16125672 5 SELKLPLGHPPDAMEPAILARLGLSATDLVSFAVARRANDARkKSAIQMVYSVDVVLRDEAAVLRRFEGDHHLRVTpdtg 84 Caulobacter crescen... 15896328 5 NNIILDIDEDLENLKNKAAKKLKVSKESFESFKILRESIDARkKDVIKFNYSVEVKCKNESKIISKIHGKDAILEKnkee 84 Clostridium acetobu... 15673161 5 TQIKISIDEPVSKVKSLVLKKLRLQESDLLDYRIYKESIDARhRGEIDFIYTVDIKLKDEARILSKKIKNVSLAPEldyv 84 Lactococcus lactis ... 20091498 7 LLIGKENQADGEEKMGSAYDVIIIGAGPAGMFAAYELAAG------ELKILVIDMGKDIDERLCPMKN--QSYCMH---- 74 Methanosarcina acet... 20093939 1 -----------------MERVVIVGAGPAGLFAAREVALRAE---RDVEVVVYEQGPSLEDRLE------SG-------- 46 Methanopyrus kandle... 14521862 1 --------------MEQKFDVVIIGAGPAGLFAAYELVERS-----NLKVLIIDEGGDVDQRVCPMYE--LGYCIG---- 55 Pyrococcus abyssi 18312326 1 MVTQYLSRLRTLDRYVGDYDVVIVGAGPAGLFAALELA-----EAGGLKIALIDGGYRASQRHCPLQT-PLEKCTY---- 70 Pyrobaculum aerophilum 14590224 1 --------------MEEKFDVVIIGAGPAGLFAAYELVEKS-----NLKVLIIEEGGDVDQRVCPMYE--LGYCIG---- 55 Pyrococcus horikoshii 15897189 1 ---------------MSSYDVVIIGGGPAGLFAAYELAGLAKdNVSNYKILLVDKGARASKRTCPLLS-PKEKCTF---- 60 Sulfolobus solfatar... 15640824 5 TELKLPLNHEEGALLDAIAAKLKIPAQQVLSFTLFRRGYDARkKSDIQLIYTVDVEVANPEKLLAKFSKDQHVRPTpdms 84 Vibrio cholerae
16125672 85 yhfvakapegFDgPRPVVIGAGPCGLFAGLILAqmgLKPIivdRGKVVRERTKDTWGLWRRSELNPESNVQFGEGGAGTF 164 Caulobacter crescen... 15896328 85 erf-qfgnekLK-HRPIVIGTGPCGMFAALTLAengYAPLvieRGENVEKRTETVDNFWKTGVLNTESNVQFGEGGAGTF 162 Clostridium acetobu... 15673161 85 npv-igskkmLH--RPVVIGFGPAGMFAALLLAqngYRPIvleRGQAVDERVKSIDKFWLEGKLNPKSNVQFGEGGAGTF 161 Lactococcus lactis ... 20091498 75 ----------CA-PCEIMCGVGGCGTFSDGTLN---LRPD---IGGDLAALTGDQTEAWELVDRVDKVFLKFGAP-QVAL 136 Methanosarcina acet... 20093939 47 ---------------EVMRGVGGAGGLSDGVLN---LRPD---VGGDLVSIVGDKRSANELVEYVDEVFLKHGAP-KELK 104 Methanopyrus kandle... 14521862 56 ----------CK-PCHIMSGVGGAGGLSDGTVN---LRPD---IGGDLTELTNDENYSWQLVWEVDQILLRHEAP-RNLY 117 Pyrococcus abyssi 18312326 71 ----------CV-PCHIMYGIGGAGTLSSGLIN---LRPD---VGGDLHELVGDWDKAMELINYIDSIFVKFGAP-EHVY 132 Pyrobaculum aerophilum 14590224 56 ----------CK-PCHIMSGVGGAGGLSDGTVN---LRPD---IGGDLTELTNDENYSWQLVWEVDQILLRHEAP-RNLY 117 Pyrococcus horikoshii 15897189 61 ----------CD-PCHIMYGFGGAGTFSSGIIN---LRPD---IGGELHEITRSWDKAQELINYVDDIFVKFGAPKDRVF 123 Sulfolobus solfatar... 15640824 85 ykfvakapenLP-ERPLVIGFGPCGLFAGLVLAqmgFNPIiveRGKEVRERTKDTFGFWRKRTLNTESNVQFGEGGAGTF 163 Vibrio cholerae
16125672 165 SDgkLYSQIKDprflgrkvlTEFVKAGAPEEILTEAHPHIGTFRLVHMVENMRALIESLGGEYRWQHRVEDFDIEVGEdg 244 Caulobacter crescen... 15896328 163 SDgkLTTRIKDprct--yvlEEFIKSGAPEEIGYVGKPHIGTDILKKVVKNIRERIISLGGEVKFNSKLEDIIIKNDS-- 238 Clostridium acetobu... 15673161 162 SDgkLTSRVRDlrgr--kvlEEFVQAGAPEDILYKAHPHVGTDLLRDIVKNIRKQIIELGGEVHFDAQVEEFLIEDEE-- 237 Lactococcus lactis ... 20091498 137 LT--EGPEIEE---------LKRRAASVGARFIEIKQRHIGSDNAPEVIGRFKQDLVDNGVDFQIETEVHDLLIEEET-- 203 Methanosarcina acet... 20093939 105 VP--EGPKVEE---------IALRAAAADVEFVRIPQRHIGSDNLPKVIGSLVRELEELGVKIVPETRV-ERILADEC-- 170 Methanopyrus kandle... 14521862 118 KG--DPEQIKY---------WERKAAQAGVKFIPIIQRHIGSDNTPKVIKSIKNYLESKGVKFLLWTKA--LEFNKGW-- 182 Pyrococcus abyssi 18312326 133 EP--NMEAINK---------LSALAARVNARIVPIRQRHMGTDGSRKVVEAMTQYLEGAGVAVMYATWALEVERGENG-- 199 Pyrobaculum aerophilum 14590224 118 KG--DPEQIKY---------WERKAAQAGVKFIPIIQRHIGSDNTPKVIKSIKNYLEKKGVKFLLWTKA--LEFNKGW-- 182 Pyrococcus horikoshii 15897189 124 EP--NMEKVRE---------IQRRAAKVGAEFVPIRQRHMGTDKTPLIIENIVNYVEKRGIKIGELTEVIDIEKKGN--- 189 Sulfolobus solfatar... 15640824 164 SDgkLYSQVKDpnfygrkviTEFVEAGAPEEILYVSKPHIGTFKLVTMIEKMRAKIIELGGEIRFSTRVDDIHMQDGQ-- 241 Vibrio cholerae
16125672 245 vrrVTGLHIAGQGHLPARHVVMALGHSSRDTFQVLYDR-GVHIEAKPFSIGVRIEHPQSWIDRarfgdcagHKDLGAAAY 323 Caulobacter crescen... 15896328 239 ----IEAVVVNGAEIPCECLVLAIGHSSRDTYEMLHKK-GIFMDPKPFAIGVRIEHPQDFINEsqygkyknHPRLKAADY 313 Clostridium acetobu... 15673161 238 ---LQAVKLADGNIIKTNQAILAIGHSARDTFSELYDK-GVTITAKPFAVGVRIEHPQSLINKaqykefadHPRLGAAEY 313 Lactococcus lactis ... 20091498 204 ---CKGVILSGGKVIRARYVVLSPGRRGCNWVSEMIEKhGLGARYGGIDIGVRVEVPAIIMDP--------VTKINRDPK 272 Methanosarcina acet... 20093939 171 ---VRGVKLEDGREVEADYVIAAPGRVGANWMMHEAKRlGLGLRYNPIDVGVRVEVPRIVMEP--------VVEVSLDPK 239 Methanopyrus kandle... 14521862 183 ---VKVQRGKDVFTIEAKYIIVAPGRGGAEWFHEVAKKiGLKARHGPIDVGVRVEVPAIIMEP--------ITSINHDPK 251 Pyrococcus abyssi 18312326 200 ---TFTVKTTRG-VLNARAVLLAPGRGGAEWLVSQLKKlGASLDFGPVDIGVRVEVPYHVMRP--------LTDAVHDPK 267 Pyrobaculum aerophilum 14590224 183 ---VKVRRGKDTFTINARYIIVAPGRGGADWFHEVAKKiGLKARHGPIDVGVRVEVPAIVMEP--------ITSINHDPK 251 Pyrococcus horikoshii 15897189 190 ---KFFLKTSRG-EIESRIVLVAPGRAGAKWFYEQSKKlGVDTIPGPLDIGVRVETESFVFDE--------LTEAVWDPK 257 Sulfolobus solfatar... 15640824 242 ---ITGVILSNGEEIQSRHVVLAVGHSARDTFEMLHAR-GVYMEAKPFSVGFRIEHKQSMIDEarfgpsagHPILGAADY 317 Vibrio cholerae
16125672 324 AISHHAKNGRTVYSFCMCPGGTVVAATSEPGRVVTNGMSQYSRNERNANSGFVVDIDPEr----------DYPGHpl-aG 392 Caulobacter crescen... 15896328 314 KLTHTTKDKRGVYSFCMCPGGEVVASSSEDERLVCNGMSYYKRDLENANAALVVTVNSEdfkaskelynkDISDNspliG 393 Clostridium acetobu... 15673161 314 RLTYKASSGRGVYTFCMCPGGLVVPAASEEGGLVTNGMSEHARDQKNANSGLLVQVFPEd----------FPTDHpl-aG 382 Lactococcus lactis ... 20091498 273 FHIQSRQYDDFVRTFCTNRRGFVVKEEYED-FVATNGHSMTNKESENTNFAFLVHIELT-----------EPMEN----T 336 Methanosarcina acet... 20093939 240 FRTRAPTYDDPVRTFCVCHGGYVVKENYEG-FVGVNGHSYRRKKSENTNFAFLVSVDLT-----------EPVEN----T 303 Methanopyrus kandle... 14521862 252 FHIYTDTYDDFVRTFCTNPYGFVVEERYDS-YVGVNGHSMREKKSNNTNFALLTRIELT-----------EPVED----T 315 Pyrococcus abyssi 18312326 268 VILYTSKYDDKVRTFCTNPRGFVVKEVYSDGTIGVNGETYLEKKSENTNFAFLVTLRLT-----------DPMED----T 332 Pyrobaculum aerophilum 14590224 252 FHIYTDTYDDFVRTFCTNPYGFVVEERYDN-YVGVNGHSMREKKSNNTNFALLTRIELT-----------EPVED----T 315 Pyrococcus horikoshii 15897189 258 VILYSKRYDDKVRTFCVNPRGYIMKEVYDDGTIGVNGETYVDKKSNNTNFAFLTTIKLS-----------DPLED----T 322 Sulfolobus solfatar... 15640824 318 KLVHHCKNGRTVYSFCMCPGGTVVAATSEEGRVVTNGMSQYSRAERNANSAIVVGISPEq----------DYPGDpl-aG 386 Vibrio cholerae
16125672 393 VDFQRKWESLAFQAGGGTyqAPGQLVGDFLAGRPS--TVFGAV--TPSYKPgVHLTDLAQCLPDFAIEAMREALPIFGRQ 468 Caulobacter crescen... 15896328 394 MEFQRYYEHLAYLAGGGNynAPIQLVGDFMKDTVS--SKLGSV--KPSYTPgYKFASLSECLPPYVIAALKEGLVNFDKK 469 Clostridium acetobu... 15673161 383 VEFQKELEHKAFELGGSNyqAPAQLVGDFLDGKAS--KAMGTV--EPSYALgVKPTNLESLFPDYVTQSMREAIVGLDKK 458 Lactococcus lactis ... 20091498 337 TKYARSIAKLATTIGGGK--PVLQRMGDLRRGRRStkERLAKNlvINTLKD-VTPGDISMALPHRIVMDIIEGLETLNEI 413 Methanosarcina acet... 20093939 304 IEYGRSIGRLATTIGGNR--PIIQRLGDLRRGRRStwDRINRShvTPTLMD-VTPGDISMALPHRVTVDIIEGLERLDEV 380 Methanopyrus kandle... 14521862 316 TAYGRSIAQLATTIGGGK--PIIQRLGDLRKGRRStwSRIRKSdvEPTLKH-VTPGDIAMALPHRVVTNIIEGLERLDKV 392 Pyrococcus abyssi 18312326 333 IEFGKSIARLATKLGGGK--PLIQRLYDLERGQRStwDRIRRSsiSPTLKD-VTPGDISLALPHRIVEDIIEGLKKLDEL 409 Pyrobaculum aerophilum 14590224 316 TAYGKSIAQLATTIGGGK--PIIQRLGDLRRGRRStwSRIRKSdvEPTLKH-VTPGDIAMALPHRVVTNIIEGLERLDKV 392 Pyrococcus horikoshii 15897189 323 IEYGKSIARLMTRLGGGK--PILQRLIDFQKGRRStwERINRStvKPTLRD-VTPGDISMGLPYRVVDNLIDGLERLDSI 399 Sulfolobus solfatar... 15640824 387 IRLQRELETNAYKLGGETydAPAQKIGDFLKGRNP--SELGDV--QPSFTPgIKLTDLSKALPAFAVEAIREAIPEFDRQ 462 Vibrio cholerae
16125672 469 IPGYDHPDVVLTGVETRTSSpVRITRGKDf-QSLNTAGLYPAGEGAGYAGGILSAAVDGIKVAEAVAKQYVAE 540 Caulobacter crescentus CB15 15896328 470 ITGYMLSDAVMTGIETRTSApLKITRNESl-ESISLKGLYPSGEGAGFAGGIISAAVDGVKSAESIMRKYKI- 540 Clostridium acetobutylicum 15673161 459 MHGFALSDAVMTGVESRSSSpVRINRDEEnyQSVSTKGIYPSGEGAGFAGGIVSAGIDGLKCAESMIAEFAKL 531 Lactococcus lactis subsp. ... 20091498 414 IPGVASDSTLLYAPEVKFYA-MHLKVDRQ--METSIKNLFAAGDGAGLSRDIVNAAATGIMAAEGILR----K 479 Methanosarcina acetivorans... 20093939 381 IPGVASDSTLLYAPEIKFYS-ARVETNED--LETRVENLFVAGDGAGLSRDIVNAAATGVIAGRAVAERIG-- 448 Methanopyrus kandleri AV19 14521862 393 IPGVASDHTLLYAPEIKYYA-MRVEVNEL--LETSIENVFAAGDGAGLSRDIVNAAATGIMAARGILVKEGLY 462 Pyrococcus abyssi 18312326 410 APGVASPQTLIYAPEIKYYS-ARPTVDAH--LMTTVPGLFVAGDGAGLSRGINVAAATGVLAARGILKYLSSA 479 Pyrobaculum aerophilum 14590224 393 IPGVASDHTLLYAPEIKYYA-MRVEVNEL--LETNIENVFAAGDGAGLSRDIVNAAATGIMAARGILVKEGLY 462 Pyrococcus horikoshii 15897189 400 APGIFSSNTLLYAPEIKYYS-VRAVVDNN--METVVDNLFAAGDGTGLSRGINVAAATGILAARGIAIKLGLD 469 Sulfolobus solfataricus 15640824 463 IKGFASEDGLLTGVETRTSSpVCIKRGKDf-QSINLKGFYPAGEGAGYAGGILSAGIDGIKVAEAVARDMMAR 534 Vibrio cholerae
Jiyao W et al.(2023). "The conserved domain database in 2023.",