELSRIVFPGFDGYKLTELSEELQIRHENPHRADSDAEVTAL 161 
52080748   82 LLHDSCFIAHNIHFDLAFVKHELQLAGFGEIECSVLDTVELSRIVFPGFDGYKLTELSEELQIRHENPHRADSDAEVTAL 161 
16803938   82 LLEDTIFVAHNVSFDWTFLEREMTRAGISLGKMKKLDTVELARIMYPGIDSYKLQDLSDEFNLGHDKPHRADSDAEVTAD 161 
154686487  82 LLDGAYFVAHNIHFDLGFVRHELSEAGYELPDCEVLDTVELSRIVFPGFEGYKLGELCAELNIVHDRPHRADSDAEVTGL 161 
217963949  82 LLEDTIFVAHNVSFDWTFLEREMTRAGISLGKMKKLDTVELARIMYPGIDSYKLQDLSDEFNLGHDKPHRADSDAEVTAD 161 
289435248  82 LLEDTIFVAHNVSFDWTFLEREMTRAGISLGKMKKLDTVELARIMYPGIDSYKLQDLSDEFGLGHDKPHQADSDAEVTAD 161 
284995486  82 LLEDTIFVAHNVSFDWTFLEREMTRAGISLGKMKKLDTVELARIMYPGIDSYKLQDLSDEFNLGHDKPHRADSDAEVTAD 161 
284802344  82 LLEDTIFVAHNVSFDWTFLEREMTRAGISLGKMKKLDTVELARIMYPGIDSYKLQDLSDEFNLGHDKPHRADSDAEVTAD 161 
15614254  161 LLLLLLQKLRQLPLMTLQQLELLSDSWISDMGPILRQLIEKKMHDHAREEEVFDIYRQLAIRKPVKMKPqeeEIITTTDT 240 
16079297  162 IFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFSVREPEAIDVRIN---EDENFSFE 238 
52786119  162 IFLHMMDRLKRLPIPVLKSIRRLSWHLISDAQELFDGLIAEK-GADAELEAGFTKVGSFVIRTPEVEDE----EAGHKSR 236 
52080748  162 IFLHMMDRLKRLPIPVLKSIRRLSWHLISDAQELFDGLIAEK-GADAELEAGFTKVGSFVIRTPEVEDE----EAGHKSR 236 
16803938  162 LLLLLLEKLENLPLPVIRQMTTISGSLKSYLPELLFEIEMRKERENKPLNPNFVEHRGIVIRKKEVEKP-----TYSRAD 236 
154686487 162 VFLDILHKLKHLPLPTLKQLRRLSQHFISDLTLLLDSFIHESRPAEEKSCIPYASFSIKEPDHIPVSRP-----VNAAID 236 
217963949 162 LLLLLLEKLENLPLPVIRQMTTISGSLKSYLPELLFEIEMRKERENKLLDPAFVEHRGLVIRKKEVEKP-----TYSRAD 236 
289435248 162 LLLLLLNKLEDLPLPVIRQMATVSGSLKSYLPELLFDIEMKKERANKPLEPKFIEHRGLVVRKKEVKKP-----TYNRAD 236 
284995486 162 LLLLLLEKLENLPLPVIRQMTTISGSLKSYLPELLFEIEMRKERENKPLDPKFVEHRGIVIRKKEVEKP-----TYSRAD 236 
284802344 162 LLLLLLEKLENLPLPVIRQMTTISGSLKSYLPELLFEIEMRKERENKPLDPKFVEHRGIVIRKKEVEKP-----TYSRAD 236 
15614254  241 FQSFKDRITQeggSLSKAFLTYEWRQGQLKMMEVVHEAFSNNEHVLIEAGTGTGKSLAYLLPAAYFAHMEKAPVVISTQT 320 
16079297  239 IESWEAGNEK---ALSELMPGYEKRDGQMMMMREVADAFANREHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYS 315 
52786119  237 VPQTEPLIWErdgGLSSLDDRFDKREGQTKMMREVWTAFQNHEHALIEAATGIGKSLGYLVPAAIHAKQTGKPVVISTYT 316 
52080748  237 VPQTEPLIWErdgGLSSLDDRFDKREGQTKMMREVWTAFQNHEHALIEAATGIGKSLGYLVPAAIHAKQTGKPVVISTYT 316 
16803938  237 LLEFPETDEAkmaLFKKAGAPLYARSGQFEMMNLVFQAMKSGKHALIEAGTGIGKSLGYFLPAIYQAKQAELPVVISTYT 316 
154686487 237 LEKWNEEKEQ---ILSGIIPRYEKRKGQLSMMDEVLGAFRNREHALIEAAPGIGKTIGYLVPAVLFAKAEQTPVIISTYS 313 
217963949 237 LLEFPETDEAkmaLFKKAGAPLYARSGQFEMMNLVFQAMKSGKHALIEAGTGIGKSLGYFLPAIYQAKQAELPVVISTYT 316 
289435248 237 LLDFPETAEEkiaLFKKAGAPLYARTGQFEMMNMVFQAMKSGKHALIEAGTGIGKSLGYFLPAIYQAKQAELPVVISTYT 316 
284995486 237 LLEFPETDEAkmaLFKKAGAPLYARSGQFEMMNLVFQAMKSGKHALIEAGTGIGKSLGYFLPAIYQAKQAELPVVISTYT 316 
284802344 237 LLEFPETDEAkmaLFKKAGAPLYARSGQFEMMNLVFQAMKSGKHALIEAGTGIGKSLGYFLPAIYQAKQAELPVVISTYT 316 
15614254  321 IPLQSQLLERDIPLLQKILPFPINVALLKGRNHYLSLWKFEQALarGCEQDSYDTILAKAAILVWLTETERGDREELNLP 400 
16079297  316 TLLQQQILTKDLPIVQDLFPFPVTAAILKGQSHYLCLYKFEQVL--HEEDDNYDAVLTKAQLLVWLTETNTGDVAELNLP 393 
52786119  317 TLLQQQMINRDIPLLEKIFPFPVKAAVLKGRSHYLSIRKFKHIL--QEDDDNYDSVLAKAQILVWLTDTETGDLSEINLP 394 
52080748  317 TLLQQQMINRDIPLLEKIFPFPVKAAVLKGRSHYLSIRKFKHIL--QEDDDNYDSVLAKAQILVWLTDTETGDLSEINLP 394 
16803938  317 NLLQAQLFEKDVPLLTKLTGFKVKASLLKGRDHYLNLFKFEQLL--QEVDTQYDVVVTKLKLLVWLTETTTGDIDEVNLS 394 
154686487 314 TLLQQQIMSKDLPLLERMFPWPVKAAILKGKSHYLCLPKFEHIL--HEEDDNYDAVLTKAQLLVWLTETETGDAAELNLP 391 
217963949 317 NLLQAQLFEKDVPLLTKLTGFKVKASLLKGRDHYLNLFKFEQLL--QEVDTQYDVVVTKLKLLVWLTETTTGDIDEVNLS 394 
289435248 317 NLLQAQLFEKDVPLLTKLTGFEVKASLLKGRDHYLNLFKFEQLL--GEVETQYDVVVTKLKLLVWLTETTTGDIDEVNLS 394 
284995486 317 NLLQAQLFEKDVPLLTKLTGFKVKASLLKGRDHYLNLFKFEQLL--QEVDTQYDVVVTKLKLLVWLTETTTGDIDEVNLS 394 
284802344 317 NLLQAQLFEKDVPLLTKLTGFKVKASLLKGRDHYLNLFKFEQLL--QEVDTQYDVVVTKLKLLVWLTETTTGDIDEVNLS 394 
15614254  401 TGPGSFWATVESDGVSSLGKYDPWFSRCFYQRARTQAAKADLIITNHALLCTDMVQKNGLLPSFKQAVIDEAHHFEEVAS 480 
16079297  394 SGGKLLWDRLAYDDDSYKRSRSEHVI-GFYERAKQIAMRSDLVITNHSLLLTDEGSHKKRLPESGTFIIDEAHHFERAAS 472 
52786119  395 SGGKLLWDRLAYDSHSYAE-SSNMRKLCFYERAKARAQKADMIITNHALLLTDETNQRIHTGDADMFIIDEAHHFERAAG 473 
52080748  395 SGGKLLWDRLAYDSHSYAE-SSNMRKLCFYERAKARAQKADMIITNHALLLTDETNQRIHTGDADMFIIDEAHHFERAAG 473 
16803938  395 SGGELFWNRMKHTGWFLSEKHDPWLAHDFYKFNIKQAKNADLVIVNHALLLNDHFSGRETLPKYAFAVIDEAHHFADSAR 474 
154686487 392 SGGRLLWERMAYDENSFFKKGKDSAA-GFYERAKEKAQAADLIITNHALLFSDQSSETKKLPASGTIIIDEAHHFERAAS 470 
217963949 395 SGGELFWNRMKHTGWFLSEKHDPWLAHDFYKFNIKQAKNADLVIVNHALLLNDHFSGRETLPKYAFAVIDEAHHFADSAR 474 
289435248 395 SGGELFWNRMKHTGWFLSEKHDPWLAHDFYKFNVEQAKNADLVIVNHALLLSDYFSGRQTLPKYAFAVIDEAHHFADSAR 474 
284995486 395 SGGELFWNRMKHTGWFLSEKHDPWLAHDFYKFNIKQAKNADLVIVNHALLLNDHFSGRETLPKYAFAVIDEAHHFADSAR 474 
284802344 395 SGGELFWNRMKHTGWFLSEKHDPWLAHDFYKFNIKQAKNADLVIVNHALLLNDHFSGRETLPKYAFAVIDEAHHFADSAR 474 
15614254  481 DHLGKQTDYYSLYYFIQRLGYGDKEGLLDRMFQLAAKEDvkLTVDEEKVKTILQECQLELDELFRMLHRYVLQNRSSSKs 560 
16079297  473 EHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQRNSl-PVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKED- 550 
52786119  474 EQYGARADYVFLHKRLMRLGTLKQRGILKKAERLYRSAGi-SSESFFQMDEWLAQLLEESDLFFTAVHSFVKRRKPRND- 551 
52080748  474 EQYGARADYVFLHKRLMRLGTLKQRGILKKAERLYRSAGi-SSESFFQMDEWLAQLLEESDLFFTAVHSFVKRRKPRND- 551 
16803938  475 MQGSFVLSYRKLKYFLNQLGSLEKYSLLTRLAMAFPEAD-----SLYDLDIAAMKLSDAVEELFVLLKMQLNFARKNLQ- 548 
154686487 471 EHLGKRASYIGLHTKLSRIGTLKEHGLLKRMRKLFYTYEl-PAESFFDADEWMKHIQSESDAFFSSVHSFVKRRKPKDD- 548 
217963949 475 MQGSFVLSYRKIKYFLNQLGSLEKYSLLTRLAMAFPEAD-----SLYDLDIAAMKLSDAVEEFFGLLKMQLNFARKNLQ- 548 
289435248 475 TQGSFVLSYRKLKYFLNQLGSLEKYSLLTRLSMAFPEAD-----SLYDLDIAAMKLNEAVEEFFNLLKMQLNHARKNVQ- 548 
284995486 475 MQGSFVLSYRKLKYFLNQLGSLEKYSLLTRLAMAFPEAD-----SLYDLDIAAMKLSDAVEELFVLLKMQLNFARKNLQ- 548 
284802344 475 MQGSFVLSYRKLKYFLNQLGSLEKYSLLTRLAMAFPEAD-----SLYDLDIAAMKLSDAVEELFVLLKMQLNFARKNLQ- 548 
15614254  561 dVGRLSYRYESFREQGTLWEAILESGMRVHLMMKEGIKKLQLVLTCFHDV---YDQLSFFDQGLLtdakGVIDRLQEEEN 637 
16079297  551 -LNRLVFKVNKES-QDKSWSILTDGAERLCSMLTHLQQLFEAQSSLMEKHlkgMKSKTVFLADEYq---RSMKGLQHYCQ 625 
52786119  552 -LNRLLYKIG-ETGESRAWSRLEEGARRLCSMLYDMHRLFMDQKKSLAEKqasFTSRQAFLLEEYd---SCMNDLEEYRK 626 
52080748  552 -LNRLLYKIG-ETGESRAWSRLEEGARRLCSMLYDMHRLFMDQKKSLAEKqasFTSRQAFLLEEYd---SCMNDLEEYRK 626 
16803938  549 -EVVLVENSEKDAWNDKVYYAAEKVLYLLKESEKNMETLLEQGKLEENEL---GEAESAFLEEMY----AFLLDWKNMAK 620 
154686487 549 -LNRLVYSLNHKS-QDKGFHMITDGAERLCAMLDQLLDMFSVQEKLLHQKldqMKSGAAFLAAEYv---KCIRGLKEYRD 623 
217963949 549 -EVVLVENSEKDAWNDQVYYAAEKVLYLLKESEKNMETLLEQGKREENEL---GEAESAFLEEMY----AFLLDWQNMVK 620 
289435248 549 -EVVLVENSEKDNWNDAVYYAAEKVLLLLKESEKNMETLLAKGKAEEDDL---GVAESAFLEEMY----AFLLDWKNIVN 620 
284995486 549 -EVVLVENSEKDAWNGKVYYAAEKVLYLLKESEKNMETLLEQGKLEENEL---GEAESAFLEEMY----AFLLDWKNMVK 620 
284802344 549 -EVVLVENSEKDAWNGKVYYAAEKVLYLLKESEKNMETLLEQGKLEENEL---GEAESAFLEEMY----AFLLDWKNMVK 620 
15614254  638 NLYELLLESDPNAVYWIEIEPRGAKNATFLYSRPIEVGESLADRFFATKKSVVLTSATLSIKGSFDYQMERLGLHDFGVR 717 
16079297  626 TLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSATLTVEGSFQFMIERLGLSDFFPR 705 
52786119  627 TLGRLMFDPVEDEVVWIEIDAKGAKNAAAIYAQPLDTSEILADRFFTEKKSVVLTSGTLVVENSFDYMIKKLGLSDFYPR 706 
52080748  627 TLGRLMFDPVEDEVVWIEIDAKGAKNAAAIYAQPLDTSEILADRFFTEKKSVVLTSGTLVVENSFDYMIKKLGLSDFYPR 706 
16803938  621 QLEQMLHKKSPILTIYLQADKNHSISSIRLKAVLMEVEPTLGKEFFAKKESVIMTSATLTVKGKFDYLRKSLGLEEEQIM 700 
154686487 624 TFSRLLFENDEKEAVWVEIDAKGAKNAVSIYAQPLEPGEMLADQFFARKKSVVLTSATLMVEHSFQFMIERLGLADFYPR 703 
217963949 621 QLEQMLHKKSPILTIYLQADKNHSISSIRLKAVLMEVEPTLGKEFFAKKESVIMTSATLTVKGKFDYLRKSLGLEEEQIM 700 
289435248 621 QLEQMLHKKSPILTIYLQADKKHSVSSIRLKAVLMEVEPTLGKEFFAKKESVIMTSATLTVNGKFDYLRKSLGLENEQIM 700 
284995486 621 QLEQMLHKKSPILTIYLQADKNHSISSIRLKAVLMEVEPTLGKEFFAKKESVIMTSATLTVKGKFDYLRKSLGLEEEQIM 700 
284802344 621 QLEQMLHKKSPILTIYLQADKNHSISSIRLKAVLMEVEPTLGKEFFAKKESVIMTSATLTVKGKFDYLRKSLGLEEEQIM 700 
15614254  718 TESIPSPFSYKEQARLLLPTDIPAIKDVSEEEYAQEVAIKIWRIADCSSGRILVLFTSYEMLKQVYQYVKDLSMDDSLAL 797 
16079297  706 TMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQDTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQL 785 
52786119  707 TLQIESPFSYDKHMNIMIPTDVSPIQNDP-GDYIQDVSRYVKALAKQKDAKVLVLFTSHDMLRDVYHTLKNEEDFP-CQL 784 
52080748  707 TLQIESPFSYDKHMNIMIPTDVSPIQNDP-GDYIQDVSRYVKALAKQKDAKVLVLFTSHDMLRDVYHTLKNEEDFP-CQL 784 
16803938  701 EKCIPSPFDYKENARVMIPDDMPPIKDTPIERYTAELAKYIRHIAVKTNGRMLVLFTASDMLQKTYYHMKNEKSLEEYVV 780 
154686487 704 TKSIPSPFSYDDQMNVIIPKEMKSVKYDGEREVIEHIAKYAEIMSKGKQPKILVLFTSHDMLKKVYQELKLSMEISGIQL 783 
217963949 701 EKRIPSPFDYKENARVMIPDDMPPIKDTPIERYTSELAKYIRHIAVKTNGRMLVLFTASDMLQKTYYHMKNEKSLEEYVL 780 
289435248 701 EKRIPSPFDYQKNARVMIPDDMPPIKDTPIERYTTELAKYIRHIAVKTKGRMLVLFTATEMLQKTYYHMRNEKSLEEYVL 780 
284995486 701 EKRIPSPFDYKENARVMIPDDMPPIKDTPIERYTAELAKYIRHIAVKTNGRMLVLFTASDMLQKTYYHMKNEKSLEEYVV 780 
284802344 701 EKRIPSPFDYKENARVMIPDDMPPIKDTPIERYTAELAKYIRHIAVKTNGRMLVLFTASDMLQKTYYHMKNEKSLEEYVV 780 
15614254  798 IGQGITSGSRAKLMKAFKLHEKAILFGTSSFWEGIDLPGNELRCLVIVRLPFAPPDQPLLKAKLDKAEEEGKNPFRHISL 877 
16079297  786 LAQGITGGSPGKLMKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKGKNPFQTVSL 865 
52786119  785 LAQGISGGSPVKVMKLFKSYPHAVLLGTNHFWEGVDFPGDELTTLIIARLPFRPPDHPVESAKCDRAKRRGESPFQAVSL 864 
52080748  785 LAQGISGGSPVKVMKLFKSYPHAVLLGTNHFWEGVDFPGDELTTLIIARLPFRPPDHPVESAKCDRAKRRGESPFQAVSL 864 
16803938  781 LAQGVSAGSAARLTKQFQMFDKAILLGTTSFWEGIDIPGEDLSCLVIVRLPFAPMDDPYTKAQISLRKERGENAFQTYSL 860 
154686487 784 LAQGISGGSPGKLMKTFKTASRAILLGTNHFWEGVDFPGDELSTVMIARLPFRAPDNPLHAAKCEFAKKQGKNPFQTISL 863 
217963949 781 LAQGVSAGSAARLTKQFQMFDKAILLGTTSFWEGIDIPGEDLSCLVIVRLPFAPMDDPYTKAQISLRKERGENAFQTYSL 860 
289435248 781 LAQGVSAGSAARLTKQFQMFDKAILLGTTSFWEGIDIPGEDLSCLVIVRLPFAPMDDPYTKAQIALRKERGENAFQTYSL 860 
284995486 781 LAQGVSAGSAARLTKQFQMFDKAILLGTTSFWEGIDIPGEDLSCLVIVRLPFAPMDDPYTKAQISLRKERGENAFQTYSL 860 
284802344 781 LAQGVSAGSAARLTKQFQMFDKAILLGTTSFWEGIDIPGEDLSCLVIVRLPFAPMDDPYTKAQISLRKERGENAFQTYSL 860 
15614254  878 PQAIIRFKQGFGRLIRTSQDKGSVFVLDKRIATTRYGRAFLESLPDVPVYKGTLESLIEAHKEWM 942 
16079297  866 PEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSVSEMTDSELEAYVAGEK 930 
52786119  865 PEAVLAFRQGIGRLLRSEKDSGTVVILDRRIRTSSYGTVFMKALPPAKVMEPTFLELEAYIAGKN 929 
52080748  865 PEAVLAFRQGIGRLLRSEKDSGTVVILDRRIRTSSYGTVFMKALPPAKVMEPTFLELEAYIAGKN 929 
16803938  861 PEAVLRFKQGFGRLIRRESDRGIVFVFDNRVDTTKFGKAFLESIPSAPILKGKQADLLEEVSEFF 925 
154686487 864 PEAVLTLRQGIGRLLRTAGDKGTIVLLDQRVKTAGYGRLFLEALPTSSLLELTDAELGAYVSQTE 928 
217963949 861 PEAVLRFKQGFGRLIRRESDRGIVFVFDNRVDTTKFGKAFLESIPSAPILKGKQADLLEEVSEFF 925 
289435248 861 PEAVLRFKQGFGRLIRRESDRGIVFIFDNRVDTTRFGKAFLDSIPSAPILKGKQVDLLEEVNEFF 925 
284995486 861 PEAVLRFKQGFGRLIRRESDRGIVFVFDNRVDTTKFGKAFLESIPSAPILKGKQADLLEEVSEFF 925 
284802344 861 PEAVLRFKQGFGRLIRRESDRGIVFVFDNRVDTTKFGKAFLESIPSAPILKGKQADLLEEVSEFF 925 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap