Conserved Protein Domain Family
GGDEF

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COG2199: GGDEF 
GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants [Signal transduction mechanisms]
Statistics
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PSSM-Id: 441801
Aligned: 920 rows
Threshold Bit Score: 51.9029
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_015775571    1 MNTATSIETGTLRRQDIIEYEPLLKTALRAIIPFSSYSLMFPAKTPENMEAEPQHPFGRATLENDRLSLPLTYSDRLLAI 80  
WP_013156700  288 ALALAERTGQTPKQFEARQDLSEVYKRQGALALALEHLEAAHRLERQVYNENSDRKLKNLQISFQVEQVRREAELERRKN 367 
WP_083833462  757 RTQLVGYDASPSQWSDQTTRTFNALPPGRYQLRVEAHDHANNASTPVLVTIVMHAQWWQTLWFHLVIALTILLLVYAVVL 836 
WP_041100416   51 HLYLILDGELRVYLADRTMPEHAVFGAGDCVGEMSLLDGQKASALVLAAHDTRLLAMPHEVLWALVDCSHGVARNLLAIM 130 
WP_012480935  266 TPTTREFWMSGSEYQANIASMLLQHKQIEVLPRFWQHTISAVLVALCVILLGLRLPWLAALCSLPLAPLLSWLLLRTSNL 345 
WP_012479591   81 ILQPHQIMVVEDALQDIRFHDNPVVTGDPHIRFYAGAPLISSDGLPLGTLCVFDAQPQHLPSDKAEALAALSRQVMLVME 160 
NP_230997     693 TKLEGFDRDWSYRGHNTQAEYTNLAPGKYRFFVSARYPYGEWNDATFSYVFIIEPHWWQRKEVIVMAGMLFLALAVSLVM 772 
WP_044618834  154 LTRTDTTYLNTLKESLLYATGLSLLILIPFGFWEGNKLVRSLKQLTTAVEKMSAGNLEQQVDINTRDETGRLGQAFNNMN 233 
WP_012479629  733 VGLPPGDYTLHVSAAHPGGAWGQQEAVWSFTVEPFWWQRRSVQLLGGLLLLAGLVVLYRLLLQQLKASNLRLARRVDEAT 812 
WP_096379120   87 TLVVPDARDDARFADNPLVVDDPNIRFYAGAPLVTPDGEALGTLCVIDTKPRELPARQQQALTALSRQASRAMELRRVSG 166 
WP_015775571   81 FEARGVDPEETARALp-----FLp-QMASLc----LEQiTIRKSAITDPLTGLFNRHCMHQGLireisgivgsimpgpea 150 
WP_013156700  368 AELAQAYAELKELHE------ALrqADQQKn---lLLQ-QLERLSLEDALTGLYNRRYLDGRLaeef------------- 424 
WP_083833462  837 LRTRHLRAQRAALEA------HIatRTAELn---lANA-RLLELSYLDALTGLPNRRRLLEALeh--------------- 891 
WP_041100416  131 AGRMRNDNLAMVNSQt-------------------QSL-EFEQASSVDALTGIHNRRWLLEAYprai------------- 177 
WP_012480935  346 WWAPATALLGVLLVL--------------LawatwRIS-AWHRQANRDALTGLGNRLRFEQALqqec------------- 397 
WP_012479591  161 LRRFALDIQKHMLERddy-erLLseYQDVLl---aQNA-DLAEQSRTDALTGLPNRRAMAAALeeav------------- 222 
NP_230997     773 WRIRILKRRELYLVE------QValQTQKLr---lQAE-KFERLSKEDDLTGLANRRAFDMYLkqaf------------- 829 
WP_044618834  234 TRLVEAYKQLEESHA-------------TIv---kQAE-ELKELSIRDSLTGLYNRRFFNEEVdrlh------------- 283 
WP_012479629  813 FDLQAKTVHLQALNQek------teLAERLa---rQAE-AFERQAREDALTGLANRRAFDETLardf------------- 869 
WP_096379120  167 ALARQLQESDWYERRllhyqgELeaSHAALe---aSNA-DLTELTRTDVLTGLPNRRAFALALeqav------------- 229 
WP_015775571  151 maddslQGHSACFGLIILDLDRFRQINENFGHNFGDKILVLAAERLRAVC-PKQTLVCRLDGDSFGVLWPQASRAKMSEL 229 
WP_013156700  425 ---iraRRYQHPLSVAIADLDNFKQINDKLSHAVGDEALRTVARLLRQCC-RETDLVARYGGEEFALVLLEASEEQARSI 500 
WP_083833462  892 ------paVPTMATLILMDVDHFKAYNDRFGHLAGDQALRHVADVLRQCA-DSDVLMARYGGEEFACLVPGDDPARGLVL 964 
WP_041100416  178 ---grcERNGESLCLIIADIDLFKRFNDRFGHLAGDGVLRRVARQLADGL-RTQDLIARYGGEEFLILLPHAGLDEALLI 253 
WP_012480935  398 ---daaRRNGKPLSLALIDVDHFKRHNDRHGHQVGDRVLRDVARLIGAHArRPRDMAARYGGDEFALVLPDTPAEGARLV 474 
WP_012479591  223 ---aeiDGQPGVACVALLDIDHFKHINDFQGHATGDRVLAELGVLLRSHF-AGRGMAARYGGEEFVAVMPGTDLRTAELQ 298 
NP_230997     830 ---srlQNPDQQVSIALLDIDHFKQINDRYSHIIGDQAIVAVSQELLGYV-GDKTRVARWGGEEFTILYVG-DPKQAWGY 904 
WP_044618834  284 ---qeaLLYQRPFCIVLGDVDHFKKINDRFSHATGDQVLQQVAEILNSSL-RDSDVLARYGGEEMVIALPGTTPAAAQEL 359 
WP_012479629  870 ---arsQRSGHPLCLVVLDIDHFKDVNDRHSHSIGDAVLVQVARLIAAAC-RDSDLPARTGGEEFALLLNDTRLEEAAQL 945 
WP_096379120  230 ----arsHSAAPLQVAVLDIDHFKTINDVHGHAEGDRVLQAVADALRLYS-AGPSGVARYGGEEFLMLFEG-PLQQALVQ 303 
WP_015775571  230 ALSLGAELAKVTarFTpL---REDVGVSASIGHVNYP-QdlqGaQfQkApEEqawlILEKAEKALNTAKAGGRSQIY--- 302 
WP_013156700  501 CEKIRSAIAEYP--WS-Tv--HPELKVTVSIGLCSDL-G---L-E-S-H-QH----MLAEADRNLYRAKHLGKNRVV--- 560 
WP_083833462  965 AECIRQTMADCA--LA-VpgqTQLMHVTLSAGIAHGPlAg--A-E-Q-A-DR----LLHHADLALYQAKRDGRNRVRrrd 1031
WP_041100416  254 AERLRDLVAACA--LE-Ts--EGMQSVTLSCGVAQMR-K---G-E-T-L-DE----LTSRADAALLNAKENGRDRVE--- 313 
WP_012480935  475 IQDLIDCVRALP--VH-Gd--GSDDRVTLTIGVFTRV-Pe--G-ElQ-P-HH----FVEGADTALYQAKANGRDGYV--- 536 
WP_012479591  299 CEFLRLAVADLP--L--------GFPVTISIGVAQHQ-P---G-E-S-V-DE----MLARADKALYRAKGNGRNRVE--- 353 
NP_230997     905 FEKLRCKIEQVD--LS-Av--APGLNVTVSIGFADAQ-Q---A-E-S-Y-ET----VLKLADHALLTAKKLGRNRVV--- 964 
WP_044618834  360 IERIRSRIEHHP--WH-Ei--AEQLTVTMSFGICDEL-D---Q-Q-H-F-EH----MLVLADEQLYLAKNAGRNQVR--- 419 
WP_012479629  946 CARLRGLFHDHP--DW-Ag--VAGLRVTFSAGLVELD-Ad--D-R-T-P-AL----LYQRADRALYRAKSDGRDRTS--- 1006
WP_096379120  304 CEFVREAIANLP--L--------GLPLTVSIGLAGRR-A---G-E-D-S-AA----TFARADQALYAAKRGGRNRVV--- 358 
WP_015775571  303 S--F 304 
WP_013156700      ----     
WP_083833462 1032 VplA 1035
WP_041100416  314 T--A 315 
WP_012480935  537 M--D 538 
WP_012479591  354 L--A 355 
NP_230997     965 K--S 966 
WP_044618834  420 C--L 421 
WP_012479629 1007 I--G 1008
WP_096379120  359 L--A 360 
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