3C7N


Conserved Protein Domain Family
HSP70

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pfam00012: HSP70 
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Hsp70 protein
Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.
Statistics
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PSSM-Id: 394970
Aligned: 27 rows
Threshold Bit Score: 744.082
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3C7N_A         6 PFGLDLGNNNSVLAVARNRGIDIVVNEVSNRSTPSVVGFGPK-NRYLGETGKNKQTSNIKNTVANLKRIIGLDYHHpdFE 84  baker's yeast
Q05036         3 VLGFDIGNLNCYIGVARQGGIEVITNDYSLHATPACVSFGPK-DRSMGVAARQAVTTNIKNTVINFKHLIGRKFSDpvAQ 81  Caenorhabditis ...
P11021        30 VVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEgERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDpsVQ 109 human
P36604        37 VIGIDLGTTYSCVAVMKNGRVEIIANDQGNRITPSYVAFTED-ERLVGEAAKNQAPSNPENTIFDIKRLIGRKFDEktMA 115 Schizosaccharom...
P22010        53 VIGIDLGTTYSCVAVMKNGKTEILANEQGNRITPSYVSFTDD-ERLIGDAAKNQAASNPKNTIFDIKRLIGLQYNDptVQ 131 Kluyveromyces l...
CAQ38673      17 AIGIDLGTTYSCVGVWRNENVDIIANDQGNRTTPSYVAFTDT-ERLIGDAAKNQVARNPENTVFDAKRLIGRKFTEssVQ 95 
XP_009519710 150 sVGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFTDT-ERLIGDAAKNQVAMNAHNTVFDAKRLIGRKFSDpiVQ 228
Q383E9         6 AIGIDLGTTYSCVGVWQNERVEIIANDQGNRTTPSYVAFVNN-EVLVGDAAKNHAARGSNGVIFDAKRLIGRKFSDsvVQ 84  Trypanosoma brucei
P0A6Z1        21 AAGIDLGTTNSLVATVRSGQAETLADHEGRHLLPSVVHYQQQ-GHSVGYDARTNAALDTANTISSVKRLMGRSLAD--IQ 97  Escherichia col...
Q01100         6 ILGIDLGTTNSAFAVMEGGDPEIIVNGEGERTTPSVVAFDDG-ERLVGKPAKNQAVKNPDETIQSIKRHMGE--DD---- 78  Haloarcula mari...
3C7N_A        85 QESKHFTSKLVELDDKKTGAEVRFA-GEkhVFSATQLAAMFIDKVKDT-VKQDTKAN--ITDVCIAVPPWYTEEQRYNIA 160 baker's yeast
Q05036        82 RFIPFIPCKVVKLPNDDIGVQVSYL-GEphTFTPEQVLAALLTKLRTI-VESQLSDVkkVSDCVLAVPSYFTDVQRRAVL 159 Caenorhabditis ...
P11021       110 QDIKFLPFKVVEK-KTKPYIQVDIGgGQtkTFAPEEISAMVLTKMKET-AEAYLGKK--VTHAVVTVPAYFNDAQRQATK 185 human
P36604       116 KDIKSFPFHIVND-KNRPLVEVNVG-GKkkKFTPEEISAMILSKMKQT-AEAYLGKP--VTHAVVTVPAYFNDAQRQATK 190 Schizosaccharom...
P22010       132 RDIKHLPYTVVNK-GNKPYVEVTVK-GEkkEFTPEEVSGMILGKMKQI-AEDYLGKK--VTHAVVTVPAYFNDAQRQATK 206 Kluyveromyces l...
CAQ38673      96 SDMKHWPFTVKSGVDEKPMIEVSYQ-GEkkLFHPEEISSMVLQKMKEN-AEAFLGKS--IKNAVITVPAYFNDSQRQATK 171
XP_009519710 229 ADIKHWPFKISSGAGDKPQITVQFK-GEskTFQPEEISSMVLIKMREV-AEAFIGKE--VKNAVITVPAYFNDSQRQATK 304
Q383E9        85 SDMKHWPFKVEEGEKGGAVMRVEHL-GEgmLLQPEQISARVLAYLKSC-AESYLGKQ--VAKAVVTVPAYFNDSQRQATK 160 Trypanosoma brucei
P0A6Z1        98 QRYPHLPYQFQASENGLPMIETAAG-----LLNPVRVSADILKALAARaTEALAGE---LDGVVITVPAYFDDAQRQGTK 169 Escherichia col...
Q01100        79 -------YSVELD-------------GE--EYTPEQVSAMILQKIKHD-AEEYLGDE--IEKAVITVPAYFNDRQRQATK 133 Haloarcula mari...
3C7N_A       161 DAARIAGLNPVRIVNDVTAAGVSYGIFKTDlpegeekPRIVAFVDIGHSSYTCSIMAFKKGQLKVLGTACDKHFGGRDFD 240 baker's yeast
Q05036       160 SAIQYAGLNSLRIVNETTAIALAYGIYKQDlpeedakSRNVVFLDIGHSSTQASLVAFNRGKLQMVNTSYDLESGGIWFD 239 Caenorhabditis ...
P11021       186 DAGTIAGLNVMRIINEPTAAAIAYGLDKREg------EKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFD 259 human
P36604       191 DAGTIAGLNVIRIVNEPTAAAIAYGLDKTDt------EKHIVVYDLGGGTFDVSLLSIDNGVFEVLATSGDTHLGGEDFD 264 Schizosaccharom...
P22010       207 DAGAIAGLNILRIVNEPTAAAIAYGLDKTe------dEHQIIVYDLGGGTFDVSLLSIENGVFEVQATAGDTHLGGEDFD 280 Kluyveromyces l...
CAQ38673     172 DAGTIAGLNVMRIINEPTAAAIAYGLHKKGk-----gEKNILIFDLGGGTFDVSLLTIEDGIFEVKATAGDTHLGGEDFD 246
XP_009519710 305 DAGAIAGLNVLRIINEPTAAAIAYGLDKKGg------ERNVLIFDLGGGTFDVSLLSIEEGIFEVKATAGDTHLGGEDFD 378
Q383E9       161 DAGTIAGLEVLRIINEPTAAAIAYGLDKADeg----kERNVLVFDFGGGTFDVSIISVSGGVFEVKATNGDTHLGGEDVD 236 Trypanosoma brucei
P0A6Z1       170 DAARLAGLHVLRLLNEPTAAAIAYGLDSGQ-------EGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFD 242 Escherichia col...
Q01100       134 DAGEIAGFEVERIVNEPTAAAMAYGLDDES-------DQTVLVYDLGGGTFDVSILDLGGGVYEVVATNGDNDLGGDDWD 206 Haloarcula mari...
3C7N_A       241 LAITEHFADEFKTK-YKI-DIRENPKAYNRILTAAEKLKKVLSA--NTNAPFSVESVMN-D-VDVSSQLSREELEELVKP 314 baker's yeast
Q05036       240 ALIREHFRKEFKTK-YGI-DAATSPRPWLRLLDECERVKKQMSAn-QTPIPLNIECFME-D-KDVTGKMQRQEFEDLAAP 314 Caenorhabditis ...
P11021       260 QRVMEHFIKLYKKK-TGK-DVRKDNRAVQKLRREVEKAKRALSS--QHQARIEIESFYE-G-EDFSETLTRAKFEELNMD 333 human
P36604       265 NRVINYLARTYNRK-NNV-DVTKDLKAMGKLKREVEKAKRTLSS--QKSVRIEIESFFN-G-QDFSETLSRAKFEEINMD 338 Schizosaccharom...
P22010       281 YKLVRHFAQLFQKK-HDL-DVTKNDKAMAKLKREAEKAKRSLSS--QTSTRIEIDSFFN-G-IDFSETLTRAKFEELNLA 354 Kluyveromyces l...
CAQ38673     247 NRLVNFCVEDFKRKnRGK-DLSKNSRALRRLRTQCERAKRTLSS--STQATIEIDSLFE-G-IDYSVTVSRARFEELCID 321
XP_009519710 379 NRLVDHFTQEFKRK-HRK-DITENQRALRRLRTACERAKRTLSS--SAQAYIEIDSLFD-G-IDFNSTITRARFEDMCGD 452
Q383E9       237 AALLEHALADIRNR-YGIeQGSLSQKMLSKLRSRCEEVKRVLSH--STVGEIALDGLLPdG-EEYVLKLTRARLEELCTK 312 Trypanosoma brucei
P0A6Z1       243 HLLADYIREQAGIP-----DRSDN-RVQRELLDAAIAAKIALSD-------ADSVTVNVaG---WQGEISREQFNELIAP 306 Escherichia col...
Q01100       207 HAIIDYLADEFEAE-HGI-DLRDDRQALQRLTEAAEEAKIELSSrkETRINLPFIATTDdGpLDLEQKITRAKFESLTED 284 Haloarcula mari...
3C7N_A       315 LLERVTEPVTKALAQAKLS-AEEVDFVEIIGGTTRIPTLKQSISEAFG-KPLSTTLNQDEAIAKGAAFICAIHSPt---- 388 baker's yeast
Q05036       315 IFNRIKQVLINLFADGVSIkPEEIDEIEIVGGSSRIPMIREIVKDLFG-KEPKTTMNQDEAVARGAAMQCAILSPt---- 389 Caenorhabditis ...
P11021       334 LFRSTMKPVQKVLEDSDLK-KSDIDEIVLVGGSTRIPKIQQLVKEFFNgKEPSRGINPDEAVAYGAAVQAGVLSGd---- 408 human
P36604       339 LFKKTLKPVEQVLKDSNLK-KSEIDDIVLVGGSTRIPKVQELLESFFG-KKASKGINPDEAVAYGAAVQAGVLSGe---- 412 Schizosaccharom...
P22010       355 LFKKTLKPVEKVLKDSGLQ-KEDIDDIVLVGGSTRIPKVQQLLEKFFNgKKASKGINPDEAVAYGAAVQAGVLSGe---- 429 Kluyveromyces l...
CAQ38673     322 YFRDTLIPVEKVLKDAMMD-KKSVHEVVLVGGSTRIPKIQTLIKEFFNgKEACRSINPDEAVAYGAAVQAAILSGdq--s 398
XP_009519710 453 YFRKTMEPVEKVLRDAKLS-KSQVHEVVLVGGSTRIPKVQQLLSDFFNgKEPNKSINPDEAVAYGATVQAAILSGnds-s 530
Q383E9       313 IFARCLSVVQRALKDASMK-VEDIEDVVLVGGSSRIPAVQAQLRELFRgKQLCSSVHPDEAVAYGAAVQAHVLSGgyges 391 Trypanosoma brucei
P0A6Z1       307 LVKRTLLACRRALKDAGVE-ADEVLEVVMVGGSTRVPLVRERVGEFFG-RPPLTSIDPDKVVAIGAAIQADILVGn---- 380 Escherichia col...
Q01100       285 LIERTVGPTEQALADADYT-KSDIDEVILVGGSTRMPQVQDQVEEMTG-QEPKKNVNPDEAVALGAAIQAGVLSG----- 357 Haloarcula mari...
3C7N_A       389 lRVRPFKFEDIHP--YSVSYSWDKQVEDEDHMEVFPAGSSfPSTKLITLNRTgDFSMAASYTDITQLPPNtpEQIANWEI 466 baker's yeast
Q05036       390 fRVREFAIKDTQP--YRIRLSWNSTGENGGENDVFSPRDEvPFSKLVSLLRSgPFNVEAHYAQPNVVPHNq-VHIGSWKV 466 Caenorhabditis ...
P11021       409 qDTGDLVLLDVCPltLGIETVGGVMTKLIPRNTVVPTKKS-QIFSTASDNQP-TVTIKVYEGERPLTKDN--HLLGTFDL 484 human
P36604       413 eGSDNIVLLDVIPltLGIETTGGVMTKLIGRNTPIPTRKS-QIFSTAVDNQN-TVLIQVYEGERTLTKDN--NLLGKFDL 488 Schizosaccharom...
P22010       430 eGVEDIVLLDVNAltLGIETTGGVMTPLIKRNTAIPTKKS-QIFSTAVDNQK-AVRIQVYEGERAMVKDN--NLLGNFEL 505 Kluyveromyces l...
CAQ38673     399 nAVQDLLLLDVCSlsLGLETAGGVMTKLIERNTTIPAKKS-QIFTTYADNQP-GVLIQVYEGERALTKDN--NLLGKFHL 474
XP_009519710 531 eKLQDLLLLDVTPlsLGLETAGGVMTTLIARNTTVPTKKS-QTFSTYADNQP-GVLIQVFEGERSMTRDN--NLLGKFNL 606
Q383E9       392 sRTAGIVLLDVVPlsIGVEVDDGKFDVIIRRNTTIPYLAT-KEYSTVDDNQS-EVEIQVFEGERPLTRHN--HRLGSFVL 467 Trypanosoma brucei
P0A6Z1       381 kPDSEMLLLDVIPlsLGLETMGGLVEKVIPRNTTIPVARA-QDFTTFKDGQT-AMSIHVMQGERELVQDC--RSLARFAL 456 Escherichia col...
Q01100       358 -DVDDIVLLDVTPlsLGVEVKGGLFERLIDKNTTIPTEES-KIFTTAQDNQT-QVQIRVFQGEREIAEEN--ELLGAFAL 432 Haloarcula mari...
3C7N_A       467 TGVQ-LPEG-QDSVPVklKLRCDPSGLHTIEEAYT-IEDIEVEEPIPLPED-APEDAEQEfkkvtktvkkddlti----- 537 baker's yeast
Q05036       467 NGARpGADGgNQKVKV--KVRVNPDGIFTIASATMyEPRIVEEVPAEAMEVdGDAKTEAPaeplepvkktklvpvdlevi 544 Caenorhabditis ...
P11021       485 TGIPpAPRG-VPQIEV--TFEIDVNGILRVTAEDK-GTGNKNKITITNDQNrLTPEEIER-------------------- 540 human
P36604       489 RGIPpAPRG-VPQIEV--TFEVDANGVLTVSAVDKsGKGKPEKLVIKNDKGrLSEEDIER-------------------- 545 Schizosaccharom...
P22010       506 SDIRaAPRG-VPQIEV--TFALDANGILTVSATDK-DTGKSESITIANDKGrLSQDDIDR-------------------- 561 Kluyveromyces l...
CAQ38673     475 DGIPpAPRK-VPQIEV--TFDIDANGILNVTAVEK-STGKQNHITITNDKGrLSPEEIDR-------------------- 530
XP_009519710 607 DGIPpMPRG-VPQIDV--TFDIDANGILNVSAVEK-STGKENKITITNDKGrLSQADIDR-------------------- 662
Q383E9       468 DGITpAKHG-EPTITV--TFSVDADGILTVTAAEE-LGSVTKTLVVENSER-LTSEEVQK-------------------- 522 Trypanosoma brucei
P0A6Z1       457 RGIPaLPAG-GAHIRV--TFQVDADGLLSVTAMEK-STGVEASIQVKPSYG-LTDSEIAS-------------------- 511 Escherichia col...
Q01100       433 SGIPpAPAG-TPQIEV--SFNIDENGIVNVEAEDK-GSGNKEDITIEGGAG-LSDDQIEE-------------------- 487 Haloarcula mari...
3C7N_A       538 vahtfgldakklneLIEKENEMLAQDKLVAETedrKNTLEEYIYTLRGKLEEEy---APFASDAEKtk--lqGMLNKAEE 612 baker's yeast
Q05036       545 esipvsydvqkfhnLELQMQESDAREKAKADA---KNSLEEYVYEMRDKVSDQy---AEFITPAAAde--frSVLTSTED 616 Caenorhabditis ...
P11021       541 --------------MVNDAEKFAEEDKKLKERidtRNELESYAYSLKNQIGDKek-lGGKLSSEDKet--meKAVEEKIE 603 human
P36604       546 --------------MVKEAEEFAEEDKILKERieaRNTLENYAYSLKGQFDDDeq-lGGKVDPEDKqa--vlDAVEDVAE 608 Schizosaccharom...
P22010       562 --------------MVEEAEKYAAEDAKFKAKseaRNTFENFVHYVKNSVNGEl---AEIMDEDDKet--vlDNVNESLE 622 Kluyveromyces l...
CAQ38673     531 --------------MVNDAEKYKAEDEENKNRieaRNSLENYCYGVKSSLEDQk--iKEKLQPSEIet--cmKSISSILE 592
XP_009519710 663 --------------MVAEAEKYKSEDEANKVRieaKNALENYAYNLRNTLNDEk--lKDQISEDDKka--idDKVTETIN 724
Q383E9       523 --------------MIEVAQKFALTDATALARmeaTERLTQWFDRLEAVMETVpqpySEKLQ---KriaflpHGKEWVGT 585 Trypanosoma brucei
P0A6Z1       512 --------------MIKDSMSYAEQDVKARMLaeqKVEAARVLESLHGALAAD-----AALLSAAEr-----QVIDDAAA 567 Escherichia col...
Q01100       488 --------------MQQEAEQHAEEDEQRRERieaRNEAEASVRRAETLLDEN----EEEIDEDLQ------SDIEAKIE 543 Haloarcula mari...
3C7N_A       613 WLYDEGfdsI---KAKYIAKYEELASLGNIIRGRYLA 646 baker's yeast
Q05036       617 WLYDEG---EdaeRDVYEKRLSELKAVGTPVVERYRE 650 Caenorhabditis elegans
P11021       604 WLESH----QdadIEDFKAKKKELEEIVQPIISKLYG 636 human
P36604       609 WLEIHG---EdasKEEFEDQRQKLDAVVHPITQKLYS 642 Schizosaccharomyces pombe 972h-
P22010       623 WLEDNS---DvaeAEDFEEKMASFKESVEPILAKASA 656 Kluyveromyces lactis NRRL Y-1140
CAQ38673     593 WLEKNql-aS---KEEYESKQKEAESVCAPIMSKIYQ 625
XP_009519710 725 WLDANqs-aE---KEEYEGKQKELEGVANPILQKMYa 757
Q383E9       586 QLHTYTdaaS---IEAKVAKIERLAKRALKSArregk 619 Trypanosoma brucei
P0A6Z1       568 HLSEVAqgdD---VDAIEQAIKNVDKQTQDFAARRMD 601 Escherichia coli K-12
Q01100       544 DVEEVLedeDa-tKEDYEAVTETLSEELQEIGKQMYQ 579 Haloarcula marismortui ATCC 43049
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