Conserved Protein Domain Family
Lbh
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pfam15317: Lbh (this model, PSSM-Id:405905 is obsolete and has been replaced by 434627)
Cardiac transcription factor regulator, Developmental protein
The family of proteins are cardiac transcription regulators, named Lbh, short for Limb, bud and heart. They regulate embryological development in the heart. More specifically, in humans, they may act as transcriptional activators in MAPK signaling pathway to mediate cellular functions. This family of proteins is found in eukaryotes. Proteins in this family are typically between 92 and 116 amino acids in length.
Links
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Statistics
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PSSM-Id: 405905
Aligned: 13 rows
Threshold Bit Score: 86.7565
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_014964224   1 MALVPGSSEdg-pwP-KDSPGSSQHAEspRL----TTPLWK------DRGEIDRVEGHQDvqvstlppcvlllahpllwp 68  mouflon
ELK13441       1 MDLVPESSEdg-pwP-RDSPGSFQHPEsaRL----TNPLWK------DRGEIDRVEDHQDiqvv---------------- 52  black flying fox
XP_003442986  19 MTEVMINST-----P-MEDMRLSPSKD--RL----SFQIFP------DPSDFDRCCKLKD-------------------- 60  Nile tilapia
EGV98321       1 MTEVMMNTP-----S-MEEIGLSPRKD--GL----SYQIFP------DPSDFDRCCKLKD-------------------- 42  Chinese hamster
XP_007476992  94 MTEVMMNTP-----T-MDEIGLNNQKD--SI----SYQIFP------DPSDYECICKLKD-------------------- 135 gray short-tail...
4_pfamImport   1 MALVPGNSEdg-pwP-RDRPGSSQHPEssRL----MNPLRM------DRGEIVRVEGHQDaqvstsppcallapppt-ws 67 
XP_008272594   1 MALVPGNSEedgpwP-RDSAGSSRCPEgpRL----TSSLWK------DTGAIGRAEGPQDvqav---------------- 53  rabbit
XP_023374203   1 MALVPGSSEedgpwT-RDSPGSSKHPEspRL----MNSLWK------DRGEISRVQGYQDfqvv---------------- 53  small-eared galago
NP_001273032   1 MALVPESSKdg-swS-GDNPDSPWHPEspQL----ANPLSK------NREETGRCEDHQDvevs---------------- 52  house mouse
XP_009244516   1 MALVPGRSKvdglwT-RNSPGSSQHPEspRL----PNPLW-------DRGKIGKVEGHQHiqdf---------------- 52  Sumatran orangutan
NP_001011389  18 MTEVIMNTQ-----P-MDEIGLSPRKD--------SYQIFP------DPSDFERCCKLKD-------------------- 57  tropical clawed...
XP_014344014  83 MAEVMSTCE-----PvMEDFILNQAPE---E----RELPFQvfpdsqET--YEKHPKLFK-------------------- 128 coelacanth
XP_030130905   1 MTEVMNTRE-----PvMEEFVLSQTPE---EeggpSSQAFA------DS--REKYPKLSK-------------------- 44  zebra finch

XP_014964224  69 sspvvpiqvtcpqtRLPSIVVEASEVN-EESGELRWPHQELLLLTDDeEEEAEVFFQDQSE 128 mouflon
ELK13441      53 ----------sqktHLPSIVVEASEIS-EESGELRWPHEELLVLTDD-EEEAEGFFQDQSE 101 black flying fox
XP_003442986  61 --------------RLPSIVVEPTE-GeVESGELRWPPEEFLVSEEE-EEDEEEEEEEQNs 105 Nile tilapia
EGV98321      43 --------------RLPSIVVEPTE-GeVESGELRWPPEEFLVQEDE-QDNCEETAKEKKE 87  Chinese hamster
XP_007476992 136 --------------RLPSIVVEPTE-GeVESGELRWPPEEFVVHEDG-KEKKEEKEKENKE 180 gray short-tailed opossum
4_pfamImport  68 krpaipiqavsqktPLPSIVVEASEVS-EDSGELGWPHDELLLLTDE-EEEAEVFFQDQSE 126
XP_008272594  54 ----------sqkpRLPSIVVETSEVN-EDGAGLQWPCEDLLLLTDG-EEEAEAFFQDQSE 102 rabbit
XP_023374203  54 ----------sqksHLPSIVVEASEVNeEESGDLQWPHEELLLLTDGeEEEAEAFFQDENE 104 small-eared galago
NP_001273032  53 -----------qkpRLPSIVVEASEGSeEDQEDHQWPHEELLVLTDG-EEDAEAFFQDQSE 101 house mouse
XP_009244516  53 ----------sqksHLPSVVVEANEVN-EESGDLHLPHEELLLLTDGeEEDAEAFFQDQSE 102 Sumatran orangutan
NP_001011389  58 --------------RLPSIVVEPTE-GdVESGELRWPPEEFVVDEDK-EGSCDQTKKENEq 102 tropical clawed frog
XP_014344014 129 --------------RLPSIVVEPTDTGeVESGELRWPPDDMKSIEDK-ATAVDQYCQKESm 174 coelacanth
XP_030130905  45 --------------RLPSIVVEPTESGdVESGELRWPPEDLKSAEDK-GLHGDQRVSVqqq 90  zebra finch
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