Conserved Protein Domain Family
HemH

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COG0276: HemH 
Protoheme ferro-lyase (ferrochelatase) [Coenzyme transport and metabolism]
Protoheme ferro-lyase (ferrochelatase) is part of the Pathway/BioSystem: Heme biosynthesis
Statistics
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PSSM-Id: 440045
Aligned: 809 rows
Threshold Bit Score: 185.697
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012803041   1 MKTGIIIGNAGSPSAptAEAVRDYLASFLVDRRirplpqpi--whlllhgiILPRRPVKSALRYKRIwqpAGSPLVIAQD 78 
WP_012945400   1 MSTGIAVLNFGEPSEpdRDAVVDYLERIFLANMeiegettpe-aarerarsLAERRVPALIEEYEAI---GGSPLNAHAE 76 
WP_013875649   1 MQTGIVLLNFGEPSTpdRDVVLDYLTRIFYDNAsleeadsee-aawersreLAQRRLPGLMEEYEEI---GGSPLQEQAD 76 
WP_014051366   1 MTTGIAVLNFGEPGAadRETVVDYLERIFLANMdiegettee-aarerarsLAERRAPGLMEEYEEI---DGSPLNAHAE 76 
WP_015322838   1 METAVVLLNFGEPAEpdRETVRDYLTRIFFDNAdleeadsed-aawersreLAERRLPSLMEEYEEI---GGSPLQEQAT 76 
WP_008526489   1 MSTGILLLNFGEPATpeREAVVSYLERIFFNNReiegdttea-earersreLAERRAGPLIEEYEEI---GGSPLNEQAR 76 
WP_050049316   1 MNVGVVLLNFGEPAGpdREAVTEYLERIFFDNAdlerydses-aarerartLAERRAPALLEEYEEI---GGSPLKEQAA 76 
WP_070365199   1 MDAGVVLLNFGEPAEptREAVEPFLERIFLDNAnlerfdsea-aareraseLASRRASGLIEEYETI---GGSPLDEQAQ 76 
WP_119817163   1 MKTGVALLNFGEPSRpdRDVVIEYLTRIFYNNAsleqadtee-eawersreLAGRRAPSLLEEYEEI---GGSPLNEQAA 76 
WP_121920031   1 MTTGIVLLNFGEPSEpdRETVVDYLERIFFANMdiegketteaeareragkLAQRRAPGLMEEYEEI---GGSPLYDHAT 77 
WP_012803041  79 RLASLLQESFARSaddadavndtDT--EVIVHSAMCYGAPSMTDALRALKDKGCNRIILLPLYPQSAYSSTYSVIDAFEQ 156
WP_012945400  77 TQAERLESELVAR----------GH--DVTTYNGFQFTEPFVEDAATAAAEDEVSNLIGLPLYPLCGPSTTVQALEDLSA 144
WP_013875649  77 AQAEALAAELADR----------GHddDVEVYRAMQFMEPLIPDVAEELADDGVDSVVAVPIYPLCGPSTTVSSINSLES 146
WP_014051366  77 RQADLLEQELKDR----------GY--DVETFLGFQFMEPFISDAAGAAKDAGVDHLVGLPVYPLCGPSTTVQSLEKLAA 144
WP_015322838  77 AQADALEDALTER----------GH--EVSVYHAMQFMEPLITDLPATLAEDGIDSVIAVPIYPLCGPSTTVAAIDSLED 144
WP_008526489  77 GQAQALEERLRER----------GH--DVETYLGMQFTEPFIDEALEAAIADGHDEIIGLPIYPLSGPSTTVDALEELRA 144
WP_050049316  77 AQAERLQSELERR----------GF--DARTYLGYQYVEPLIGDAVATAFDDGVGHVIGLPVYPLSGPSTNVFAVDDLEA 144
WP_070365199  77 AQKSAVEDELAAR----------GF--DPVVSLAMQYTDPLIDDVAAEMAAQDLDRVIVVPVYPLSGPSTNIAAVGDFES 144
WP_119817163  77 AQREALSAELSER----------GH--DVELFHGMQFMEPLIPDVAEQLAEAGIEAVVGMPIYPLCGHSTNVAALNDLED 144
WP_121920031  78 TQASMLADELDRR----------GY--DVNTYYGMQYTDPFITDAVEQAREDGVDHLIGLPIYPLCGPSTTVQSLDELDE 145
WP_012803041 157 AIDALH-WpdAADIQVIKRYADRPRYLDAIAGSIQKAgFGDR------SDDKLLISLHAIPLKDERNGDSYRAQIHQMIE 229
WP_012945400 145 GVDDLD-W--SPEYHEITGWHTHSAYLRLRADAIRDT-LEQNgle-lgTETRLVFSAHGTPQYYLEEGSRYAQYVDEYAE 219
WP_013875649 147 AIDEIEgY--DPDVASLTGWHRSPAYNRIRADSIAEF-ADDEgvdltdSDTAFVFSAHGTPTKYLEEGSRYDQYVEEHAE 223
WP_014051366 145 AVEELA-W--DVEYDELTGYHTHSAYARLRADNIRRT-LDRAgle-ldEDTRLIFSAHGTPTYYLDEGSRYVQYVEEYCD 219
WP_015322838 145 AIEDREgY--DPEFTAITGWHRVPAYNRLRAEGIREF-VDEEgvdlddPDTAFVFSAHGTPKKYLEEGSRYDQYVEEHAS 221
WP_008526489 145 AADERE-F--DA-LQEISGWHRHPDYPRLRVDNIEAF-ADERdvdltdPDTALVFSAHGTPQHYLAEGSRYDIYVTEYVE 219
WP_050049316 145 AVDERD-R--EVEWHAVTGWHRHPTYPRMRAENVQSF-VSEAgldlqaPDTELVFSAHGTALSYLEEGSRYDQYVEEYTE 220
WP_070365199 145 ALAEHD-A--DVEFRAVTGWHRHATYTRLRVENVQSF-LQAQgvdlgtPGTELLFSAHGTPTSYLEAGSRYDQYVTEYAD 220
WP_119817163 145 AIADIDgY--DPEFAGITGWHRAPTYNRIRAETITAF-LEENdldpsaPDTAFVFSAHGTPVHYLEAGNRYDTYVEEHAE 221
WP_121920031 146 ALDEVG-W--DVPVDGLTGWHKHPAYNRVRIDNIREF-LDENdle-lgDGTKLVFSAHGTPQYYLDEGSRYEEYVEEFCG 220
WP_012803041 230 HIAERLESdvDDITLGFQSVFGphKA-SWTTPLSTDILKKWH--DEgLtSRVFFICPGFALDCLETLHDIPREMMALLEf 306
WP_012945400 220 IVNRMLGD--PGYELGYQNHEN--RDvAWTEPDVESVVEDL----D-A-ERVVVDPVSFMHEQSETLSELDLELREEAE- 288
WP_013875649 224 ALARMIGI--DDYEIGYQNHEN--RDiSWTEPETEEVVEEIGrnDE-A-DRVVVEPMSFMHEQSETLVELDIDLREDAE- 296
WP_014051366 220 MVAGMLGN--PDYELGYQNHAN--RDvEWTQPDVEDVVETI----D-A-DRIVVDPSSFMHEQSETLSELDVELREEAE- 288
WP_015322838 222 AIADMIGI--DDYEIGYQNHAN--RGiEWTEPDTEDVVEGLA--GE-A-ERVVVEPMSFMHEQSETLVELDVDLQEDAA- 292
WP_008526489 220 TVAGLLGI--DEYELGYQNHEN--RGiPWTEPEVEDVIERV----D-A-ERVVVEPISFMHEQSETLSELDVELREEAE- 288
WP_050049316 221 TIAALLGV--DEYTLGFQNHEN--RDvSWTEPDIETAIESV----D-A-DRVVVEPASFLHEQSETLSELDLELAAEAE- 289
WP_070365199 221 TMAALLGR--ESYTLGFQNHAN--RDiPWTEPDIEDALESI----E-A-DRVVVEPMSFLHEQSETLHELDVELREAAE- 289
WP_119817163 222 TLARMVDV--DDYELGFQNHSN--RDiPWTEPEIEDVIEGLE--GE-A-ERVVLEPMSFIHEQSETLVELDIDLREDAE- 292
WP_121920031 221 VVAAALGA--EDYELGYQNHEN--RDvDWTEPDVEEVIETV----D-A-DRVVVEPVSFMHEQSETLSELDIELREEAE- 289
WP_012803041 307 GAtaddlevlaaaGDtaaaaalaaideaqrrmvettetlslagdeaRFKGVRCLGPSPEEVALLHEVALDA 377
WP_012945400 289 ER-----------GL-------------------------------GFFRVPVPYDDDRFIELLADLVEPF 317
WP_013875649 297 EV-----------GL-------------------------------DLHRVPVPHDDLRFPELLSDLVEPF 325
WP_014051366 289 ER-----------GI-------------------------------EFTRVPVPYDDERFIGLLSDMIEPF 317
WP_015322838 293 EA-----------GL-------------------------------ELHRVPVPHDDPRFATLLADTVEPF 321
WP_008526489 289 AA-----------GL-------------------------------EFYRVPIPHDDERFVGVLEDLVEPF 317
WP_050049316 290 AA-----------GL-------------------------------EFYRVPVPHGEPRLAGIMADLVEPF 318
WP_070365199 290 TQ-----------GL-------------------------------EFYRVPVPHDDPRLATVLGDLIEPF 318
WP_119817163 293 AV-----------GL-------------------------------DLHRVPVPHDDPRLAELFADLLEPF 321
WP_121920031 290 EA-----------GL-------------------------------DFYRVPIPYDDERFVGALADLVEPF 318
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