2LFH


Conserved Protein Domain Family
bHLH_dnHLH_ID3
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cd19693: bHLH_dnHLH_ID3 
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basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar proteins
ID3, also termed Class B basic helix-loop-helix protein 25 (bHLHb25), or helix-loop-helix protein HEIR-1, or ID-like protein inhibitor HLH 1R21, or inhibitor of DNA binding 3, or inhibitor of differentiation 3, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It negatively regulates muscle differentiation by inhibiting the DNA-binding activities of the myogenic regulatory factors.
Links
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Statistics
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PSSM-Id: 381536
Aligned: 6 rows
Threshold Bit Score: 99.8566
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interface
Conserved site includes 47 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:HLH region of bHLH forms homo- and heterodimers
  • Structure:2LFH; Homo sapiens ID-3 forms a homodimer, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ############## ##   ##  ########## ##########  ## ## ### ##  
2LFH_A         8 HSHMGGGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVV 68  human
AAK93835      27 IARSSNNKSPALEEPMNLLYDMNDCYSKLRELVPGIPQGTKLSQVEILQHVIDYIFDLQIV 87  chicken
Q688C4        27 IARGSSHKGPGVDEPMGLLYDMNGCYSKLKELVPGIPQGSKLSQVEILQHVIDYIFDLQIV 87  western clawed frog
Q02535        23 AIARGRGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVV 83  human
XP_023250079  12 SSRNKSQAAEDPQVPVLLLRDMNLCYRLLRQLVPGVPPGRAASRVEILQHVIDYILDLQTE 72  Seriola lalandi dorsalis
XP_003962550  24 SLVIGRNKHSCLEEPVSALHDMNDCYSRLKQLVPSIPQNESVSQVEILQHVIDYIFDLQIA 84  torafugu

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