2PKD,2IF7


Conserved Protein Domain Family
Ig_SLAM-like_N
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cd16842: Ig_SLAM-like_N 
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family
The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.
Links
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Statistics
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PSSM-Id: 409517
Aligned: 14 rows
Threshold Bit Score: 109.332
Created: 17-Aug-2016
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1IF7, human NTB-A receptor dimer interface, contacts based on 3.5 A distance.
  • Structure:2PKD; human CD84 dimer interface, contacts based on 3.5 A distance.
  • Comment:of the two dimerization modes suggested by the 2PKD crystal structure, the head to tail dimer is believed to be the physiologically relevant species.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                # #                                                     
2PKD_A         7 FTVNGILGESVTFPVNiqeprqvKIIAWTs--kTSVAYVTpgds--etaPVVTVThrn-yyeRIHALGp--nYNLVISDL 79  human
2IF7_A         6 LMVNGILGESVTLPLEfpagekvNFITWLfn-eTSLAFIVphe---tksPEIHVTnpk-qgkRLNFTQs---YSLQLSNL 77  human
XP_545760     53 MEVPGILEGSVTFILNisidkelEHVTWSr--pQKALAFAna------qKDIIIMdks-yqdRLNISFn--sYSLSLNNL 121 dog
XP_001054622  53 RVISGILGGSVTFPLNisinaeiELITWTylskTLVLAITs-------rSGITILlke-ysgRLNISQd--gYSLCMSNL 122 Norway rat
NP_001069386  53 TVVKAIVGGSVILSLNisvdaeiEQITWSg--pKDALVLAfp------sGEILFLdks-ykgRINIPKn---NSLSINKL 120 cattle
NP_001069386 253 KTVLGVLGESITLSLAlldsqhiDNVVWIf--nTSIISKEwree--ataNQLIEFkdp-dqnTVWVSSq--dYSLKIVQL 325 cattle
XP_423077    375 TDVFGTEGKSATFHLQnl---igEYLTWSfh-gEPILVIRlg-----arPELVFSdks-ftsRVTFSNn--gSSLTILQL 442 chicken
XP_001379334  32 QMLTGVLGESAILPLTipkekqiTYILWTs--kRSLAIIEmgke--gnaNKTTIIdph-ykeRVNFLKqsynYAMQINHL 106 gray short-tail...
XP_001379526  34 KELMLVLGESVSLPVNieegeeiEKIIWSf--hSTLAVIQqea---mkePSISIVpdprynvIVNISDh--tYSLHISNL 106 gray short-tail...
XP_001518697  26 RELNGTIGGMVTFPLDipagrrvTNIDWRa--kQTIAKVSpgeagnlpkLNFVLPqy---keRLSVSTd---YSLTISNL 97  platypus

Feature 1                # # #                   
2PKD_A        80 RMEDAGDYKADINtqa--dpyTTTKRYNLQIY 109 human
2IF7_A        78 KMEDTGSYRAQIStk----tsAKLSSYTLRIL 105 human
XP_545760    122 TLEDAGPYKAQINykn--akvTTDKEFFLHLY 151 dog
XP_001054622 123 TKSDSGSYQAQIIqkn--vdhTVRNEFILHIY 152 Norway rat
NP_001069386 121 TLKDAGSYKARINqkg---seDFNERFILYIY 149 cattle
NP_001069386 326 KMEHAGLYQAYLCsna---rvASVKHINLRIY 354 cattle
XP_423077    443 TRSDAGTYLAKSD--------EVKVNFTLHVY 466 chicken
XP_001379334 107 KMEDAGSYQAEITian--itePMKKMFTLHIH 136 gray short-tailed opossum
XP_001379526 107 SKEDEGTYRAEMNfeg--fpgTITQKFILRVY 136 gray short-tailed opossum
XP_001518697  98 RPEDAGTYRVRINtvnatsnsFTNMEFSLRVY 129 platypus

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