Conserved Protein Domain Family
VIR_N

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pfam15912: VIR_N 
Virilizer, N-terminal
VIR_N is the conserved N-terminus of the protein virilizer, necessary for male and female viability and required for the production of eggs capable of embryonic development.
Statistics
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PSSM-Id: 464938
Aligned: 8 rows
Threshold Bit Score: 311.054
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9W1R5          6 DGSELLFFDTFSHEEVTd-INLDLVQFPKPVFITQVRIIPLGARVQADFPGGVRLGATNPSKFDLEFFVNDLGMPAASAF 84   fruit fly
XP_011603954    5 NSTELLFLDTFKHQNSE--TNVDVVRFPCGVLITEVRVIPPGIKAHTNLPDNRAFGETSPHAFQLDLFFNNLTKPNNPAF 82  
XP_688748       5 SAMELLFLDTFKHQNAEl-TNVDVVRFPYGVLITEVRVIPPGIKAHSNLPDSRAFGETAPHAFQLDLFFNNVSKPNSPVF 83  
EFX79202       14 dNEELLFFDTFAHGPTEe-LNLDLVQFPKPVYINQVRVIPLGAKVQADFPGGVRLGATNPSQFKLELFVNDLSKPGASAF 92  
XP_028036106    5 EKPDLLFFDTFSHDTSEe-LNLDLVQFPKSVYVREIRVIPLGARVEGDFPGRVRLGATNPTKFHIDFFVNDLSKPGASTF 83  
XP_014348456    5 SAMELLFLETFKHQTPEpsTNVDVVRFPCVVYINEVRVIPPGVRAHSGIPENRAYGETSPHAFQLDLFFNNVSKPSAPVF 84  
A2AIV2          5 SSMELLFLDTFKHPSAEqsSHIDVVRFPCVVYINEVRVIPPGVRAHSGLPDNRAYGETSPHTFQLDLFFNNVSKPSAPVF 84   house mouse
XP_022070404    5 TSTELLFLDTFKHQSAEl-TNVDVVRFPCGVLITEVRVIPPGIKAHSNLPDSRAFGETSPHAFQLELFFNNVTKPNNPTF 83   spiny chromis
Q9W1R5         85 ENLGLLRYNQNDCIHLDc----SQEKIVTDGLVLRGWYSTITLAIYGIFTNSVTEPIAS--PTL----P-----CEPVGP 149  fruit fly
XP_011603954   83 NRLGSLEYDENKSIVFR-----PSGKVNTDGLVLRGWYTSLTVAVYGTAERPHGHDQVSspPPP----P-----PPPQQP 148 
XP_688748      84 DRLGSLEYDENKSIIFR-----PNGKINTDGLVLRGWYTCLTLAVYGTAERPHSHERDSppPPP----P-----PPP--Q 147 
EFX79202       93 ETLGVLDYNQNSNIHYD-----SDKKVPTDGLVLRGWYTTVTLAVYGVITRA---PIISipPPP----P-----AAPIK- 154 
XP_028036106   84 EALGSLDYCQNGQIHMEcgadgDHPRIPTDGLVLRGCYTTITLAVYGTLTQILPETPVGinPPPtiqrPavnrdAPS--- 160 
XP_014348456   85 DRLGSLEYDENTSIIFR-----PNVKINTDGLVLRGWYSCLTLAVYGTVDRVISHDRDSppPPP----P-----PPPPPP 150 
A2AIV2         85 DRLGSLEYDENTSIIFR-----PNSKVNTDGLVLRGWYNCLTLAIYGSVDRVISHDRDSppPPP----P-----PPPPPQ 150  house mouse
XP_022070404   84 HRLGSLEYDENKSIVFR-----PSGKVNTDGLVLRGWYTSLTVAVYGTAERSHGHDQDSppPPP----P-----PPP--Q 147  spiny chromis
Q9W1R5        150 E-----------------------IANLSGEVLLQEDVLKDEWQEPMQAellta------hkgnvSDYDP--EDMEYgms 198  fruit fly
XP_011603954  149 Ggpk-----------------rttKQEWEKDDQYNGSPPRPAPRGPRTP----------------PGPPPpdDDDEE--- 192 
XP_688748     148 Qqqigs--------------krliKLEWENEDQFNGSPPRPQPRGPRTP----------------PGPPPpdDDDEE--- 194 
EFX79202      155 -------------------------P---------ASPVPVEPAQPPVPelapvftnqiideklrTSTPPfeEKAELikc 200 
XP_028036106  161 -----------------------------------ANVTQPPDWNPEPTnpips------ytgnvASTNPd--------- 190 
XP_014348456  151 QqqqqqqqqqpglkrnpkhemfllLKDGDKEDQYNGSPPRPQPRGPRTP----------------PGPPPpdDDEEE--- 211 
A2AIV2        151 Pqptlk--------------rnlkHADGEKEDQFNGSPPRPQPRGPRTP----------------PGPPPpdDDEDD--- 197  house mouse
XP_022070404  148 Qpsgl---------------krivKQDWEKDDQYNGSPPRPAPRGPRTP----------------PGPPPpdDDEEE--- 193  spiny chromis
Q9W1R5        199 rdhYHQHAEEqEQREMRRLR-RSTHSTDHSPpppRRsHTHSESNDREYIRCSRd-----------KGSRDWSRSPEYSSH 266  fruit fly
XP_011603954  193 ---QVHVTVG-LVKDESCQG-REDYLEAVSP---ER-SLPADETYSDAEQEEE------------GDEEEEEEQEEEEDA 251 
XP_688748     195 ---AMPAPGQcPVKVENTEHpGDDYLEPVSP---ERgSLPADETYSDAEQEDD----------------EGPADEEEDDV 252 
EFX79202      201 enaFVTSTVV-----------ESEVKREDEPe--KEtKVKVEEKVVEKVREKS------------RRSDEFTRTRDTSDF 255 
XP_028036106  191 --vYTPNTYP--ENYENPIY-RNEYYENEPPk-dPRtYHV--EGDWE---KNRdincegegdrlrRSSRSIERDRD-RQG 258 
XP_014348456  212 ---PMPETLG-DEKEVDGEH-KQDYFEPISP---DRtSIQQDEQYSD-GEAED------------DQQEEGEDDEED--V 268 
A2AIV2        198 ---PMSLPVS-GDKEEDVPH-REDYFEPISP---DRnSVPQEGQYSDEGEVEE------------EPQEEGEDDEDDVDV 257  house mouse
XP_022070404  194 ---QVPVTVG-VVKDEACEG-RDDYLEAVSP---ER-SLPADETYSDAeqeeegdeeeeeeeqeeeedartegsapeede 264  spiny chromis
Q9W1R5        267 RSRRKRSER 275  fruit fly
XP_011603954  252 RTEGSAPEE 260 
XP_688748     253 QSEGTEGDE 261 
EFX79202      256 REREWESDR 264 
XP_028036106  259 HGRRRSMDR 267 
XP_014348456  269 EGEEDEDEE 277 
A2AIV2        258 EEEEDEDED 266  house mouse
XP_022070404  265 eeeeeedeg 273  spiny chromis
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