Conserved Protein Domain Family
DUF3730

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pfam12530: DUF3730 
Focadhesin/RST1, DUF3730
This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION 1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function in gliomas. RST1 was originally identified in a genetic screen for factors involved in the biosynthesis of epicuticular waxes. Later, RST1 and RST1 INTERACTING PROTEIN (RIPR) have been shown to act as cofactors of the cytoplasmic exosome and the Ski complex in plants. It is involved in the suppression of siRNA-mediated silencing of transgenes and certain endogenous transcripts. Structure predictions suggest that this is an alpha-helical domain with and armadillo-like fold.
Statistics
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PSSM-Id: 463619
Aligned: 30 rows
Threshold Bit Score: 129.702
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEF40946       82 LLELQSALEGT-DEKFVSLFVKGLGFLIRVGfnrnh---gswrFGSPENHPFVRILLCRtevqtELVQQVLLFMAKNMRL 157 
XP_009301365  492 LPVLMFKLSRVsDPALSLSVLYTLPKLGTHK------------LCIPQVLHVLQTVGSS-----SRLRPVALRLLALLWK 554 
EEB15748      277 LCLLFHKLVKEsHPIMQKKYLFCLPSLAVQK------------ENIPLIIGIIESLKKGn---sTIMTPVIIQLYLKLWK 341 
EDW01062      479 LMTYIFKLAHEhNPELQLELMRGLPSFAVSK------------DNVPMILNTIRNLSTDn-------GTFCVDLYLRLWR 539 
EDS25627      472 MTPMLYALANDtNPRKKLLLLQHLASMGAKD----------------HVLGVLKALSKDi------DRATSLDLYLRLWK 529 
EFX77621      442 LTLLLKKLTTPsNGKTKLAILYHLPSLAIDK------------TCVPRVLQIYEALSSS-----PQLKPVRIKLLADLWK 504 
XP_001629707  497 LPLLLYKLGKEaNPDLKLQILYTIPELATHK------------LSVAPVLRSVQTLSLS-----PALRSVALRLVCRVWM 559 
XP_003291326  582 IPLFFYAIQREeKSEVILELFETLPELAKNK------------DCFASVLKILSNLDQQkkkesSILPSFILRIYCKLWK 649 
KAE8278840    428 IPVLLFKLGKEkNPFQAHAVLNCLPNLGTHK------------LCVPMVLQTLQMLASA-----PKLRAVAMRLMTVLWK 490  large yellow ...
CAF93350        6 IPVLLYRLGRDrNPEVVHALLYCLPTLGTHRrlqlakvlallqLCIPLLLQTLSTLAAA-----PKMTAVAMRLLTALWK 80   spotted green...
EEF40946      158 GMVKVCEFLKPLAVFsilsipfsNSTSSLFARQLIPSMASFCCSlpeealpvlklLMGCLKYLPHKNSDVgilvyrildc 237 
XP_009301365  555 KQDRVYPDLQRLMCQl------dKSSVVMGKDTQWEQILARAAC-----------VRDICRERPYQHGGD---------- 607 
EEB15748      342 VDNRTYSYLHKMLH------------EYPSENLKLELNLSKAIA-----------LKEICCVAPHFHGKS---------- 388 
EDW01062      540 VEVRTYPFLLKQIA-----------QPLPDSDKRWETEIARTHA-----------MREICQEKPTLHGSE---------- 587 
EDS25627      530 AEPRTYPFLYDILK----------DTAVRPREDPWEVSFARTFT-----------IREICLIKPQQHGAD---------- 578 
EFX77621      505 IEDRVYPFLEKVLN--------------ADQQQTEEFLIAKATA-----------IDIICMNRSDKYGAE---------- 549 
XP_001629707  560 KQNRVFPHLHKALLG--------AKAGIRDKGLLMEVNVSVAAT-----------IRDICKHRASQHGGD---------- 610 
XP_003291326  650 SNSLVFPKIEELIYSviqqvqqqKEEETNKFDQLFEDKLSTAQT-----------IKDICEFDPDQ-GQE---------- 707 
KAE8278840    491 KQDRIYPELQRLLGQq-------DSRVVVGRDAQWEQVLARAAC-----------LRDICRERPYQHGGD---------- 542  large yellow ...
CAF93350       81 LQDRVYPELQLLLG---------RDSQVVGRDARWEQALARAAS-----------IRDICRQRPYQHGGD---------- 130  spotted green...
EEF40946      238 yyflecVVDAYTVVLrs-lVQTGLLVT--KAQLFGVELSETILSLlthvhgrsggaEpIVELVKRLIVIQKDLSLCY--- 311 
XP_009301365  608 ------MLAAIRDTL----LQFSRKDQa-TPVALALQALQELCRA-----------E-VVDICSTWKALSPKLLSDT--- 661 
EEB15748      389 ------VIGLLSKIL----NESEDEVHg-SASALSIEAVIELCKA-----------C-VIDISGTWDAIRPKLSIDK--- 442 
EDW01062      588 ------LLPHLSNTL----NSCTDESGd-LATSLALDAIYALCDS-----------H-TVNIASTWQALGSKFRSEQ--- 641 
EDS25627      579 ------LVNLFSEIL----SHPEDANNe-AAVALAIDAIAVLCEN-----------H-VVNIVSTWKVLGFKFSQEK--- 632 
EFX77621      550 ------LLSVISDLLnsslGKLTASSA--TIATLSLRSLVSLCRA-----------E-VVDLKSVWDLLAPKLNQDH--- 606 
XP_001629707  611 ------MLGILSNLInehtGKMAGDEKsaVVIVLSLQGIKALCEA-----------E-VVDLCTVWRVLAPKLSDDR--- 669 
XP_003291326  708 ------LIQPLSQFL------CKESNP--SILSLSCEALSSLCKY-----------E-IISFTSAWNVIKKNLGHEEgfe 761 
KAE8278840    543 ------MLAAITLTL----NQCTKPDMa-TPAALALQGLQELCRa------------eVVDIISTWRSLGPELSCDS--- 596  large yellow ...
CAF93350      131 ------MLAAITLTL----SQCSSPEMa-VPAAIALHGLKELCCA-----------E-VVDILSTWRSLGPRLSCDQ--- 184  spotted green...
EEF40946      312 ----IPELSSVILSSFAILIQSE----LEHEQLSLLKLVIFLVKW-KGENECAfDRATCALSEEV 367 
XP_009301365  662 ----RPLVLKATAELLALVPDLN----VKTEEYEKFGSEAVGVLW-GYALSQD-SVVASQGFKAL 716 
EEB15748      443 ----RPKVIKALCSFFGEIPNIH----IPEKKFDQLKEDIIPLLW-NFTFLNN-DEIAEEAFRAL 497 
EDW01062      642 ----RPQTLKSLYHLFGLVPLLQ----TPTLEYEKLADDALEQLWqAVSRPNTdATHVRNALVAL 698 
EDS25627      633 ----RPRIIRSLCNFFSNVPSIK----VNSIEQEKLVNEIITTLW-HFVTDFDdREVIVAALEAL 688 
EFX77621      607 ----RASVVSEMCNLLALTAELR----IDNEEYDEFIHQAILTLF-RVSLSTNvTEVHSLALRSL 662 
XP_001629707  670 ----RPAVMKCLCELFALVPRLA----TDTQQYQEFKQEVLGFLW-RMTRYRT-AWVSGAAFSAL 724 
XP_003291326  762 ndrrSPIVLVSLLEFFSNGINDFngqaSLEQKTIDVITDIIKRVW-NLSSHQD-SNVSSKAYYVL 824 
KAE8278840    597 ----RPLMVKAIAELLALVPQLN----VKSEEYEKLKEEVVSFLW-NYAASKD-SEVASCGYKAL 651  large yellow croaker
CAF93350      185 ----RPLMVQATAKLLALVPQLS----VPTEEYQKLKEEAVSLLW-NYAASQD-ADVASCGYEAL 239  spotted green pufferfish
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