Conserved Protein Domain Family
SIRT4
?
cd01409: SIRT4 
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Links
?
Statistics
?
PSSM-Id: 238700
Aligned: 14 rows
Threshold Bit Score: 381.26
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Comment:by similarity to Archaeoglobus fulgidus Sir2 homolog, Sir2_Af2, structure 1MA3
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
Q9Y6E7       47 LQRFITl--sKRLLVMTGAGISTESGIPDYRSEkvGLYartdrrPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPA 124 human
Q9RL35       25 VADALRa---GGVLVLSGAGISTESGIPDYRGEg-GSLsr--htPMTYQDFTAHPEARRRYWARSHLGWRTFGRARPNAG 98  Streptomyces coe...
Q8FUC8       10 VVKLLEa---GSVLAVTGAGVSTDSGIPDYRSPr-GSLnq--grPMTYQEFRFDPVASHRYWARSFVGWRVMADAQPNRT 83  Corynebacterium ...
NP_961194    11 LVAVLAg---RRIAVLTGAGISTDSGIPDYRGPe-SPPs----nPMTIRQFTGDPAFRQRYWARNHVGWRHMDDTLPNAG 82  Mycobacterium av...
ZP_00025931   7 LQDFVEr--hRRLFVLTGAGISTDSGIPGYRDEq-GRWqr--saPMTISAFMSGHAARQRYWARSMVGWPVAAGAHPNVS 81  Wautersia metall...
NP_568207    85 LYRLFEq--sSRLTILTGAGVSTECGIPDYRSPn-GAYssg-fkPITHQEFTRSSRARRRYWARSYAGWRRFTAAQPGPA 160 thale cress
Q8PDM9       12 LQEFVEr--hQRLFVLSGAGCSTDSGIPDYRDLq-GGWkr--pqPVTFQAFMGELSTRQRYWARSLVGWPRFGLARPNAT 86  Xanthomonas camp...
Q882K4       13 LRRTMAe---KSFLVVTGAGISTASGIPDYRDKd-GVRrg--aqPMMYQEFVGNPAARQRYWARAMLGWPRISASQANAA 86  Pseudomonas syri...
NP_510220    20 FKSLVGt--vDKLLIITGAGISTESGIPDYRSKdvGLYtktalePIYFQDFMKSKKCRQRYWSRSYLNWPRFAQALPNFN 97  nematode
CAB55543     11 LERCSArkrgRGCVVLTGAGCSTESGIPDYRGPn-GQYhradfvLLTFQKFMRDDNEKRRYWARSMLGYSTMCGASCNAA 89  Leishmania major

Feature 1                           #                                 #                         
Q9Y6E7      125 HWALSTWEklgkLYWLVTQNVDALHTKAGSr------------------rLTELHGCMDRVLCLDCGEQTPRGVLQERFQ 186 human
Q9RL35       99 HRSVAAFGrhglLTGVITQNVDGLHQAAGSe------------------gVVELHGSLDRVVCLSCGVLSPRRELARRLE 160 Streptomyces coe...
Q8FUC8       84 HYALVELEraglLSGIVTQNVDGLHRRAGSe------------------nLVALHGDLATIVCLQCGHREARELLDARLD 145 Corynebacterium ...
NP_961194    83 HRALATLEdaavVTGVITQNVDLLHTKAGSr------------------nVIDLHGSYARVICLGCGDTTSRAALAERLE 144 Mycobacterium av...
ZP_00025931  82 HRVVARLGdagrVSALVTQNVDGLHQQAGSr------------------dVVELHGSIRQVVCLSCATRYPRAELQHWLW 143 Wautersia metall...
NP_568207   161 HTALASLEkagrINFMITQNVDRLHHRAGSd-------------------PLELHGTVYTVMCLECGFSFPRDLFQDQLK 221 thale cress
Q8PDM9       87 HHALAALEargqLELLLTQNVDRLHQAAGSq------------------aVIDLHGRLDVVRCMGCEQRMPRTEFQLLLE 148 Xanthomonas camp...
Q882K4       87 HRALAALQaenlIKGLITQNVDALHTQAGSq------------------dVIELHGSLHRVLCLDCQQRSDRTAIQEQML 148 Pseudomonas syri...
NP_510220    98 HYALSKWEaankFHWLITQNVDGLHLKAGSk------------------mITELHGNALQVKCTSCEYIETRQTYQDRLN 159 nematode
CAB55543     90 HMALQAFTksgaVAHILTQNVDGLHHLATYggvgdaeeehyykyttsdapLKELHGNIHNVICTSCGFFMPRARLQRELR 169 Leishmania major

Feature 1                                                                     # #####           
Q9Y6E7      187 VLNPTWsaea----------------hglaPDGDVFLSEEQVRSFQVPTCVQCg-GHLKPDVVFFGDTVNpdkVDFVHKR 249 human
Q9RL35      161 EANAGFspva----------------aginPDGDADLTDEQVGDFRVVPCAVCg-GVLKPDVVFFGENVPp-rRVEHCRE 222 Streptomyces coe...
Q8FUC8      146 HLNPGYfdsial------------dpsavnPDGDVTLDDHHVQRFTMAGCARCgsVLLKPDVVYFGEPVPs-iRKTRVAQ 212 Corynebacterium ...
NP_961194   145 ALNPGFiertea-------------igglaVAPDADAVVADTASFRYLDCARCa-GMLKPDIVYFGESVPk-dVVAAAYR 209 Mycobacterium av...
ZP_00025931 144 QHNPDFrdmt----------------alpaADGDAHLESPLFDNFAVPVCERCe-GVLKPDVVFFGESVPrerVDTGRAA 206 Wautersia metall...
NP_568207   222 AINPKWaeaiesidhgdpgseksfgmkqrpDGDIEIDEKFWEEGFHIPVCEKCk-GVLKPDVIFFGDNIPk-eRATQAME 299 thale cress
Q8PDM9      149 RDNPGWadle----------------aaqaPDGDADLDNVAFDNFVVPACPACg-GVLKPDVVFFGENVPrerVERAFAH 211 Xanthomonas camp...
Q882K4      149 AHNLYLadvh----------------atqaPDGDTLLDPAYEAGFKVPECPHCqgKRLKPDVVFFGENVAshtAARATLS 212 Pseudomonas syri...
NP_510220   160 YANPGFkeqfvs-------------pgqqeLDADTALPLGSEQGFKIPECLNCg-GLMKTDVTLFGENLNtdkIKVCGKK 225 nematode
CAB55543    170 ERNPGFyeqyga------------dvsrtrPDGDYSAPTEAVNAMHLVMCPRCn-GFFKPHVVLFGENVPk-pIVEATMS 235 Leishmania major

Feature 1                       ###                                          
Q9Y6E7      250 VKE--ADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELL 308 human
Q9RL35      223 LVRg-ASSLLVLGSSLTVMSGLRFVRQAAEAGKPVLIVNRDATRGDRLAVTRVALPLGPAL 282 Streptomyces coelicolor
Q8FUC8      213 LLDg-ADAVVVAGSSLAVMSGYRIVIEAQRAGKPVAVINGGPGRADHRVDILWRTRVGPAF 272 Corynebacterium efficiens
NP_961194   210 LIDe-SDALLVAGSSLTVFSGYRFVRHAAARGIPIAIVNRGDTRGDHLATVKIDGGCSELL 269 Mycobacterium avium subsp. paratube...
ZP_00025931 207 LAS--SDAVLVVGSSLTVFSGYRFCLWANELGLPIAALNLGTTRADPLLTLKVSAPIGPTL 265 Wautersia metallidurans
NP_568207   300 VAKq-SDAFLVLGSSLMTMSAFRLCRAAHEAGAMTAIVNIGETRADDIVPLKINARVGEIL 359 thale cress
Q8PDM9      212 LQA--ADAVLVVGSSLMVYSGFRFVQAAARAGLPIAALNFGRTRADDLLSLKVEQSCAQAL 270 Xanthomonas campestris pv. campestris
Q882K4      213 VEQ--AEGLLVVGTSLMAWSAFRLCKAMAEQGKPVIAINHGKTRADELLRMKIEAPCEQVL 271 Pseudomonas syringae pv. tomato
NP_510220   226 VNE--CNGVLTLGTSLEVLSGYQIVNHAHMQNKPIFIVNIGPTRADQMATMKLDYRISDVL 284 nematode
CAB55543    236 LVRdkASCLLCLGTSLQVYSAYRYVLQANQLGIPVAIVNAGTTRGDAIADLKLDVESVGSV 296 Leishmania major

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap