Conserved Protein Domain Family
ELMO_CED12
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pfam04727: ELMO_CED12 
ELMO/CED-12 family
This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.
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Statistics
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PSSM-Id: 461411
Aligned: 200 rows
Threshold Bit Score: 65.7073
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5CY83        81 HYIRNKCLISLNCADPNHEQLFQDYWALAY---PDYPEIN-----------------------RISSNWRLLGFQNDD-P 133 Cryptosporidium...
ESN90675     292 NVIDEKQNAPVDVNDSNALLQIKELRQIAF---DTDPDLTpia-----------------krqSQLKDFKRLGFQNHMnP 351
XP_002407441 292 NTYEEKRTATLDISNPVLTEKLQLLLKFGFcinPEELDLKqrg------------------srRFSAEYTALGFRHVAaP 353
EKC26896      38 NMYETRMNTPADPDDPNVQKQIDSLTKICF---DVDNETAqs-------------------gnRKSTLYRKLGFQDQSnP 95 
EEN43554     285 NLNEDRMYTKINPSDTAHLEKLYELSQIAF---GRDSDSEsfatpnpggnartqarkgrgvsdRAQVEFKKLGFSNLAnP 361
EEN61692     116 CCLDDRIQTELDPGDPEQLDKVRKLYALAF---DRDLSAQgsalfaenk------gairrskvEYMENYKKLGFTNHTsP 186
XP_023350810 291 GLLEPRMRTPLDPYNQEQREQLQALRQAAF---ELDGESQgsglsa------------drrrsLCAREFRKLGFSNSN-P 354
XP_016851703 291 TLLECRMRTPMDPYSQEQRELLHSLRHAAF---VSENESSagnsnte------------rrhslcSKEFRKLGFMNNSnP 355
XP_005052491 150 NLCEHRMKMSMDPYSQEQRDLLQSLRQAAF---ESEGEAPagtfste------------rrrslcAKEFRKLGFVNNSnP 214
TNN00950     277 NHLEKRMMVPLDCYNQEQRDVLHVLRQLAF---ECESESslsher---------------rrslcAKEFKKLGFSNNSnP 338 Takifugu bimacu...

Q5CY83       134 RFDFK---CAELLTLENLVYFAENYRNIFKVILKESQrfsssekikyshqhsiqrsiinshkingmmspfetphnfqpss 210 Cryptosporidium...
ESN90675     352 IEDFLa-tPPGLLPLHNMMYFAENHRENYTKVVLENScrg---------------------------------------- 390
XP_002407441 354 LKDFMy--PTGKFAFENLCYFAENHSASFTRVVQENVccs---------------------------------------- 391
EKC26896      96 GNDFSlntPPGLLALDNICYFSNKYQESCVKVVLENCtra---------------------------------------- 135
EEN43554     362 LMDFAk-rPPGVLALDCIVYFAANYPDSFTRLVLENScrq---------------------------------------- 400
EEN61692     187 ILDFEe-tPPGLLALDCMLYFAENHTESYNKLVFENScrd---------------------------------------- 225
XP_023350810 355 AQDLEr-aPPGLLALDNMLYFSSHAPNAYSRFVLENSsre---------------------------------------- 393
XP_016851703 356 AMDLHr-iPPGLLALDCMVYFSRHFPSAYSRFILENSsre---------------------------------------- 394
XP_005052491 215 AEDLRr-aPPGLLALDNMVYFSRNTPNAYSRFVLENSsre---------------------------------------- 253
TNN00950     339 GQDLVr-tPPGLLALDTMYYFARRYPDAYSRFVLENSsre---------------------------------------- 377 Takifugu bimacu...

Q5CY83       211 snlsiittpinmkdskkefgsnfepllpkvtelrstiseisnssqidqmnfSYPLSTALINVSIMIclylnfipsiykip 290 Cryptosporidium...
ESN90675     391 ------------------------------------------------ddhDMPFAQASIELTQLI-------------- 408
XP_002407441 392 ------------------------------------------------pqhRCPLTQSSIMLSELL-------------- 409
EKC26896     136 ------------------------------------------------dehDCPFIKASIMLTKTL-------------- 153
EEN43554     401 ------------------------------------------------dnyVCPFARTSIDMTKLL-------------- 418
EEN61692     226 ------------------------------------------------dqyVCPFARCAIALTLLL-------------- 243
XP_023350810 394 ------------------------------------------------dkhECPFARSSIQLTLLL-------------- 411
XP_016851703 395 ------------------------------------------------dkhECPFARSSIQLAFTL-------------- 412
XP_005052491 254 ------------------------------------------------dkhECPFARSSIQLTLIL-------------- 271
TNN00950     378 ------------------------------------------------dkhECPFARSSIQLTLIL-------------- 395 Takifugu bimacu...

Q5CY83       291 gvpnvsasrkaMKNFMRlTNEFS-------------FNTISELFSVCAIRFHAEWLDivkflgHKvAISEFDKVL 352 Cryptosporidium parvum
ESN90675     409 -----------GETLKI-ADQPTedgrsyhplfftnDHSFEEFYCICIQLFNKTWKEm-----KA-TVADFTKVI 465
XP_002407441 410 -----------CRIFRI-GEPISdqgtfy-lmfyshDRFFEELFSVCMVLVFKTWREm-----RA-TTEDIHKVF 465
EKC26896     154 -----------CEILRI-GEPPQeeetayypmlfshDKPFEEFFCICIQLLNKTWREm-----RA-SMEDFPKVL 210
EEN43554     419 -----------CKMLKI-GELPSetgteyypmlftqESPLEELFCLCIQLLNKTWREm-----RA-MDEDYDKVM 475
EEN61692     244 -----------CKILQV-GEPPSetgqdyhpmffatPNAFEEVFCVCIQSLNKTWREm-----RA-IHEDFDKVM 300
XP_023350810 412 -----------CELLHI-GEPCSetaqdfspmffgqDNSFQELFCVCIQLLNKTWKEm-----RA-TQEDFDKVM 468
XP_016851703 413 -----------CEILHV-GEPCSetaqafypmffgqEHFFEELFCTCIQLLNKTWKEm-----RA-TQEDFDKVM 469
XP_005052491 272 -----------CEILHI-GEPCSetaqafypmffgqDHFFEELFCICIQLVNKTWKEm-----RA-TQEDFNKVM 328
TNN00950     396 -----------CEILRI-GETPSetgsdyhpiffnqDRLLEELFCVCIQLLNKTWKEm-----RA-TQEDFDKVM 452 Takifugu bimaculatus
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