Conserved Protein Domain Family
FWWh

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pfam14922: FWWh 
Protein of unknown function
This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.
Statistics
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PSSM-Id: 464378
Aligned: 24 rows
Threshold Bit Score: 165.114
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
A0E418        50 YTPLPNQVEFKKINTNVLNSMKFPSksnDKedgllevKSMFTQWQKYLNLEEHKAVVSDSFWYvvtkFFKREIQPDETS- 128 Paramecium tetr...
CBN80211     239 IPMEPNEMNPKLLLSYACERTVL--------------PGGARMFKHFATSLESQHLFVYVFWF----IHCKFFQEDSRRe 300
XP_008255259  75 PNELPNGVGFCDMVGNVVRAEKNPIt--GKs------FCSDKELKKFLSSPLPRAMWLDSFWW----LFHERYQPNKEI- 141
F5H4B4       146 PNKLPNGVDFCDMVGNVVRAERDCLs-gKH-------FCSGRELEKFLSSSSPRAIWLDSFWW----IFHERYQPNKEL- 212 human
ELK10226      95 PNELPNGVDFCDMVDNVVQSERSPLt-gKS-------FCTDRELEKFFCSPSLTAIWLDSFWW----IFHERYQPNKEI- 161
NP_001124053 147 PNKLPNGVDFCEMVGNVIRSEKNPLs-gKS-------YCLDRELEKFLCSPFLVAIWLDSFWW----LFHERYHPDRET- 213
XP_007503259 147 PSELPNGVNYSDMVGNVIRAQENSIt--GKt------FCAPLEMAKFFSSPYSKAIILDCFWW----IFHERYEPNKEI- 213
XP_023360128 153 PNELPNRVNYFEMVGNIVRAQGNTTisgKA-------ICAPAEMTKFFCCPYTKSIVLDCFWW----IFHERYDSNKAT- 220
XP_015216594 159 PTLLPNNITLDTIISRVMKAQSHLA---RK-------HRCQAEFRSLLALPVMEYFLLDSFWF----IFLQTYQPEQDS- 223
XP_005899526 147 PNNLPNGVDFCDLVGNVILAEKNPLs-gKS-------FCSGRELEKFLSSPSVRAIWLDSFWW----IFHERYQPKKEV- 213 wild yak
A0E418       129 EtypkinfnklpkedQKLLTRISRNYINLFLTIDRKDDRQLFFKTYFDILAQSVFYALFYSFPLSRSKFND-DLKKQLLD 207 Paramecium tetr...
CBN80211     301 Q--------------AHLLRSVSNCYVGVLGTDGMEDYKDFFFKHYPFLVANAVIWGFHYLCPGSRHLYSN-AFKRVLYL 365
XP_008255259 142 Q--------------DKLFDRTARCYAVLLVQQPRSHYEEALLKRLPSLLSRALYTSFCCCFPQSW--FNMhEFKSCVCN 205
F5H4B4       213 Q--------------NNLFDRIAQHYALLLFRVPKSHSEEALLKRLPSLLSKAVYTSFCCCFPQSW--FDThEFKSDICN 276 human
ELK10226     162 Q--------------NKLFDRISLHYAFLLFHESRSYHEEAILKRLPSLLSKALYTSFCCCFPQSW--FNThEFKSNICN 225
NP_001124053 214 Q--------------KKLFDRIARNYASLIFKMRRSHYEEALLKRLSSLLSKAMYTSFCCCFPQSW--FNThEFKSEICN 277
XP_007503259 214 Q--------------KKLFNRVSKNYAHLLTNTHRSPYEESILKKFSSLVSQALYTSFCTCFPQSW--FDNhEFKSVICN 277
XP_023360128 221 Q--------------RKLFDRVSENYAHLLLDLPSSGFKEVLLRIFPSLLSQALYTSFCACFPQSW--FGShEFKSFVCD 284
XP_015216594 224 Q--------------DQLFSRLSENYIQLLTHCLFSRYGDIFLKEFPSTLCQILYCCFCCCFPQSCSTFHCdTFLSQLCN 289
XP_005899526 214 Q--------------SKLFDRIAQNYAFLLFCESRTHYEEALLKRLPSLLSKALYTSFCCCFPQSW--FNThEFKSDICN 277 wild yak
A0E418       208 EFSYLFTGIEiaNSQKYLKEWN 229 Paramecium tetraurelia
CBN80211     366 QCARILSGIEvtPSCTTEMRTK 387
XP_008255259 206 TMSLWITGTY--PCPQGYAGWN 225
F5H4B4       277 TMSLWISGTY--PSPQSYDSWD 296 human
ELK10226     226 TMSLWISGIH--PCPQSYNSWD 245
NP_001124053 278 TMNLWISGTY--PCPQSYNNWD 297
XP_007503259 278 TMTQWIAGTF--PNPKSYVHWN 297
XP_023360128 285 TMHQWIGGTL--PNPKSYMNWN 304
XP_015216594 290 TAYQWIGGTR--PTPGVFSQWD 309
XP_005899526 278 TMSLWISGiypcphsynswdys 299 wild yak
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