2BUS,1PCE


Conserved Protein Domain Family
Kazal_1

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pfam00050: Kazal_1 
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Kazal-type serine protease inhibitor domain
Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family.
Statistics
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PSSM-Id: 395004
Aligned: 25 rows
Threshold Bit Score: 48.05
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2BUS_A    7 CAEFKDPk--vYCT---RESNPHCGSNGETYGNKCAF----CKAVM-KSGGKINLKHRGKC 57   cattle
P01002   12 CSNYKGKgsqiACP---RLHQPICGTDHKTYSNECMF----CALTL-NKKFEVRKLQDTAC 64   dog
P08480    8 CSQYNRKgsgiTCS---KEWKPICGIDHKTYSNECMF----CQLNQ-NKRFQLRKLHDNKC 60   domestic cat
P13213   95 CQDPTS------CPapiGEFEKVCSNDNKTFDSSCHFfatkCTLEGtKKGHKLHLDYIGPC 149  cattle
P24054  426 CQDPET------CPp-aKILDQACGTDNQTYASSCHLfatkCMLEGtKKGHQLQLDYFGAC 479  Norway rat
P10184  467 CREFQKVs--pICT---MEYVPHCGSDGVTYSNRCFF----CNAYV-QSNRTLNLVSMAAC 517  chicken
P01002   68 CTEYSDM-----CT---MDYRPLCGSDGKNYSNKCSF----CNAVK-KSRGTIFLAKHGEC 115  dog
P08480   64 CTNYSA-----ICT---MEYFPLCGSDGQEYSNKCLF----CNEVV-KRRGTLFLAKYGQC 111  domestic cat
P01000   14 CKVYTEA-----CT---REYNPICDSAAKTYSNECTF----CNEKM-NNDADIHFNHFGEC 61   cattle
P25304  237 MLLRPEN-----CP---AQHTPICGDDGVTYENDCVMsrigA-----TRGLLLQKVRSGQC 284  Norway rat
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