6NT8


Conserved Protein Domain Family
TMEM173
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pfam15009: TMEM173 (this model, PSSM-Id:405665 is obsolete and has been replaced by 464441)
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Transmembrane protein 173
Transmembrane protein 173, also known as stimulator of interferon genes protein (STING), is a transmembrane adaptor protein which is involved in innate immune signalling processes. It induces expression of type I interferons (IFN-alpha and IFN-beta) via the NF-kappa-B and IRF3, pathways in response to non-self cytosolic RNA and dsDNA.
Links
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Statistics
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PSSM-Id: 405665
Aligned: 26 rows
Threshold Bit Score: 269.88
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6NT8_A               50 IRSVCTQLAALQLGVLLKGCCCLAEE-IFHLHSRHHGS--LWQVLCSCFP-PRWYLALLLVGGSAYLDPPE--------- 116 chicken
EFN63910             23 CLTTSVFLVIFLLCDVMLHLCQTVIS-LTNMDPRSRQS--FSSIISYYFIlNIASAVVVLIGVFLFLITSTtivrec--- 96  Florida ...
XP_014328830         43 IHLVALATLIVTLGPLLHGLYLLLEElLHHSNTRYRGRslLGHVLPACGLgPKTLLAAAMAALLLYLTRHS--------- 113 southern...
A7SLZ2               57 SFTFSLAYLAFLVGELLRRCCLFAEE-YRHIETRYNGS--LKKAIQTTFSfGHNNVLFVASLLFFVVFVASndpngsssv 133 starlet ...
WGS:AAQB:GK20640-PA  31 IDTVVRIVITISLADLLQRVFLSAYEyIWNPRFYLPDEr-FWTILRRTHTySNKHVYLMLAFGCLGLARFGvt------- 102 Drosophi...
WGS:AAPP:GF11767-PA  37 advsirvvATVFLADFLQRLFRCVVEyIRYSRYYLPEDr-LWTILRRGCTyESKHIYLAMAFVIAGLSRISvt------- 108 Drosophi...
XP_002033149          6 iDTSVRIVATVFLADLLRRLYHCVIEyGSNGRYYLPEDr-LWVILRRSCTyNNRSIYLIVGFVLVAFFRISvtgnyrdvv 84  Drosophi...
XP_002005921         24 idyavriCIVIFVADLLQRLFFVFKEyLCHRIYYLPEDr-LTTIIKRAYTyNIKTVYLALLVIFTGLTRFG--------- 93  Drosophi...
EDW04563              6 IDTCVRILIVIFVADFMQRLSYALAEyFLYGNHYLLEEr-LLTILRRAFTyNSKTICLTFGIMFLGFARFGrtgnlnqll 84  Drosophi...
XP_011066564         47 TFVASVFLVIFLLCDVTLRLCQTLISfTTNVNQHSEES--FWSVAKYHFSlNTLSATIIIIAALLFLGLSItirgcp--- 121 Panamani...

6NT8_A              117 ---------------DNGHSPRLALTLSCl-------CQLLVLA--LGLQKLSAVEVSELtesSKKNVAHGLAWSYYIGY 172 chicken
EFN63910             97 ---------plshvwDFGPDVYVPSMIFS--------FYLLKITdlAKRERGPLLDLDIM---KGLDYGTGMAYSFYYGY 156 Florida ...
XP_014328830        114 ---------------LMHKGQSWELVVLVpvl--yalFKCLGVL------GPSEVEVSDIceeRKMNVAHGLAWSFYLGY 170 southern...
A7SLZ2              134 iqgnstaephtemrqTSGWQGLWGQFIISal-----lTPLVVHL--LGLRELSKVEESQLnekENKNVADGLAWSYYFGY 206 starlet ...
WGS:AAQB:GK20640-PA 103 --------------gNL-KPILPSAMYLAc-------MPLYWLF--NDLGESTLSYANWVrdtHGLDYASGMASSYFHGY 158 Drosophi...
WGS:AAPP:GF11767-PA 109 --------------gDFTVVIPTALYLAQ--------IPLYWLF--FDLSQSTLTYSHWIrenHGLDYAAGMASNYFHGY 164 Drosophi...
XP_002033149         85 pttlflvhmplywiwSF-----------------------------SDMDHSTLSYSHWIrdsHGLDYAAGMASNYFHGY 135 Drosophi...
XP_002005921         94 ---------------RTN-----NLALLLprgeplllIPLYWIFtyVQLSHSSLSYAHWIrdsHGLDYAAGMASSYFHGY 153 Drosophi...
EDW04563             85 pscsdfaymplywiyIY-----------------------------AQMSQSSLSYAHWIrdaHGLDYAAGMASNYFHGY 135 Drosophi...
XP_011066564        122 ----------lryawDFGPYMCVPLMIFS--------FCLVRMSnlAEWETGSLSDLNIM---KGLDYGTGMAYNFYYGY 180 Panamani...

6NT8_A              173 LKVVLPR--------LKECMEELSRTNPMlraHRDTWKLHILVPLGCDIWDDLEKAD----SNIQYLADLPETILTRAGI 240 chicken
EFN63910            157 LQLILPNrgttdsksIIEKIENFEDKHEV---TFPVHKLFILIPSSGYISPHLKEMSd---QWMEIAGELEEEKRDRAGL 230 Florida ...
XP_014328830        171 LQLVLPS--------LEKSIDSFRGSHRDsfwGRGSQKLLILIPLNANISHKLEDED----GNIQFYDSLPNSELDRAGV 238 southern...
A7SLZ2              207 LKFVLPE--------LEKQIEKTSKFRSK---EKFVKKMFILIPSNCFWDDKIPGSDydpqNRITFEGNTEPLEKTRGGV 275 starlet ...
WGS:AAQB:GK20640-PA 159 LNLALPDrsd---dgLQHRMRRYEDSHNV---TFGVHRLIILIPDEMWVGGRIN--S----DLLEPAQPLETININRAGV 226 Drosophi...
WGS:AAPP:GF11767-PA 165 LKLALPDtkd---dgLKHRMAVYEAKNNV---TFGVDRLIILCPDEMFVEKKLENNS----TLLDKAEPLETKYLHRAGV 234 Drosophi...
XP_002033149        136 LKLSLPErkd---dgLKQRMEMYEDKNNV---TFGIKRLVILIPDEMFVNGVLE--S----HLLDKAEPLETQFINRAGV 203 Drosophi...
XP_002005921        154 LKLSLPEren---dgLQKRMEKYEDMQNV---KFGIKRLIILIPDEMFVNRVIQ--S----EWLDKAEPLETQFINRAGV 221 Drosophi...
EDW04563            136 LKLSLPArng---egLQQRMTDYEDSQNV---KFGLRRLIILVPDEMFVKGLID--S----PLFEKAKPLETHFINRAGV 203 Drosophi...
XP_011066564        181 LRLTLPSsetg-kkgIIEKIENFEDYHNV---TFPVHKLFLLIPSSGYIPPDLKEASc---QWMENIHELEEEKRNRAGN 253 Panamani...

6NT8_A              241 KRRVYKHSLYVI----RDKDNKLRPCVLEFASPLQTLCAMSQDDCAA--FSREQRLEQARLFYRSLRDILGSSKECAGLY 314 chicken
EFN63910            231 RGKTYHNNVYKIypngRNSGASPIYVVAEGATTLLTFYEVQQHSHPEsiVYKQYKNEITMMFYKKLAEILESEPTTKNLC 310 Florida ...
XP_014328830        239 RGRVYKHSVYRV----KDKRGKAHDCAVEYATPLLTLYRMSQERSAG--FGASERRQQVLLFYRTLRDVLDQSLECRNRY 312 southern...
A7SLZ2              276 FLRHYKHSVYEI----KDGENEPWFCIMEYATPLLTLYDMSVAQPGE--LSREERDAQVVVFLRKLQDILEGDRACQGKY 349 starlet ...
WGS:AAQB:GK20640-PA 227 KGRPYKIAVYRLn---RKINGKYYYFALEGATPMLSFFESIQSNLSAtwYMRELKREIWLKFSAHLKNLLTTWPETRGKV 303 Drosophi...
WGS:AAPP:GF11767-PA 235 H-RPFKHDVYRLn---KKIDGKTYYFAMEGATPMLSFFDAMESNLSAtwQMKELKREIWLKFCKHLKHLIETWPETRNEV 310 Drosophi...
XP_002033149        204 Y-RPFKHAVYRMn---KKVNGRTYYFAIEGATPLISFFDAIYSNLSAtwQMQELKREIWLKFYKHLRELITTWPETRDLI 279 Drosophi...
XP_002005921        222 N-RPFKHAVYRLn---KQINGTTYYFAMEGATPMLTFFESMHFQLSAtwQMQEMKREIWLKFCKHLQELLNNWPETRREV 297 Drosophi...
EDW04563            204 N-RPFKHDVYRLn---RKINNTSYYFAIEGATPMLSFFDAMHHQLSAtwQMQEMKREIWLKFCKHLKGLLSTWPETRNEV 279 Drosophi...
XP_011066564        254 IGRTYRNNAYKIypggRKLGNKPIYIVVEGATPLLTYYEVQKHNHPEsaIYKQYKSKIIEKFYTKLQEILQSNPETRDLC 333 Panamani...

6NT8_A              315 RLIAYEEPAEpeSHF-LSGLILWHLQQQQ 342 chicken
EFN63910            311 ELIYYNDYDSkgTRVnVAKVILQRISEIT 339 Florida carpenter ant
XP_014328830        313 RLILIKDEHEddPNF-LSNTILRHLEQQN 340 southern platyfish
A7SLZ2              350 ELVTFSpDRD------LADVMLRKLKDSE 372 starlet sea anemone
WGS:AAQB:GK20640-PA 304 ELLMYNSLDDngNAIdVGELVIAQMEKWN 332 Drosophila willistoni
WGS:AAPP:GF11767-PA 311 DLLVYNAHDQkgKLVdIGELLIAHLKNKT 339 Drosophila ananassae
XP_002033149        280 ELIIYNSHDSkgNLVdVGELLVANMQNKT 308 Drosophila sechellia
XP_002005921        298 QLIIYNSHKQngELQdVGDVLISHVLThi 326 Drosophila mojavensis
EDW04563            280 ELIFYSAHNSngEHVdEAEVIINHVFkdk 308 Drosophila grimshawi
XP_011066564        334 ELIYYDDFDAqgNKInVATILLERISKIT 362 Panamanian leafcutter ant
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