Conserved Protein Domain Family
HSR
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pfam03172: HSR 
HSR domain
The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.
Links
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Statistics
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PSSM-Id: 460835
Aligned: 52 rows
Threshold Bit Score: 109.933
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_015216561   8 EDADLRSQLRMLRTEIAMAIDDPFPLLYGLADHDIITEQLFKDTLDKK--KHEGIHKAVYSLLSRLLEKETLTIqnfWSN 85 
XP_023366055  24 IWNRIFDHFQQHKVDISYAIKKTFPFFERLHDRKLITDKLFKDSQDSCg-NLVPVQKVVYNVLSELEKTFNLEV---LSE 99 
BAC37804      21 LIECMLKHFKTQKVAISNAIRSTFPFLESLRDHEFITGKMYEDLLDSCr-SLVPVDKVIYRALEELEKKFDMTV---LCE 96 
XP_008756287  49 PFELIFQHFKRQKVAISNAIKNPFPFLEGLRDHELITAKMYEDLQDSYr-ALVPVDKVIYRALDELEKTFSMKV---LCE 124
EHB00132      11 LMVTLFQYFKAHKVEISYAIKKTFPFLEGLRDRELITNKMYKAYQDSCreSLVPVHRVMYNVLNDLEKIFDMAV---LEA 87 
XP_007667882   5 LEKQLLIKFREKKLAISDAVNKLFPFIYSLRDQALISNRMLQHYKNES----VPMKERIYNVLEKLEKNFNKKV---LKV 77 
XP_013124273  25 RDTNLRSLLRELRTDIAMAVDDPFPLVYGLADKNIITEQLLKETLEKE--AREGIHKAMYSLLSWVLEQSRSTVqafLNN 102
CAG07656       5 GETNLRSLLKHLRTDIAMAVDDSFPLVYGLADKNIITDQLQKDTLEKE--SREGIHKAMYSLLSWVLQQRRSVIrafWSN 82 
XP_009296781   8 EESDLRSQLRACRTEIAMAIHDPFPLLYGLADHNVISEQILRETLERK--KKDGIHKAIYSLLTLLLDQDTTVLkafWKN 85 
NP_001258486   4 GDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLK--EKEGCPQAFHALLSWLLTRDSGAIldfWRI 81 

XP_015216561  86 LFKDYNLERYPKLQSVFTSFPKD 108
XP_023366055 100 LFSDFHLQEYPDLIPIYESFKNV 122
BAC37804      97 LFNEVNMEKYPDLNLIRRSFGCV 119
XP_008756287 125 VFSNVNMEKYPDLQLIHQSFEHV 147
EHB00132      88 LFSEVNREVYPALMNIYKDFQNV 110
XP_007667882  78 LFSRNNVKEYPDLKRIRRTFEDV 100
XP_013124273 103 LSKDYNLDSYPRLQTLLTNLDCR 125
CAG07656      83 LFKDYNLDSYPKLQKLITNLPSG 105
XP_009296781  86 LCKEYNKECYPKLETVFMNLPKG 108
NP_001258486  82 LFKDYNLERYSRLHSILDGFPKD 104
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