2IXO,2IXN


Conserved Protein Domain Family
PTPA
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pfam03095: PTPA (this model, PSSM-Id:397284 is obsolete and has been replaced by 460802)
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Phosphotyrosyl phosphate activator (PTPA) protein
Phosphotyrosyl phosphatase activator (PTPA) proteins stimulate the phosphotyrosyl phosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognized phosphoserine/ threonine protein phosphorylase activity. The specific biological role of PTPA is unknown, Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumor suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1.
Links
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Statistics
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PSSM-Id: 397284
Aligned: 250 rows
Threshold Bit Score: 251.615
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2IXO_B               16 PVKRIFDTQTTLDFQSSLAIHRIKYHLHKYTTLIS--------HcSDPdphatassiamVNGLMGVLDKLAHLI------ 81  baker's ...
XP_003245316         43 vCQRVREPRDMFDWERSEARADLLVFVRHMNDVAKry----paAaAARrrrrprpfddnVDRAMAVLRTVGEWAvkrcgp 118 pea aphid
ETN57795             17 PEKKIKSAMDMAKWEKSEAYYDLLGFISSMSVALQgtrasqnlEvSPV-----------VEKLMNAIDRLEQLA------ 79  Anophele...
Q17M03               15 PEKLIKTRADMELWERSEAYYDVFGFISSMCVALQgtkqsqplElSPI-----------IEKLIEALKRLEQLA------ 77  yellow f...
EDW35372             30 PKRQVLCLEDMDDWVRSQAYKDTIAYINNTSMAIQgkklssefPvSEK-----------VRRLCDIFDGLEILL------ 92  Drosophi...
WGS:AAPP:GF19862-PA  27 PVKQVRSLEDLDRWVRSQAFYDTIAYISNTSMAIQgrrltrefPiSEQ-----------MRKLCQIFDGLEHLL------ 89  Drosophi...
XP_002044198         27 PVKQVRSLEDLDRWVRSQAYYDIIAYISNTSKAIQghrltqafPvTEQ-----------MRRLGEIFDGLEQLI------ 89  Drosophi...
XP_002073342         33 aVTRVRKLSDVEVWKRSVGYHKLIAYINNTSSVIQgirqsddyPvSET-----------MSRLLTIFDKLENLL------ 95  Drosophi...
Q9VNG7               23 PVCRVQSSSDMEAWLASRAYFTLITYLNDVSAEIQgirntdlfPiSKN-----------IKRLTTIFEQLDSMI------ 85  fruit fly
XP_001955226         25 PHNRVETPADMEFWQQSKAYVILTTYLFDVSSHVQgvrttdpfPvSRS-----------IKRLLGIFDALDVLI------ 87  Drosophi...

2IXO_B               82 ---DETPPLPG-P---------RRYGN------------LACREWHHKLDERLPQWLQEMLPSEYHEV--VPELQYYLGN 134 baker's ...
XP_003245316        119 agqDDRPESAA-----------ERFCH-----------------FHSQLRADGRCLLNRTYGGRGRAEyrDVMLPAYLER 170 pea aphid
ETN57795             80 ---VETPPIDQ-P---------ARFGN------------AAFKTWFQKMRSESTQLIADALPETAKe--aVKELQVYFEE 132 Anophele...
Q17M03               78 ---IETPPVDQ-P---------ARFGN------------IAFRSWFQKMQGETAKLIEQAIPEHLKd--aVPELNVYFQE 130 yellow f...
EDW35372             93 ---SENTP---------------KFESahswltaqqgnaNAYRNWMRLMHQFVFSVLDEAVQPECKH---INELGQYLRR 151 Drosophi...
WGS:AAPP:GF19862-PA  90 ---VEHSP---------------KSEDydtsisisqvksRAYRVWMRHMFQHVFFKLDEAIKAKCKH---INELGQYLRR 148 Drosophi...
XP_002044198         90 ---VEHTP---------------KMEDsnlalpfgqvrsKAYRTWMRQMYQHVFSKLDEAINVNCKH---INELGQYLRR 148 Drosophi...
XP_002073342         96 ---AANPPIYM-AgsikgsldkDRRGN------------PAYRNWSRHMLRDIFPILEQAVSNKNCIH--INELGQYLCE 157 Drosophi...
Q9VNG7               86 ---VANSPAPLvLgan----mdSRT--------------KSYRRWAHGMLRDIYKIVEKAVPSSKCRH--VNELGVYLSG 142 fruit fly
XP_001955226         88 ---VANPPVVTgEpkt----smTESGN------------RAFRKWARCMLRDIYYMVEKAVPTKKCQH--VNELGQYLSS 146 Drosophi...

2IXO_B              135 SFGSSTRLDYGTGHELSFMATVAALDMLGMFPH--HRGADVFLLFNKYYTIMRRLILTYTLEPAGSH-----GVWGLDDH 207 baker's ...
XP_003245316        171 SFGDPVTMAYGPAHELSFCAFLVSLFKLHHLTWa-DEPFVVTVIFDKYLDVVDYVIRSYQLYPSSSEyggnlGNWCLSGY 249 pea aphid
ETN57795            133 SFGNSTRIDYGTGHELAFVMFLMCLFKIGAIer-kDEVAVGLKLFDKYIILVRKLQVTYRMEPAGSH-----GVWSLDDF 206 Anophele...
Q17M03              131 SFGNATRIDYGTGHELSFIMFLMCLFKIGAIer-kDEVAVGLRLFVQYLNFVRKLQVTYRMEPAGSH-----GVWSLDDF 204 yellow f...
EDW35372            152 SFGCSSSLEFGPGNELMFLFFLCGLFRAGILFAd-DTVAAALLLFHRYIRLVRRLILTYSLSLTKD------SRFSMDDY 224 Drosophi...
WGS:AAPP:GF19862-PA 149 SFGNATSLDFGPGNELMFLFFLCGLFRSGILLAk-DTVAAALMLFGRYIHLVRRLVTTYALPIAKNP-----RSF-IDDY 221 Drosophi...
XP_002044198        149 SFGNANTLDFGPANELMFLFFLCGLFRAGILLAk-DTVAAALMLFNRYVNVVRRLISTYGLTIAKDP-----ACT-IEDY 221 Drosophi...
XP_002073342        158 SFGNSTRMSYGTGHELSFLFFLCALFEAEILDEd-DLAASALLLFDRYLKFVRRLQVLYNLYAAGRH-----GAYSLDDF 231 Drosophi...
Q9VNG7              143 SFGSSAKIEYGTGHELSFLFFVCALFKAEILDKeqDLAASALVLFDRYLHFVRRLQVTYSVNSSNWH-----GGYSLDKF 217 fruit fly
XP_001955226        147 SFGNSTKIEYGTTHELNFLFFVAGLFQARILNKeeDLAASGLILFVRYLKLVRRLQITYSMVPPANH-----GAYSLDKF 221 Drosophi...

2IXO_B              208 FHLVYILGSSQwqlldaqAPLQ------------P-----REILDKSLV-REYKDTNFYCQGINFIN-EVKM-GPFEEHS 267 baker's ...
XP_003245316        250 QFVGFLWGSAQ-------LAGScgdgdgsapdgiPslsspTAVISDAYAcRRHRDDYVFAKCMDAVYrRARKdVPLWYHS 322 pea aphid
ETN57795            207 QFVPFIWGSAQ-------LAVN------------Spi-epAQFVEDKSI-DKYRKELMFVGCIDYIR-QVKT-GHFAEHS 263 Anophele...
Q17M03              205 QFVPFIWGSAQ-------LAVR------------Spi-epAQFIEDNII-DVYRKEYMFVSCIDYIR-QVKT-GHFAEHS 261 yellow f...
EDW35372            225 YVIPYIWGSAQ-------LSLDa-----------Pfs--pMESEMQLIM-EAHRQDYMLLEVIDHLR-KTRG-LQLNQVA 281 Drosophi...
WGS:AAPP:GF19862-PA 222 YVLPYLWGAAQ-------LSSEe-----------Lfs--pIQCEQPKLI-ENYRQDYMMMELIEHLQ-KTRG-GQLSHVA 278 Drosophi...
XP_002044198        222 YFLPYLWGAAQ-------LSLNs-----------Pfs--pMQCEQGKIM-DSYRQDYMMLEIIDHLQ-KTRR-GPLSRVA 278 Drosophi...
XP_002073342        232 QFVPFLWGCAQ-------LSYN------------Apf-vpNRMLDADVV-SEYKKDYMLMGCVGHIS-DTKD-GTFAMHS 288 Drosophi...
Q9VNG7              218 QFVPFVWGFAQ-------LCHEa-----------Pfs--pKKMLDEDTI-AKYRDAYMLINCVGHMA-TTNV-GTFARHS 274 fruit fly
XP_001955226        222 QFIPFIWGAAQ-------LCYDa-----------Pfs--pRKMLDEDTV-AKYKNSYLLADCVGHIM-MTNI-GPFAGHS 278 Drosophi...

2IXO_B              268 PILYDIAVTVPrWSKVCKGLLKMYSVEVEKKFPVVQHFWFGTgFFPW 314 baker's yeast
XP_003245316        323 YQLWNLTALPR-WDRVNGCLITAYQRDVLGRFEVIRQLAFCE-LFKF 367 pea aphid
ETN57795            264 NQLWSISAVPQ-WSKISTGLLKMYQKEVLSKFPVIQHVFFGS-ILTL 308 Anopheles darlingi
Q17M03              262 NQLWSISAVPS-WAKISTGLIKMYQKEVMSKFPVIQHVYFGS-ILTL 306 yellow fever mosquito
EDW35372            282 FQLWCILSVPT-WPEVYGAIERAYVSNVLSSFETVENAIFCE-LMSF 326 Drosophila persimilis
WGS:AAPP:GF19862-PA 279 FQLWCILSIPS-WSQVYRGLERNYISHVLSSFETVENAIFCE-LMSF 323 Drosophila ananassae
XP_002044198        279 LQLWSILSIPT-WPQVYRGLNRNYVDHVLSSFGTVEQAIFCE-LMSF 323 Drosophila sechellia
XP_002073342        289 SQLWCIASLSS-WNELYGGLLDMYDKVVLRQFDLMQLARFGQ-LISF 333 Drosophila willistoni
Q9VNG7              275 SQLWSLAALSS-WTKIHRSLMFMYMEDILMDIDNLNALRFGE-LMSF 319 fruit fly
XP_001955226        279 SQLWCLAALSQ-WPDIYRGLIFRYTEDIVVDFDLIQPMRFGA-LMPF 323 Drosophila ananassae
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