1D1Q,1C0E,1D1P,1D1P,1D2A,1DG9,1P8A,1U2P,1XWW,2CWD,2GI4,2LUO,2P4U,3IDO,3JVI,3ROF,4ETM,4LRQ,4Z99,5PNT,2WMY,2FEK


Conserved Protein Domain Family
LMWPTP
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cd16343: LMWPTP 
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Low molecular weight protein tyrosine phosphatase
Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.
Links
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Statistics
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PSSM-Id: 319971
Aligned: 553 rows
Threshold Bit Score: 129.865
Created: 18-Nov-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1D1Q; Saccharomyces cerevisiae low molecular weight protein-tyrosine phosphatase with bound 4 nitrophenylphosphate, contact 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ########                               #                                  
1D1Q_A      8 ISVAFIALGNFCRSPMAEAIFKHEvekanlenrfnKIDSFGTSNYHvge---spDHRTVSICKQHGVKIn-hKGKQIKTK 83  baker's yeast
AFH49591    2 KKILFVCMGNICRSPAAEGVMKSLvnqng-lkdkvFIDSAGTIEYHage---lpDLRMIEAAAERGYELn-hKARQITKS 76  Ignavibacterium al...
KGI55902    2 NKICFVCLGNICRSPMAEFVMKNLaqkyg-lndklNITSAGTAGYHdge---dmDKRTKKKLSEKGINAthfISKKLTQK 77  Campylobacter sp. ...
BAQ68670    3 LRILTVCTGNICRSPVAAALLRALrp-------daVLASAGLAAEPgr----saDPLTAEVALGLGIDLsghRARRFSAA 71  Rhodovulum sulfido...
KUJ00441    3 DKILVICAGNICRSPYAARRLQRLmp-------ahTVHSAGLLTEKsglvgasvATEAQEVAGTLGLDLtdhRAQQITIA 75  Vibrio sp. MEBiC08052
EOD79092    3 NHILVVCTGNICRSPIAEALLKKLlp-------elVIESAGTAVTKsnitdataHPYSQQVCNENGLDIfnhNARQLTPE 75  Grimontia sp. AK16
KLN63540    3 DSILLVCTANICRSPIAEALFRHHfp-------nkRIFSAGTKVEAlnlidvpaDKGSIQATKWNGLDIsdhRATQVTSE 75  Vibrio sp. VPAP30
KOO07471    3 NSILIVCTANICRSPMAEVIFRKLlp-------nhTICSAGTCVSTlnfddmpaDKNARLVAQQFELDLeqhRAQQLTPE 75  Vibrio hepatarius
KHT47846    3 KRVLVVCSGNICRSPLAQVLLSRLlp-------niSIDSAGVLVDHhdlsahpaVNNSRVVAKENGLDLsnhKAKQLTSE 75  Vibrio sinaloensis
KGY13321    2 NNILIVCSGNICRSPIAHALFEKHmp-------slNIDSAGVFVDRhqlsgvhpVTNSQSVAKQNGLDIsrlQAQQLTPE 74  Vibrio tubiashii

Feature 1                                                       # #                       
1D1Q_A     84 hfdeYDYIIGMDeSNINNLKkiqpe-gskaKVCLFgdwntndgtvqtiIEDPWYgdiqDFEYNFKQITYFSKQFLK 158 baker's yeast
AFH49591   77 dlenFDYIITMDdHIHKSVKhldsqkkfqnKIYKMtdflte--mkadeIPDPYYgdksDFEYSLDLIEDAAKGLLK 150 Ignavibacterium album ...
KGI55902   78 lcdeSKLLLVMDkMNYKAVQsnfk--glenKLFYLldfce---ntekeIPDPYYt--nTFEECHELILKACEGLCK 146 Campylobacter sp. MIT ...
BAQ68670   72 mgreTDLILAMApRHCEDIVriap--eltgRTFLLdhwc-----gaigIPDPYGkpraCHESVVDAILRATESWAE 140 Rhodovulum sulfidophilum
KUJ00441   76 mvdsCDLILAMN-QNQIDILsrmfp-karhKAMLFghwl-----gvsqIDDPYQkssaVFQQVYAVLDRAARAWAD 144 Vibrio sp. MEBiC08052
EOD79092   76 lcdrFDLILVMShEHIEEVAlvsp--gsrgKTMLIgqwi-----glgdIADPILepkaSFDTLYHTLVRATNTWAK 144 Grimontia sp. AK16
KLN63540   76 llenSDLILVMDeTQKECLSryss--gvrsKTLLIgqwi-----nigeVADPYGksdeAFDVCFRCLEQAVLSWKK 144 Vibrio sp. VPAP30
KOO07471   76 lidqYDLVLVMNrHQLEEVAevtr--garsKTLLIgqwi-----qlgdIADPYGkgltEFEQCYKTLARAALSWSK 144 Vibrio hepatarius
KHT47846   76 liddCDLILVMThEHLEQVAqlgr--garaKALLLgqwi-----gageIEDPIGkdidAFRQSYELLEKACLSWSK 144 Vibrio sinaloensis
KGY13321   75 lvsqHDLILVMThEHIEQVAqvsq--garaKTLLIgqwi-----gvgeVHDPIGqemeVFEQCFSVLERAVLSWKS 143 Vibrio tubiashii

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