1DS7,1BKJ,2B67,5J6C,5LQ4,2WZV,3G14,5KO7,3M5K,3H4O,2ISJ,1NOX,2IFA,3BM1,4DN2,3EO8,2FRE


Conserved Protein Domain Family
Nitro_FMN_reductase
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cd02062: Nitro_FMN_reductase 
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nitroreductase family protein
Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.
Links
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Statistics
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PSSM-Id: 380311
Aligned: 92 rows
Threshold Bit Score: 51.1437
Created: 13-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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FMN bindingdimer interface
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:FMN binding site [chemical binding site]
Evidence:
  • Structure:1DS7_A binds FMN: contacts at 3.5A
    - View structure with Cn3D
  • Comment:binding involves contacts from two monomers
  • Citation:PMID 9654450
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        # # #                          #                                             
1DS7_A      7 ALKRHSTKAFdaskklTPEQAEQIKTLLqySPSSTNSQPWHFIVAsteegkarvaks----------------------- 63  Escherichia coli
2ISJ_A     30 IETRRDVRDEflpeplSEELIARLLGAAhqAPSVGFMQPWNFVLVrqdetrekvwqafqrandea--------------- 94  Sinorhizobium meli...
YP_193777   6 FTKRRATRQFltn-siSDDKIQKIVAAFqtSPCGMHQNDVMNLVVvkdealrke-------------------------- 58  Lactobacillus acid...
AAF10838    7 MLNRRTTNGPfrpdpvSREHQHLLMRVAqaAPSHFNSQPWRFVLIedpgtiarvadlsgqsmtelieagvfferyrryfr 86  Deinococcus radiod...
NP_294995   8 LNRRTTNGPFrpd-pvSREHQHLLMRVAqaAPSHFNSQPWRFVLIedpgtiarvadlsgqsmtelieagvfferyrryfr 86  Deinococcus radiod...
NP_971320   8 MLTRVSVRKFtae-rvEDEKLKTIVECAkaSPTGKNRQMRKFTVVhnrekiqelaka----------------------- 63  Treponema denticol...
3BM1_A      7 LINRRSASRLaep-apTGEQLQNILRAGmrAPDHKSMQPWHFFVIegegrerfsavleqgai------------------ 67  Escherichia coli K-12
OQY71908    7 ILNRRTVRRFsqq-svTEETILDILDAGtwAPSHGNNQPWEFFLIgpqtrkklaemylnymedgpl-------------- 71  Ignavibacteriales ...
OIO74688    7 LKTRRSIRKFlsk-pvEKEIIEDIIDCGrlAPTANNVQPWEFIVVtdseirkkia------------------------- 60  Elusimicrobia bact...
PNV79435    8 IKSRVSVRKFlek-evPKEILEDLIDCGrlAPSGYNRQPWIFLVVtdkelknrla------------------------- 61  Dictyoglomus turgidum

Feature 1                                                                                     
1DS7_A     64 -------------------------------------------aagnyvfnerkmLDASHVVVFCaktamddvwlklvvd 100 Escherichia coli
2ISJ_A     95 -----------------------------------aemfsgerqakyrslklegiRKAPLSICVTcdrtrggavvl---- 135 Sinorhizobium meli...
YP_193777  59 ----------------------------------------------iekatdnscYGAPVLFIINtkken---------- 82  Lactobacillus acid...
AAF10838   87 fteaemderrdgihidrlpgplkpftrqvfsdaglklmrqlgvpkklgednrklvAGSPLLLAALldkseyrpg------ 160 Deinococcus radiod...
NP_294995  87 fteaemderrdgihidrlpgplkpftrqvfsdaglklmrqlgvpkklgednrklvAGSPLLLAALldkseyrpge----- 161 Deinococcus radiod...
NP_971320  64 -------------------------------------------vssvldipnyriYDCDALILISfeedd---------- 90  Treponema denticol...
3BM1_A     68 ---------------------------------------aagsddkaidkarnapFRAPLIITVVakceenhk------- 101 Escherichia coli K-12
OQY71908   72 -----------------------------------knpdlpeerkqsmrnfaqnfGDAPVLLAVTyappktnl------- 109 Ignavibacteriales ...
OIO74688   61 ----------------------------------------------ditdygkfiSSAPVCIVIFskdtk---------- 84  Elusimicrobia bact...
PNV79435   62 ----------------------------------------------eitpwgrflKEAGAGILIFcekda---------- 85  Dictyoglomus turgidum

Feature 1                                                                     ##              
1DS7_A    101 qedadgrfatpeakaandkgrkffadmhrkdlhddaewmakQVYLNVGNFLLGVaalGLDAVPIEGfd-----aAILDAE 175 Escherichia coli
2ISJ_A    136 ------------------------------grthnpqmdlySTVCAVQNLWLAAraeGVGVGWVSIfh-----eSEIKAI 180 Sinorhizobium meli...
YP_193777  83 ------------------------------------mfgerDASVAAENIMLEAadlGLGSVYVMGgaiklndyTDIQRE 126 Lactobacillus acid...
AAF10838  161 --------------------------------elsgfysvfGLGAAIENIWNTVgtlGMGIQFVSTpmeiprqwQAIQEL 208 Deinococcus radiod...
NP_294995 162 --------------------------------lsgfysvfgLGAAIENIWNTVGt-lGMGIQFVSTpmeiprqwQAIQEL 208 Deinococcus radiod...
NP_971320  91 ------------------------------------rfgycDSSVAIENIYLAAhalGLGSVWINQlrek-cnsPEIRRV 133 Treponema denticol...
3BM1_A    102 ---------------------------------vprweqemSAGCAVMAMQMAAvaqGFGGIWRSGalt---esPVVREA 145 Escherichia coli K-12
OQY71908  110 ----------------------------------eqydfplATAAAIQNIFLAAwekQIAGVWLSFgm-----nRKVEEL 150 Ignavibacteriales ...
OIO74688   85 -------------------------------------yyleDGSAATENILLAAnsyGLGSCWVAGdkk--ryaDDIRKL 125 Elusimicrobia bact...
PNV79435   86 ------------------------------------etaleDACAAGENIIIAAqsyGLGTCWINSykk--aysEDVKRL 127 Dictyoglomus turgidum

Feature 1                         
1DS7_A    176 FGLkek--gytSLVVVPVGH 193 Escherichia coli
2ISJ_A    181 LGIpdh---veIVAWLCLGF 197 Sinorhizobium meliloti
YP_193777 127 LDIdpd---fqTTVVVPVGK 143 Lactobacillus acidophilus NCFM
AAF10838  209 LKVp------dDLELMAVYR 222 Deinococcus radiodurans R1
NP_294995 209 LKVpdd---leLMAVYRLGY 225 Deinococcus radiodurans
NP_971320 134 LDSfnipknhvVCGISAIGY 153 Treponema denticola ATCC 35405
3BM1_A    146 FGCreq---dkIVGFLYLGT 162 Escherichia coli K-12
OQY71908  151 LKIpen---gkIAGLLAMGF 167 Ignavibacteriales bacterium UTCHB2
OIO74688  126 LNVpeg---yrLVSLIPVGY 142 Elusimicrobia bacterium CG1_02_37_114
PNV79435  128 VKCpnn---meLMVMLAVGY 144 Dictyoglomus turgidum

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