2G2Q,2FGX


Conserved Protein Domain Family
Glrx-like

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pfam05768: Glrx-like 
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Glutaredoxin-like domain (DUF836)
These proteins are related to the pfam00462 family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterized member is G4L from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L.
Statistics
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PSSM-Id: 399055
Aligned: 33 rows
Threshold Bit Score: 51.9082
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2G2Q_C   5 LIIFGKPYCSICENVSDAVE--ELKSE-----YDILHVDILsfflkdG-DSs---xLGDvkrgtlignfaahlsnyivsi 73  Vaccinia virus
Q05530  23 LTFFSKPNCGLCDQAKEVIDdvFERKEfhnkaVSLEIVNIT------DrRNa---kWWK--------------------- 72  Saccharomyces cerevis...
Q98227   5 LLLLGKPLCPVCALANTILS--HLEDK-----YPILRVNILslf-tkKnVVd---vLGMrtyelvsalme-ffggeyvmv 72  Molluscum contagiosum...
Q8V3P4   5 IILFGKPLCGVCETISDVIK--KLEDD-----YNVLRINILsff-skNgQIk---eLGInegivfinnffkylgnevacm 73  Swinepox virus
Q6TUW0   5 LILFGKPFCGMCESISEVMK--ELEDE-----YDVLRINILsff-skTgQIk---eFEVdqsvvfinnffkylninfasl 73  Yaba monkey tumor virus
Q9Q8P8   5 LILFGKPLCGVCEAISEALQ--MLEND-----YDILRINIIsff-skNgQIk---eFDTdhgvafinnffkylatdaasl 73  Myxoma virus
Q9J5D4   5 IILFGKPNCPLCKFSNEILSnkKIASK-----YEIVRINIAtf--fdK--SkvveiLGMdksydllnsigeklgneyvlv 75  Fowlpox virus
Q8FSG1 516 VELIVRDNCGSCVRVREQIMpvLTAAG-----VHLVVSNVD------DdPA-----LKA--------------------- 558 Corynebacterium effic...
Q6NJK2   6 VELMVRSTCGSCARVAAQIRpvVAAAG-----AELVIVDVD------SdSA-----LAS--------------------- 48  Corynebacterium dipht...
P9WKS9   6 VELLTRAGCAICVRVAEQLAelSSELG-----FDMMTIDVDvaa-stGnPG-----LRA--------------------- 53  Mycobacterium tubercu...
2G2Q_C  74 fKYNPQTKQXAFVDINKSLDfTKTDKSLVNLEILKSEIE 112 Vaccinia virus
Q05530  73 -EYCFDIPVLHIEKVGDPKS-CTKILHFLEEDDISDKIR 109 Saccharomyces cerevisiae S288C
Q98227  73 lKMQPDTGEVAFVPFKEYLVvGQISMDALDYDQLERSVE 111 Molluscum contagiosum virus subtype 1
Q8V3P4  74 fKYNPETEELAFVDISSFFNlAIIDKSFIQVDHIRDVIE 112 Swinepox virus
Q6TUW0  74 fKYDPESGKIGFVNISKFFNlAMIDKSFVKNESLKEEIE 112 Yaba monkey tumor virus
Q9Q8P8  74 fKYDPESKQMAYVNISQFFNlAIIDKSFVKKELIEEEIE 112 Myxoma virus
Q9J5D4  76 fRYDDTSKQMAYIPFKKYIViGQISQDSIDFDKLLNELE 114 Fowlpox virus
Q8FSG1 559 -EFGDRVPVILVDD-------EEFASWEVDNDELAHALL 589 Corynebacterium efficiens
Q6NJK2  49 -EFGDRVPVVVIDD-------EEFSCWEVDNEELAAELA 79  Corynebacterium diphtheriae
P9WKS9  54 -EFGDRLPVVLLDG-------REHSYWEVDEHRLRADIa 84  Mycobacterium tuberculosis H37Rv
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