2VV5


Conserved Protein Domain Family
MS_channel
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pfam00924: MS_channel (this model, PSSM-Id:395738 is obsolete and has been replaced by 459999)
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Mechanosensitive ion channel
Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.
Links
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Statistics
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PSSM-Id: 395738
Aligned: 36 rows
Threshold Bit Score: 123.088
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2VV5_F  72 LVRYGIIAFTLIAALGRVGVQ-TASVIAVLGAAGLVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLG--------GVA 142 Escherichia coli
P0AAT4 144 IKLIGAILVGILMISLLIGQS-PAILISGLGAMAAVLMLVFKDPILGLVAGIQLSANDMLKLGDWLEMPk------yGAD 216 Escherichia coli K-12
P71915 117 VARFALIGIGLAVILSYIWGVrVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIDDWLETP--------TAR 188 Mycobacterium tubercu...
Q58111  83 IFKYLVYVCVTLMIFGVIYQN-VSSLVVSVGLIGAAVTYALQKPILNFAGWIIILYTRTIKIGDRIFIKnmgagdvfDID 161 Methanocaldococcus ja...
O34897  69 IFAYTLIFIFFVMVLDLFHYD-PSALLAGAGIVGLAVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVS--------TFD 139 Bacillus subtilis sub...
P75783 516 ALAVIISTITIMIVLSEIGVN-IAPLLAGAGALGLAISFGSQTLVKDIITGVFIQFENGMNTGDLVTIG--------PLT 586 Escherichia coli K-12
O05781  89 VSIVLIYVVVVYEVIDVLPVP-VGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSmvg--speNAA 165 Mycobacterium tubercu...
Q55987 387 MVTVVISASGLLTALIILGIP-TGSVVAIGGLLALAISFGAQSLVKDLVDGFLVLAEDQYAIGDVIDVG--------FAA 457 Synechocystis sp. PCC...
P72735 526 GISVLLTILGILGTIWLFGIN--PLVLASFGGVAFVLAFLGRNVVEDMLNGTLILWTDRYAIGDVVQIG--------DVF 595 Synechocystis sp. PCC...
P73148 474 INLVVCIFTAFVFSLSLFDVP-VATVLAGAGIIGFAVSFGSQNLIKDLIAGISNLMSDAFAINDFVLIG--------EFE 544 Synechocystis sp. PCC...

2VV5_F 143 GTVLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSR---EPVRRNEFIIGVAYDSD---IDQVKQILTNIIQSEDRIL 216 Escherichia coli
P0AAT4 217 GAVIDIGLTTVKVRNWDNTITTIPTWSLVSDSFKNWSGmsaSGGRRIKRSISIDVTSIrflDEDEMQRLNKAHLLKPYLT 296 Escherichia coli K-12
P71915 189 GRVVEVNWRAVHIDTGSG-LQIMPNSMLATTAFTNLSR----PAGAHECSITTTFSTSd-pPDKVCAMLNRAASALPHVK 262 Mycobacterium tubercu...
Q58111 162 TQHIYLSELTTDTFEPTGRVLIIPNSYIFTASIENLTKg--SPYIWDNIVVHFTLNSNinkAEKIVFESADEVIGNLMRE 239 Methanocaldococcus ja...
O34897 140 GIVEQVGLRTTQIRSFDGTLHYIPNRNIT--NVSNHSR----GTMQALVDIKVPAERN---IDEMIHILQQVCDETAAAL 210 Bacillus subtilis sub...
P75783 587 GTVERMSIRSVGVRQDTGAYHIIPWSSIT--TFANFVR----GIGSVVANYDVDRHEDadkANQALKDAVAELMENEEIR 660 Escherichia coli K-12
O05781 166 GTVEDVTLRVTKLRSSEGEVFTVPNGNIV--KSVNLSK----DWARAVVDIPVPTSADlgrVNEVLHQECEHARHDSLLG 239 Mycobacterium tubercu...
Q55987 458 GGVENLNLRVTQLRSAGGELVTIPNSAIT--QVKNLTR----SWSRANLSVNVAYDTDpvkAINVLRQVGEDLYNDPEWH 531 Synechocystis sp. PCC...
P72735 596 GLVENMNIYITQLRGPEGRLSTIPNGKIS--VVQNLTK----DWSRAEFIVEIDQSSNvdkALNLIRVVSEQMREDPLWQ 669 Synechocystis sp. PCC...
P73148 545 GVVEDTNLFVTRIRCPNGDLVTIPNGAIG--TVCNQTK----DWSRVDYSVMVAADADpkkAIAVLQQVALGLYHDPWWH 618 Synechocystis sp. PCC...

2VV5_F 217 Kd----------------------------------------------REMTVRLNELGASSINFVVRVWSNS---GDLQ 247 Escherichia coli
P0AAT4 297 SrhqeinewnrqqgstesvlnlrrmtnigtfraylneylrnhprirkdMTLMVRQLAPGDNGLPLEIYAFTNTvvwLEYE 376 Escherichia coli K-12
P71915 263 --------------------------------------------------PGVVPATIARGAAEYRTTVRLTSp--ADEG 290 Mycobacterium tubercu...
Q58111 240 Lyekwskr----------------------------------kylisrKLSDKPVVRVGITRSSFYIKALYLVn-vYEKA 284 Methanocaldococcus ja...
O34897 211 Pq---------------------------------------------iKEGPNVIGIQELGTSEIVIRVIAKTe-nMEQW 244 Bacillus subtilis sub...
P75783 661 Gl---------------------------------------------iIGEPNFAGIVGLSNTAFTLRVSFTTl-pLKQW 694 Escherichia coli K-12
O05781 240 El---------------------------------------------lLDEPTVMGVERIEVDTVTLRLVARTl-pGKQF 273 Mycobacterium tubercu...
Q55987 532 Dk---------------------------------------------mLAVPDVLGIDSLTHEGMTITIWIQTa-pAQQW 565 Synechocystis sp. PCC...
P72735 670 Ek---------------------------------------------iLEPAAILGVDDIASKGIRLQVWIKTq-aGQHW 703 Synechocystis sp. PCC...
P73148 619 Pk---------------------------------------------mLQAPELKGIEEVSHQGILIRIWLKTl-pGEQW 652 Synechocystis sp. PCC...

2VV5_F 248 NVYWDVLER-IKREFDAAGIS 267 Escherichia coli
P0AAT4 377 SIQADIFDH-IFAIVEEFGLR 396 Escherichia coli K-12
P71915 291 PTQATFLRW-VWYAARREGLH 310 Mycobacterium tuberculosis
Q58111 285 KIRSEINKRiLEKVNKENDVK 305 Methanocaldococcus jannaschii DSM 2661
O34897 245 RVERVLRKE-IKNAFDR---A 261 Bacillus subtilis subsp. subtilis str. 168
P75783 695 TVRFALDSQ-VKKHFDLAGVR 714 Escherichia coli K-12
O05781 274 EAGRQLRVL-VIRALTRAGIV 293 Mycobacterium tuberculosis
Q55987 566 SVGRELRFR-VRQALTENNIE 585 Synechocystis sp. PCC 6803
P72735 704 PVGREFRLR-MKKAFELAGIA 723 Synechocystis sp. PCC 6803
P73148 653 DVARELRLR-VKVAFESQEIA 672 Synechocystis sp. PCC 6803
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