Conserved Protein Domain Family
Type_ISP_C
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pfam18135: Type_ISP_C (this model, PSSM-Id:407967 is obsolete and has been replaced by 465663)
Type ISP C-terminal specificity domain
This is the C-terminal domain of Type ISP restriction-modification enzyme LLaBIII present in Lactococcus lactis subsp. cremoris. Type ISP restriction-modification (RM) enzymes provide a potent defence against infection by foreign and bacteriophage DNA. This domain interacts extensively with DNA and is known as the target recognition domain (TRD). TRD works by recognising 6/7 base pairs of asymmetric sequence.
Links
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Statistics
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PSSM-Id: 407967
Aligned: 83 rows
Threshold Bit Score: 213.274
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
BAM32310      421 EIFELFSQGVVTGKDNWSFNFSKENLAKNIALCIDTY--NTEREAlvanpAYKLCN--------DLSKVTWSGSLDKRVR 490  Helicobacter ...
EFL88046      725 NLFSSNVLGFQTHRDGFAIAETLKELNSRIEDLSNKNltDATLRE-----KYKV-R--------DNRDWNLSQA-RERLA 789  Ahrensia sp. ...
Q3SKA9        702 EFMPLHGNGVVTKRDRLNIHETESGVREVIDDFLTRT--EEVVRA-----KYKLPK--------DVRDWRYSWALDD--- 763  Thiobacillus ...
KQU49940      711 ELMPENVAGIVSARDHLVIALNEAELINRINVFTDTEltDSEVRN-----RFFGGKkagkyapgDSRGWKLPAARKA--- 782  Bosea sp. Lea...
Q0ASV4        712 EFAPQHAIGIITKRDGVVLSSNREKVESLVQDLALLS--VDEVRA-----KRPEIH--------DTAGWSLSRAKEN--- 773  Maricaulis ma...
EIJ35287      703 ELFVVQSIGIATARDSFCIKFSENEVKKLVGDFSLMQ--IEDARE-----KYQLGK--------DVRDWKVEWA-KADLL 766  Thiothrix niv...
WP_045576530  745 DLFINKNTGIQTKNDKLTIGFKKSDTQLVVNDFKCLQ--KFEIEK-----KYG--S--------KSGTWSIESAQ----- 802  Desulfosporos...
GAK61488      837 EIFKQDSSGVTTHRDHFVVGYTEEEIKQRIKLFVSDL--TDETLS-----IKLDLK--------ETSDFKIEFARKK-L- 899  Candidatus Ve...
ESQ15151      765 KLFRISGMGVKSRRDHFLIDETKEALHSRMLGLACCN--EVERLR-----EVLKVK--------DNSQWTLSKM--RDLV 827  uncultured Th...
WP_045056389  738 EAMSTNGWGIATRKDYLLTDFTVESLTQRMSIVVNGT--LDEAYQ-----EG--VK--------DNESWSFSKI-KNRL- 798  Aliterella at...

BAM32310      491 ANRELVFDESRIRICSYRPFTKEFLYFDNG---YNHSHCqmDKIYPFG--NKgeaivcingdfENVAIQVLGV---GATH 562  Helicobacter ...
EFL88046      790 ---QYEKPNDFVSLCDYRPFDTRYCFLDEV---TMDYPR--TEIVKNFl-GL-----------DNLALTVSRQ---QSTV 846  Ahrensia sp. ...
Q3SKA9        764 --IKANHISAPIVRIQYRPFDPQYIFYSGNargLVGWPV--KQIMRHYl-DG-----------QNIGLLAPKA---IRDS 824  Thiobacillus ...
KQU49940      783 --LQTSDWINDIKPILYRPFDTRSILSRPD---MVDWGR--FDFMEDFr-AW-----------PNLGIAYTRTi--EGGR 841  Bosea sp. Lea...
Q0ASV4        774 --IIACGTKEKIKPVLNFPFDVKYTYHSDRslgFL--ARpvYPTMRHF--YN-----------DNIGLMFTR----ITKD 832  Maricaulis ma...
EIJ35287      767 KS---NIDENKVEKIFYRPFDERYTYYTGNsrgFHCMPR--NDVMQHLv-SG-----------ENIGICFNRRv--EENR 827  Thiothrix niv...
WP_045576530  803 --SDLSTNEYTIVPILFRPFDIRYTALTTRsggFLGRPR--YTTMCHMi-HS-----------NNVALLVGRQ---NKSE 863  Desulfosporos...
GAK61488      900 ---KQTNWEKFIVPYLYRPFDDRYICYVPE---LIDRDR--YDIMCHF--FK-----------ENLGLAVMRQylyESVK 958  Candidatus Ve...
ESQ15151      828 AR---EGVADCIYPIMYRPFDVRYIWYHRE---AIERGDarWPVMKHV--LP-----------DGLSLLTARQ---SMNH 885  uncultured Th...
WP_045056389  799 ----GSDIKSRVYSYYYRPFDYRYIFYEPL---MIERGDhrLPIAKNFihER-----------NNLSLLISRT---GAAS 857  Aliterella at...

BAM32310      563 Q---Fs-ALTSNGIVDLEHIS------KGHCFPLYYYERVE---SSTENGqmtmdydkaessafchfeqsekshaqssdk 629  Helicobacter ...
EFL88046      847 G---Fr-HAFTAKYPANDCFVstksreANQVFPLYLYPDEP----ELDQT------------------------------ 888  Ahrensia sp. ...
Q3SKA9        825 Q---FahAFVTRDITEAIFLSgtt-gsNAMNFPLYLYPTEQ----DLDQT------------------------------ 866  Thiobacillus ...
KQU49940      842 E---FadFLVHDLPITHHSLSik---eVNYTAPLYLHPRKG----KLATE------------------------------ 881  Bosea sp. Lea...
Q0ASV4        833 A---Fs-VFVTKFMATHKSASry---dGTYIAPLYLYPAED----ELDQA------------------------------ 871  Maricaulis ma...
EIJ35287      828 R---FtdVFLFKGIVQLHSLSik---eANSIAPIFVSKEGI-------CG------------------------------ 864  Thiothrix niv...
WP_045576530  864 T---IdsFLVTNCVSEMKCAErt---iQSYHLPLFVVSKTYq------GS------------------------------ 901  Desulfosporos...
GAK61488      959 D---YnyVLCVNNISDRRLFIsn--rgAGFVYPLYLYPKRAk--KDLFSAlee--------------------------- 1004 Candidatus Ve...
ESQ15151      886 D---FtaAFIARGLSEMKTAEst---rGSYSFPERLQETSGk--IGLEAD------------------------------ 927  uncultured Th...
WP_045056389  858 GspiWdvMFVGDSLSDLNLFRr----gGAFIFPLYLYPDTDnlhQSTTAE------------------------------ 903  Aliterella at...

BAM32310      630 trndnktayyRRKDAIRDEALAFFQNA-------------------YNDSSITKEAMFYYIYAILNHKDYIAKYKDNLSK 690  Helicobacter ...
EFL88046      889 -----------RRVNFDPKIRAEIEKAat----------------sDGGDVPDEVAIFDYIYGVLHCPAYRETYAEFLKI 941  Ahrensia sp. ...
Q3SKA9        867 -----------RRVNFDAKLYKRLQALak----------------hPERGVPDELAVFDYIYGILHCPAYRKTYAEFLKL 919  Thiobacillus ...
KQU49940      882 -----------VHLNFEPKLYAKLRKLaglsapfvqpnpkedfrraTGDDRRDEVKVFDYVYGAMYSPSYREANSKSLKL 950  Bosea sp. Lea...
Q0ASV4        872 -----------RRINFDPKLHAKLRKLat----------------hPEFGEPGEVAVFDYIYGVLHSPDYRETFAEFLKI 924  Maricaulis ma...
EIJ35287      865 ----------EKIANFNDEIITKISRIikvpf---------slemsNNKESFSALDVVDYIYSILHSPAYREKYNEFLCS 925  Thiothrix niv...
WP_045576530  902 ----------KLIPNLSEPIVKNISNSlglsls--------qnviiDSEYSFSSLDLLDYIYAVLYSNRYRERYRELLKI 963  Desulfosporos...
GAK61488     1005 --------pkKKEININPNIFKVLTE--------------------KYNAHPNPEDIFHYIYAILHSPEYRRRYAEFLKI 1056 Candidatus Ve...
ESQ15151      928 ------------ASNIRSELLGNS------------------------LQKRSPDGVISYIYAVLHSPAYRSRYAGALRI 971  uncultured Th...
WP_045056389  904 ----------QRRPNFSEDFLNAIKD--------------------KLGYIPTPEAIFYYIYAIFHSPTYRTRYAEFLKI 953  Aliterella at...

BAM32310      691 MLPRIPLMQDFWGF---VASGRALAELHINYES--HNKLDSGAfsclakdlhefktsakglfekdfrqkareD--Ieh-- 761  Helicobacter ...
EFL88046      942 DFPRILYPASPETFadiSAKGTQLRRLHLMEEAaiGDTPFPFE-----------------------------GeaP---- 988  Ahrensia sp. ...
Q3SKA9        920 DFPRIPWPASPAEFwdvSDKGNQLRCLHLM-DP---DAIGLTP-----------------------------YpfR---- 962  Thiobacillus ...
KQU49940      951 GFPRVPLPTSLKHFatvSAAGEKLRRLHLM-ED---AAIGKAS-----------------------------YpfE---- 993  Bosea sp. Lea...
Q0ASV4        925 DFPRIPWPATPDVFwsvREKGEALRRLHLMEDT----AVGETP-----------------------------YpfL---- 967  Maricaulis ma...
EIJ35287      926 DYPRIPYPDNVNMFwnlVQLGNELRQVHLL-ES---VLLNKAI-----------------------------TsyP---- 968  Thiothrix niv...
WP_045576530  964 DFPRVPYPTDQEMFwklVELGRYLRQLHLM-ES---PALDNLI-----------------------------TsyP---- 1006 Desulfosporos...
GAK61488     1057 DFPRIPFTADYGLFqqlAALGADLAALHLLQDDyaYASWTQAG-----------------------------QasPlhap 1107 Candidatus Ve...
ESQ15151      972 EFPKIPTTCSPELAqrlCGLGRDLVSLHLM-ES---AILEEFI-----------------------------TtyA---- 1014 uncultured Th...
WP_045056389  954 DFPRVPLTSCDRLFrqlATYGEELVALHLM-KS---PKLDNLI-----------------------------TqfVe--- 997  Aliterella at...

BAM32310      762 ---lNEGD--FRIET--IKFHA-------KGVKDSILLNDT---------------I-AIVDIPHKAYAYKVNG-KSAIE 810  Helicobacter ...
EFL88046      989 ----DGED--GSVAK--PQFVEt------GKGTGLVAINGTass----------pgQ-HFQNVPKIAWEFFIGGyQPAQK 1043 Ahrensia sp. ...
Q3SKA9        963 ----GEGD--STVDK--PRYED-----------GKVWVNET---------------Q-YFDTTPEAAWGFYIGGyQPAQK 1007 Thiobacillus ...
KQU49940      994 ----GCGN--SVVVK--PRYEP-----------KRVWINDT---------------Q-YFSNVPGAAWNLYVGGyQPAQK 1038 Bosea sp. Lea...
Q0ASV4        968 ----GDGDpvLEARH--PDFKAt------KDGLGDVWINKS---------------Q-RFTNVPEIAWGFPIGGyQPAQK 1019 Maricaulis ma...
EIJ35287      969 ----KVGD--NTVTR--KILSKdwelydvDRSLGRIWINDE---------------Q-YFDQIPLLAWEFYIGGyQPAQK 1024 Thiothrix niv...
WP_045576530 1007 ----AGGS--NVVEN--PIYKD-----------GAIFINKDg--------------Q-GFFGVPQVAWEFYIGGyQPAQK 1052 Desulfosporos...
GAK61488     1108 ltsfVEGV--NGKTM--GAFSKs-----sCYKGGRVFLDTSlkg----------qsS-YFAGVPEDVWHFQIGG-YQVCY 1166 Candidatus Ve...
ESQ15151     1015 ----GPKH--PEVGR--VGWSD-----------GTVWLDAGrtsaregyraadagaI-GFVGVPKEVWDFHIGG-YQVCH 1073 uncultured Th...
WP_045056389  998 ----GRGD--RLVDAghPKF-----------SQGEVVINKK---------------GdKFTGVPENVWNFHVGG-YQVCQ 1044 Aliterella at...

BAM32310      811 -WILDRYKISTDKASGIVND-PNLYEstsgalkglKGGRYVLEL 852  Helicobacter cinaedi CCUG 18818 = ATCC BAA-847
EFL88046     1044 -WLKDRKGRTLSFDD-IRHY-QKIIKi-------lSETDRIMKT 1077 Ahrensia sp. R2A130
Q3SKA9       1008 -WLKDRKGRALSFD-----D-VKHYQril---kilSETDRIMRT 1041 Thiobacillus denitrificans ATCC 25259
KQU49940     1039 -WLKDRRSSELT-----WDD-IRHYQkii---kvlEETHRIMHE 1072 Bosea sp. Leaf344
Q0ASV4       1020 -WLKDRKGRTLGFDD-IRHY-QKIIKi-------lAETDRIMKE 1053 Maricaulis maris MCS10
EIJ35287     1025 -WLKDRTGRVLTRDD------IRHYQkii---valKETDRLMQE 1058 Thiothrix nivea DSM 5205
WP_045576530 1053 -WLKDRKGMAVTKDDILHYQ-KIIVAl--------TETDRIMKE 1086 Desulfosporosinus sp. I2
GAK61488     1167 kWLYDRRAVGKAPGRTLTDDdIAHYHkiv---ialRETLRLMRR 1207 Candidatus Vecturithrix granuli
ESQ15151     1074 kWLKDRKGRTLSD-QDITHY-QKIIVa-------iSETIRIMGE 1108 uncultured Thiohalocapsa sp. PB-PSB1
WP_045056389 1045 kWLKDRKGRTLS-DEDILHY-QKIVVs-------lQETIEIMEK 1079 Aliterella atlantica
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